Pterostilbene monograph

Alternative Medicine Review

Volumn 15, Issue 2, 2010, Pages 159-163

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

PTEROSTILBENE; STILBENE DERIVATIVE; UNCLASSIFIED DRUG; PROTECTIVE AGENT;

ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; DIABETES MELLITUS; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DYSLIPIDEMIA; HUMAN; INFECTION; NEOPLASM; NONHUMAN; REVIEW; ANIMAL; APOPTOSIS; DRUG EFFECTS; EVIDENCE BASED MEDICINE; INFLAMMATION; NEOPLASMS; PHYTOTHERAPY; PROCEDURES;

ANIMALS; APOPTOSIS; EVIDENCE-BASED MEDICINE; HUMANS; INFLAMMATION; NEOPLASMS; PHYTOTHERAPY; PROTECTIVE AGENTS; STILBENES;

EID: 77954628599     PISSN: 10895159     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (43)

1. Bavaresco L, Fregoni C, Cantu E, Trevisan M. Stilbene compounds: from the grapevine to wine. Drugs Exp Clin Res 1999;25:57-63.
2. Langcake P, Cornford CA, Pryce RJ. Identification of pterostilbene as a phytoalexin from Vitis vinifera leaves. Phytochemistry 1979;18:1025-1027.
3. Pezet R, Pont V. Identification of pterostilbene in grape berries of Vitis vinifera. Plant Physiol Biochem (Paris) 1988;26:603-607.
4. Gehm BD, Levenson AS, Liu H, et al. Estrogenic effects of resveratrol in breast cancer cells expressing mutant and wild-type estrogen receptors: role of AF-1 and AF-2. J Steroid Biochem Mol Biol 2004;88:223-234. (Pubitemid 38553755)
5. Paul B, Masih I, Deopujari J, Charpentier C. Occurrence of resveratrol and pterostilbene in age-old darakchasava, an Ayurvedic medicine from India. J Ethnopharmacol 1999; 68:71-76. (Pubitemid 29502461)
6. Maurya R, Singh R, Deepak M, et al. Constituents of Pterocarpus marsupium: an Ayurvedic crude drug. Phytochemistry 2004;65:915-920. (Pubitemid 38471771)
7. Joseph JA, Fisher DR, Cheng V, et al. Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging. J Agric Food Chem 2008;56:10544-10551.
8. Grover JK, Vats V, Yadav SS. Pterocarpus marsupium extract (Vijayasar) prevented the alteration in metabolic patterns induced in the normal rat by feeding an adequate diet containing fructose as sole carbohydrate. Diabetes Obes Metab 2005;7:414-420. (Pubitemid 40916584)
9. Manickam M, Ramanathan M, Jahromi MA, et al. Antihyperglycemic activity of phenolics from Pterocarpus marsupium. J Nat Prod 1997;60:609-610. (Pubitemid 27274379)
10. Pan MH, Chiou YS, Chen WJ, et al. Pterostilbene inhibited tumor invasion via suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells. Carcinogenesis 2009;30:1234-1242.
11. Suh N, Paul S, Hao X, et al. Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats. Clin Cancer Res 2007;13:350-355.
12. Ferrer P, Asensi M, Segarra R, et al. Association between pterostilbene and quercetin inhibits metastatic activity of B16 melanoma. Neoplasia 2005;7:37-47.
13. Paul S, Rimando AM, Lee HJ, Ji Y et al. Anti-inflammatory action of pterostilbene is mediated through the p38 mitogen-activated protein kinase pathway in colon cancer cells. Cancer Prev Res (Phila Pa) 2009;2:650-657.
14. Rimando AM, Suh N. Biological/chemopreventive activity of stilbenes and their effect on colon cancer. Planta Med 2008;74:1635-1643.
15. Pan MH, Chang YH, Badmaev V, et al. Pterostilbene induces apoptosis and cell cycle arrest in human gastric carcinoma cells. J Agric Food Chem 2007;55:7777-7785.
16. Rimando AM, Nagmani R, Feller DR, Yokoyama W. Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters. J Agric Food Chem 2005;53:3403-3407.
17. Satheesh MA, Pari L. Effect of pterostilbene on lipids and lipid profiles in streptozotocin-nicotinamide induced type 2 diabetes mellitus. J Appli Biomed 2008;6:31-37.
18. Satheesh MA, Pari L. The antioxidant role of pterostilbene in streptozotocin-nicotinamide-induced type 2 diabetes mellitus in Wistar rats. J Pharm Pharmacol 2006;58:1483-1490. (Pubitemid 44785537)
19. Hougee S, Faber J, Sanders A, et al. Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers. Planta Med 2005;71:387-392. (Pubitemid 40839768)
20. Schmidlin L, Poutaraud A, Claudel P, et al. A stress-inducible resveratrol O-methyltransferase involved in the biosynthesis of pterostilbene in grapevine. Plant Physiol 2008;148:1630-1639.
21. Rimando AM, Cuendet M, Desmarchelier C, et al. Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. J Agric Food Chem 2002;50:3453-3457. (Pubitemid 34580577)
22. de la Lastra CA, Villegas I. Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res 2005;49:405-430. (Pubitemid 40780389)
23. Remsberg CM, Yáñez JA, Ohgami Y, et al. Pharmacometrics of pterostilbene: preclinical pharmacokinetics and metabolism, anticancer, antiinflammatory, antioxidant and analgesic activity. Phytother Res 2008;22:169-179. (Pubitemid 351363234)
24. Lin HS, Yue BD, Ho PC. Determination of pterostilbene in rat plasma by a simple HPLC-UV method and its application in pre-clinical pharmacokinetic study. Biomed Chromatogr 2009; 23:1308-15.
25. Jeandet P, Douillet-Breuil AC, Bessis R, et al. Phytoalexins from the Vitaceae: biosynthesis phytoalexin gene expression in transgenic plants, antifungal activity, and metabolism. J Agric Food Chem 2002;50:2731-2741 (Pubitemid 34493577)
26. Gastaminza P, Whitten-Bauer C, Chisari FV. Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection. Proc Natl Acad Sci U S A 2010;107:291-296.
27. Pan Z, Agarwal AK, Xu T, et al. Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol. BMC Med Genomics 2008;1:7.
28. Stivala LA, Savio M, Carafoli F, et al. Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol. J Biol Chem 2001;276:22586-22594.
29. Amorati R, Lucarini M, Mugnaini V, et al. Antioxidant activity of hydroxystilbene derivatives in homogenous solution. J Org Chem 2004;69:7101-7107.
30. Perecko T, Jancinova V, Drabikova K, et al. Structure-efficiency relationship in derivatives of stilbene. Comparison of resveratrol, pinosylvin and pterostilbene. Neuro Endocrinol Lett 2008; 29:802-805.
31. Pari L, Satheesh MA. Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin- and nicotinamide-induced diabetic rats. Life Sci 2006;79:641-645.
32. Mikstacka R, Przybylska D, Rimando AM, Baer-Dubowska W. Inhibition of human recombinant cytochromes P450 CYP1A1 and CYP1B1 by trans-resveratrol methyl ethers. Mol Nutr Food Res 2007;51:517-524. (Pubitemid 47083688)
33. Mikstacka R, Rimando AM, Szalaty K, et al. Effect of natural analogues of trans-resveratrol on cytochromes P450 1A2 and 2E1 catalytic activities. Xenobiotica 2006;36:269-285. (Pubitemid 43754754)
34. Rakic B, Sagan SM, Noestheden M, et al. Peroxisome proliferator-activated receptor alpha antagonism inhibits hepatitis C virus replication. Chem Biol 2006;13:23-30. (Pubitemid 43099921)
35. Paul S, Decastro A, Lee HJ, et al. Dietary intake of pterostilbene, a constituent of blueberries, inhibits the (beta)-catenin/p65 downstream signaling pathway and colon carcinogenesis in rats. Carcinogenesis. 2010 Jan 8. [Epub ahead of print]
36. Ferrer P, Asensi M, Priego S, et al. Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma. J Biol Chem 2007;282:2880-2890. (Pubitemid 47086274)
37. Schneider JG, Alosi JA, McDonald DE, McFadden DW. Effects of pterostilbene on melanoma alone and in synergy with inositol hexaphosphate. Am J Surg 2009;198:679-684.
38. Mannal PW, Alosi JA, Schneider JG, et al. Pterostilbene inhibits pancreatic cancer in vitro. J Gastrointest Surg 2010;14:873-879.
39. Schneider JG, Alosi JA, McDonald DE, McFadden DW. Pterostilbene inhibits lung cancer through induction of apoptosis. J Surg Res 2010;161:18-22.
40. Alosi JA, McDonald DE, Schneider JS, Privette AR, McFadden DW. Pterostilbene inhibits breast cancer in vitro through mitochondrial depolarization and induction of caspase-dependent apoptosis. J Surg Res 2010;161:195-201.
41. Cichocki M, Paluszczak J, Szaefer H, et al. Pterostilbene is equally potent as resveratrol in inhibiting 12-0-tetradecanoylphorbol-13-acetate activated NFkappaB, AP-1, COX-2, and iNOS in mouse epidermis. Mol Nutr Food Res 2008;52 Suppl 1:S62-70.
42. Kim JS, Ha TY, Ahn J, et al. Pterostilbene from Vitis coignetiae protect H2O2-induced inhibition of gap junctional intercellular communication in rat liver cell line. Food Chem Toxicol 2009;47:404-409.
43. Ruiz MJ, Fernández M, Picó Y, et al. Dietary administration of high doses of pterostilbene and quercetin to mice is not toxic. J Agric Food Chem 2009;57:3180-3186.