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Volumn 103, Issue 12, 2010, Pages 1746-1754

Dietary supplementation with medium-chain TAG has long-lasting cognition-enhancing effects in aged dogs

Author keywords

Brain ageing; Cognitive functions; Dogs; Ketone bodies; Medium chain TAG

Indexed keywords

3 HYDROXYBUTYRIC ACID; MEDIUM CHAIN TRIACYLGLYCEROL; KETONE BODY; TRIACYLGLYCEROL;

EID: 77954616718     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510000097     Document Type: Article
Times cited : (106)

References (30)
  • 2
    • 33847760962 scopus 로고    scopus 로고
    • The canine model of human brain aging: Cognition, behavior and neuropathology
    • Burlington, MA: Academic Press
    • Tapp PD & Siwak CT (2006) The canine model of human brain aging: cognition, behavior and neuropathology. In Handbook of Models for Human Aging, pp. 415-434. Burlington, MA: Academic Press.
    • (2006) Handbook of Models for Human Aging , pp. 415-434
    • Tapp, P.D.1    Siwak, C.T.2
  • 3
    • 0020350534 scopus 로고
    • Brain metabolism and blood flow during development and aging of the Fischer-344 rat
    • Rapoport SI, London ED & Takei H (1982) Brain metabolism and blood flow during development and aging of the Fischer-344 rat. Exp Brain Res Suppl 5, 86-101.
    • (1982) Exp Brain Res Suppl , vol.5 , pp. 86-101
    • Rapoport, S.I.1    London, E.D.2    Takei, H.3
  • 4
    • 0021051719 scopus 로고
    • Regional cerebral metabolic rate for glucose in beagle dogs of different ages
    • London ED, Ohata M, Takei H, et al. (1983) Regional cerebral metabolic rate for glucose in beagle dogs of different ages. Neurobiol Aging 4, 121-126.
    • (1983) Neurobiol Aging , vol.4 , pp. 121-126
    • London, E.D.1    Ohata, M.2    Takei, H.3
  • 5
    • 0037123756 scopus 로고    scopus 로고
    • Age-related changes in cerebral blood flow and glucose metabolism in conscious rhesus monkeys
    • Noda A, Ohba H, Kakiuchi T, et al. (2002) Age-related changes in cerebral blood flow and glucose metabolism in conscious rhesus monkeys. Brain Res 936, 76-81.
    • (2002) Brain Res , vol.936 , pp. 76-81
    • Noda, A.1    Ohba, H.2    Kakiuchi, T.3
  • 6
    • 0034544570 scopus 로고    scopus 로고
    • Comparison of regional cerebral blood flow and glucose metabolism in the normal brain: Effect of aging
    • Bentourkia M, Bol A, Ivanoiu A, et al. (2000) Comparison of regional cerebral blood flow and glucose metabolism in the normal brain: effect of aging. J Neurol Sci 181, 19-28.
    • (2000) J Neurol Sci , vol.181 , pp. 19-28
    • Bentourkia, M.1    Bol, A.2    Ivanoiu, A.3
  • 7
    • 0036235195 scopus 로고    scopus 로고
    • Longitudinal PET evaluation of cerebral metabolic decline in dementia: A potential outcome measure in Alzheimer's disease treatment studies
    • Alexander GE, Chen K, Pietrini P, et al. (2002) Longitudinal PET evaluation of cerebral metabolic decline in dementia: a potential outcome measure in Alzheimer's disease treatment studies. Am J Psychiatry 159, 738-745.
    • (2002) Am J Psychiatry , vol.159 , pp. 738-745
    • Alexander, G.E.1    Chen, K.2    Pietrini, P.3
  • 8
    • 0042736668 scopus 로고    scopus 로고
    • Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: A PET follow-up study
    • Drzezga A, Lautenschlager N, Siebner H, et al. (2003) Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study. Eur J Nucl Med Mol Imaging 30, 1104-1113.
    • (2003) Eur J Nucl Med Mol Imaging , vol.30 , pp. 1104-1113
    • Drzezga, A.1    Lautenschlager, N.2    Siebner, H.3
  • 9
    • 1942532069 scopus 로고    scopus 로고
    • High carbohydrate diets and Alzheimer's disease
    • Henderson ST (2004) High carbohydrate diets and Alzheimer's disease. Med Hypotheses 62, 689-700.
    • (2004) Med Hypotheses , vol.62 , pp. 689-700
    • Henderson, S.T.1
  • 10
    • 1242338801 scopus 로고    scopus 로고
    • Effects of b-hydroxybutyrate on cognition in memory-impaired adults
    • Reger MA, Henderson ST, Hale C, et al. (2004) Effects of b-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging 25, 311-314.
    • (2004) Neurobiol Aging , vol.25 , pp. 311-314
    • Reger, M.A.1    Henderson, S.T.2    Hale, C.3
  • 11
    • 65549125306 scopus 로고    scopus 로고
    • Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia
    • Page KA, Williamson A, Yu N, et al. (2009) Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia. Diabetes 58, 1237-1244.
    • (2009) Diabetes , vol.58 , pp. 1237-1244
    • Page, K.A.1    Williamson, A.2    Yu, N.3
  • 12
    • 0036819096 scopus 로고    scopus 로고
    • Landmark discrimination learning in the dog: Effects of age, an antioxidant fortified diet, and cognitive strategy
    • Milgram NW, Head E, Muggenburg B, et al. (2002) Landmark discrimination learning in the dog: effects of age, an antioxidant fortified diet, and cognitive strategy. Neurosci Biobehav Rev 26, 679-695.
    • (2002) Neurosci Biobehav Rev , vol.26 , pp. 679-695
    • Milgram, N.W.1    Head, E.2    Muggenburg, B.3
  • 13
    • 35948957816 scopus 로고    scopus 로고
    • Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests
    • Milgram NW, Araujo JA, Hagen TM, et al. (2007) Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests. J FASEB 13, 3756-3762.
    • (2007) J FASEB , vol.13 , pp. 3756-3762
    • Milgram, N.W.1    Araujo, J.A.2    Hagen, T.M.3
  • 14
    • 15744381465 scopus 로고    scopus 로고
    • A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog
    • Christie LA, Studzinski CM, Araujo JA, et al. (2005) A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog. Prog Neuropsychopharmacol Biol Psychiatry 29, 361-369.
    • (2005) Prog Neuropsychopharmacol Biol Psychiatry , vol.29 , pp. 361-369
    • Christie, L.A.1    Studzinski, C.M.2    Araujo, J.A.3
  • 15
    • 0036752043 scopus 로고    scopus 로고
    • Dietary enrichment counteracts age-associated cognitive dysfunction in canines
    • Milgram NW, Zicker SC, Head E, et al. (2002) Dietary enrichment counteracts age-associated cognitive dysfunction in canines. Neurobiol Aging 23, 737-745.
    • (2002) Neurobiol Aging , vol.23 , pp. 737-745
    • Milgram, N.W.1    Zicker, S.C.2    Head, E.3
  • 16
    • 0035999629 scopus 로고    scopus 로고
    • Visuospatial impairments in aged canines: The role of cognitive-behavioral flexibility
    • Chan ADF, Nippak P, Murphey H, et al. (2002) Visuospatial impairments in aged canines: the role of cognitive-behavioral flexibility. Behav Neurosci 116, 443-454.
    • (2002) Behav Neurosci , vol.116 , pp. 443-454
    • Adf, C.1    Nippak, P.2    Murphey, H.3
  • 17
    • 77955775648 scopus 로고    scopus 로고
    • Five minute veterinary consult: Canine and feline
    • Ames, IA: Blackwell Publishing
    • Laflamme DP (2007) Five minute veterinary consult: canine and feline. In Obesity, pp. 982-983. Ames, IA: Blackwell Publishing.
    • (2007) Obesity , pp. 982-983
    • Laflamme, D.P.1
  • 18
    • 0028331373 scopus 로고
    • Cognitive functions and aging in the dog: Acquisition of non spatial visual tasks
    • Milgram NW, Head E, Weiner E, et al. (1994) Cognitive functions and aging in the dog: acquisition of non spatial visual tasks. Behav Neurosci 108, 57-68.
    • (1994) Behav Neurosci , vol.108 , pp. 57-68
    • Milgram, N.W.1    Head, E.2    Weiner, E.3
  • 19
    • 0032410562 scopus 로고    scopus 로고
    • Visual-discrimination learning ability and beta-amyloid accumulation in the dog
    • Head E, Callahan H, Cummings BJ, et al. (1998) Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiol Aging 19, 415-425.
    • (1998) Neurobiol Aging , vol.19 , pp. 415-425
    • Head, E.1    Callahan, H.2    Cummings, B.J.3
  • 20
    • 0013015637 scopus 로고    scopus 로고
    • Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging
    • Tapp PD, Siwak CT, Estrada J, et al. (2003) Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learn Mem 10, 64-73.
    • (2003) Learn Mem , vol.10 , pp. 64-73
    • Tapp, P.D.1    Siwak, C.T.2    Estrada, J.3
  • 21
    • 0032955087 scopus 로고    scopus 로고
    • Landmark discrimination learning in the dog
    • Milgram NW, Adams B, Callahan H, et al. (1999) Landmark discrimination learning in the dog. Learn Mem 6, 54-61.
    • (1999) Learn Mem , vol.6 , pp. 54-61
    • Milgram, N.W.1    Adams, B.2    Callahan, H.3
  • 22
    • 77955771476 scopus 로고    scopus 로고
    • Novel task for assessing attention in canines: Age effects on accuracy and response latency
    • In the press
    • Christie LA, Araujo JA, De Rivera C, et al. (2010) Novel task for assessing attention in canines: age effects on accuracy and response latency. Neuroscience (In the press).
    • (2010) Neuroscience
    • Christie, L.A.1    Araujo, J.A.2    De Rivera, C.3
  • 23
    • 0019506026 scopus 로고
    • Fat mobilization and plasma hormone levels in fasted dogs
    • De Bruijne JJ, Altszuler N, Hampshire J, et al. (1981) Fat mobilization and plasma hormone levels in fasted dogs. Metabolism 30, 190-194.
    • (1981) Metabolism , vol.30 , pp. 190-194
    • De Bruijne, J.J.1    Altszuler, N.2    Hampshire, J.3
  • 24
    • 58149293400 scopus 로고    scopus 로고
    • Lack of toxicity by medium chain triglycerides (MCT) in canines during a 90-day feeding study
    • Matulka RA, Thompson DV & Burdock GA (2009) Lack of toxicity by medium chain triglycerides (MCT) in canines during a 90-day feeding study. Food Chem Toxicol 47, 35-39.
    • (2009) Food Chem Toxicol , vol.47 , pp. 35-39
    • Matulka, R.A.1    Thompson, D.V.2    Burdock, G.A.3
  • 25
    • 70349579720 scopus 로고    scopus 로고
    • Role of glutamate in neuron-glia metabolic coupling
    • Magistretti PJ (2009) Role of glutamate in neuron-glia metabolic coupling. Am J Clin Nutr 90, 875S-880S.
    • (2009) Am J Clin Nutr , vol.90
    • Magistretti, P.J.1
  • 26
    • 45149104267 scopus 로고    scopus 로고
    • Cognitive dysfunction and diabetes mellitus
    • Kodl CT & Seaquist ER (2008) Cognitive dysfunction and diabetes mellitus. Endocr Rev 29, 494-511.
    • (2008) Endocr Rev , vol.29 , pp. 494-511
    • Kodl, C.T.1    Seaquist, E.R.2
  • 28
    • 23944442745 scopus 로고    scopus 로고
    • Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats
    • Taha AY, Ryan MA & Cunnane SC (2005) Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats. Metab Clin Exp 54, 1127-1132.
    • (2005) Metab Clin Exp , vol.54 , pp. 1127-1132
    • Taha, A.Y.1    Ryan, M.A.2    Cunnane, S.C.3
  • 29
    • 68349133045 scopus 로고    scopus 로고
    • Dietary enrichment with medium chain triglycerides (AC-1203) elevates polyunsaturated fatty acids in the parietal cortex of aged dogs: Implications for treating age-related cognitive decline
    • Taha AY, Henderson ST & Burnham WM (2009) Dietary enrichment with medium chain triglycerides (AC-1203) elevates polyunsaturated fatty acids in the parietal cortex of aged dogs: implications for treating age-related cognitive decline. Neuro-chem Res 34, 1619-1625.
    • (2009) Neuro-chem Res , vol.34 , pp. 1619-1625
    • Taha, A.Y.1    Henderson, S.T.2    Burnham, W.M.3
  • 30
    • 0345507956 scopus 로고    scopus 로고
    • National Research Council Washington, DC: National Academy Press
    • National Research Council (2006) Nutrient Requirements of Dogs and Cats. Washington, DC: National Academy Press.
    • (2006) Nutrient Requirements of Dogs and Cats


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.