Survival and comfort after treatment of pneumonia in advanced dementia

Archives of Internal Medicine

Volumn 170, Issue 13, 2010, Pages 1102-1107

  Givens, Jane L ^a,b   Jones, Richard N ^b   Shaffer, Michele L ^c   Kiely, Dan K ^b   Mitchell, Susan L ^a,b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b Hebrew SeniorLife Institute for Aging Research   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT;

AGED; ANTIMICROBIAL THERAPY; ARTICLE; DEMENTIA; FEMALE; FOLLOW UP; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NURSING HOME PATIENT; OUTCOME ASSESSMENT; PNEUMONIA; PRIORITY JOURNAL; PROSPECTIVE STUDY; SURVIVAL TIME; TREATMENT OUTCOME; UNITED STATES;

ACTIVITIES OF DAILY LIVING; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CONFIDENCE INTERVALS; DEMENTIA; DRUG ADMINISTRATION ROUTES; FEMALE; FOLLOW-UP STUDIES; HUMANS; LONG-TERM CARE; MALE; MASSACHUSETTS; ODDS RATIO; PNEUMONIA; PROSPECTIVE STUDIES; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 77954571541     PISSN: 00039926     EISSN: 15383679     Source Type: Journal    
DOI: 10.1001/archinternmed.2010.181     Document Type: Article

References (28)

1. Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol. 2003;60(8):1119-1122.
2. Mitchell SL, Teno JM, Miller SC, Mor V. A national study of the location of death for older persons with dementia. J Am Geriatr Soc. 2005;53(2):299-305.
3. Chen JH, Lamberg JL, Chen YC, et al. Occurrence and treatment of suspected pneumonia in long-term care residents dying with advanced dementia. J Am Geriatr Soc. 2006;54(2):290-295.
4. Beard CM, Kokmen E, Sigler C, Smith GE, Petterson T, O'Brien PC. Cause of death in Alzheimer's disease. Ann Epidemiol. 1996;6(3):195-200.
5. Thomas BM, Starr JM, Whalley LJ. Death certification in treated cases of presenile Alzheimer's disease and vascular dementia in Scotland. Age Ageing. 1997;26(5):401-406.
6. D'Agata E, Mitchell SL. Patterns of antimicrobial use among nursing home residents with advanced dementia. Arch Intern Med. 2008;168(4):357-362.
7. Mitchell SL, Teno JM, Kiely DK, et al. The clinical course of advanced dementia. N Engl J Med. 2009;361(16):1529-1538.
8. van der Steen JT, Ooms ME, van der Wal G, Ribbe MW. Withholding or starting antibiotic treatment in patients with dementia and pneumonia: prediction of mortality with physicians' judgment of illness severity and with specific prognostic models. Med Decis Making. 2005;25(2):210-221.
9. van der Steen JT, Ooms ME, Ader HJ, Ribbe MW, van der Wal G. Withholding antibiotic treatment in pneumonia patients with dementia: a quantitative observational study. Arch Intern Med. 2002;162(15):1753-1760.
10. Mehr DR, van der Steen JT, Kruse RL, Ooms ME, Rantz M, Ribbe MW. Lower respiratory infections in nursing home residents with dementia: a tale of two countries. Gerontologist. 2003;43(special issue 2):85-93.
11. van der Steen JT, Kruse RL, Ooms ME, et al. Treatment of nursing home residents with dementia and lower respiratory tract infection in the United States and the Netherlands: an ocean apart. J Am Geriatr Soc. 2004;52(5):691-699.
12. Kruse RL, Mehr DR, van der Steen JT, et al. Antibiotic treatment and survival of nursing home patients with lower respiratory tract infection: a cross-national analysis. Ann Fam Med. 2005;3(5):422-429.
13. van der Steen JT, Mehr DR, Kruse RL, Ribbe MW, van der Wal G. Treatment strategy and risk of functional decline and mortality after nursing-home acquired lower respiratory tract infection: two prospective studies in residents with dementia. Int J Geriatr Psychiatry. 2007;22(10):1013-1019.
14. Van Der Steen JT, Pasman HR, Ribbe MW, Van Der Wal G, Onwuteaka-Philipsen BD. Discomfort in dementia patients dying from pneumonia and its relief by antibiotics. Scand J Infect Dis. 2009;41(2):143-151.
15. van der Steen JT, Ooms ME, van der Wal G, Ribbe MW. Pneumonia: the demented patient's best friend? discomfort after starting or withholding antibiotic treatment. J Am Geriatr Soc. 2002;50(10):1681-1688.
16. Givens JL, Kiely DK, Carey K, Mitchell SL. Healthcare proxies of nursing home residents with advanced dementia: decisions they confront and their satisfaction with decision-making. J Am Geriatr Soc. 2009;57(7):1149-1155.
17. Mitchell SL, Kiely DK, Jones RN, Prigerson H, Volicer L, Teno JM. Advanced dementia research in the nursing home: the CASCADE study. Alzheimer Dis Assoc Disord. 2006;20(3):166-175. (Pubitemid 44259791)
18. Morris JN, Fries BE, Mehr DR, et al. MDS Cognitive Performance Scale. J Gerontol. 1994;49(4):M174-M182.
19. Reisberg B, Ferris SH, de Leon MJ, Crook T. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry. 1982;139 (9):1136-1139. (Pubitemid 12051593)
20. Volicer L, Hurley AC, Blasi ZV. Scales for evaluation of end-of-life care in dementia. Alzheimer Dis Assoc Disord. 2001;15(4):194-200.
21. Kiely DK, Volicer L, Teno J, Jones RN, Prigerson HG, Mitchell SL. The validity and reliability of scales for the evaluation of end-of-life care in advanced dementia. Alzheimer Dis Assoc Disord. 2006;20(3):176-181.
22. Albert M, Cohen C. The Test for Severe Impairment: an instrument for the assessment of patients with severe cognitive dysfunction. J Am Geriatr Soc. 1992; 40(5):449-453.
23. Volicer L, Hurley AC, Lathi DC, Kowall NW. Measurement of severity in advanced Alzheimer's disease. J Gerontol. 1994;49(5):M223-M226.
24. Huber P. The behavior ofmaximumlikelihood estimates under nonstandard conditions. In: Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability. Vol 1. Berkeley: University of California Press; 1967:221-233.
25. White H. A heteroskedasticity-consistent covariance matrix estimator and a direct test for heteroskedasticity. Econometrica. 1980;48:817-838.
26. Grambsch P, Therneau T. Proportional hazards tests and diagnostics based on weighted residuals. Biometrika. 1994;81(3):515-526.
27. Luchins DJ, Hanrahan P. What is appropriate health care for end-stage dementia? J Am Geriatr Soc. 1993;41(1):25-30. (Pubitemid 23018046)
28. Morrison RS, Ahronheim JC, Morrison GR, et al. Pain and discomfort associated with common hospital procedures and experiences. J Pain Symptom Manage. 1998;15(2):91-101.