Differential gene expression in classic giant cell tumours of bone: Tenascin C as biological risk factor for local relapses and metastases

Histopathology

Volumn 57, Issue 1, 2010, Pages 59-72

  Pazzaglia, Laura ^a   Conti, Amalia ^a   Chiechi, Antonella ^a   Novello, Chiara ^a   Magagnoli, Giovanna ^a   Astolfi, Annalisa ^a   Pession, Andrea ^a   Krenacs, Tibor ^b   Alberghini, Marco ^c   Picci, Piero ^a   Benassi, Maria Serena ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

gene expression profile; giant cell tumour; real time PCR; Tenascin C; tissue microarray

Indexed keywords

BIOLOGICAL MARKER; MESSENGER RNA; TENASCIN; RNA; TUMOR MARKER;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER RECURRENCE; CANCER RELAPSE; CORRELATION ANALYSIS; DISEASE FREE SURVIVAL; FEMALE; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; HIGH RISK PATIENT; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; MICROARRAY ANALYSIS; OSTEOCLASTOMA; PATIENT IDENTIFICATION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR; TISSUE SECTION; BONE TUMOR; DNA MICROARRAY; GENE EXPRESSION; GENETICS; METABOLISM; MIDDLE AGED; PRESCHOOL CHILD; SECONDARY; TUMOR RECURRENCE; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; BONE NEOPLASMS; CHILD, PRESCHOOL; DISEASE-FREE SURVIVAL; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GIANT CELL TUMOR OF BONE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RISK FACTORS; RNA, MESSENGER; RNA, NEOPLASM; TENASCIN; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 77954556987     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2010.03597.x     Document Type: Article

References (37)

1. Jaffe HL, Lichtenstein L, Portis RB. Giant cell tumor of bone. His pathologic appearance, grading, supposed variants and treatment. Arch. Pathol. 1940 30 993 1031.
2. Athanasou N, Bliss E, Gatter K et al. An immunohistological study of giant cell tumor of bone: evidence for an osteoclast origin of the giant cells. J. Pathol. 1985 147 153 158.
3. Campanacci M. Giant cell tumor of bone. Curr. Orthop. 1993 7 26 35.
4. Reid R, Banerjee SS, Sciot R. Giant cell tumour. In Fletcher CDM, Unni KK, Mertens F eds. Pathology and genetics of tumours of soft tissue and bone.
5. Picci P, Manfrini M, Zucchi V, Gherlinzoni F et al. Giant cell tumor of bone in skeletally immature patients. J. Bone Joint Surg. Am. 1983 65 486 490.
6. McGough RL, Rutledge J, Lewis WO et al. Impact severity of local recurrence in giant cell tumor of bone. Clin. Orthop. Relat. Res. 2005 438 116 122.
7. Cheng JC, Johnston JO. Giant-cell tumor of bone: prognosis and treatment of pulmonary metastases. Clin. Orthop. 1997 338 205 214.
8. Tubbs WS, Brown LR, Beabout JW, Rock MG, Unni KK. Benign giant-cell tumor of bone with pulmonary metastases: clinical findings and radiological appearance of metastases of 13 cases. AJR Am. J. Roentgenol. 1992 158 331 334.
9. Katz E, Nyska M, Okon E et al. Growth rate analysis of lung metastases from histologically benign giant cell tumors of bone. Cancer 1987 59 1831 1836.
10. Landanyi M, Tragano F, Huvos A. Benign metastasizing giant cell tumours of bone. Cancer 1989 64 1521 1526.
11. Mankin HJ, Connor JF, Schiller AL et al. Grading of bone tumor by analysis of DNA content using flow cytometry. J. Bone Joint Surg. Am. 1985 67 404 413.
12. Murata H, Kusuzaki K, Takeshita H et al. Cytofluorometric DNA ploidy analysis in giant cell tumor of bone: histologic and prognostic value. Cancer Lett. 1999 136 223 229.
13. Smith LT, Mayerson J, Nowak NJ et al. 20q11.1 amplification in giant cell tumor of bone. Array CGH, FISH, and association with outcome. Genes Chromosomes Cancer 2006 45 957 966.
14. Wuelling M, Delling G, Kaiser E. Differential gene expression in stromal cells of human giant cell tumor of bone. Virchows Arch. 2004 445 621 630.
15. Gamberi G, Benassi MS, Bohling T et al. Prognostic relevance of Cmyc gene expression in giant-cell tumor of bone. J. Orthop. Res. 1998 16 1 7.
16. Gamberi G, Benassi MS, Ragazzini P et al. Proteases and interleukin-6 gene analysis in 92 giant cell tumors of bone. Ann. Oncol. 2004 15 498 503.
17. Gamberi G, Serra M, Ragazzini P et al. Identification of markers of possible prognostic value in 57 giant cell tumors of bone. Oncol. Rep. 2003 10 351 356.
18. Bulloogh PG, Bansal M. Malignancy in giant cell tumour. In Fletcher CDM, Unni KK, Mertens F eds. Pathology and genetics of tumours of soft tissue and bone.
19. Wolf RE, Enneking WF. The staging and surgery of musculoskeletal neoplasms. Orthop. Clin. North Am. 1996 27 473 481.
20. Irizzary RA, Hobbs B, Collin F et al. Exploration, normalization and summaries of high density oligonucleotide array probe level data. Biostatistics 2003 4 249 264.
21. Winer J, Jung CK, Shackel I, Williams PM. Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal. Biochem. 1999 270 41 49.
22. Wulling M, Delling G, Kaiser E. The origin of neoplastic stromal cell in giant cell tumor of bone. Hum. Pathol. 2003 34 983 993.
23. Werner M. Giant cell tumor of bone: morphological, biological and histogenetical aspects. Int. Orthop. 2006 30 484 489.
24. Lau YS, Sabokbar A, Gibbons CL, Giele H, Athanasou N. Phenotypic and molecular studies of giant cell tumors of bone and soft tissue. Hum. Pathol. 2005 36 945 954.
25. Cheng YY, Huang L, Lee KM, Xu JK, Zheng MH, Kumta SM. Bisphosphonates induce apoptosis of stromal tumor cells in giant cell tumor of bone. Calcif. Tissue Int. 2004 75 71 77. (Pubitemid 38989221)
26. Chang SS, Suratwala SJ, Jung KM et al. Bisphosphonates may reduce recurrence in giant cell tumor by inducing apoptosis. Clin. Orthop. Relat. Res. 2004 1 103 109.
27. Sawyer JR, Goosen LS, Binz RL, Swanson CM, Nicholas RW. Evidence for telomeric fusion as a mechanism for recurring structural aberrations of chromosome 11 in giant cell tumor of bone. Cancer Genet. Cytogenet. 2005 159 32 36.
28. Forsyth RG, Boeck G, Bekaert S et al. Telomere biology in giant cell tumour of bone. J. Pathol. 2008 214 555 563.
29. Moskovszky L, Szuhai K, Krenács T et al. Genomic instability in giant cell tumour of bone. A study of 52 cases using DNA ploidy, relocalization FISH, and array-CGH analysis. Genes Chromosomes Cancer 2009 48 468 479.
30. Antal I, Sapi Z, Szendroi M. The prognostic significance of DNA cytophotometry and proliferation index (Ki-67) in giant cell tumors of bone. Int. Orthop. 1999 23 315 319.
31. Campanacci M, Giunti A, Olmi R. Giant cell tumor of bone. A study of 209 cases with long-term follow-up. J. Orthop. Traumatol. 1975 1 2944 2977.
32. Guenther R, Krenn V, Morawietz L et al. Giant cell tumors of bone. Molecular profiling and expression analysis of Ephrin A receptor, Claudin 7, CD52, FGFR3 and AMFR. Pathol. Res. Pract. 2005 201 649 663.
33. Skubitz KM, Cheng EY, Clohisy DR, Thompson RC, Skubitz AP. Gene expression in giant cell tumors. J. Lab. Clin. Med. 2004 144 193 200.
34. Jones PL, Jones FS. Tenascin C in development and disease; gene regulation and cell function. Matrix Biol. 2000 19 581 596.
35. Orend G, Chiquet-Ehrismann R. Tenascin-C induced signaling in cancer. Cancer Lett. 2006 244 143 146.
36. Chen G, Gharib TG, Huang CC et al. Discordant protein and mRNA expression in lung adenocarcinomas. Mol. Cell Proteomics 2002 1 304 313.
37. Gygi SP, Rochon Y, Franza BR et al. Correlation between protein and mRNA abundance in yeast. Mol. Cell. Biol. 1999 19 1720 1730.