Research and Development of Antischistosomal Drugs in the People's Republic of China. A 60-Year Review

Advances in Parasitology

Volumn 73, Issue C, 2010, Pages 231-295

  Xiao, Shu Hua ^a   Keiser, Jennifer ^b,c   Chen, Ming Gang ^a   Tanner, Marcel ^b,c   Utzinger, Jürg ^b,c  

^a CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AGRIMONIA PILOSA EXTRACT; AMMONIUM ANTIMONY GLUCONATE; AMOSCANATE; ANTIMONY DERIVATIVE; ANTIMONY GLUCONATE; ANTISCHISTOSOMAL AGENT; ARTEMETHER; ARTESUNATE; AS 846; CISTICIDE; CUCURBITINE; FURADIAMINE; FURAPROMIDIUM; FURAPROMIDUM; FUVINAZOLE; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HEMEROCALLINE; HEXACHLORXYLOL; MEFLOQUINE; METRIFONATE; NIRIDAZOLE; NIRIDAZOLE DERIVATIVE; PARAROSANILINE EMBONATE; PHENITHIONATE; PLACEBO; PRAZIQUANTEL; S 72014; SB 273; SB 58; SODIUM ANTIMONY SUBGALLATE; STIBOCAPTATE; SUPEROXIDE DISMUTASE; THIOURACIL DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTHELMINTIC AGENT;

ABDOMINAL PAIN; BOOK; CHINA; CHINESE MEDICINE; CLINICAL TRIAL; DIZZINESS; DRUG MANUFACTURE; DRUG RESEARCH; DRUG WITHDRAWAL; DRYOPTERIS; ENANTIOMER; FEVER; GASTROINTESTINAL IRRITATION; HEADACHE; HEART ARRHYTHMIA; HEMEROCALLIS; HISTORY OF MEDICINE; HUMAN; MIRACIDIUM; NONHUMAN; PLANT SEED; PRIORITY JOURNAL; PUMPKIN; SCHISTOSOMA JAPONICUM; SCHISTOSOMIASIS; SINGLE DRUG DOSE; UNSPECIFIED SIDE EFFECT; ANIMAL; DRUG DEVELOPMENT; DRUG EFFECTS; HISTORY; PARASITOLOGY; SCHISTOSOMIASIS JAPONICA; TRENDS;

ANIMALS; ANTHELMINTICS; CHINA; DRUG DISCOVERY; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; SCHISTOSOMA JAPONICUM; SCHISTOSOMIASIS JAPONICA;

EID: 77954587831     PISSN: 0065308X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-308X(10)73009-8     Document Type: Chapter

References (278)

1. Andrews P., Thomas H., Pohlke R., Seubert J. Praziquantel. Med. Res. Rev. 1983, 3:147-200.
2. Bergquist R., Tanner M. Controlling schistosomiasis in Southeast Asia: a tale of two countries. Adv. Parasitol. 2010, 72:109-144.
3. Blum J.A., Hatz C.F. Treatment of cutaneous leishmaniasis in travelers 2009. J. Travel Med. 2009, 16:123-131.
4. Botros S.S., Bennett J.L. Praziquantel resistance. Expert Opin. Drug Discov. 2007, 2(Suppl. 1):S35-S40.
5. Brewer T.G., Grate S.J., Peggins J.O., Weina P.J., Petras J.M., Levine B.S., et al. Fatal neurotoxicity of arteether and artemether. Am. J. Trop. Med. Hyg. 1994, 51:251-259.
6. Caffrey C.R. Chemotherapy of schistosomiasis: present and future. Curr. Opin. Chem. Biol. 2007, 11:433-439.
7. Chen Z.D. Treatment of schistosomiasis. Schistosomiasis 1963, 331-351. People's Health Publication House, Beijing. S.B. Mao (Ed.).
8. Chen M.G. Chemotherapy of schistosomiasis japonica in China. Southeast Asian J. Trop. Med. Public Health 1985, 16:473-479.
9. Chen M.G. Use of praziquantel for clinical treatment and morbidity control of schistosomiasis japonica in China: a review of 30 years' experience. Acta Trop. 2005, 96:168-176.
10. Chen M.G., Feng Z. Schistosomiasis control in China. Parasitol. Int. 1999, 48:11-19.
11. Chen Z.D., Li Y.H., Fang P.J., Kao C. Further observations on three-day course treatment of 189 cases of schistosomiasis japonica with trivalent ammonium antimony gluconate. National Academia Meeting of Parasitic Diseases (Abstract), November 1958 1958, 15-16. Shanghai Scientific-Technic Publisher, Shanghai, (English Part).
12. Chen C., Zheng X.Y., Quian Y.F., Xiao S.H., Shao B.R., Huang L.S. Studies on Hemerocallis thunbergii Baker. III. Isolation and characterization of active principle against schistosomiasis. Acta Pharm. Sin. 1962, 9:579-586.
13. Chen D.J., Fu L.F., Shao P.P., Wu F.Z., Shu H., Ren C.S., et al. Studies on antischistosomal activity of qinghaosu in experimental therapy. Natl. Med. J. China 1980, 80:422-428.
14. Chen M.G., Fu S., Xu L.Q., Wang M.J., Chen Y.S., Jin Q.Y., et al. Studies on fuvinazole-depeterex combination in treatment of schistosomiasis in 318 cases. Acta Acad. Med. Sin. 1980, 2:204-205.
15. Chou H.J., Hu S.G., Jue T.E. China congress on parasitic diseases. Abstract of Papers Presented in November 1958 1958, 16. China Scientific Publishing House, Beijing.
16. Chu C.C., Liang Y.I., Tao Z.Q., Ting K.S. Studies on antibilharzial drugs XXI. Toxicity and therapeutic activity of Sb-58, Sb-126 and TWSb and the distribution and excretion of antimony after administration of these compounds. Acta Pharm. Sin. 1959, 7:320-326.
17. Chu C.C., Liang Y.I., Tsen Y.L., Shen M.L., Lu B.F., Yu Y.G., et al. Studies on antibilharzial drugs XXVII. Screening of 377 compounds on schistosomiasis japonica in mice. Acta Pharm. Sin. 1962, 9:84-108.
18. Cioli D. Praziquantel: is there real resistance and are there alternatives?. Curr. Opin. Infect. Dis. 2000, 13:659-663.
19. Cioli D., Pica-Mattoccia L. Praziquantel. Parasitol. Res. 2003, 90(Suppl. 1):S3-S9.
20. Cioli D., Pica-Mattoccia L., Archer S. Antischistosomal drugs: past, present and future?. Pharmacol. Ther. 1995, 68:35-85.
21. Dai Y.H., Lu G.Y., Liu Z.Y., Zhang D.P. The effect analysis of using artesunate on large-scale to prevent schistosomiasis during fighting a flood in the Yangtze River. Chin. J. Schisto. Control 1999, 11:143-145.
22. Danso-Appiah A., Utzinger J., Liu J., Olliaro P. Drugs for treating urinary schistosomiasis. Cochrane Database Syst. Rev. 2008, CD000053.
23. Observation on efficacy of hexachloroparaxylene against experimental schistosomiasis. Proceedings of Schistosomiasis Research (1961-1979) 1985, 499-500. Department of Infectious Diseases and Epidemiology, Chongqing Medical college, Sichuan Institute for Parasitic Disease Control, National Schistosomiasis Research Committee, Ministry of Health.
24. Clinical observation on the efficacy of Xuefang-846 in treatment of schistosomiasis. Proceedings of Schistosomiasis Research (1961-1979) 1985, 318-319. Department of Infectious Diseases and Epidemiology, Chongqing Medical College, National Schistosomiasis Research Committee, Ministry of Health.
25. Division of Traditional Chinese Herbs, Shengyang College of Pharmacy and Liaoning Institute of Materia Medica, Shengyang and Institute of Material Medica, Chinese Academy of Medicinal Science, Peking. (1974). Agrimol structure-The taenifuga constituent from root-sprout of Agrimonia Pilosa Ledeb. National Med. J. China 54, 346-347.
26. Doenhoff M.J., Cioli D., Utzinger J. Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis. Curr. Opin. Infect. Dis. 2008, 21:659-667.
27. Doenhoff M.J., Hagan P., Cioli D., Southgate V., Pica-Mattoccia L., Botros S., et al. Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs. Parasitology 2009, 136:1825-1835.
28. Eastman R.T., Fidock D.A. Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria. Nat. Rev. Microbiol. 2009, 7:864-874.
29. Efferth T., Kaina B. Toxicity of the antimalarial artemisinin and its derivatives. Crit. Rev. Toxicol. 2010, 40:405-421.
30. Fang S.D., Li L.C., Liu J.Y., Zhen G.F. Chemical study of Cucurbita moschata Duch. 1. The isolation and structural study of cucurbitine, a new amino acid. Sci. Sin. 1961, 10:845-851.
31. Fenwick A., Webster J.P. Schistosomiasis: challenges for control, treatment and drug resistance. Curr. Opin. Infect. Dis. 2006, 19:577-582.
32. Fenwick A., Savioli L., Engels D., Bergquist N.R., Todd M.H. Drugs for the control of parasitic diseases: current status and development in schistosomiasis. Trends Parasitol. 2003, 19:509-515.
33. Finkelstein J.L., Schleinitz M.D., Carabin H., McGarvey S.T. Decision-model estimation of the age-specific disability weight for schistosomiasis japonica: a systematic review of the literature. PLoS Negl. Trop. Dis. 2008, 2:e158.
34. Fu S., Chen M.G., Yang J.S., Wang M.J., Zhum P.J., Chen L.D., et al. Clinical studies on treatment of schistosomiasis japonica with a combination of pyquiton and furapromide. Acta Acad. Med. Sin. 1981, 3(Suppl. 1):66-68.
35. Gönnert R., Andrews P. Praziquantel, a new broad-spectrum antischistosomal agent. Z. Parasitenkd 1977, 52:129-150.
36. Guo Y., Xu P.S., Xuan Y.X., Wu L.J., Li S.W. Observation on the effect of artesunate on ultrastructure of schistosomula with electron microscope. Chin. J. Schisto. Control 1997, 9:34-36.
37. Guo Y., Wu L.J., Xu P.S., Yang M.J., Fan J.T., Li S.W. Safety assessment for long-term oral treatment with artesunate in rats. Chin. J. Schisto. Control 2000, 12:27-29.
38. Hang P.Y., Liang Y.S., Dai J.R., Zhu Y.C., Ning A., Yu D.B., et al. Study on susceptibility of Schistosoma japonicum in different stages to praziquantel. Chin. J. Schisto. Control 1999, 13:343-346.
39. He Y.X., Yang H.Z. Histochemical studies on the effects of F30066 on Schistosoma japonicum in vitro and in vivo. Acta Pharm. Sin. 1964, 11:174-178.
40. He K., Quan Y.Z., Qiu Z.Y. The stereoselective binding of praziquantel enantiomers to plasma proteins. Acta Pharm. Sin. 1991, 26:488-492.
41. He Y.X., Hu Y.Q., Yu Q.F. Sensitivity of different isolates of Schistosoma japonicum from China to praziquantel. Southeast Asian J. Trop. Med. Public Health 1992, 23:261-263.
42. He Y.X., Hu Y.Q., Yu Q.F., Ni C.H., Xue H.C., Qiu L.S., et al. Strain complex of Schistosoma japonicum in the mainland of China. Southeast Asian J. Trop. Med. Public Health 1994, 25:232-242.
43. Hsiao S.H., Ho Y.H., Le W.C., Shao B.R., Mao S.P. Experimental studies on certain problems pertaining to the use of antimony compounds in schistosomiasis japonica. Chin. Med. J. 1962, 81:229-245.
44. Hsiao S.H., Shao B.R., Yang Y.C., Chan C.C., Yang H.C., Liu J.C., et al. The efficacy and toxicity of S72055 in experimental chemotherapy of schistosomiasis japonica. Chin. Med. J. 1978, 4(New):440-448.
45. Hsieh Y.Y., Chang S., Yang I.T., Kyi Z.Y. Chemotherapeutic studies on schistosomiasis II. Antimony derivatives of some mercaptocarboxylic acids. Acta Chem. Sin. 1957, 23:105-111.
46. Hsu J.K., Wu Y.S., Lu C.P., Chen M.G., Lu C.S. Sodium antimony dimercapto-succinate (Sb-58) in treatment of schistosomiasis japonica. Chin. Med. J. 1960, 80:530-537.
47. Hsu J.K., Lu C.P., Lv X.S., Yang J.Z., Jiang X.R. Preliminary treatment of human schistosomiasis japonica with F30066 and F30069. Chin. J. Intern. Med. 1962, 9:539-541.
48. Hsu J.K., Lu C.P., Yang C.C. Preliminary trials with F30066 and F30069 in Schistosoma japonicum infections in man. Chin. Med. J. 1963, 82:92-96.
49. Huang L.S., Chen C., Cheng H.Y., Chen C.H., Liang H.T. The structure of hemerocallin. Chin. Sci. Bull. 1974, 19:93-94.
50. Huang L.S. Advances in the pharmaceutical chemistry of schistosomicidal agents. Pharmaceutic. Bull. 1979, 14:347-353.
51. Huang T.Y., Wang G.F., Yu T.C. Observations on the fate of F30066, a new schistosomicide, in man and in laboratory animals. Chin. Med. J. 1963, 82:242-249.
52. Huang M.X., Jiang S.J., Xiao S.T. Observation report on severe reaction elicited in large scale application of 3-day course antimony therapy for schistosomiasis. Chin. J. Intern. Med. 1965, 13:202-203.
53. Huang L.S., Wang A., Ma Z., Si B.X. Synthesis of a new schistosomicide S72014 and its homologs. Acta Pharm. Sin. 1980, 15:346-350.
54. Huang W.T., Xiao H.Z., Mao P.H., Wang X.Y., He Z.D., Tan P.P., et al. An experimental study on the effect of nithiocyamine against Schistosoma japonicum. Acta Pharm. Sin. 1980, 15:341-345.
55. Huang L.S., Hu Y.Q., Ma R.S., Zhou D.H., Wang A., Huang L.X., et al. Synthesis of new antischistosomal agent related to fuvinazole. Acta Pharm. Sin. 1982, 17:579-586.
56. Hubei Nithiocyaminum Coordination Research Group Clinical studies on 4022 cases of schistosomiasis japonica treated with nithiocyaminum. Natl. Med. J. China 1980, 60:679-682.
57. Treatment of 300 cases with schistosomiasis japonica with fuvinazole (S72055) in combination with dipterex suppository. Proceedings of Schistosomiasis Research (1961-1979) 1985, 361. Institute of Parasitic Diseases, Chinese Academy of Medical Sciences, National Schistosomiasis Research Committee, Ministry of Health.
58. Jia T.W., Zhou X.N., Wang X.H., Utzinger J., Steinmann P., Wu X.H. Assessment of the age-specific disability weight of chronic schistosomiasis japonica. Bull. World Health Organ. 2007, 85:458-465.
59. Jiang B.R. Prophylactic effect of ammonium antimony gluconate against Schistosoma japonicum infection in mice. Chin. J. Intern. Med. 1955, 3:617-619.
60. Jiang B.R., Le W.J., Mao C.P. Experimental therapy of schistosomiasis japonica IX. Effectiveness of ammonium antimony gluconate in treatment of experimental schistosomiasis in animals. Natl. Med. J. China 1957, 43:605-606.
61. Jin B.R., Xuan R.X., Nie J.R., Li Z.F., Li M.C., Hu X.G. Effect of dihydroartemisinin in experimental animals infected with schistosomiasis. Acta Zhejiang Med. Inst. 1981, 32:87.
62. Keiser J., Utzinger J. Artemisinins and synthetic trioxolanes for treatment of helminth infections. Curr. Opin. Infect. Dis. 2007, 20:605-612.
63. Keiser J., Utzinger J., Tanner M., Dong Y., Vennerstrom J.L. The synthetic peroxide OZ78 is effective against Echinostoma caproni and Fasciola hepatica. J. Antimicrob. Chemother. 2006, 58:1193-1197.
64. Keiser J., Xiao S.H., Dong Y., Utzinger J., Vennerstrom J.L. Clonorchicidal properties of the synthetic trioxolane OZ78. J. Parasitol. 2007, 93:1208-1213.
65. Keiser J., Chollet J., Xiao S.H., Mei J.Y., Jiao P.Y., Utzinger J., et al. Mefloquine-an aminoalcohol with promising antischistosomal properties in mice. PLoS Negl. Trop. Dis. 2009, 3:e350.
66. Keiser J., Vargas M., Doenhoff M.J. Activity of artemether and mefloquine against juvenile and adult Schistosoma mansoni in athymic and immunocompetent NMRI mice. Am. J. Trop. Med. Hyg. 2010, 82:112-114.
67. Keiser J., N'Guessan N., Adoubryn K.D., Silué K.D., Vounatsou P., Hatz C., et al. Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate and praziquantel against Schistosoma haematobium: randomised, exploratory open-label trial. Clin. Infect. Dis. 2010, 50:1205-1213.
68. King C.H., Bertino A.M. Asymmetries of poverty: why global burden of disease valuations underestimate the burden of neglected tropical diseases. PLoS Negl. Trop. Dis. 2008, 2:e209.
69. King C.H., Dangerfield-Cha M. The unacknowledged impact of chronic schistosomiasis. Chron. Illn. 2008, 4:65-79.
70. King C.H., Dickman K., Tisch D.J. Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis. Lancet 2005, 365:1561-1569.
71. Lambert C.R. Chemotherapy of experimental Schistosoma mansoni infection with a nitro-thiazole derivative CIBA 32,644-Ba. Ann. Trop. Med. Parasitol. 1964, 58:292-303.
72. Le W.J., You J.Q., Yang Y.Q., Mei J.Y., Guo H.F., Yang H.Z., et al. Studies on the efficacy of artemether in experimental schistosomiasis. Acta Pharm. Sin. 1982, 17:187-193.
73. Le W.J., You J.Q., Mei J.Y. Chemotherapeutic effect of artesunate in experimental schistosomiasis. Acta Pharm. Sin. 1983, 18:619-621.
74. Li L.S., Zhang J.E. Experimental therapy of schistosomiasis with Chinese herb "Lilu" (Ye Jin Zhen Cai). Natl. Med. J. China 1960, 46:100-112.
75. Li S.W., Wu L.J., Liu Z.D., Hu L.S., Xu Y.X., Liu Y.M., et al. Studies on prophylactic effect of artesunate on schistosomiasis japonica. Chin. Med. J. 1996, 109:848-853.
76. Li H.Y., Liu Z.D., Hu L.S., Liu Y.M., Hu F., Chen Y.H., et al. Observation on the prevention of schistosomiasis japonica by administration of artesuante long term. Chin. J. Parasit. Dis. Control 1999, 12:412.
77. Li Y.S., Chen H.G., He H.B., Hou X.Y., Ellis M., McManus P. A double-blind field trial on the effects of artemether on Schistosoma japonicum infection in a highly endemic focus in southern China. Acta Trop. 2005, 96:184-190.
78. Liang H.T. A preliminary study on ammonium antimonyl-(III)-gluconate, a potential drug for the treatment of schistosomiasis. Acta Pharm. Sin. 1957, 5:93-95.
79. Liang X.T., Xie J.X., Xue Z., Chen S.F., Zhu R. Structure of cucurbitine. Acta Pharm. Sin. 1962, 9:725-733.
80. Liu X., Lu S.Z. A review on furapromidum in pharmacology and clinical trial. Chin. J. Intern. Med. 1965, 13:568-571.
81. Liu Y.H., Wang Q.N., Wang X.G., Zhan Q.D., Ma Y.X., Liu Z.L., et al. Phenithionate (phenyl-4-nitrodiphenylamine-4'-thiono-carbamate) in the treatment of schistosomiasis japonica-a preliminary report on 463 cases. Chin. J. Intern. Med. 1982, 21:609-613.
82. Liu Y.H., Wang Q.N., Wang X.G., Zhan Q.D., Lu X.E., Ma Y.X., et al. Phenithionate in schistosomiasis japonica-preliminary report of 463 cases. Chin. Med. J. 1983, 96:269-274.
83. Liu X., Lu C.Z., Chen F.X., Zheng W.Q., Fu F.Y., Lu X.Z. Clinical observation on Xuefang-846 in treatment of schistosomiasis and the follow-up survey of delayed toxicity. Proceedings of Schistosomiasis Research (1961-1979) 1985, 320. National Schistosomiasis Research Committee, Ministry of Health.
84. Liu Y.H., Qian M.X., Wang X.G., Jia J., Wang Q.N., Jiang Y.F., et al. Comparative efficacy of praziquantel and its optic isomers in experimental therapy of schistosomiasis japonica in rabbits. Chin. Med. J. 1986, 99:935-940.
85. Liu Y.H., Wang X.G., Qian M.X., Yan S.H., Chen B.Y., Li J.S., et al. A comparative trial of single dose treatment with praziquantel and levo-praziquantel in human schistosomiasis japonica. Jpn. J. Parasitol. 1988, 37:331-334.
86. Liu Y.H., Qian M.X., Wang X.G., Quan Y.Z., Yan S.H., Chen B.Y., et al. Levo-praziquantel versus praziquantel in experimental and clinical treatment of schistosomiasis japonica. Chin. Med. J. 1993, 106:593-596.
87. Liu Z.D., Liu H.G., Lin Y.M., Lin D.D., Zhang S.J., Hu L.H., et al. Observation for the effect of artesunate on schistosomiasis control in the field sites. Acta Nachang Univer. 1998, 22:1-8.
88. Lu S.T., Liu H. A survey of short-course antimony tartrate therapy for schistosomiasis japonica in China. Chin. Med. J. 1963, 82:46-54.
89. Lu G.Y., Lin G.J., Sun M.X., Cui J.E., Wu Q.Z. Probe on scheme with oral artesunate protecting people from infection of schistosome. Chin. J. Parasit. Dis. Control 2000, 13:212-214.
90. Luo W.Y., Lin D.D., Chen Z.P., Gao Z.L., Hu F., Liu Y.M., et al. Effect of artesunate for preventing armed forces schistosomiasis during anti-flood. Med. J. Armed Police Troops 2000, 11:334-336.
91. Maegraith B. Schistosomiasis in China. Lancet 1958, 271:208-214.
92. Manneck T., Haggenmüller Y., Keiser J. Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni. Parasitology 2010, 137:85-98.
93. Mao C.P. A review of the epidemiology of schistosomiasis japonica in China. Am. J. Trop. Med. 1948, 28:659-672.
94. Mao S.P., Shao B.R. Schistosomiasis control in People's Reoublic of China. Am. J. Trop. Med. Hyg. 1982, 31:92-99.
95. Studies on sodium antimony dimercaptosuccinate (Sb-58) in clinical treatment of schistosomiasis japonica. Natl. Med. J. China 1960, 46:88-92. Medical Research Committee of Ministry of Health & National Schistosomiasis Research Committee.
96. Studies on "Lilu" in treatment of schistosomiasis. Natl. Med. J. China 1960, 46:95-100. Medical Research Committee of Ministry of Health & National Schistosomiasis Research Committee.
97. Proceedings of Schistosomiasis Research (1959) 1961, Medical Research Committee of Ministry of Health & National Schistosomiasis Research Committee, Shanghai Scientific Press, Shanghai, pp. 122-124.
98. Melman S.D., Steinauer M.L., Cunningham C., Kubatko L.S., Mwangi I.N., Wynn N.B., et al. Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni. PLoS Negl. Trop. Dis. 2009, 3:e504.
99. Miao H.Z. Amoscanate induced liver injury. I. Clinical observation. Chin. J. Intern. Med. 1981, 20:430-432.
100. Muth S., Sayasone S., Odermatt-Biays S., Phompida S., Duong S., Odermatt P. Schistosoma mekongi in Cambodia and Lao People's Democratic Republic. Adv. Parasitol. 2010, 72:179-203.
101. Studies on schistosomiasis japonica in new China. Chin. Med. J. 1959, 78:461-489. National Schistosomiasis Research Committee.
102. Ohnmacht C.J., Patel A.R., Lutz R.E. Antimalarials. 7. bis(trifluoromethyl)-(2-piperidyl)-4-quinolinemethanols. J. Med. Chem. 1971, 14:926-928.
103. Qian Y.S., Quan Y.Z. Stereoselectivity of arrhythmogenic effect of praziquantel in conscious rabbits. Acta Pharmacol. Sin. 1989, 10:245-248.
104. Qian S.H., Wu L.J., Nie J.R., Hu X.G. Pararosaniline pamoate, a nonantimony anti-schistosomiasis agent was tested for its chemotherapeutic activity against Schistosoma japonicum. Acta Pharm. Sin. 1980, 15:153-157.
105. Qian M.X., Liu Y.H., Quan Y.Z., Qiu Z.Y. The liver first pass effects and bile concentrations of (-)-, (+)- and (+/-)-praziquantel in rabbits. Acta Pharmacol. Sin. 1989, 10:92-96.
106. Quan Y.Z., Huang W.Y., Zhou Q.X., Li Y.Z. Studies on the antischistosomal action and toxicity of phenyl-4-nitro-diphenylamino-4'-thioncarbamate (7720). Acta Pharm. Sin. 1982, 17:481-486.
107. Sabah A.A., Fletcher C., Webbe G., Doenhoff M.J. Schistosoma mansoni: chemotherapy of infections of different ages. Exp. Parasitol. 1986, 61:294-303.
108. Summary on clinical trials with furadiamine in treatment of 163 patients with schistosomiasis japonica. Proceedings of Schistosomiasis Research (1961-1979) 1985, 360. Section of Schistosomiasis, Jiaxing First Hospital, National Schistosomiasis Research Committee, Ministry of Health.
109. Combined oral furapromidum and rectal dipterex in schistosomiasis japonica. Chin. Med. J. 1977, 3(New):103-106. Shanghai Furapromidum Research Coordinating Group.
110. Shao B.R., Xiao S.H., He Y.X., Zhang Y.M., Xi Y.R., Ma C.P. Preliminary studies on F-30066 against experimental schistosomiasis in animals. Natl. Med. J. China 1963, 49:316-321.
111. Shao B.R., Xiao S.H., Zhan C.Q., Shang Y.C., Ho Y.H., Xi Y.R. Experimental studies on F30385-a new antischistosomal drug. Acta Pharm. Sin. 1965, 12:642-649.
112. Shao B.R., Xiao S.H., Wu H.M., Zhan C.Q. Heart rhythm disturbance in rabbits induced by pyquiton and the drugs for its treatment and prevention. Acta Pharm. Sin. 1981, 16:407-410.
113. Shen J.F., Liu B.Q., Huang L.S. Isolation and identification of the active principle against schistosome from Dryopteris crassirhizoma. Chin. Pharm. Bull. 1981, 16:79-80.
114. Shi M.Z., Yu D.B., Wei W.Y., Zhang C.S., He H.B., Yang G.F., et al. Experimental study on susceptibility of praziquantel against Schistosoma japonicum in repeated chemotherapy areas in Dongting Lake region. Chin. J. Schisto. Control 2004, 16:171-173.
115. Shiao S.H., Shang Y.C. Studies on the effect of F-30066 on Schistosoma japonicum in vitro. Acta Pharm. Sin. 1963, 10:701-707.
116. Shiao S.H., Yang Y.Q., Loh W.C., Chow H.Y., Mao S.P. Studies on the effect of pumpkin seed on experimental schistosomiasis japonica. Acta Pharm. Sin. 1959, 7:300-308.
117. Shiao S.H., Yang Y.Q., Cie Y.R., Shang Y.C. Experimental therapy of schistosomiasis japonica, XII. Effectiveness of 8-hydroxyquinoline antimony complex in the oral treatment of experimental schistosomiasis in mice. Acta Pharm. Sin. 1960, 8:197-205.
118. Shiao S.H., Shao B.R., He Y.X., Yang Y.Q., Mao C.P. Studies on the prophylactico-therapeutic effect of cucurbitine in experimental schistosomiasis japonica in mice. Sci. Sin. 1962, 11:1527-1534.
119. Shiao S.H., Shao B.R., Tseng S.Y., Chen C., Chang Y.C., Huang L.S. Studies on Hemerocallis thungergii Baker 1. The toxicity of Hererocallis thunbergii Baker. Acta Pharm. Sin. 1962, 9:208-217.
120. Shiao S.H., Shao B.R., He Y.X., Yang Y.Q., Yang H.Z., Chang Y.C. Studies on Hemerocallis thunbergii Baker II. Effectiveness of Hemerocallis thunbergii in oral treatment of experimental schistosomiasis in mice. Acta Pharm. Sin. 1962, 9:218-224.
121. Song Y., Xiao S.H., Wu W., Zhang S.J., Xie H.Q., Xu X.P., et al. Preventive effect of artemether on schistosome infection. Chin. Med. J. 1998, 111:123-127.
122. Song H.T., Liang Y.S., Dai J.R., Li L.G., Shen X.H., Tian Q.A., et al. Studies on sensitivity of Schistosoma japonicum to praziquantel situation in low endemic areas. Chin. J. Schisto. Control 2004, 16:58-59.
123. Song Y., Bao Z.P., Gao Z.L., Hu Q.L., Nin A., Chen M.G., et al. Effect of oral artemether in controlling schistosomiasis in a heavy endemic area of Nanji town, Xinjian county, Jiangxi province. J. Trop. Med. 2006, 6:1182-1185.
124. Steinmann P., Keiser J., Bos R., Tanner M., Utzinger J. Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk. Lancet Infect. Dis. 2006, 6:411-425.
125. Striebel H.P. 4-Isothiocyanato-4'-nitrodiphenylamine (C 9333-GO/CGP 4540), an anthelminthic with an unusual spectrum of activity against intestinal nematodes, filariae and schistosomes. Experientia 1976, 32:457-458.
126. Tanaka H., Tsuji M. From discovery to eradication of schistosomiasis in Japan: 1847-1996. Int. J. Parasitol. 1997, 27:1465-1480.
127. Tang R.Z., Shao B.R., Xie R.R. Some pharmacological actions of F30066. Acta Pharma. Sin. 1964, 10:450-453.
128. Tian Z.Y., Xiao S.H., Xiao J.W., Zhou Y.C., Liu D.S., Zheng J., et al. Reduction of Schistosoma japonicum infection in an endemic area in islet with embankment after prophylaxis with oral artemether throughout the transmission season. Chin. J. Parasitol. Parasit. Dis. 1997, 15:208-211.
129. Tian Z.Y., Liu D.S., Xiao Z.W., Zhou Y.C., Qu G.S., Yao X.M., et al. A cost-effectiveness study of artesunate in the prophylaxis of schistosomiasis in an endemic area. Chin. J. Schisto. Control 2001, 13:299-300.
130. Tsen Y.L. Studies on antibilharzial drugs XXVI. Structure-activity studies on rosaniline and its combined therapy with tartar emetic. Acta Pharm. Sin. 1960, 8:134-140.
131. Tuon F.F., Amato V.S., Graf M.E., Siqueira A.M., Nicodemo A.C., Amato Neto V. Treatment of New World cutaneous leishmaniasis-a systematic review with a meta-analysis. Int. J. Dermatol. 2008, 47:109-124.
132. Utzinger J., Keiser J. Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and control. Expert Opin. Pharmacother. 2004, 5:263-285.
133. Utzinger J., Chollet J., You J.Q., Mei J.Y., Tanner M., Xiao S.H. Effect of combined treatment with praziquantel and artemether on Schistosoma japonicum and Schistosoma mansoni in experimentally infected animals. Acta Trop. 2001, 80:9-18.
134. Utzinger J., Xiao S.H., Keiser J., Chen M.G., Zheng J., Tanner M. Current progress in the development and use of artemether for chemoprophylaxis of major human schistosome parasites. Curr. Med. Chem. 2001, 8:1841-1860.
135. Utzinger J., Xiao S.H., N'Goran E.K., Bergquist R., Tanner M. The potential of artemether for the control of schistosomiasis. Int. J. Parasitol. 2001, 31:1549-1562.
136. Utzinger J., Keiser J., Xiao S.H., Tanner M., Singer B.H. Combination chemotherapy of schistosomiasis in laboratory studies and clinical trials. Antimicrob. Agents Chemother. 2003, 47:1487-1495.
137. Utzinger J., Zhou X.N., Chen M.G., Bergquist R. Conquering schistosomiasis in China: the long march. Acta Trop. 2005, 96:69-96.
138. Utzinger J., Xiao S.H., Tanner M., Keiser J. Artemisinins for schistosomiasis and beyond. Curr. Opin. Investig. Drugs 2007, 8:105-116.
139. van der Werf M.J., de Vlas S.J., Brooker S., Looman C.W.N., Nagelkerke N.J.D., Habbema J.D.F., et al. Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa. Acta Trop. 2003, 86:125-139.
140. Van Nassauw L., Toovey S., Op V., den Bosch J., Timmermans J.P., Vercruysse J. Schistosomicidal activity of the antimalarial drug, mefloquine, in Schistosoma mansoni-infected mice. Travel Med. Infect. Dis. 2008, 6:253-258.
141. Vennerstrom J.L., Arbe-Barnes S., Brun R., Charman S.A., Chiu F.C., Chollet J., et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature 2004, 430:900-904.
142. Wang Z.H. The effect of nithiocyaminum on cardiovascular system in the treatment of schistosomiasis. Chin. J. Intern. Med. 1981, 20:355-357.
143. Wang X.Q., Mao S.P. Comparison of morphology, pathogenicity and drug response among three isolates of Schistosoma japonicum in the mainland of China. Ann. Parasitol. Hum. Comp. 1989, 64:110-119.
144. Wang G.F., Huang T.Y., Sun L.F. Studies on the metabolism of F-30066. Acta Pharm. Sin. 1965, 12:601-605.
145. Wang G.F., Yang Y.Q., Le W.J., Yang H.Z., You J.Q. The effect of agrimophol and its combination with niridazole in experimental schistosomiasis. Acta Pharm. Sin. 1979, 14:379-384.
146. Wang D.Q., Ying H.Q., Wang R., Dai X.F., Cao Z.Z., Pan X.H. Synthesis of Sb-273. Proceedings of Schistosomiasis Research (1961-1979) 1985, 501-502. National Schistosomiasis Research Committee, Ministry of Health.
147. Wang X.G., Liu Y.H., Qian M.X. Comparative efficacy of levo-praziquantel and praziquantel in the treatment of Schistosoma japonicum infection. Chin. J. Intern. Med. 1987, 26:476-478.
148. Wang X.G., Liu Y.H., Yan S.H., Chen B.Y., Qian M.X., Zheng X.P., et al. Comparative efficacy of levo-praziquantel and praziquantel in the treatment of chronic schistosomiasis japonica. Acta Chongqing Med. Univ. 1987, 12:9-12.
149. Wang Z.H., Liu Y.H., Hu M.D., Cai S.Q., Zhang J.W., Qian M.X. Observation on the efficacy of levo-praziquantel in treatment of schistosomiasis japonica in a heavy endemic area. Chin. J. Intern. Med. 1988, 27:497.
150. Wang J.L., Xiao S.H., Yang Z., Wang M.K., Yang H., Liu Y.H., et al. Effect of oral artemether in controlling schistosomiasis in Yunan mountainous endemic area. Chin. J. Parasitol. Parasit. Dis. 1997, 15:138-142.
151. Wang L.D., Utzinger J., Zhou X.N. Schistosomiasis control: experiences and lessons from China. Lancet 2008, 372:1793-1795.
152. Wang L.D., Chen H.G., Guo J.G., Zeng X.J., Hong X.L., Xiong J.J., et al. A strategy to control transmission of Schistosoma japonicum in China. N. Engl. J. Med. 2009, 360:121-128.
153. White N.J. Qinghaosu (artemisinin): the price of success. Science 2008, 320:330-334.
154. The control of schistosomiasis: report of a WHO expert committee. WHO Tech. Rep. Ser. No. 728 1985, WHO, pp. 1-114.
155. Prevention and control of schistosomiasis and soil-transmitted helminthiasis: report of a WHO expert committee. WHO Tech. Rep. Ser. No. 912 2002, WHO, pp. 1-57.
156. William S., Sabra A., Ramzy F., Mousa M., Demerdash Z., Bennett J.L., et al. Stability and reproductive fitness of Schistosoma mansoni isolates with decreased sensitivity to praziquantel. Int. J. Parasitol. 2001, 31:1093-1100.
157. Wu L.S., Li F. Side effects on the nervous system caused by nithiocyamine. Clinical observation of 47 cases. Chin. J. Intern. Med. 1983, 22:477-479.
158. Wu G.Z., Liu S.X., Xiao S.H. Effects of praziquantel on immunological response in mice infected with Schistosoma japonicum. Acta Pharmacol. Sin. 1988, 9:163-166.
159. Wu L.J., Xu P.S., Xuan Y.X., Li S.W. Experimental studies on the prophylactic effect of artesunate in early treatment of schistosomiasis by oral administration. Chin. J. Schisto. Control 1995, 7:129-133.
160. Wu L.J., Li S.W., Xuan Y.X., Xu P.S., Liu Z.D., Hu L.S., et al. Field application of artesunate in prophylaxis of schistosomiasis: an observation of 346 cases. Chin. J. Schisto. Control 1995, 7:323-327.
161. Wu L.J., Xuan Y.X., Xu P.S., Guo R., Fan J.T., Yang M.J., et al. Study on artesunate in the prophylactic treatment of schistosomiasis: an observation of pathological changes in the rabbits. Chin. J. Schisto. Control 1996, 8:156-157.
162. Wu L.J., Xuan Y.X., Xu P.S., Li S.W. Studies on the effect of artesunate to the energy-metabolic enzymes. Chin. J. Schisto. Control 1996, 8:267-269.
163. Wu L.J., Xu P.S., Fang J.T., Yang M.J., Li S.W. Experimental study on the prophylaxis of artesunate against acute schistosomiasis. Chin. J. Schisto. Control 1997, 9:284-286.
164. Wu L.J., Xu P.S., Yang M.J., Fan J.T., Li S.W. Study on the interaction of artesunate and praziquantel in the treatment of schistosomiasis. Chin. J. Schisto. Control 1998, 10:65-68.
165. Wu L.J., Guo Y., Xu P.S., Yang M.J., Yan X.L., Lou L.J., et al. Discussion on the optimal scheme of artesunate on prevention of schistosomiaisis in rabbits. Chin. J. Schisto. Control 1999, 11:217-221.
166. Xiao S.H. A review on pharmacological studies of schistosomicide, furapromidum. Medicinal Ind. (Shanghai) 1979, 10:55-61.
167. Xiao S.H. Pharmacology and therapeutics. Agents for Treatment of Schistosomiasis, Other Trematodiasis and Filariasis 2000, 1721-1734. People Health Publishing House, Beijing. Z.S. Yang (Ed.).
168. Xiao S.H. Development of antischistosomal drugs in China, with particular consideration to praziquantel and the artemisinins. Acta Trop. 2005, 96:153-167.
169. Xiao S.H., Shen B.G. Scanning electron microscope observation on tegumental damage of 21-d-old Schistosoma japonicum induced by praziquantel. Acta Pharmacol. Sin. 1995, 16:273-275.
170. Xiao S.H., Shen B.G. Scanning electron microscope observation on tegumental alteration of Schistosoma japonicum induced by levo- and dextro-praziquantel. Chin. Parasitol. Parasitic Dis. 1995, 13:46-50.
171. Xiao S.H., Zhang C.W. Histopathological alteration of juvenile Schistosoma japonicum in mice following treatment with single-dose mefloquine. Parasitol. Res. 2009, 105:1733-1740.
172. Xiao S.H., Liu R.J., Chan C.C. Experimental studies on combined oral furapromidum and rectal dipteres in treatment of rabbits infected with schistosomiasis. Natl. Med. J. China 1973, 53:391-396.
173. Xiao S.H., Liu R.J., Chan C.C. Combined oral F30066 and rectal dipterex in treatment of experimental schistosomiasis japonica. Chin. Med. J. 1975, 1(New):51-59.
174. Xiao S.H., Shao B.R., Yang Y.Q., Chan C.C., Yang H.Z., Liu R.J., et al. Studies on fuvinazole in treatment of experimental schistosomiasis japonica. Chin. J. Intern. Med. 1977, 16:272-277.
175. Xiao S.H., Shao B.R., Xue Y.Q., Pan Q.R. The actions of pyquiton on the morphological changes of schistosomes, oviposition of female worms and hatching of ova. Natl. Med. J. China 1980, 60:137-141.
176. Xiao S.H., Shao B.R., Yan K.J., Zhan C.Q., Liu R.J., Yang H.Z., et al. Studies on the effectiveness and toxicity of a niridazole derivative S72014 in experimental chemotherapy of schistosomiasis japonica. Acta Pharm. Sin. 1980, 15:456-462.
177. Xiao S.H., Yang Y.Q., Shu Y.S., Wang Z.W. Ultrastructural changes of the tegument, syncithium, vitelline cells and muscles of Schistosoma japonicum caused by pyquiton. Acta Zool. Sin. 1981, 27:305-309.
178. 14 C] glucose uptake in Schistosoma japonicum. Acta Pharmacol. Sin. 1981, 2:204-211.
179. Xiao S.H., Wang C.Y., Jiao P.Y. Effect of praziquantel on nucleic acid synthesis in Schistosoma japonicum. Acta Pharmacol. Sin. 1981, 2:275-280.
180. Xiao S.H., Xue H.C., Guo H.F., Yang H.Z., Shao B.R. The appearance of surface antigen of Schistosoma japonicum recovered from infected mice after the treatment with pyquiton. Shanghai J. Immunol. 1981, 1:9-15.
181. Xiao S.H., Wang C.Y., Jiao P.Y., Chen G.Z., Yu Y.G., Yuan X.J. Effect of praziquantel on ATP uptake and metabolism of Schistosoma japonicum. Acta Pharmacol. Sin. 1982, 3:130-135.
182. Xiao S.H., Yang Y.Q., Yang H.Z., Guo H.F., Shao B.R. Observation on tegument damage of Schistosoma japonicum and penetration of host leucocytes into the worm body caused by pyquiton. Acta Pharm. Sin. 1983, 18:241-246.
183. Xiao S.H., Catto B.A., Webster L.T. Quantitative determination of praziquantel in serum by high-performance liquid chromatography. J. Chromatogr. 1983, 275:127-132.
184. Xiao S.H., Shao B.R., Yu Y.G. Preliminary studies on the mode of action of pyquiton against Schistosoma japonicum. Chin. Med. J. 1984, 97:839-848.
185. Xiao S.H., Friedman P.A., Catto B.A., Webster L.T. Praziquantel-induced vesicle formation in the tegument of male Schistosoma mansoni is calcium dependent. J. Parasitol. 1984, 70:177-179.
186. Xiao S.H., Sun H.L., Jiao P.Y. Effect of pyquiton on calcium uptake of male Schistosoma japonicum. Acta Pharm. Sin. 1984, 19:727-731.
187. Xiao S.H., Guo H.F., Dai Z.Q., Zhang R.Q. Effect of calcium, magnesium and temperature on praziquantel-induced tegument damage of male Schistosoma japonicum. Acta Pharmacol. Sin. 1985, 6:59-63.
188. 2+ in male Schistosoma japonicum. Acta Pharm. Sin. 1985, 20:815-820.
189. Xiao S.H., Guo H.F., Zhang R.Q., Xue H.C., Qiu L.S. Effect of immune serum on the male Schistosoma japonicum subjected to pyquiton. Acta Pharm. Sin. 1985, 20:10-16.
190. Xiao S.H., You J.Q., Zhang R.Q. Scanning electron microscope observation on tegumental surface alterations of Schistosoma japonicum induced by praziquantel at different developmental stages. Acta Pharm. Sin. 1985, 20:577-583.
191. Xiao S.H., Yue W.J., Mei J.Y. Analysis of prophylactic effect of praziquantel on mice infected with Schistosoma japonicum cercariae. Acta Pharm. Sin. 1985, 20:641-646.
192. Xiao S.H., Guo H.F., Xue H.C., Qiu L.S., Zhang R.Q. Attachment of mouse neutrophils in vitro on praziquantel-damaged surface of adult Schistosoma japonicum in the presence of immune sera. Acta Pharmacol. Sin. 1986, 7:165-170.
193. Xiao S.H., Qiu L.S., Wu G.Z., Yue W.J., Xue H.C., You J.Q., et al. Relationship between the efficacy of praziquantel on rabbits infected with Schistosoma japonicum and immune level of the host. Acta Pharm. Sin. 1986, 21:725-730.
194. 3 H-praziquantel in tissues of Schistosoma japonicum at different developmental stages. Acta Pharm. Sin. 1986, 21:377-381.
195. Xiao S.H., Yang Y.Q., Zhang R.Q., Zhang C.W. Morphological alterations of schistosomulae invading the skin of mice treated orally with praziquantel before infection and cellular reaction of the skin. Acta Pharmacol. Sin. 1986, 7:358-360.
196. Xiao S.H., You J.Q., Guo H.F., Yang B. Relationship between the efficacy and plasma concentration of praziquantel in mice and rabbits infected with Schistosoma japonicum. Chin. J. Pharmacol. Toxicol. 1987, 1:287-292.
197. Xiao S.H., Yue W.J., Yang Y.Q., You J.Q. Susceptibility of Schistosoma japonicum of different developmental stages to praziquantel. Chin. Med. J. 1987, 100:759-768.
198. Xiao S.H., Yue W.J., Mei J.Y. Susceptibility of schistosomula at various ages to praziquantel during invasion in mouse skin and observations on certain characteristics of the schistosomula surface. Acta Pharmacol. Sin. 1987, 8:261-266.
199. Xiao S.H., Yue W.J., Mei J. Effects of praziquantel in vitro on adherence of neutrophils to schistosomula and killing of the worms. Acta Pharmacol. Sin. 1987, 8:547-551.
200. Xiao S.H., Yue W.J., Mei J.Y., Zhang R.Q. Effect of praziquantel on Schistosoma japonicum cercariae. Acta Pharmacol. Sin. 1987, 8:358-362.
201. Xiao S.H., Xue H.C., Le W.J., Qiu L.S., Mei J.Y. Conversion of Schistosoma japonicum cercariae to schistosomula under the action of praziquantel. Chin. J. Parasitol. Parasit. Dis. 1987, 5:133-135.
202. Xiao S.H., Yang Y.Q., Shen B.G., Xu D.H., Yang H.Z., Mei J.Y., et al. Effect of praziquantel on ultrastructure of Schistosoma japonicum cercariae and schistosomula within mouse skin. Acta Pharmacol. Sin. 1988, 9:360-363.
203. Xiao S.H., Fu S., Catto B.A. Recent laboratory investigations by Chinese workers on antischistosomal activities of praziquantel. Chin. Med. J. 1991, 107:599-606.
204. Xiao S.H., You J.Q., Guo H.F. Plasma pharmacokinetics and therapeutic efficacy of praziquantel and 4-hydroxypraziquantel in Schistosoma japonicum-infected rabbits after oral, rectal, and intramuscular administration. Am. J. Trop. Med. Hyg. 1992, 46:582-588.
205. Xiao S.H., Yin J.W., Mei J.Y., You J.Q., Li Y., Jiang H.J. Effect of arteether on Schistosoma japonicum. Acta Pharm. Sin. 1992, 27:161-165.
206. Xiao S.H., You J.Q., Mei J.Y., Jiao P.Y. Early treatment of schistosomal infection with artemether and praziquantel in rabbits. Acta Pharm. Sin. 1994, 15:447-452.
207. Xiao S.H., You J.Q., Mei J.Y., Jiao P.Y., Guo H.F., Feng J.J., et al. Early treatment with artemether and praziquantel in rabbits repeatedly infected with Schistosoma japonicum cercariae. Chin. J. Parasitol. Parasit. Dis. 1994, 12:252-256.
208. Xiao S.H., You J.Q., Yang Y.Q., Wang C.Z. Experimental studies on early treatment of schistosomal infection with artemether. Southeast Asian J. Trop. Med. Public Health 1995, 26:306-318.
209. Xiao S.H., You J.Q., Mei J.Y., Jiao P.Y., Guo H.F., Yang Y.Q. Experimental studies on the preventive effect of artemether against schistosomal infection. Chin. J. Parasitol. Parasit. Dis. 1995, 13:241-248.
210. Xiao S.H., Yang Y.Q., Zhang C.W., You J.Q. Microscopic observation on livers of rabbits and dogs infected with Schistosoma japonicum cercariae and early treatment with artemether or praziquantel. Acta Pharmacol. Sin. 1996, 17:167-170.
211. Xiao S.H., Shi Z.G., Zhou S.J., Wang C.Z., Zhang Z.G., Chu B., et al. Field studies on the preventive effect of oral artemether against schistosomal infection. Chin. Med. J. 1996, 109:272-275.
212. Xiao S.H., Shen B.G., Catto B.A. Effects of artemether on ultrastructure of Schistosoma japonicum. Chin. J. Parasitol. Parasit. Dis. 1996, 14:181-187.
213. Xiao S.H., Shen B.G., Horner J., Catto B.A. Tegumental changes of Schistosoma japonicum and Schistosoma mansoni in mice treated with artemether. Acta Pharmacol. Sin. 1996, 17:535-537.
214. Xiao S.H., Wang J.L., Wang Z., Yang Z., Chu B., Yang H., et al. Protection of the residents from schistosome infection using oral artemether in mountainous endemic area. Chin. J. Parasitol. Parasit. Dis. 1996, 14:11-14.
215. Xiao S.H., You J.Q., Mei J.Y., Guo H.F., Jiao P.Y., Sun H.L., et al. Effect of artemether on glucose uptake and glycogen content in Schistosoma japonicum. Acta Pharm. Sin. 1997, 18:363-367.
216. Xiao S.H., You J.Q., Mei J.Y., Hu Y.Q., Zhou D.H., Catto B.A. In vitro and in vivo effect of levopraziquantel, dextropraziquantel versus racemic praziquantel on different developmental stages of Schistosoma japonicum. Chin. J. Parasitol. Parasit. Dis. 1998, 16:335-341.
217. Xiao S.H., You J.Q., Mei J.Y., Jiao P.Y., Guo H.F., Feng Z. Preventive effect of artementer in rabbits infected with Schistosoma japonicum cercariae. Acta Pharmacol. Sin. 1998, 19:63-65.
218. Xiao S.H., You J.Q., Guo H.F., Jiao P.Y., Mei J.Y., Yao M.Y., et al. Effect of artemether on hexokinase, glucose phosphate isomerase and phosphor-fructokinase of Schistosoma japonicum harbored in mice. Chin. J. Parasitol. Parasit. Dis. 1998, 16:25-28.
219. Xiao S.H., You J.Q., Guo H.F., Jiao P.Y., Mei J.Y., Yao M.Y., et al. Effect of artemether on glyceraldehyde-3-phosphate dehydrogenase, phosphoglycerate kinase, and pyruvate kinase of Schistosoma japonicum harbored in mice. Acta Pharmacol. Sin. 1998, 19:279-281.
220. Xiao S.H., You J.Q., Guo H.F., Mei J.Y., Jiao P.Y., Yao M.Y., et al. Effect of artemether on phosphorylase, lactate dehydrogenase, adenosine triphosphatase, and glucosephosphatase dehydrogenase of Schistosoma japonicum harbored in mice. Acta Pharmacol. Sin. 1999, 20:750-754.
221. Xiao S.H., Booth M., Tanner M. The prophylactic effects of artemether against Schistosoma japonicum infections. Parasitol. Today 2000, 16:122-126.
222. Xiao S.H., Hotez P.J., Tanner M. Artemether, an effective new agent for chemoprophylaxis against schistosomiasis in China: its in vivo effect on the biochemical metabolism of the Asian schistosome. Southeast Asian J. Trop. Med. Public Health 2000, 31:724-732.
223. Xiao S.H., You J.Q., Mei J.Q., Guo H.F., Jiao P.Y., Tanner M. Effect of praziquantel together with artemether on Schistosoma japonicum parasites of different ages in rabbits. Parasitol. Int. 2000, 49:25-30.
224. Xiao S.H., Chollet J., Utzinger J., Matile H., Mei J.Y., Tanner M. Artemether administered together with haemin damages schistosomes in vitro. Trans. R. Soc. Trop. Med. Hyg. 2001, 95:67-71.
225. Xiao S.H., Tanner M., N'Goran E.K., Utzinger J., Chollet J., Bergquist R., et al. Recent investigations of artemether, a novel agent for the prevention of schistosomiasis japonica, mansoni and haematobia. Acta Trop. 2002, 82:175-181.
226. Xiao S.H., Yang Y.Q., You J.Q., Utzinger J., Guo H.F., Jiao P.Y., et al. Potential long-term toxicity of repeated orally administered doses of artemether in rats. Am. J. Trop. Med. Hyg. 2002, 66:30-34.
227. Xiao S.H., You J.Q., Gao H.F., Mei J.Y., Jiao P.Y., Chollet J., et al. Schistosoma japonicum: effect of artemether on glutathione S-transferase and superoxide dismutase. Exp. Parasitol. 2002, 102:38-45.
228. Xiao S.H., Wu Y.L., Tanner M., Wu W.M., Utzinger J., Mei J.Y., et al. Schistosoma japonicum:in vitro effects of artemether combined with haemin depend on cultivation media and appraisal of artemether products appearing in the media. Parasitol. Res. 2003, 89:459-466.
229. Xiao S.H., Keiser J., Chollet J., Utzinger J., Dong Y., Endriss Y., et al. In vitro and in vivo activities of synthetic trioxolanes against major human schistosome species. Antimicrob. Agents Chemother. 2007, 51:1440-1445.
230. Xiao S.H., Mei J.Y., Jiao P.Y. Further study on mefloquine concerning several aspects in experimental treatment of mice and hamsters infected with Schistosoma japonicum. Parasitol. Res. 2009, 106:131-138.
231. Xiao S.H., Mei J.Y., Jiao P.Y. The in vitro effect of mefloquine and praziquantel against juvenile and adult Schistosoma japonicum. Parasitol. Res. 2009, 106:237-246.
232. Xiao S.H., Chollet J., Utzinger J., Mei J.Y., Jiao P.Y., Keiser J., et al. Effect of single-dose oral mefloquine on the morphology of adult Schistosoma japonicum in mice. Parasitol. Res. 2009, 105:853-861.
233. Xiao S.H., Xue J., Shen B.G. Tegumental alteration of adult Schistosoma japonicum harbored in mice treated with a single oral dose of mefloquine. Chin. J. Parasitol. Parasit. Dis. 2010, 28:1-7.
234. Xiao S.H., Xue J., Shen B.G. Transmission electron microscopic observation on ultrastructural alterations in Schistosoma japonicum caused by mefloquine. Parasitol. Res. 2010, 106:1179-1187.
235. Xu M.S. The effect analysis of using artesunate to prevent schistosome infection in the field. Chin. J. Parasit. Dis. Control 2001, 14:26-27.
236. Xu M.S., Xiao S.H., Song Q., Tao C.G., Xia C.G., Wang H., et al. Observation on the effect of artemether on controlling schistosomiasis japonica in an endemic area of marshland. Chin. J. Parasitol. Parasit. Dis. 1997, 15:212-215.
237. Xu M.S., Xia C.G., Wang H., Gao F.H., Wu Y.X., Chui D.Y. Study on preventive effect of artesunate against infection due to Schistosoma japonicum in an endemic marshland area. Chin. J. Schisto. Control 1997, 9:268-271.
238. Xu M.S., Zhang S.Q., Li S.W., Wang T.P., Chen J.R., Qu N., et al. Field application of oral artesunate for preventing Schistosoma japonicum infection. Chin. J. Parasitol. Parasit. Dis. 1999, 17:241-243.
239. Yan K.J., Yang J.Z., Gu Y.Q., Li L.J., Chen X.Z., Quan Y.D., et al. Clinical observation on 9 patients with schistosomiasis japonica and treated with new antischistosomal drug S72014. Technical Report of Shanghai Institute for Parasitic Diseases in 1975 1975, 120-122.
240. Yan X.H., Li J.S., Chen B.Y., Qiu Z.Y. Synthesis and antischistosomal action of phenithionate and related derivatives of thiocarbamic acid. Acta Pharm. Sin. 1982, 17:667-673.
241. Yan Q.S., Liu T.P. Central mechanism of pyquiton-induced arrhythmia. Acta Pharm. Sin. 1984, 18:85-89.
242. Yan H.Y., Sun F.Z., Yang Y.J., Ying Z.Q., Qian S.J., Wang Y.Z., et al. Toxicity of Sb-273 and experimental therapy in animals infected with Schistosoma japonicum. Proceedings of Schistosomiasis Research (1961-1979) 1985, 502-503. National Schistosomiasis Research Committee, Ministry of Health.
243. Yang Y.Q., Yang H.Z., Xiao S.H. Effects of praziquantel on the tegument of different developmental stages of Schistosoma japonicum and host cell response. Chin. J. Parasitol. Parasit. Dis. 1987, 5:207-209.
244. Yi Z.H., Lu M., Feng D.C., Huang Z.H., Xiang C.P., Gou Z.Q., et al. Clinic observation on preventive effect of artesunate against schistosomiasis among the population contacting infested water in short term. Chin. J. Schisto. Control 2000, 12:100-101.
245. Yin J.W., Yang Y.Q., Xiao S.H., Li Y., Jiang H.J. Comparative studies on histological and histochemical alterations of Schistosoma japonicum induced by arteether and artemether. Acta Pharmcol. Sin. 1991, 12:478-480.
246. Yokogawa M. Programme of schistosomiasis control in Japan. Southeast Asian J. Trop. Med. Public Health 1976, 7:322-329.
247. You J.Q., Le W.J., Mei J.Y. The in vitro effect of agrimophol on Schistosoma japonicum. Acta Pharm. Sin. 1982, 17:663-666.
248. You J.Q., Xiao S.H., Yue W.J. Effect of praziquantel in vitro on different developmental stages of Schistosoma japonicum. Acta Pharmacol. Sin. 1986, 7:82-84.
249. You J.Q., Guo H.F., Mei J.Y., Jiao P.Y., Feng Z., Yao M.Y., et al. Effect of artemether on glycogen, protein, alkaline phosphatase and acid phosphatase of Schistosoma japonicum. Chin. J. Parasitol. Parasit. Dis. 1994, 12:275-278.
250. Yu H.Z. Experimental therapy and mechanism of action of nithiocyamine on Schistosoma japonicum. Acta Pharm. Sin. 1981, 16:641-647.
251. Yu Y., Yan A.H., Hu X.L., Wang X.G., Zhou C. Preparation of liposome of levo-praziquantel and praziquantel and their comparative efficacy in experimental therapy of schistosomiasis in mice. West China J. Pharmaceut. Sci. 1999, 14:315-318.
252. Yu D.B., Li Y., Sleigh A.C., Yu X.L., Li Y.S., Wei W.Y., et al. Efficacy of praziquantel against Schistosoma japonicum: field evaluation in an area with repeated chemotherapy compared with a newly identified endemic focus in Hunan, China. Trans. R. Soc. Trop. Med. Hyg. 2001, 95:537-541.
253. Yue W.J., You J.Q., Mei J.Y. Effects of artemether on Schistosoma japonicum adult worms and ova. Acta Pharmacol. Sin. 1984, 5:60-63.
254. Yue W.J., You J.Q., Mei J.Y. The activity of Dryoteris crassirhizoma Nakai against Schistosoma japonicum. Information Chin. Pharmacol. Soc. 1985, 2:31-33.
255. Yue W.J., You J.Q., Mei J.Y. Prophylactic activity of praziquantel in animals infected with Schistosoma japonicum. Acta Pharmacol. Sin. 1985, 6:186-188.
256. Yue W.J., Mei J.Y., Xiao S.H. Effects of praziquantel and artemether on tegumental surface antigens of different developmental stages of Schistosoma japonicum. Chin. J. Parasitol. Parasit. Dis. 1986, 4:284-287.
257. Yue W.J., Xu X.J., Mei J.Y., Xiao S.H. Observation on susceptibility of different geographic Schistosoma japonicum to praziquantel in mice. Chin. Pharmacol. Bull. 1988, 4:355-357.
258. Yue W.J., Yu S.H., Xu X.J. Failure to induce resistance of Schistosoma japonicum to praziquantel. Southeast Asian J. Trop. Med. Public Health 1990, 21:85-89.
259. Zhai Z.L., Zhang Y., Liu H.X., Feng T., Xiao S.H. Effect of artemether on enzymes involved in carbohydrate metabolism of Schistosoma japonicum. Chin. J. Parasitol. Parasit. Dis. 2000, 18:162-164.
260. Zhai Z.L., You J.Q., Guo H.F., Jiao P.Y., Mei J.Y., Xiao S.H. Effect of artemether on phosphoglucomutase, aldolase, phosphoglycerate mutase and enolase of Schistosoma japonicum harbored in mice. Chin. J. Parasitol. Parasit. Dis. 2000, 18:336-338.
261. Zhai Z.L., Mei J.Y., Jiao P.Y., Xiao S.H. Reduction of total antioxidant capacity in artemether-treated female Schistosoma japonicum. Chin. J. Parasitol. Parasit. Dis. 2002, 20:354-357.
262. Zhai Z.L., You J.Q., Guo H.F., Jiao P.Y., Mei J.Y., Xiao S.H. Inhibition of superoxide dismutase and glutathione reductase of Schistosoma japonicum by artemether. Endemic Dis. Bull. 2002, 17:19-22.
263. Zhai Z.L., Mei J.Y., Jiao P.Y., Xiao S.H. Artemether induces lipid peroxidation in Schistosoma japonicum. Chin. J. Zoonoses 2002, 18:55-57.
264. Zhai Z.L., Jiao P.Y., Mei J.Y., Xiao S.H. Glutathione inhibits the antischistosomal activity of artemether. Chin. J. Parasitol. Parasit. Dis. 2002, 20:212-215.
265. Zhang Y.J., Quan Y.Z. Involvement of cytochrome P4503A in the mono- hydroxylation of ring A of praziquantel in rat liver michrosomes. Acta Pharm. Sin. 1997, 32:5-10.
266. Zhang C.W., Yang Y.Q., Xiao S.H. Pathological changes in the livers of rabbits infected with schistosome cercariae and treated with artemether or praziquantel in the early stage of infection. Chin. J. Parasitol. Parasit. Dis. 1995, 13:51-53.
267. Zhang Y.J., Quan Y.Z., Huang W.Y. Metabolic profile and mass spectroscopic identification of metabolites of praziquantel in induced and non-induced rat liver microsomes. Chin. J. Pharmacol. Toxicol. 1996, 10:56-61.
268. Zhang Y.J., Quan Y.Z., Qiu Z.Y. Stereoselective metabolism of praziquantel enantiomers in rat liver microsomes with and without cytochrome P450 inducers. Chin. J. Pharmacol. Toxicol. 1996, 10:62-66.
269. Zhang S.J., Lin D.D., Xu M.S., Yi Z.H., Zhang S.Q., Liu Z.D., et al. Clinical trials on preventive effect of artesunate on schistosomiasis japonica. Med. Diagn. Treat. 2000, 11:68-72.
270. Zhang Y.P., Huang Y.X., Hong Q.B., Xu Y.L., Sun L.P., Xi W.P., et al. Observation on early co-treatment with artesunate and praziquantel for schistosomiasis in rabbits. Chin. J. Schisto. Control 2003, 15:192-194.
271. Zhang L., Liu F., Cui S.J., Xu B., Zhou X.N., Hu W. Proteomic analysis of adult Schistosoma japonicum treated with praziquantel. Chin. J. Parasitol. Parasit. Dis. 2008, 26:258-262.
272. Zhang C.W., Xiao S.H., Utzinger J., Chollet J., Keiser J., Tanner M. Histopathological changes in adult Schistosoma japonicum harbored in mice treated with a single dose of mefloquine. Parasitol. Res. 2009, 104:1407-1416.
273. Zhao L.L., Huang W.Y., Quan Y.Z. Metabolism of praziquantel in erythromycin, acetylspiramycin and dexamethasone induced rat liver microsomes. J. Chin. Pharm. Sci. 1995, 4:75-81.
274. Clinical observation on 987 cases of schistotomiasis japonica treated with pararosaniline pamoate. Natl. Med. J. China 1981, 61:172-173. Zhejiang Pararosaniline Pamoate Research Group.
275. Clinical studies on Sb-273 (sodium antimony gallate). Proceedings of Schistosomiasis Research (1961-1979) 1985, 321-322. Zhejiang Sb-273 Research Coordinating Group, National Schistosomiasis Research Committee, Ministry of Health.
276. Zhou G.X., Huang N.X., Zhang K.S., Ye Z.B., Zhong G.H., Jiang M.X., et al. Clinical observation on schistosomiasis japonica treated with amoscanate and phenithionate in a hyperendemic area. Chin. J. Intern. Med. 1983, 22:634-635.
277. Zhou X.N., Wang L.Y., Chen M.G., Wu X.H., Jiang Q.W., Chen X.Y., et al. The public health significance and control of schistosomiasis in China-then and now. Acta Trop. 2005, 96:97-105.
278. Zhou X.N., Bergquist R., Leonardo L., Yang G.J., Yang K., Sudomo M., et al. Schistosomiasis japonica: research and control. Adv. Parasitol. 2010, 72:145-178.