Sphingosine-based liposome as DNA vector for intramuscular gene delivery

Pharmaceutical Research

Volumn 19, Issue 8, 2002, Pages 1144-1149

  Baraldo, Karin ^a   Leforestier, Nicolas ^b   Bureau, Michel ^a   Mignet, Nathalie ^a   Scherman, Daniel ^a  

^a UMR 7001 CNRS/ENSCP/Av Phar Gen   (France)

^b Lilly France ^*  (France)

Author keywords

Cationic liposomes; Colloidal stability; Gene therapy; Non viral gene transfer; Serum resistance; Sphingosine

Indexed keywords

DEOXYRIBONUCLEASE I; LIPOSOME; NAKED DNA; PHOSPHATIDYLCHOLINE; PLASMID DNA; SPHINGOSINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DNA VECTOR; DRUG FORMULATION; DRUG STABILITY; FEMALE; GENE EXPRESSION REGULATION; GENE TRANSFER; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

ANIMALS; DNA; DRUG DELIVERY SYSTEMS; FEMALE; GENE THERAPY; GENETIC VECTORS; INJECTIONS, INTRAMUSCULAR; LIPOSOMES; MICE; MICE, INBRED C57BL; SPHINGOSINE;

EID: 0036689416     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1019894008885     Document Type: Article

References (14)

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5. In vitro gene transfer in mammalian cells via a new cationic liposome formulation
6. Sphingosine-mediated electroporative DNA transfer through lipid bilayers
7. High-efficiency gene transfer into skeletal muscle mediated by electric pulses
8. Virus-sized self-assembling lamellar complexes between plasmid DNA and cationic micelles promote gene transfer
9. Formulations which increase the size of lipoplexes prevent serum-associated inhibition of transfection
10. Rapid and sensitive ethidium bromide fluorescence quenching assay of polyamine conjugate-DNA interactions for the analysis of lipoplex formation in gene therapy
11. Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: Implications for intravenous lipofection
12. Importance of association between permeabilization and electrophoretic forces for intramuscular DNA electrotransfer
13. Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities
14. ATP stimulates the hydrolysis of phosphatidylethanolamine in NIH 3T3 cells. Potentiating effects of guanosine triphosphates and sphingosine