The effects of enamel matrix derivative on the proliferation and differentiation of human mesenchymal stem cells

Clinical Oral Implants Research

Volumn 21, Issue 7, 2010, Pages 741-746

  Jue, Seong Suk ^a   Lee, Won Young ^a   Kwon, Yong Dae ^a   Kim, Young Ran ^a   Pae, Ahran ^a   Lee, Baeksoo ^a  

^a Kyung Hee University   (South Korea)

Author keywords

EMD; Enamel matrix derivative; Gene expression; Mesenchymal stem cell

Indexed keywords

4 CARBOXYGLUTAMIC ACID; CELL SURFACE RECEPTOR; COLLAGEN TYPE 1; ENAMEL MATRIX PROTEINS; ENAMEL PROTEIN; ENG PROTEIN, HUMAN; FAS ANTIGEN; INTEGRIN BINDING SIALOPROTEIN; INTEGRIN-BINDING SIALOPROTEIN; LEUKOCYTE ANTIGEN; MESSENGER RNA; OSTEOCALCIN; SIALOGLYCOPROTEIN; BONE SIALOPROTEIN; IBSP PROTEIN, HUMAN;

ANALYSIS OF VARIANCE; ARTICLE; BIOSYNTHESIS; BONE MINERALIZATION; BONE REGENERATION; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOCHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; ILIAC BONE; MESENCHYMAL STEM CELL; METABOLISM; OSTEOBLAST; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; MESENCHYMAL STROMA CELL;

1-CARBOXYGLUTAMIC ACID; ANALYSIS OF VARIANCE; ANTIGENS, CD; ANTIGENS, CD95; BONE REGENERATION; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN TYPE I; DENTAL ENAMEL PROTEINS; GENE EXPRESSION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HISTOCYTOCHEMISTRY; HUMANS; ILIUM; MESENCHYMAL STEM CELLS; OSTEOBLASTS; OSTEOCALCIN; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIALOGLYCOPROTEINS; INTEGRIN-BINDING SIALOPROTEIN; MESENCHYMAL STROMAL CELLS;

EID: 77954575655     PISSN: 09057161     EISSN: 16000501     Source Type: Journal    
DOI: 10.1111/j.1600-0501.2009.01901.x     Document Type: Article

References (30)

1. Boyan BD, Weesner TC, Lohmann CH, Andreacchio D, Carnes DL, Dean DD, Cochran DL, Schwartz Z. Porcine fetal enamel matrix derivative enhances bone formation induced by demineralized freeze dried bone allograft in vivo. Journal of Periodontology 2000, 71:1278-1286.
2. Chamberlain G, Fox J, Ashton B, Middleton J. Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 2007, 25:2739-2749.
3. Deutsch D, Haze-Filderman A, Blumenfeld A, Dafni L, Leiser Y, Shay B, Gruenbaum-Cohen Y, Rosenfeld E, Fermon E, Zimmermann B, Haegewald S, Bernimoulin JP, Taylor AL. Amelogenin, a major structural protein in mineralizing enamel, is also expressed in soft tissues: brain and cells of the hematopoietic system. European Journal of Oral Science 2006, 114((Suppl. 1)):183-189. discussion 201-182, 381
4. Donos N, Bosshardt D, Lang N, Graziani F, Tonetti M, Karring T, Kostopoulos L. Bone formation by enamel matrix proteins and xenografts: an experimental study in the rat ramus. Clinical Oral Implants Research 2005, 16:140-146.
5. Donos N, Kostopoulos L, Tonetti M, Karring T, Lang NP. The effect of enamel matrix proteins and deproteinized bovine bone mineral on heterotopic bone formation. Clinical Oral Implants Research 2006, 17:434-438.
6. Ganss B, Kim RH, Sodek J. Bone sialoprotein. Crticial Reviews in Oral Biology & Medicine 1999, 10:79-98.
7. Gestrelius S, Andersson C, Lidstrom D, Hammarstrom L, Somerman M. In vitro studies on periodontal ligament cells and enamel matrix derivative. Journal of Clinical Periodontology 1997, 24:685-692.
8. Guida L, Annunziata M, Carinci F, Di Feo A, Passaro I, Oliva A. In vitro biologic response of human bone marrow stromal cells to enamel matrix derivative. Journal of Periodontology 2007, 78:2190-2196.
9. Hama H, Azuma H, Seto H, Kido J, Nagata T. Inhibitory effect of enamel matrix derivative on osteoblastic differentiation of rat calvaria cells in culture. Journal of Periodontal Research 2008, 43:179-185.
10. Hammarstrom L. Enamel matrix, cementum development and regeneration. Journal of Clinical Periodontology 1997, 24:658-668.
11. Hammarstrom L, Heijl L, Gestrelius S. Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. Journal of Clinical Periodontology 1997, 24:669-677.
12. Harrison JW, Roda RS. Intermediate cementum. Development, structure, composition and potential functions. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology 1995, 79:624-633.
13. He J, Jiang J, Safavi KE, Spangberg LS, Zhu Q. Emdogain promotes osteoblast proliferation and differentiation and stimulates osteoprotegerin expression. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology 2004, 97:239-245.
14. Jiang J, Fouad AF, Safavi KE, Spangberg LS, Zhu Q. Effects of enamel matrix derivative on gene expression of primary osteoblasts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology 2001a, 91:95-100.
15. Jiang J, Goodarzi G, He J, Li H, Safavi KE, Spangberg LS, Zhu Q. Emdogain-gel stimulates proliferation of odontoblasts and osteoblasts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology 2006, 102:698-702.
16. Jiang J, Safavi KE, Spangberg LS, Zhu Q. Enamel matrix derivative prolongs primary osteoblast growth. Journal of Endodontics 2001b, 27:110-112.
17. Kawase T, Okuda K, Yoshie H, Burns DM. Cytostatic action of enamel matrix derivative (emdogain) on human oral squamous cell carcinoma-derived scc25 epithelial cells. Journal of Periodontal Research 2000, 35:291-300.
18. Klein MO, Reichert C, Koch D, Horn S, Al-Nawas B. In vitro assessment of motility and proliferation of human osteogenic cells on different isolated extracellular matrix components compared with enamel matrix derivative by continuous single-cell observation. Clinical Oral Implants Research 2007, 18:40-45.
19. Lamour V, Detry C, Sanchez C, Henrotin Y, Castronovo V, Bellahcene A. Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression. Journal of Biological Chemistry 2007, 282:36240-36249.
20. Lossdorfer S, Sun M, Gotz W, Dard M, Jager A. Enamel matrix derivative promotes human periodontal ligament cell differentiation and osteoprotegerin production in vitro. Journal of Dental Research 2007, 86:980-985.
21. Parkar MH, Tonetti M. Gene expression profiles of periodontal ligament cells treated with enamel matrix proteins in vitro: analysis using cDNA arrays. Journal of Periodontology 2004, 75:1539-1546.
22. Schwartz Z, Carnes D, Pulliam R, Lohmann C, Sylvia V, Liu YEA. Porcine fetal enamel matrix derivative stimulates proliferation but not differentiation of pre-osteoblastic 2T9 cells, inhibits proliferation and stimulates differentiation of osteoblast-like MG63 cells, and increases proliferation and differentiation of normal human osteoblast nhost cells. Journal of Periodontology 2000, 71:1287-1296.
23. Sculean A, Chiantella GC, Arweiler NB, Becker J, Schwarz F, Stavropoulos A. Five-year clinical and histologic results following treatment of human intrabony defects with an enamel matrix derivative combined with a natural bone mineral. International Journal of Periodontics and Restorative Dentistry 2008a, 28:153-161.
24. Sculean A, Kiss A, Miliauskaite A, Schwarz F, Arweiler NB, Hannig M. Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue regeneration. Journal of Clinical Periodontology 2008b, 35:817-824.
25. Shimizu E, Nakajima Y, Kato N, Nakayama Y, Saito R, Samoto H, Ogata Y. Regulation of rat bone sialoprotein gene transcription by enamel matrix derivative. Journal of Periodontology 2004, 75:260-267.
26. Stein GS, Lian JB, Stein JL, Van Wijnen AJ, Montecino M. Transcriptional control of osteoblast growth and differentiation. Physiological Reviews 1996, 76:593-629.
27. van den Dolder J, Vloon AP, Jansen JA. The effect of emdogain on the growth and differentiation of rat bone marrow cells. Journal of Periodontal Research 2006, 41:471-476.
28. Van der Pauw MT, Van den Bos T, Everts V, Beertsen W. Enamel matrix-derived protein stimulates attachment of periodontal ligament fibroblasts and enhances alkaline phosphatase activity and transforming growth factor beta1 release of periodontal ligament and gingival fibroblasts. Journal of Periodontology 2000, 71:31-43.
29. Venezia E, Goldstein M, Boyan BD, Schwartz Z. The use of enamel matrix derivative in the treatment of periodontal defects: a literature review and meta-analysis. Criticial Reviews in Oral Biology & Medicine 2004, 15:382-402.
30. Yoneda S, Itoh D, Kuroda S, Kondo H, Umezawa A, Ohya K, Ohyama T, Kasugai S. The effects of enamel matrix derivative (emd) on osteoblastic cells in culture and bone regeneration in a rat skull defect. Journal of Periodontal Research 2003, 38:333-342.