Mutations in 23S rRNA and ribosomal protein L4 account for resistance in Chlamydia trachomatis strains selected in vitro by macrolide passage

Andrologia

Volumn 42, Issue 4, 2010, Pages 274-280

  Zhu, H ^a   Wang, H P ^a   Jiang, Y ^a   Hou, S P ^a   Liu, Y J ^a   Liu, Q Z ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

23S rRNA; Chlamydia trachomatis; macrolide; point mutation; resistance; ribosomal protein L4

Indexed keywords

AZITHROMYCIN; ERYTHROMYCIN; JOSAMYCIN; RIBOSOMAL PROTEIN L4; RIBOSOME PROTEIN; RNA 23S; UNCLASSIFIED DRUG; BACTERIAL DNA; MACROLIDE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; CHLAMYDIA TRACHOMATIS; GENE MUTATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; CHEMISTRY; DRUG EFFECTS; GENETICS; MICROBIAL SENSITIVITY TEST; MOLECULAR GENETICS; MULTIDRUG RESISTANCE; NUCLEOTIDE SEQUENCE; POINT MUTATION;

BASE SEQUENCE; CHLAMYDIA TRACHOMATIS; DNA, BACTERIAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; MACROLIDES; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; POINT MUTATION; RIBOSOMAL PROTEINS; RNA, RIBOSOMAL, 23S;

EID: 77954590230     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/j.1439-0272.2009.01019.x     Document Type: Article

References (28)

1. Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HA, Fucini P, Yonath A (2003) Structural insight into the antibiotic action of telithromycin against resistant mutants. J Bacteriol 185: 4276 4279.
2. Binet R, Maurelli AT (2007) Frequency of development and associated physiological cost of azithromycin resistance in Chlamydia psittaci 6BC and Chlamydia trachomatis L2. Antimicrob Agents Chemother 185: 4267 4275.
3. Canu A, Malbruny B, Coquemont M, Davies TA, Appelbaum PC, Leclercq R (2002) Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae. Antimicrob Agents Chemother 46: 125 131.
4. Chen J-O (2009) An exploration of relationship between the infection of Chlamydia trachomatis and male sterility. Guide of China Medicine 17: 17 18.
5. Colombo U, Pifarotti G, Amidani M, Viezzoli T, Pifarotti P (1998) Rokitamycin in the treatment of female genital Chlamydia and Mycoplasma infections. Comparative study vs josamycin. Minerva Ginecol 50: 491 497.
6. Corsaro D, Venditti D (2004) Emerging chlamydial infections. Crit Rev Microbiol 30: 75 106.
7. Dessus-Babus S, Bébéar CM, Charron A, Bébéar C, de Barbeyrac B (1998) Sequencing of gyrase and topoisomerase IV quinolone-resistance-determining regions of Chlamydia trachomatis and characterization of quinolone-resistant mutants obtained in vitro. Antimicrob Agents Chemother 42: 2474 2481.
8. Gregory ST, Cate JH, Dahlberg AE (2001) Spontaneous erythromycin resistance mutation in a 23S rRNA gene, rrlA, of the extreme thermophile Thermus thermophilus IB-21. J Bacteriol 183: 4382 4385.
9. Horner P (2006) The case for further treatment studies of uncomplicated genital Chlamydia trachomatis infection. Sex Transm Infect 82: 340 343.
10. Kutlin A, Kohlhoff S, Roblin P, Hammerschlag MR, Riska P (2005) Emergence of resistance to rifampin and rifalazil in Chlamydophila pneumoniae and Chlamydia trachomatis. Antimicrob Agents Chemother 49: 903 907.
11. Lenart J, Andersen AA, Rockey DD (2001) Growth and development of tetracycline-resistant Chlamydia suis. Antimicrob Agents Chemother 45: 2198 2203.
12. Liu W (2005) Etiological detection and analysis of sexually transmitted diseases. World J Infect 5: 151 152.
13. Michéa-Hamzehpour M, Kahr A, Pechère JC (1994) In vitro stepwise selection of resistance to quinolones, beta-lactams and amikacin in nosocomial gram-negative bacilli. Infection 22 (Suppl 2 S105 S110.
14. Misyurina OY, Chipitsyna EV, Finashutina YP, Lazarev VN, Akopian TA, Savicheva AM, Govorun VM (2004) Mutations in a 23S rRNA gene of Chlamydia trachomatis associated with resistance to macrolides. Antimicrob Agents Chemother 48: 1347 1349.
15. Mourad A, Sweet RL, Sugg N, Schachter J (1980) Resistance to erythromycin in Chlamydia trachomatis. Antimicrob Agents Chemother 18: 696 698.
16. Ostergaard P, Phan H, Johansen LB, Egebjerg J, Ostergaard L, Porse BT, Garrett RA (1998) Assembly of proteins and 5S rRNA to transcripts of the major structural domains of 23S rRNA. J Mol Biol 284: 227 240.
17. Pfister P, Corti N, Hobbie S, Bruell C, Zarivach R, Yonath A, Böttger EC (2005) 23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A→G. Proc Natl Acad Sci USA 102: 5180 5185.
18. Pihlajamäki M, Kataja J, Seppälä H, Elliot J, Leinonen M, Huovinen P, Jalava J (2002) Ribosomal mutations in Streptococcus pneumoniae clinical isolates. Antimicrob Agents Chemother 46: 654 658.
19. Roberts MC, Sutcliffe J, Courvalin P, Jensen LB, Rood J, Seppala H (1999) Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants. Antimicrob Agents Chemother 43: 2823 2830.
20. Somani J, Bhullar VB, Workowski KA, Farshy CE, Black CM (2000) Multiple drug-resistant Chlamydia trachomatis associated with clinical treatment failure. J Infect Dis 181: 1421 1427.
21. Suchland RJ, Geisler WM, Stamm WE (2003) Methodologies and cell lines used for antimicrobial susceptibility testing of Chlamydia spp. Antimicrob Agents Chemother 47: 636 642.
22. Vester B, Douthwaite S (2001) Macrolide resistance conferred by base substitutions in 23S rRNA. Antimicrob Agents Chemother 45: 1 12.
23. Veznik Z, Pospisil L, Svecova D, Zajicova A, Unzeitig V (2004) Chlamydiae in the ejaculate: their influence on the quality and morphology of sperm. Acta Obstet Gynecol Scand 83: 656 660.
24. Wang X-L, Xu Q-H (2007) Analysis of detection results of Neisseria gonorrhoeae, Chlamydia trachomatis and ureaplasma urealyticum in infertility. Chinese J Eugen Genet 15: 105 106.
25. Wang SA, Papp JR, Stamm WE, Peeling RW, Martin DH, Holmes KK (2005) Evaluation of antimicrobial resistance and treatment failures for Chlamydia trachomatis: a meeting report. J Infect Dis 191: 917 923.
26. Weisblum B (1995) Erythromycin resistance by ribosome modification. Antimicrob Agents Chemother 39: 577 585.
27. Welsh LE, Gaydos CA, Quinn TC (1992) In vitro evaluation of activities of azithromycin, erythromycin, and tetracycline against Chlamydia trachomatis and Chlamydia pneumoniae. Antimicrob Agents Chemother 36: 291 294.
28. Wyrick PB, Knight ST (2004) Pre-exposure of infected human endometrial epithelial cells to penicillin in vitro renders Chlamydia trachomatis refractory to azithromycin. J Antimicrob Chemother 54: 79 85.