Cationic and anionic lipoplexes inhibit gene transfection by electroporation in vivo

Journal of Gene Medicine

Volumn 12, Issue 6, 2010, Pages 491-500

  Mignet, Nathalie ^a   Vandermeulen, Gäelle ^b   Pembouong, Gäelle ^a   Largeau, Ćeline ^a   Thompson, Betty ^a   Spanedda, Maria Vittoria ^c   Wasungu, Luc ^d   Rols, Marie Pierre ^d   Bessodes, Michel ^a   Bureau, Michel F ^a   Pŕeat, V́eronique ^b   Scherman, Daniel ^a  

^a Centre National de la Recherche Scientifique   (France)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

Electrotransfer; Gene therapy; Lipoplexes; Lyophilization; Nonviral vectors; Uptake of DNA complexes

Indexed keywords

ANION; CATION; LIPID; LIPOPLEX; NAKED DNA; THIOUREA; DNA; LIPOSOME;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPORATION; FEMALE; FREEZE DRYING; GENE EXPRESSION; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; CHO CELL LINE; CRICETULUS; CYTOLOGY; GENE TRANSFER; GENETICS; HAMSTER; METABOLISM; PHYSIOLOGY; PLASMID; PROCEDURES; SKELETAL MUSCLE; SKIN;

ANIMALS; CATIONS; CHO CELLS; CRICETINAE; CRICETULUS; DNA; ELECTROPORATION; FEMALE; GENE TRANSFER TECHNIQUES; LIPOSOMES; MICE; MICE, INBRED BALB C; MUSCLE, SKELETAL; PLASMIDS; SKIN; TRANSFECTION;

EID: 77954613599     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1460     Document Type: Article

References (24)

1. Mir LM, Bureau MF, Gehl J, et al. High-efficiency gene transfer into skeletal muscle mediated by electric pulses. Proc Natl Acad Sci USA 1999; 96: 4262-4267.
2. Favard C, Dean D, Rols MP. In vivo electroporation for gene delivery. Curr Gene Ther 2007; 7: 67-77.
3. Schertzer, JD, Lynch, GS. Comparative evaluation of IGF-1 gene transfer and IGF-1 protein administration for enhancing skeletal muscle regeneration after injury. Gene Ther 2006; 13: 1657-1664.
4. Payen E, Bettan M, Rouyer-Fessard P, Beuzard Y, Scherman D. Improvement of mouse beta-thalassemia by electrotransfer of erythropoietin cDNA. Exp Hematol 2001; 29: 295-300. (Pubitemid 32220120)
5. Nicolazzi C, Garinot M, Mignet N, Scherman D, Bessodes M. Cationic lipids for transfection. Curr Med Chem 2003; 10: 1263-1277.
6. Thompson B, Mignet N, Hofland H, et al. Neutral post-grafted colloidal particles for gene delivery. Bioconjugate chem 2005; 16: 608-614.
7. Hood J, Bednarski M, Frausto R, et al. Tumor regression by targeted gene delivery to the neovasculature. Science 2002; 296: 2404-2407. (Pubitemid 34734217)
8. Nicolazzi C, Garinot M, Mignet N, Scherman D, Bessodes M. Cationic lipids for transfection. Curr Med Chem 2003; 10: 1263-1277.
9. Patil SD, Rhodes DG, Burgess DJ. Biophysical characterization of anionic lipoplexes. Biochim Biophys Acta 2005; 1711: 1-11.
10. Mignet N, Richard C, Seguin J, Largeau C, Bessodes M, Scherman D. Anionic pH-sensitive pegylated lipoplexes to deliver DNA to tumors. Int J Pharm 2008; 361: 194-201.
11. Aoyama Y, Kanamori T, Nakai T, et al. Artificial viruses and their application to gene delivery. Size-controlled gene coating with glycocluster nanoparticles. J Am Chem Soc 2003; 125: 3455-3457.
12. Leblond J, Mignet N, Largeau C, et al. Lipopolythiourea a new non cationic system for gene transfer. Bioconjugate Chem 2007; 18: 484-493.
13. Andre F, Mir L. DNA electrotransfer: it principles and an updates review of its therapeutic applications. Gene Ther 2004; 11(suppl 1): S33-S42.
14. Pavselj N, Pŕeat V. DNA electrotransfer into the skin using a combination of one high- and one low-voltage pulse. J Control Release 2005; 106: 407-415.
15. Heller L, Heller R. In vivo electroporation for gene therapy. Hum Gene Ther 2006; 17: 890-897.
16. Heller L, Jaroszeski M, Coppola D, McCray A, Hickey J, Heller R. Optimization of cutaneous electrically mediated plasmid DNA delivery using novel electrode. Gene Ther 2007; 14: 275-280. (Pubitemid 46152631)
17. Vandermeulen G, Staes E, Vanderhaeghen ML, Bureau MF, Scherman D, Preat V. Optimisation of intradermal DNA electrotransfer for immunisation. J Control Release 2007; 124: 81-87.
18. Coulberson A, Hud N, LeDoux J, Vilfan I, Prausnitz M. Gene packaging with lipids, peptides and viruses inhibits transfection by electroporation in vitro. J Control Rel 2003; 86: 361-370.
19. Heller L, Jaroszeski M, Coppola D, Heller R. Comparison of electrically mediated and liposome-complexed plasmid DNA delivery to the skin. Gen Vaccines Ther 2008; 6: 16-25.
20. Sen A, Zhao YL, Hui SW. Saturated anionic phospholipids enhance transdermal transport by electroporation. Biophys J 2002; 83: 2064-2073.
21. Bloquel C, Trollet C, Pradines E, Seguin J, Scherman D, Bureau MF. Optical imaging of luminescence for in vivo quantification of gene electrotransfer in mouse muscle and knee. BMC Biotechnol 2006; 6: 16.
22. Tranchant I, Thompson B, Nicolazzi C, Mignet N, Scherman D. Physico-chemical optimisation of plasmid delivery by cationic lipids. J Gene Med 2004; 6(Suppl 1): S24-S35.
23. Baraldo K, Leforestier K, Bureau M, Mignet N, Scherman D. Sphingosine-based liposome as DNA vector for intramuscular gene delivery. Pharm Research 2002; 19: 1143-1148.
24. Breton M, Leblond J, Seguin J, et al. Comparative gene transfer between cationic and thiourea lipoplexes. J Gene Med 2009; 12: 45-54.