Pharmacological evaluation of some new 1-substituted-4-hydroxy-phthalazines

European Journal of Medicinal Chemistry

Volumn 37, Issue 10, 2002, Pages 793-801

  Sivakumar, Ramaiya ^a   Kishore Gnanasam, Sundararaj ^a   Ramachandran, Somasundaram ^a   Thomas Leonard, Joseph ^a  

^a VELS INSTITUTE OF SCIENCE   (India)

Author keywords

Amphetamine antagonism; Anticonvulsant; Aryloxyaminopropanes; Aryloxypropanolamines; Phthalazine; Sympatholytic

Indexed keywords

1 (3' DIETHANOLAMINO 2' HYDROXYPROPYLOXY) 4 HYDROXYPHTHALAZINE; 1 (3' DIETHYLAMINO 2' HYDROXYPROPYLOXY) 4 HYDROXYPHTHALAZINE; 1 (3' DIMETHYLAMINO 2' HYDROXYPROPYLOXY) 4 HYDROXYPHTHALAZINE; 1 (3' HYDRAZINOPHENYL 2' HYDROXYPROPYLOXY) 4 HYDROXYPHTHALAZINE; 1 (3' IMIDAZOLO 2' HYDROXYPROPYLOXY) 4 HYDROXYPHTHALAZINE; 1 (3' METHYLAMINO 2' HYDROXYPROPYLOXY) 4 HYDROXYPHTHALAZINE; 1 (3' PIPERAZINO 2' HYDROXYPROPYLOXY) 4 HYDROXYPHTHALAZINE; 1 (3' PIPERIDINO 2' HYDROXYPROPYLOXY) 4 HYDROXYPHTHALAZINE; 1 [3' (2'' AMINOPHENYLAMINO) 2' HYDROXYPROPYLOXY] 4 HYDROXYPHTHALAZINE; 1 [3' (6'' AMINOPYRIDYL 2'' AMINO) 2' HYDROXYPROPYLOXY] 4 HYDROXYPHTHALAZINE; 1 [3' (HYDROXYPHENYLAMINO) 2' HYDROXYPROPYLOXY] 4 HYDROXYPHTHALAZINE; PENTETRAZOLE; PHTHALAZINE DERIVATIVE; UNCLASSIFIED DRUG; ADRENALIN; AMPHETAMINE; ANTICONVULSIVE AGENT; PHENOBARBITAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SYNTHESIS; ELECTRIC SHOCK; HEART FUNCTION; INFRARED SPECTROMETRY; MOTOR ACTIVITY; NEUROLOGIC DISEASE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SEIZURE; SYMPATHETIC BLOCKING; ANIMAL; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG INTERACTION; FROG; HEART; HEART CONTRACTION; MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMPHETAMINE; ANIMALS; ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EPINEPHRINE; HEART; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOTOR ACTIVITY; MYOCARDIAL CONTRACTION; PENTYLENETETRAZOLE; PHENOBARBITAL; PHTHALAZINES; RANIDAE; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036809145     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(02)01405-8     Document Type: Article

References (27)

1. Lemke L.E., McQueen C.A. Drug Metab. Dispos. 23:1995;559.
2. Grasso S., De Sarro G., Micale N., Zappala M., Puia G., Baraldi M., DeMicheli C. J. Med. Chem. 43:2000;2851.
3. Soliman R., Gabr M., Abouzeit-Har M.S., Sharabi F.M. J. Pharm. Sci. 70:1981;94.
4. Go K., Tsurumi K., Fujimura H. Jpn. J. Pharmacol. 28:1978;1.
5. Nomoto Y., Obase H., Takai H., Teranishi M., Nakamura J., Kubo K. Chem. Pharm. Bull. (Tokyo). 38:1990;2179.
6. Watanabe N., Kabasawa Y., Takase Y., Matsukura M., Miyazaki K., Ishihara H., Kodama K., Adachi H. J. Med. Chem. 41:1998;3367.
7. Watanabe N., Adachi H., Takase Y., Ozaki H., Matsukura M., Miyazaki K., Ishibashi K., Ishihara H., Kodama K., Nishino M., Kakiki M., Kabasawa Y. J. Med. Chem. 43:2000;523.
8. Razvi M., Ramalingam T., Sattur P.B. Indian J. Chem., Sect. B. 28:1989;695.
9. Razvi M., Ramalingam T., Sattur P.B. Indian J. Chem., Sect. B. 28:1989;987.
10. Nathanson A.J., Hunnicutt E.J. J. Pharm. Pharmacol. 40:1998;803.
11. Samant S.D., Gupte S.M., Kulkarni R.A. Indian J. Chem., Sect. B. 19:1980;524.
12. Agarwal S.K., Saxena A.K., Jain P.C., Anand N., Sur R.N., Srimal R.C., Dhawan B.N. Indian J. Chem., Sect. B. 30:1991;413.
13. Ahmed B., Siddiqui A.A., Agarwal M. Indian J. Pharmacol. 31:1999;33.
14. Agarwal S.K., Saxena A.K., Jain P.C., Anand N., Sur R.N., Srimal R.C., Dhawan B.N. Indian J. Chem., Sect. B. 29:1990;80.
15. Sur R.N., Shanker G., Rathore R.K.S., Chak I.M., Agarwal S.K., Jain P.C. Indian J. Exp. Biol. 18:1980;1190.
16. Starling S.K., Rastogi S.N., Anand N., Srimal R.C., Kar K. Indian J. Chem., Sect. B. 15:1977;715.
17. Agarwal S.K., Kumar Y., Saxena A., Jain P.C., Anand N. Indian J. Chem., Sect. B. 21:1982;435.
18. Thomas L.J., Anbalagan N., Sadish K.S., Kishore G.S., Sridhar S.K. Biol. Pharm. Bull. 25:2002;215.
19. L.J. Thomas, R. Sivakumar. N. Anbalagan, K.S. Sadish, S.K. Sridhar, Boll. Chim. Farm (in press) No: 75/01.
20. Thomas L.J., Gangadhar R., Kishore G.S., Ramachandran S., Saravanan M., Sridhar S.K. Biol. Pharm. Bull. 25:2002;798.
21. Krall R.L., Penry J.K., White B.G., Kupferberg H.J., Swinyard E.A. Epilepsia. 19:1978;409.
22. Porter R.J., Cereghino J.J., Gladding G.D., Hessie B.J., Kupferberg H.J., Scoville B., White B.G. Cleveland Clin. Q. 51:1984;293.
23. Fitton A.O., Smalley R.K., Practical Heterocyclic Chemistry. 1968;116 Academic Press, London.
24. Simpson J.C.E. Condensed Pyridazine and Pyrazine rings. 1953;157 Interscience Publishers, New York.
25. Spiegel M.R., Meddis R. Probability and Statistics. 1980;120 McGraw-Hill Book Company, New York.
26. Turner R.A., Hebborn P., Screening Methods in Pharmacology. 1965;77 Academic Press, New York.
27. S.K. Kulkarne, Handbook of Experimental Pharmacology, Vallabh, Prakasham, Bombay, 1999, p. 75