Role of exogenous melatonin on adriamycin-induced changes in the rat heart

European Review for Medical and Pharmacological Sciences

Volumn 14, Issue 5, 2010, Pages 435-441

  Aydemir, Songul ^a   Ozdemir I ^a   Kart, A ^b  

^a INONU UNIVERSITY   (Turkey)

^b KAFKAS UNIVERSITY   (Turkey)

Author keywords

Adriamycin; Catalase; Melatonin; Superoxide dismutase; TBARS

Indexed keywords

CATALASE; DOXORUBICIN; MELATONIN; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; ANTINEOPLASTIC ANTIBIOTIC; ANTIOXIDANT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; ENZYME ACTIVITY; HEART PROTECTION; LIPID PEROXIDATION; NONHUMAN; RAT; SINGLE DRUG DOSE; ANIMAL; CARDIOMYOPATHY; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; METABOLISM; OXIDATIVE STRESS; WISTAR RAT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIOXIDANTS; CARDIOMYOPATHIES; CATALASE; DOXORUBICIN; LIPID PEROXIDATION; MELATONIN; OXIDATIVE STRESS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 77954627162     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. OUTOMURO D, GRANA DR, AZZATO F, MILEI J. Adriamycin-induced myocardial toxicity: new solutions for an old problem? Int J Cardiol 2007; 117: 6-15.
2. SIMUNEK T, STERBA M, POPELOVA O, ADAMCOVA M, HRDINA R, GERSL V. Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron. Pharmacol Reports 2009; 61: 154-171.
3. TAKEMURA G, FUJIWARA H. Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to management. Prog Cardiovasc Dis 2007; 49: 330-352.
4. DAVIES KJ, DOROSHOW JH. Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase. J Biol Chem 1986; 261: 3060-3067.
5. OLSON RD, MUSHLIN PS. Doxorubicin cardiotoxicity: analysis of prevailing hypotheses. FASEB J 1990; 4: 3076-3086.
6. KUMAR D, KIRSHENBAUM L, LI T, DANELISEN I, SINGAL PK. Apoptosis in isolated adult cardiomyocytes exposed to adriamycin. Ann N Y Acad Sci 1999; 874: 156-168.
7. ILISKOVIC N, SINGAL PK. Lipid lowering: an important factor in preventing adriamycin-induced heart failure. Am J Pathol 1997; 150: 727-734.
8. JEYASEELAN R, POIZAT C, WU HY, KEDES L. Molecular mechanisms of doxorubicin-induced cardiomyopathy. Selective suppression of Reiske iron-sulfur protein, ADP/ATP translocase, and phosphofructokinase genes is associated with ATP depletion in rat cardiomyocytes. J Biol Chem 1997; 272: 5828-5832.
9. FABER M, COUDRAY C, HIDA H, MOUSSEAU M, FAVIER A. Lipid peroxidation products, and vitamin and trace element status in patients with cancer before and after chemotherapy, including adriamycin. A preliminary study. Biol Trace Elem Res 1995; 47: 117-123.
10. SINGAL PK, SIVESKI-ILISKOVIC N, HILL M, THOMAS TP, LI T. Combination therapy with probucol prevents adriamycin-induced cardiomyopathy. J Mol Cell Cardiol 1995; 27: 1055-1063.
11. MIMNAUGH EG, TRUSH MA, BHATNAGAR M, GRAM TE. Enhancement of reactive oxygen-dependent mitochondrial membrane lipid peroxidation by the anticancer drug adriamycin. Biochem Pharmacol 1985; 34: 847-856.
12. LUO X, EVROVSKY Y, COLE D, TRINES J, BENSON LN, LEHOTAY DC. Doxorubicin-induced acute changes in cytotoxic aldehydes, antioxidant status and cardiac function in the rat. Biochim Biophys Acta 1997; 1360: 45-52.
13. ODOM AL, HATWIG CA, STANLEY JS, BENSON AM. Biochemical determinants of adriamycin toxicity in mouse liver, heart and intestine. Biochem Pharmacol 1992; 43: 831-836.
14. KIM SY, KIM SJ, KIM BJ, RAH SY, CHUNG SM, IM MJ, KIM UH. Doxorubicin-induced reactive oxygen species generation and intracellular Ca2+ increase are reciprocally modulated in rat cardiomyocytes. Exp Mol Med 2006; 38: 535-545.
15. MORISHIMA I, MATSUI H, MUKAWA H, HAYASHI K, TOKI Y, OKUMURA K, ITO T, HAYAKAWA T. Melatonin, a pineal hormone with antioxidant proper ty, protects against adriamycin cardiomyopathy in rats. Life Sci 1998; 63: 511-521.
16. CAO Y, KENNEDY R, KLIMBERG VS. Glutamine protects against doxorubicin-induced cardiotoxicity. J Surg Res 1999; 85: 178-182.
17. VENKATESAN N. Curcumin attenuation of acute adriamycin myocardial toxicity in rats. Br J Pharmacol 1998; 124: 425-427.
18. KOCAK G, ERBIL KM, OZDEMIR I, AYDEMIR S, SUNAR B, TUNCEL M, ATALAY S. The protective effect of melatonin on adriamycin-induced acute cardiac injury. Can J Cardiol 2003; 19: 535-541.
19. ERTEN SF, KOCAK A, OZDEMIR I, AYDEMIR S, COLAK A, REEDER BS. Protective effect of melatonin on experimental spinal cord ischemia. Spinal Cord 2003; 41: 533-538.
20. REITER RJ, TANG L, GARCIA JJ, MUNOZ-HOYOS A. Pharmacological actions of melatonin in oxygen radical pathophysiology. Life Sci 1997; 60: 2255-2271.
21. REITER RJ, TAN DX. Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart.Cardiovasc Res 2003; 58: 10-19.
22. GILAD E, CUZZOCREA S, ZINGARELLI B, SALZMAN AL, SZABO C. Melatonin is a scavenger of peroxynitrite. Life Sci 1997; 60: PL169-174.
23. RAYNAUD F, MAUVIARD F, GEOFFRIAU M, CLAUSTRAT B, PEVET P. Plasma 6-hydroxymelatonin, 6-sulfa-toxymelatonin and melatonin kinetics after melatonin administration to rats. Biol Signals 1993; 2: 358-366.
24. RODRIGUEZ C, MAYO JC, SAINZ RM, ANTOLIN I, HERRERA F, MARTIN V, REITER RJ. Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 2004; 36: 1-9.
25. KOTLER M, RODRIGUEZ C, SAINZ RM, ANTOLIN I, MENENDEZ-PELAEZ A. Melatonin increases gene expression for antioxidant enzymes in rat brain cortex. J Pineal Res 1998; 24: 83-89.
26. OKHAWA H, OOHISHI N, YAGI N. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Ann Biochem 1979; 95: 351-358.
27. MCCORD JM, FRIDOVICH I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 1969; 244: 6049-6055.
28. LUCK H. Catalase. New York: Academic Press, 1963.
29. LOWRY OH, ROSEBROUGH NJ, FARR AL, RANDALL RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-275.
30. OTHMAN AI, EL-MISSIRY MA, AMER MA, ARAFA M. Melatonin controls oxidative stress and modulates iron, ferritin, and transferrin levels in adriamycin treated rats. Life Sci 2008; 83: 563-568.
31. LIU B, LI H, QU H, SUN B. Nitric oxide synthase expressions in ADR-induced cardiomyopathy in rats. J Biochem Mol Biol 2006; 39: 759-765.
32. WU S, KO YS, TENG MS, KO YL, HSU LA, HSUEH C, CHOU YY, LIEW CC, LEE YS. Adriamycin-induced cardiomyocyte and endothelial cell apoptosis: in vitro and in vivo studies. J Mol Cell Cardiol 2002; 34: 1595-1607.
33. SCHIMMEL KJ, RICHEL DJ, VAN DEN BRINK RB, GUCHELAAR HJ. Cardiotoxicity of cytotoxic drugs. Cancer Treat Rev 2004; 30: 181-191.
34. AHMED HH, MANNAA F, ELMEGEED GA, DOSS SH. Cardioprotective activity of melatonin and its novel synthesized derivatives on doxorubicin-induced cardiotoxicity. Bioorg Med Chem 2005; 13: 1847-1857.
35. MAHIEU S, CONTINI MDEL C, GONZALEZ M, MILLEN N. Melatonin reduces oxidative damage induced by aluminium in rat kidney. Toxicol Lett 2009; 190: 9-15.
36. TENGATTINI S, REITER RJ, TAN DX, TERRON MP, RODELLA LF, REZZANI R. Cardiovascular diseases: protective effects of melatonin. J Pineal Res 2008; 44: 16-25.
37. LIN HW, LEE EJ. Effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages. Neuropsychiatr Dis Treat 2009; 5: 157-162.
38. DZIEGIEL P, MURAWSKA-CLALOWICZ E, JETHON Z, JANUSZEWSKA L, PODHORSKA-OKOLOW M, SUROWIAK P, ZAWADZKI M, RABCZYNSKI J, ZABEL M. Melatonin stimulates the activity of protective antioxidative enzymes in myocardial cells of rats in the course of doxorubicin intoxication. J Pineal Res 2003; 35: 183-187.
39. COLE MP, CHAISWING L, OBERLEY TD, EDELMANN SE, PIASCIK MT, LIN SM, KININGHAM KK, ST CLAIR DK. The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity. Cardiovasc Res 2006; 69: 186-197.