In vivo and in vitro effect of a nutrient mixture on human hepatocarcinoma cell line SK-HEP-1

Experimental Oncology

Volumn 32, Issue 2, 2010, Pages 84-91

  Roomi, M W ^a   Roomi, N W ^a   Kalinovsky, T ^a   Niedzwiecki, A ^a   Rath, M ^a  

^a Dr Rath Research Institute   (United States)

Author keywords

Apoptosis; Athymic nude mice; Hepatocellular carcinoma; Invasion; Nutrient mixture; SK Hep 1

Indexed keywords

ASCORBIC ACID; GREEN TEA EXTRACT; MATRIGEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER INVASION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DIET SUPPLEMENTATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; METASTASIS INHIBITION; MOUSE; NONHUMAN; NUDE MOUSE; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ASCORBIC ACID; CAMELLIA SINENSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; DIETARY SUPPLEMENTS; HUMANS; LIVER NEOPLASMS; LYSINE; MALE; MATRIX METALLOPROTEINASES; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; PLANT EXTRACTS; PROLINE; TEA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77954616106     PISSN: 18129269     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. American Cancer Society. Detailed guide: liver cancer: What are the key statistics about liver cancer? http://www.cancer.org/docroot/CRI/content/CRI-2- 4-2X-What-are-the-risk-factors-for-liver-cancer-25.asp?rnav=cri
2. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA Cancer J Clin 2009; 59: 225-49.
3. Korn WM. Moving toward an understanding of the metastatic process in hepatocellular carcinoma. World J Gastro enterol 2001; 7: 777-8.
4. Sakamoto Y, Mafune K, Mori M, et al. Overexpression of MMP-9 correlates with growth of small hepatocellular carcinoma. Int J Oncol 2000; 17: 237-43.
5. Jiang YF, Yang ZH, Hu JQ. Recurrence or metastasis of HCC: predictors, early detection and experimental antiangiogenic therapy. World J Gastroenterol 2000; 6: 61-5.
6. Määta M, Soini Y, Liakka A, et al. Differential expression of matrix metalloproteinase (MMP)-2 and MMP-9 and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: implications for tumor progression and clinical prognosis. Clin Cancer Res 2000; 6: 2726-34.
7. Kashiwagi A. Matrix metalloproteases in hepatocellular carcinoma. A study in resected specimens from 25 patients. Tokyo Jikekai Med J 2001; 118: 33-48.
8. Qin LX, Tang ZY. The prognostic molecular markers in hepatocellular carcinoma. World J Gastroenterol 2002; 8: 385-92.
9. Guo RP, Zhong C, Shi M, et al. Clinical value of apoptosis and angiogenesis factors in estimating the prognosis of hepatocellular carcinoma. J Cancer Res Clin Oncol 2006; 132: 547-55. (Pubitemid 44078523)
10. Rath M, Pauling L. Plasmin-induced proteolysis and the role of apoprotein(a), lysine and synthetic analogs. Orthomolecular Med 1992; 7: 17-23.
11. Roomi MW, Roomi N, Ivanov V, et al. Inhibitory effect of a mixture containing ascorbic acid, lysine, proline and green tea extract on critical parameters in angiogenesis. Oncol Rep 2005; 14: 807-15.
12. Ivanov V, Ivanova S, Roomi MW, et al. Naturally-produced extracellular matrix inhibits growth rate and invasiveness of human osteosarcoma cancer cells. Med Oncol 2007; 24: 209-17. (Pubitemid 350135973)
13. Roomi MW, Ivanov V, Kalinovsky T, et al. Inhibition of pulmonary metastasis of melanoma B16FO cells in C57BL/6 mice by a nutrient mixture consisting of ascorbic acid, lysine, proline, arginine, and green tea extract. Exp Lung Res 2006; 32: 517-30. (Pubitemid 44973608)
14. Sun Z, Chen YH, Wang P, et al. The blockage of high-affinity lysine binding sites of plasminogen by EACA significantly inhibits prourokinase-induced plasminogen activation. Biochem Biophys Acta 2002; 1596: 182-92.
15. Valcic S, Timmermann BN, Alberts DS, et al. Inhibitory effect of six green tea catechins and caffeine on the growth of four selected human tumor cell lines. Anticancer Drugs 1996; 7: 461-8. (Pubitemid 26249199)
16. Mukhtar H, Ahmed N. Tea polyphenols: prevention of cancer and optimizing health. Am J Clin Nutr 2000; 71: 1698s-702s. (Pubitemid 30396266)
17. Yang GY, Liao J, Kim K, et al. Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols. Carcinogenesis 1998; 19: 611-6. (Pubitemid 28376804)
18. Taniguchi S, Fujiki H, Kobayashi H, et al. Effect of (-) epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines. Cancer Lett 1992; 65: 51-4.
19. Hara Y. Green tea: health benefits and applications. New York, Basel: Marcel Dekker, 2001. 252 p.
20. Kawakami S, Kageyama Y, Fujii Y, et al. Inhibitory effects of N-acetyl cysteine on invasion and MMP 9 production of T24 human bladder cancer cells. Anticancer Res 2001; 21: 213-9. (Pubitemid 32267645)
21. Morini M, Cai T, Aluigi MG, et al. The role of the thiol N-acetyl cysteine in the prevention of tumor invasion and angiogenesis. Int J Biol Markers 1999; 14: 268-71. (Pubitemid 30064181)
22. Yoon SO, Kim MM, Chung AS. Inhibitory effects of selenite on invasion of HT 1080 tumor cells. J Biol Chem 2001; 276: 20085-92.
23. Maramag C, Menon M, Balaji KC, et al. Effect of vitamin C on prostate cancer cells in vitro: effect on cell number, viability and DNA synthesis. Prostate 1997; 32: 188-95. (Pubitemid 27337953)
24. Cooke JP, Dzau VJ. Nitric oxide synthase: Role in the genesis of vascular disease. Annu Rev Med 1997; 48: 489-509. (Pubitemid 27101848)
25. Duffy MJ. The role of proteolytic enzymes in cancer invasion and metastasis. Clin Exp Metastasis 1992; 10: 145-55.