Elevated dietary magnesium prevents connective tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6)

Journal of Investigative Dermatology

Volumn 129, Issue 6, 2009, Pages 1388-1394

  Larusso, Jennifer ^a   Li, Qiaoli ^a   Jiang, Qiujie ^a   Uitto, Jouni ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAGNESIUM; PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIFICATION; CONNECTIVE TISSUE; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; HUMAN; HUMAN CELL; MINERALIZATION; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PSEUDOXANTHOMA ELASTICUM;

ANIMAL NUTRITION SCIENCES; ANIMALS; AORTA; ATP-BINDING CASSETTE TRANSPORTERS; CONNECTIVE TISSUE; DISEASE MODELS, ANIMAL; HUMANS; MAGNESIUM; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUSCLE, SMOOTH; PARATHYROID HORMONE; PHOSPHATES; PHOSPHORUS; PSEUDOXANTHOMA ELASTICUM;

EID: 67349122284     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2008.391     Document Type: Article

References (24)

1. Baker SB, Worthley LIG (2002) The essentials of calcium, magnesium and phosphate metabolism: part I. Physiology. Crit Care Resusc 4: 301-6
2. Calap J, Mascaro JM, Alonso J (1977) Scanning electron microscopic and X ray microanalysis study of the mineral deposits in pseudoxanthoma elasticum. Arch Dermatol Res 259:91-6
3. Ditmar R, Steidl L (1989) The importance of magnesium in orthopedics. VI. The importance of magnesium in the treatment of ectopic calcification and ossification. Acta Chir Orthop Traumatol Cech 56:190-200
4. Ford ES, Mokdad AH (2003) Dietary magnesium intake in a national sample of US adults. J Nutr 133:2879-82
5. Hendig D, Arndt M, Szliska C, Kleesiek K, Götting C (2007) SPP1 promoter polymorphisms: identification of the first modifier gene for pseudox-anthoma elasticum. Clin Chem 53:829-36
6. Jiang Q, Li Q, UittoJ (2007) Aberrant mineralization of connective tissues in a mouse model of pseudoxanthoma elasticum: systemic and local regulatory factors. J Invest Dermatol 127:1392-4102
7. KlementJF, Matsuzaki Y, Jiang Q, TerlizziJ, Choi HY, Fujimoto N etal. (2005) Targeted ablation of the ABCC6 gene results in ectopic mineralization of connective tissues. Mol Cell Biol25:8299-310
8. LaRusso J, Jiang Q, Li Q, Uitto J (2007) Ectopic mineralization of connective tissue in Abcc6-/- mice: effects of dietary modifications and a phosphate binder -a preliminary study. Exp Dermatol 17:203-7
9. Li Q, Grange DK, Armstrong NL, Whelan AL, Hurley MY, Rishavy M et al. (2008a) Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes. J Invest Dermatol. PMID:18800149
10. Li Q, Schurgers LJ, Smith ACM, Tsokos M, Uitto J, Cowen EW (2008b) Coexistent pseudoxanthoma elasticum and vitamin K-dependent coagulation factor deficiency: compound heterozygocity for mutations in the EECX gene. Am J Pathol. (in press)
11. Li Q, Jiang Q, Pfendner E, Váradi A, Uitto J (2009) Pseudoxanthoma elasticum: clinical phenotypes, molecular genetics and putative patho-mechanisms. Exp Dermatol. (in press)
12. Mori S, Harada S, Okazaki R, Inoue D, Matsumoto T, Ogata E (1992) Hypomagnesemia with increased metabolism of parathyroid hormone and reduced responsiveness to calcitropic hormones. Intern Med 31: 820-824
13. Neldner KH (1988) Pseudoxanthoma elasticum. Clin Dermatol 6:1-159
14. Neldner KH, Struk B (2002) Pseudoxanthoma elasticum. In: Connective Tissue and its Heritable Disorders: Molecular, Genetic and Medical Aspects. (Royce PM, Steinmann B, eds). NY: Wiley-Liss Inc., 561-83
15. Pfendner E, Uitto J, Gerard GF, Terry SF (2008) Pseudoxanthoma elasticum: genetic diagnostic markers. Exp Opin Med Diagn 2:1-17
16. Pfendner EG, Vanakker OM, Terry SF, Vourthis S, McAndrew PE, McClain MR et al. (2007) Mutation detection in the ABCC6 gene and genotype-phenotype analysis in a large international case series affected by pseudoxanthoma elasticum. J Med Genet 44:621-8
17. Renie WA, Pyeritz RE, Combs J, Fine SL (1984) Pseudoxanthoma elasticum: high calcium intake in early life correlates with severity. Am J Med Genet 19:235-44
18. Rude RK, Gruber HE, Norton HJ, Wei LY, Frausto A, Kilburn J (2006) Reduction of dietary magnesium by only 50% in the rat disrupts bone and mineral metabolism. Osteoporos Int 17:1022-32
19. Schön S, Schulz V, Prante C, Hendig D, Szliska C, Kuhn J et al. (2006) Polymorphisms in the xylosyltransferase genes cause higher serum XT-1 activity in patients with pseudoxanthoma elasticum (PXE) and are involved in a severe disease course. J Med Genet 43:745-9
20. Sherer DW, Singer G, Uribarri J, Phelps RG, Sapadin AN, Freund KB et al. (2005) Oral phosphate binders in the treatment of pseudoxanthoma elasticum. J Am Acad Dermatol 53:610-5
21. Siegel S, Castellan NJ (1988) Nonparametric Statistics for the Behavioral Sciences. Singapore: McGraw-Hill, 180-1
22. Steidl L, Ditmar R (1990) Soft tissue calcification treated with local and oral magnesium therapy. Magnes Res 3:113-9
23. Vanakker OM, Martin L, Gheduzzi D, Leroy BP, Loeys BL, Guerci VI et al. (2007) Pseudoxanthoma elasticum-like phenotype with cutis laxa and multiple coagulation factor deficiency represents a separate genetic entity. J Invest Dermatol 127:581-7
24. Zarbock R, Hendig D, Szliska C, Kleesiek K, Götting C (2007) Pseudox-anthoma elasticum: genetic variations in antioxidant genes are risk factors for early disease onset. Clin Chem 53:1734-40