Anti-inflammatory effect of Guan-Xin-Er-Hao via the nuclear factor-kappa B signaling pathway in rats with acute myocardial infarction

Experimental Animals

Volumn 59, Issue 2, 2010, Pages 207-214

  Zhang, Xue Ya ^a   Huang, Xi ^a,b   Qin, Feng ^b   Ren, Ping ^b  

^a SICHUAN UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Acute myocardial infarction; Anti inflammatory; Guan xin er hao; Nf kb pathway; Traditional chinese medicine

Indexed keywords

C REACTIVE PROTEIN; CHINESE DRUG; GUAN XIN ER HAO; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; PHENOBARBITAL; SODIUM CHLORIDE; TRIPHENYLTETRAZOLIUM; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG DOSE COMPARISON; DRUG EFFICACY; HEART INFARCTION SIZE; HEART LEFT VENTRICLE; HEART PROTECTION; MALE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HEART; IMMUNOENZYME TECHNIQUES; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

RATTUS;

EID: 77954617997     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.59.207     Document Type: Article

References (37)

1. Bassuk, S.S., Rifai, N., and Ridker, P.M. 2004. High- sensitivity C-reactive protein: clinical importance. Curr. Probl. Cardiol. 29: 439-493.
2. Chen, K.J. 1981. Certain progress in the treatment of coronary heart disease with traditional medicinal plants in China. Am. J. Chin. Med. 9: 193-196.
3. Chung, H.Y., Cesari, M., Anton, S., Marzetti, E., Giovannini, S., Seo, A.Y., Carter, C, Yu, B.P., and Leeuwenburgh, C. 2009. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res. Rev. 8: 18-30.
4. Ding, G., Cheng, L., Qin, Q., Frontin, S., and Yang, Q. 2006. PPARdelta modulates lipopolysaccharide-induced TNFalpha inflammation signaling in cultured cardiomyocytes. J. Mol. Cell. Cardiol. 40: 821-828.
5. Frantz, S. 2005. Drug discovery: playing dirty. Nature 437: 942-943.
6. Gabriel, A.S., Martinssona, A., Wretlind, B., and Ahnve, S. 2004. IL-6 levels in acute and post myocardial infarction: their relation to CRP levels, infarction size, left ventricular systolic function, and heart failure. Eur. J. Intern. Med. 15: 523-528.
7. Gao, H.L., Li, Y.K., Tong, Y, and Li, L.D. 2007. Comparative study on the protective effects of different Guanxin II Formula on acute myocardial ischemia in dogs. Pharmacol. Clin. Chin. Mater. Med. 23: 1-4 (in Chinese).
8. Gao, H.L., Li, Y.K., Tong, Y, and Li, L.D. 2008. The study of Guanxin II formula on myocardial ischemia in rats. ShangXi J. Tradit. Chin. Med. 29: 231-233 (in Chinese).
9. Gilles, S., Zahler, S., Welsch, U., Sommerhoff, C.P., and Becker, B.F. 2003. Release of TNF-alpha during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers. Cardiovasc. Res. 60: 608-616.
10. Hamirani, Y.S., Pandey, S., Rivera, J.J., Ndumele, C, Budoff, M.J., Blumenthal, R.S., and Nasir, K. 2008. Markers of inflammation and coronary artery calcification: a systematic review. Atherosclerosis 201: 1-7.
11. Huang, X. 2002. Idea, background and significance of traditional Chinese medicine research according to bioethnopharmaceutical analyses. Zhongguo Zhong Xi Yi Me He Za Zhi 2: 251-252 (in Chinese).
12. Huang, X., Qin, F., Zhang, H.M., Xiao, H.B., Wang, L.X., Zhang, X.Y, and Ren, P. 2009. Cardioprotection by Guanxin II in rats with acute myocardial infarction is related to its three compounds. J. Ethnopharmacol. 121: 268-273.
13. Kanda, T. and Takahashi, T. 2004. Interleukin-6 and cardiovascular diseases. Jpn. Heart J. 45: 183-193.
14. Kobayashi, S., Nagino, M., Komatsu, S., Naruse, K., Nimura, Y, Nakanishi, M., and Sokabe, M. 2003. Stretch-induced IL-6 secretion from endothelial cells requires NF-kappaB activation. Biochem. Biophys. Res. Commun. 308: 306- 312.
15. Koenen, R.R. and Hundelshausen, P. 2008. The chemokine system as therapeutic target in cardiovascular disease. Drug Discov. Today Dis. Mech. 5: e285-292.
16. Laws, P.E., Spark, J.I., Cowled, P.A., and Fitridge, R.A. 2004. The role of statins in vascular disease. Eur. J. Vase. Endovasc. Surg. 27: 6-16.
17. Li, J.J. and Fang, C.H. 2004. C-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular disease. Med. Hypotheses 62: 499-506.
18. Li, X., Li, C, Ji, X., Song, Z., Wang, L., Zhang, J., and Zhang, Y. 2008. Huang-Lian-Jie-Du-Tang inhibits myocardial remodeling in a rat model of metabolic syndrome. J. Ethnopharmacol. 119: 259-265.
19. Lopez, L., Arai, K., Gimenez, E., Jimenez, M., Pascuzo, C., Rodriguez-Bonfante, C., and Bonfante-Cabarcas, R. 2006. C-reactive protein and interleukin-6 serum levels increase as Chagas disease progresses towards cardiac failure. Rev. Esp. Cardiol. 59: 50-56.
20. Maehir, F., Miyagi, I., and Eguchi, Y. 2003. Selenium regulates transcription factor NF-kappaB activation during the acute phase reaction. Clin. Chim. Ada 334: 163-171.
21. Maulik, N., Engelman, R.M., Rousou, J.A., Flack, J.E. 3rd., Deaton, D., and Das, D.K. 1999. Ischemic preconditioning reduces apoptosis by upregulating anti-death gene Bcl-2. Circulation 100: 369-375.
22. Pinkie, D. 1958. The use of body surface area as a criterion of drug dosages in cancer chemotherapy. Cancer Res. 18: 853-856.
23. Pudil, R., Pidrman, V., Krejsek, J., Gregor, J., Tichy, M., AndrDs, C., and Drahosova, M. 1999. Cytokines and adhesion molecules in the course of acute myocardial infarction. Clin. Chim. Ada 280: 127-134.
24. Qin, F., Liu, Y.X., Zhao, H.W., Huang, X., Ren, P., and Zhu, Z.Y. 2009. Chinese medicinal formula Guan-Xin-Er-Hao protects the heart against oxidative stress induced by acute ischemic myocardial injury in rats. Phytomedicine 16: 215-221.
25. Ross, R. 1999. Atherosclerosis-An inflammatory disease. N. Engl. J. Med. 340: 115-126.
26. Schins, A., Tulner, D., Lousberg, R., Kenis, G., Delanghe, J., Crijns, H.J, Grauls, G., Stassen, F., Maes, M., and Honig, A. 2005. Inflammatory markers in depressed post-myocardial infarction patients. J. Psychiatr. Res. 39: 137-144.
27. Wang, L., Zhou, G.B., Liu, P., Song, J.H., Liang, Y, Yan, X.J., Xu, F., Wang, B.S., Mao, J.H., Shen, Z.X., Chen, S.J., and Chen, Z. 2008. Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc. Natl. Acad. Sci.USA. 105: 4826-4831.
28. Wei, H., Yang, L., Li, Q., and Li, L. 2008. Effects of Guanxin II formula on myocardial apoptosis of acute myocardial ischemia in rats. Pharmacol. Clin. Chin. Mater. Med. 24: 1-2 (in Chinese).
29. Wongcharoen, W. and Phrommintikul, A. 2009. The protective role of curcumin in cardiovascular diseases. Int. J. Cardiol. 133: 145-151.
30. Xu, R., Huang, X., Li, Y, Zhang, L., Wang, L.L., and Cui, P. 2001. Clinical observation in the treatment of coronary heart disease with angina pectoris with traditional Chinese prescription Guanxin II. J. Chengdu Univ. TCM 24: 17-19 (in Chinese).
31. Yamashita, N., Hoshida, S., Taniguchi, N., Kuzuya, T., and Hori, M. 1998. A second window of protection occurs 24 h after ischemic preconditioning in the rat heart. J. Mol. Cell. Cardiol. 30: 1181-1189.
32. Ye, G., Li, Y.Z., Li, Y.Y., Guo, H.Z., and Guo, D.A. 2003. SPE-HPLC method for the determination and pharmacokinetic studies on paeoniflorin in rat serum after oral administration of traditional Chinese medicinal preparation Guan-Xin-Er- Hao decoction. J. Pharm. Biomed. Anal. 33: 521-527.
33. Yuan, Z., Liu, Y, Liu, Y, Zhang, J., Kishimoto, C, Wang, Y., Ma, A., and Liu, Z. 2005. Cardioprotective effects of peroxisome proliferator activated receptor gamma activators on acute myocarditis: anti-inflammatory actions associated with nuclear factor kappaB blockade. Heart 91: 1203- 1208.
34. Zeng, X., He, H., Yang, J., Yang, X., Wu, L., Yu, J., and Li, L. 2008. Temporal effect of Guanxin No. 2 on cardiac function, blood viscosity and angiogenesis in rats after long- term occlusion of the left anterior descending coronary artery. J. Ethnopharmacol. 118: 485-94.
35. Zhang, B., Wang, Y, Wang, C, and Ke, J. 2005. Effect of Shenfu injection on nuclear factor-kappaB during myocardial ischemia/reperfusion injury in rats. Chin. J. Traumatol. 8: 200-204.
36. Zhao, H.W., Qin, F., Liu, Y.X., Huang, X., and Ren, P. 2008. Antiapoptotic mechanisms of Chinese medicine formula, Guan-Xin-Er-Hao, in the rat ischemic heart. Tohoku J. Exp. Med. 216:309-316.
37. Zhao, J., Huang, X., Tang, W., Ren, P., Xing, Z., Tian, X., Zhu, Z., and Wang, Y. 2007. Effect of oriental herbal prescription Guan-Xin-Er-Hao on coronary flow in healthy volunteers and anti-apoptosis on myocardial ischemia- reperfusion in rat models. Phytother. Res. 21: 926-931.