Mechanisms of polymyxin B endotoxin removal from extracorporeal blood flow: Hydrodynamics of sorption

Contributions to Nephrology

Volumn 167, Issue , 2010, Pages 55-64

  Fiore, G B ^a   Soncini, M ^a   Vesentini, S ^a   Redaelli, A ^a  

^a POLITECNICO DI MILANO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; POLYMYXIN B;

ADSORPTION; ARTICLE; BLOOD; BLOOD FLOW VELOCITY; CHEMICAL STRUCTURE; DETOXIFICATION; EXTRACORPOREAL CIRCULATION; HUMAN; HYDROGEN BOND; ISOLATION AND PURIFICATION; KINETICS; METHODOLOGY; MOLECULAR COMPUTER; ULTRAFILTRATION;

ADSORPTION; BLOOD FLOW VELOCITY; COMPUTERS, MOLECULAR; ENDOTOXINS; EXTRACORPOREAL CIRCULATION; HUMANS; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; POLYMYXIN B; SORPTION DETOXIFICATION; ULTRAFILTRATION;

EID: 77954614453     PISSN: 03025144     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000315919     Document Type: Article

References (23)

1. Martin GS, Mannino DM, Eaton S, Moss M: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003;348:1546-1554.
2. Murphy SL: Deaths: final data for 1998. Natl Vital Stat Rep 2000;48:1-105.
3. Friedman G, Silva E, Vincent JL: Has the mortality of septic shock changed with time? Crit Care Med 1998;26:2078-2086.
4. Balk RA: Pathogenesis and management of multiple organ dysfunction or failure in severe sepsis and septic shock. Crit Care Clin 2000;16:337-352, vii.
5. Opal SM, Gluck T: Endotoxin as a drug target. Crit Care Med 2003;31:S57-S64.
6. Palmer JD, Rifkind D: Neutralization of the hemodynamic effects of endotoxin by polymyxin B. Surg Gynecol Obstet 1974;138: 755-759.
7. From AH, Fong JS, Good RA: Polymyxin B sulfate modification of bacterial endotoxin: effects on the development of endotoxin shock in dogs. Infect Immun 1979;23:660-664.
8. Baldwin G, Alpert G, Caputo GL, Baskin M, Parsonnet J, Gillis ZA, Thompson C, Siber GR, Fleisher GR: Effect of polymyxin B on experimental shock from meningococcal and Escherichia coli endotoxins. J Infect Dis 1991;164:542-549.
9. Cooperstock MS: Inactivation of endotoxin by polymyxin B. Antimicrob Agents Chemother 1974;6:422-425.
10. Danner RL, Joiner KA, Rubin M, Patterson WH, Johnson N, Ayers KM, Parrillo JE: Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide. Antimicrob Agents Chemother 1989;33: 1428-1434.
11. Wheeler AP: Bacterial peritonitis: innovative experimental treatment. Crit Care Med 1999;27:1055-1056.
12. Suzuki H, Nemoto H, Nakamoto H, Okada H, Sugahara S, Kanno Y, Moriwaki K: Continuous hemodiafiltration with polymyxin-B immobilized fiber is effective in patients with sepsis syndrome and acute renal failure. Ther Apher 2002;6:234-240.
13. Shoji H: Extracorporeal endotoxin removal for the treatement of sepsis: endotoxin adsorbtion cartridge (Toraymyxin). Ther Apher Dial 2003;7:108-114.
14. Kushi H, Miki T, Okamaoto K, Nakahara J, Saito T, Tanjoh K: Early hemoperfusion with an immobilized polymyxin B fiber column eliminates humoral mediators and improves pulmonary oxygenation. Crit Care 2005;9: R653-R661.
15. Cruz DN, Antonelli M, Fumagalli R, et al: Early use of polymyxin B hemoperfusion in abdominal septic shock. The EUPHAS randomized control trial. JAMA 2009;301: 2445-2452.
16. Nakamura T, Matsuda T, Suzuki Y, Shoji H, Koide H: Polymyxin B-immobilized fiber hemoperfusion in patients with sepsis. Dial Transplant 2003;32:602-607.
17. Nemoto H, Nakamoto H, Okada H, Sugahara S, Moriwaki K, Arai M, Kanno Y, Suzuki H: Newly developed immobilized polymyxin B fibers improve the survival of patients with sepsis. Blood Purif 2001;19:361-369.
18. Vincent JL, Laterre PF, Cohen J, Burchardi H, Bruining H, Lerma FA, Wittebole X, De Backer D, Brett S, Marzo D, Nakamura H, John S: A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection. Shock 2005;23:400-405.
19. Fiore B, Soncini M, Vesentini S, Penati A, Visconti G, Redaelli A: Multiscale analysis of the Toraymyxin adsorption cartridge. Part II: computational fluid-dynamic study. Int J Artif Organs 2006;29:251-260.
20. Wells R: Syndromes of hyperviscosity. N Engl J Med 1970;283:183-186.
21. Vesentini S, Soncini M, Zaupa A, Silvestri V, Fiore GB, Redaelli A: Multi-scale analysis of the Toraymyxin adsorption cartridge. Part I: molecular interaction of polymyxin B with endotoxins. Int J Artif Organs 2006;29: 239-250.
22. Ronco C, Brendolan A, Scabardi M, Ronco F, Nakamura H: Blood flow distribution in a polymyxin coated fibrous bed for endotoxin removal. Effect of a new blood path design. Int J Artif Organs 2001;24:167-172.
23. Wang NL, Keller KH: Augmented transport of extracellular solutes in concentrated erythrocyte suspensions in Couette flow. J Colloid Interface Sci 1985;103:210-225.