Can increasing the dose of radiation by HDR brachytherapy boost following pre operative chemoradiotherapy for advanced rectal cancer improve surgical outcomes?

Colorectal Disease

Volumn 12, Issue SUPPL. 2, 2010, Pages 30-36

  Sun Myint, A ^a   Mukhopadhyay, T ^a   Ramani, V S ^a   Perkins, K ^a   Snee, A J ^a   Jelley, F ^a   Wong, H ^a   Lee, C D ^a  

^a CLATTERBRIDGE CENTRE FOR ONCOLOGY   (United Kingdom)

Author keywords

Advanced rectal cancer; Downstaging; HDR brachytherapy; Improve RO resection; Preoperative chemoradiotherapy; Tumour regression

Indexed keywords

CAPECITABINE; FLUOROURACIL;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BRACHYTHERAPY; CANCER CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER LOCALIZATION; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER REGRESSION; CANCER SURGERY; CONTROLLED STUDY; DRUG INFUSION; EXTERNAL BEAM RADIOTHERAPY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; METASTASIS; PILOT STUDY; PREOPERATIVE CARE; PRIORITY JOURNAL; RADIATION DOSE; RECTUM CANCER; SURGICAL TECHNIQUE; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR CLASSIFICATION; ADJUVANT THERAPY; CANCER STAGING; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; NEOPLASM RECURRENCE, LOCAL; PROCEDURES; RADIATION RESPONSE; RECTAL NEOPLASMS; SURVIVAL; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BRACHYTHERAPY; COMBINED MODALITY THERAPY; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PILOT PROJECTS; RECTAL NEOPLASMS; SURVIVAL ANALYSIS;

EID: 77954640754     PISSN: 14628910     EISSN: 14631318     Source Type: Journal    
DOI: 10.1111/j.1463-1318.2010.02322.x     Document Type: Article

References (16)

1. Sebag-Montefiore D, Steele R, Quirk P. Preliminary results of MRC CR07/NCIC CO16 randomised trial. J Clin Oncol 2006, 24. Proceedings of ASCO, Abst. 3511
2. Nagtegaal ID, Quirke P. What is the role for the circumferential margin in the modern treatment of rectal cancer. J Clin Oncol 2008, 26:303-12.
3. Sebag-Montefiore D, Glynn-Jones R, Mortensen N. Pooled analysis of out comes measures including the histopathological RO resection rate after preoperative chemoradiation for locally advanced rectal cancer. Colorectal Dis 2005, 7(Suppl.1). 020 abstract
4. Bosset JF, Collette L, Calais G. Chemotherapy with preoperative radiotherapy in Rectal Cancer. N Engl J Med 2006, 355:1114-23.
5. Gerard JP, Conroy T, Bonnetain F. Preoperative Radiotherapy with or without concurrent Fluorouracil and Leucovorin in T3-T4 rectal cancer: results of FFCD 9203. J Clin Oncol 2006, 24:4620-5.
6. Mohiuddin M, Regine WF, John WJ. Preoperative chemoradiation in fixed distal rectal cancer: dose time factors for pathological complete response. Int J Radiat Oncol Biol Phys 2000, 46:883-8.
7. Wiltshire K, Brierley J, Cummings B. Preoperative radiation with concurrent chemotherapy for resectable rectal cancer: effect of dose escalation on pathological complete response, local recurrence free survival, and disease free survival. Int J Radiat Oncol Biol Phys 2004, 60. ASTRO proc 46: Abstract1061
8. Gerard JP, Chapet O, Nermoz C. Improved sphincter preservation in low rectal cancer with high-dose preoperative radiotherapy: the Lyon R96-02 randomised trial. J Clin Oncol 2004, 22:2404-9.
9. Sun Myint A, Lee CD, Wong H. High dose rate brachytherapy as a boost after preoperative chemoradiotherapy for more advanced rectal tumours-Clatterbridge experience. Clin Oncol 2007, 19:711-9.
10. Papillon J. Present status of radiation therapy in the conservative management of rectal cancer. Radiother Oncol 1990, 17:275-83.
11. Yanagi H, Kusunoki M, Kamikonya N. Results of preoperative Intraluminal brachytherapy combined with radical surgery for middle and lower rectal carcinomas. J Surg Oncol 1997, 65:76-81.
12. Yanagi H, Kusunoki M, Yamamura T. The effectiveness of preoperative intraluminal brachytherapy in preventing wall penetration and nodal involvement of rectal cancer. Surg Today 2000, 30:410-5.
13. Borschitz T, Wachtlin D, Möhler M. Neoadjuvant Chemoradiation and Local Excision for T2-3 Rectal Cancer. Ann Surg Oncol 2008, 15:712-20.
14. Rodel C, Martus P, Papadoupolos T. Prognostic significance of tumour regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol 2005, 23(34):8688-8696.
15. Gollins S, Sun Myint S, Susnerwala S. Preoperative chemoradiotherapy using concurrent capecitabine and irinotecan in MRI defined locally advanced rectal cancer: impact on long-term clinical outcomes. J Clin Oncol 2010 Supp, 28(7S):3636. Proceedings of ASCO, Abstract no
16. Jakobsen J, Mortensen JP, Bisgaard C. Preoperative chemoradiation of locally advanced T3 rectal cancer combined with an endorectal boost. Int J Radiat Oncol Biol Phys 2006, 64:461-5.