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Volumn 13, Issue 3, 2010, Pages 160-167

The impact of subthalamic deep brain stimulation on nigral neuroprotection - Myth or reality?

Author keywords

High frequency stimulation; microstimulator; movement disorders; neurostimulation; Parkinson's disease; rats; stimulator

Indexed keywords

DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA; PLACEBO; SELEGILINE;

EID: 77954553468     PISSN: 10947159     EISSN: 15251403     Source Type: Journal    
DOI: 10.1111/j.1525-1403.2010.00282.x     Document Type: Review
Times cited : (17)

References (62)
  • 2
    • 0036930380 scopus 로고    scopus 로고
    • Introduction to the programming of deep brain stimulators
    • Suppl
    • Volkmann J, Herzog J, Kopper F, Deuschl G. Introduction to the programming of deep brain stimulators. Mov Disord 2002 17 (Suppl. 3 S181 S187.
    • (2002) Mov Disord , vol.17 , Issue.3
    • Volkmann, J.1    Herzog, J.2    Kopper, F.3    Deuschl, G.4
  • 4
    • 33746403927 scopus 로고
    • Psychiatry
    • Heath RG. Psychiatry. Annu Rev Med 1954 5 : 223 236.
    • (1954) Annu Rev Med , vol.5 , pp. 223-236
    • Heath, R.G.1
  • 5
    • 14644402983 scopus 로고    scopus 로고
    • Deep brain stimulation for treatment-resistant depression
    • Mayberg HS, Lozano AM, Voon V et al. Deep brain stimulation for treatment-resistant depression. Neuron 2005 45 : 651 660.
    • (2005) Neuron , vol.45 , pp. 651-660
    • Mayberg, H.S.1    Lozano, A.M.2    Voon, V.3
  • 6
    • 56249088314 scopus 로고    scopus 로고
    • Subthalamic nucleus stimulation in severe obsessive-compulsive disorder
    • Mallet L, Polosan M, Jaafari N et al. Subthalamic nucleus stimulation in severe obsessive-compulsive disorder. N Engl J Med 2008 359 : 2121 2134.
    • (2008) N Engl J Med , vol.359 , pp. 2121-2134
    • Mallet, L.1    Polosan, M.2    Jaafari, N.3
  • 7
    • 0014541418 scopus 로고
    • Radiostimulation of the brain in primates and man. Fourth Becton, Dickinson and Company Oscar Schwidetzky Memorial Lecture
    • Delgado JM. Radiostimulation of the brain in primates and man. Fourth Becton, Dickinson and Company Oscar Schwidetzky Memorial Lecture. Anesth Analg 1969 48 : 529 542.
    • (1969) Anesth Analg , vol.48 , pp. 529-542
    • Delgado, J.M.1
  • 8
    • 0023578840 scopus 로고
    • Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease
    • Benabid AL, Pollak P, Louveau A, Henry S, de Rougemont J. Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease. Appl Neurophysiol 1987 50 : 344 346.
    • (1987) Appl Neurophysiol , vol.50 , pp. 344-346
    • Benabid, A.L.1    Pollak, P.2    Louveau, A.3    Henry, S.4    De Rougemont, J.5
  • 10
    • 34548037454 scopus 로고    scopus 로고
    • Thirty days complication rate following surgery performed for deep-brain-stimulation
    • Voges J, Hilker R, Botzel K et al. Thirty days complication rate following surgery performed for deep-brain-stimulation. Mov Disord 2007 22 : 1486 1489.
    • (2007) Mov Disord , vol.22 , pp. 1486-1489
    • Voges, J.1    Hilker, R.2    Botzel, K.3
  • 11
    • 43049175254 scopus 로고    scopus 로고
    • Multicenter study on deep brain stimulation in Parkinson's disease: An independent assessment of reported adverse events at 4 years
    • Hariz MI, Rehncrona S, Quinn NP, Speelman JD, Wensing C. Multicenter study on deep brain stimulation in Parkinson's disease: an independent assessment of reported adverse events at 4 years. Mov Disord 2008 23 : 416 421.
    • (2008) Mov Disord , vol.23 , pp. 416-421
    • Hariz, M.I.1    Rehncrona, S.2    Quinn, N.P.3    Speelman, J.D.4    Wensing, C.5
  • 12
    • 33748139412 scopus 로고    scopus 로고
    • A randomized trial of deep-brain stimulation for Parkinson's disease
    • Deuschl G, Schade-Brittinger C, Krack P et al. A randomized trial of deep-brain stimulation for Parkinson's disease. N Engl J Med 2006 355 : 896 908.
    • (2006) N Engl J Med , vol.355 , pp. 896-908
    • Deuschl, G.1    Schade-Brittinger, C.2    Krack, P.3
  • 13
    • 58149385649 scopus 로고    scopus 로고
    • Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: A randomized controlled trial
    • Weaver FM, Follett K, Stern M et al. Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial. JAMA 2009 301 : 63 73.
    • (2009) JAMA , vol.301 , pp. 63-73
    • Weaver, F.M.1    Follett, K.2    Stern, M.3
  • 14
    • 33750706519 scopus 로고    scopus 로고
    • Pallidal deep-brain stimulation in primary generalized or segmental dystonia
    • Kupsch A, Benecke R, Muller J et al. Pallidal deep-brain stimulation in primary generalized or segmental dystonia. N Engl J Med 2006 355 : 1978 1990.
    • (2006) N Engl J Med , vol.355 , pp. 1978-1990
    • Kupsch, A.1    Benecke, R.2    Muller, J.3
  • 16
    • 33846860660 scopus 로고    scopus 로고
    • Bilateral, pallidal, deep-brain stimulation in primary generalised dystonia: A prospective 3 year follow-up study
    • Vidailhet M, Vercueil L, Houeto JL et al. Bilateral, pallidal, deep-brain stimulation in primary generalised dystonia: a prospective 3 year follow-up study. Lancet Neurol 2007 6 : 223 229.
    • (2007) Lancet Neurol , vol.6 , pp. 223-229
    • Vidailhet, M.1    Vercueil, L.2    Houeto, J.L.3
  • 19
    • 26044468127 scopus 로고    scopus 로고
    • Bilateral deep brain stimulation in Parkinson's disease: A multicentre study with 4 years follow-up
    • Rodriguez-Oroz MC, Obeso JA, Lang AE et al. Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up. Brain 2005 128 : 2240 2249.
    • (2005) Brain , vol.128 , pp. 2240-2249
    • Rodriguez-Oroz, M.C.1    Obeso, J.A.2    Lang, A.E.3
  • 20
    • 33646925626 scopus 로고    scopus 로고
    • Evolution of Parkinson's disease during 4 years of bilateral deep brain stimulation of the subthalamic nucleus
    • Ostergaard K, Aa SN. Evolution of Parkinson's disease during 4 years of bilateral deep brain stimulation of the subthalamic nucleus. Mov Disord 2006 21 : 624 631.
    • (2006) Mov Disord , vol.21 , pp. 624-631
    • Ostergaard, K.1    Aa, S.N.2
  • 21
    • 0031696407 scopus 로고    scopus 로고
    • Subthalamic nucleus-mediated excitotoxicity in Parkinson's disease: A target for neuroprotection
    • Rodriguez MC, Obeso JA, Olanow CW. Subthalamic nucleus-mediated excitotoxicity in Parkinson's disease: a target for neuroprotection. Ann Neurol 1998 44 : S175 S188.
    • (1998) Ann Neurol , vol.44
    • Rodriguez, M.C.1    Obeso, J.A.2    Olanow, C.W.3
  • 22
    • 0024457355 scopus 로고
    • DATATOP: A multicenter controlled clinical trial in early Parkinson's disease
    • DATATOP: a multicenter controlled clinical trial in early Parkinson's disease. Arch Neurol 1989 46 : 1052 1060.
    • (1989) Arch Neurol , vol.46 , pp. 1052-1060
  • 23
    • 2142640816 scopus 로고    scopus 로고
    • Neuroprotective strategies for Parkinson's disease: Conceptual limits of animal models and clinical trials
    • Meissner W, Hill MP, Tison F, Gross CE, Bezard E. Neuroprotective strategies for Parkinson's disease: conceptual limits of animal models and clinical trials. Trends Pharmacol Sci 2004 25 : 249 253.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 249-253
    • Meissner, W.1    Hill, M.P.2    Tison, F.3    Gross, C.E.4    Bezard, E.5
  • 24
    • 0033960907 scopus 로고    scopus 로고
    • A randomized controlled trial comparing pramipexole with levodopa in early Parkinson's disease: Design and methods of the CALM-PD Study
    • A randomized controlled trial comparing pramipexole with levodopa in early Parkinson's disease: design and methods of the CALM-PD Study. Clin Neuropharmacol 2000 23 : 34 44.
    • (2000) Clin Neuropharmacol , vol.23 , pp. 34-44
  • 25
    • 0037785449 scopus 로고    scopus 로고
    • Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study
    • Whone AL, Watts RL, Stoessl AJ et al. Slower progression of Parkinson's disease with ropinirole versus levodopa: the REAL-PET study. Ann Neurol 2003 54 : 93 101.
    • (2003) Ann Neurol , vol.54 , pp. 93-101
    • Whone, A.L.1    Watts, R.L.2    Stoessl, A.J.3
  • 26
    • 33645543539 scopus 로고    scopus 로고
    • Pergolide versus levodopa monotherapy in early Parkinson's disease patients: The PELMOPET study
    • Oertel WH, Wolters E, Sampaio C et al. Pergolide versus levodopa monotherapy in early Parkinson's disease patients: the PELMOPET study. Mov Disord 2006 21 : 343 353.
    • (2006) Mov Disord , vol.21 , pp. 343-353
    • Oertel, W.H.1    Wolters, E.2    Sampaio, C.3
  • 27
    • 0032890731 scopus 로고    scopus 로고
    • Parkinson disease, the effect of levodopa, and the ELLDOPA trial. Earlier vs later L-DOPA
    • Fahn S. Parkinson disease, the effect of levodopa, and the ELLDOPA trial. Earlier vs later L-DOPA. Arch Neurol 1999 56 : 529 535.
    • (1999) Arch Neurol , vol.56 , pp. 529-535
    • Fahn, S.1
  • 28
    • 0036894795 scopus 로고    scopus 로고
    • A controlled trial of rasagiline in early Parkinson disease: The TEMPO Study
    • Parkinson Study Group
    • Parkinson Study Group. A controlled trial of rasagiline in early Parkinson disease: the TEMPO Study. Arch Neurol 2002 59 : 1937 1943.
    • (2002) Arch Neurol , vol.59 , pp. 1937-1943
  • 29
    • 70349456475 scopus 로고    scopus 로고
    • A double-blind, delayed-start trial of rasagiline in Parkinson's disease
    • Olanow CW, Rascol O, Hauser R et al. A double-blind, delayed-start trial of rasagiline in Parkinson's disease. N Engl J Med 2009 361 : 1268 1278.
    • (2009) N Engl J Med , vol.361 , pp. 1268-1278
    • Olanow, C.W.1    Rascol, O.2    Hauser, R.3
  • 30
    • 14844300111 scopus 로고    scopus 로고
    • Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity
    • Hilker R, Schweitzer K, Coburger S et al. Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity. Arch Neurol 2005 62 : 378 382.
    • (2005) Arch Neurol , vol.62 , pp. 378-382
    • Hilker, R.1    Schweitzer, K.2    Coburger, S.3
  • 31
    • 0028021805 scopus 로고
    • The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism
    • Bergman H, Wichmann T, Karmon B, DeLong MR. The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism. J Neurophysiol 1994 72 : 507 520.
    • (1994) J Neurophysiol , vol.72 , pp. 507-520
    • Bergman, H.1    Wichmann, T.2    Karmon, B.3    Delong, M.R.4
  • 32
    • 0028224977 scopus 로고
    • Glutamate and Parkinson's disease
    • Greenberg DA. Glutamate and Parkinson's disease. Ann Neurol 1994 35 : 639.
    • (1994) Ann Neurol , vol.35 , pp. 639
    • Greenberg, D.A.1
  • 33
    • 0029897501 scopus 로고    scopus 로고
    • Subthalamic nucleus lesion in rats prevents dopaminergic nigral neuron degeneration after striatal 6-OHDA injection: Behavioural and immunohistochemical studies
    • Piallat B, Benazzouz A, Benabid AL. Subthalamic nucleus lesion in rats prevents dopaminergic nigral neuron degeneration after striatal 6-OHDA injection: behavioural and immunohistochemical studies. Eur J Neurosci 1996 8 : 1408 1414.
    • (1996) Eur J Neurosci , vol.8 , pp. 1408-1414
    • Piallat, B.1    Benazzouz, A.2    Benabid, A.L.3
  • 34
    • 0032964444 scopus 로고    scopus 로고
    • Ablation of the subthalamic nucleus supports the survival of nigral dopaminergic neurons after nigrostriatal lesions induced by the mitochondrial toxin 3-nitropropionic acid
    • Nakao N, Nakai E, Nakai K, Itakura T. Ablation of the subthalamic nucleus supports the survival of nigral dopaminergic neurons after nigrostriatal lesions induced by the mitochondrial toxin 3-nitropropionic acid. Ann Neurol 1999 45 : 640 651.
    • (1999) Ann Neurol , vol.45 , pp. 640-651
    • Nakao, N.1    Nakai, E.2    Nakai, K.3    Itakura, T.4
  • 35
    • 0034562426 scopus 로고    scopus 로고
    • Prevention of neurotoxin damage of 6-OHDA to dopaminergic nigral neuron by subthalamic nucleus lesions
    • Chen L, Liu Z, Tian Z, Wang Y, Li S. Prevention of neurotoxin damage of 6-OHDA to dopaminergic nigral neuron by subthalamic nucleus lesions. Stereotact Funct Neurosurg 2000 75 : 66 75.
    • (2000) Stereotact Funct Neurosurg , vol.75 , pp. 66-75
    • Chen, L.1    Liu, Z.2    Tian, Z.3    Wang, Y.4    Li, S.5
  • 36
    • 0034800339 scopus 로고    scopus 로고
    • Subthalamic nucleus lesions are neuroprotective against terminal 6-OHDA-induced striatal lesions and restore postural balancing reactions
    • Carvalho GA, Nikkhah G. Subthalamic nucleus lesions are neuroprotective against terminal 6-OHDA-induced striatal lesions and restore postural balancing reactions. Exp Neurol 2001 171 : 405 417.
    • (2001) Exp Neurol , vol.171 , pp. 405-417
    • Carvalho, G.A.1    Nikkhah, G.2
  • 37
    • 0346374579 scopus 로고    scopus 로고
    • Ablation of the subthalamic nucleus protects dopaminergic phenotype but not cell survival in a rat model of Parkinson's disease
    • Paul G, Meissner W, Rein S et al. Ablation of the subthalamic nucleus protects dopaminergic phenotype but not cell survival in a rat model of Parkinson's disease. Exp Neurol 2004 185 : 272 280.
    • (2004) Exp Neurol , vol.185 , pp. 272-280
    • Paul, G.1    Meissner, W.2    Rein, S.3
  • 38
    • 0035074475 scopus 로고    scopus 로고
    • Subthalamic infusion of an NMDA antagonist prevents basal ganglia metabolic changes and nigral degeneration in a rodent model of Parkinson's disease
    • Blandini F, Nappi G, Greenamyre JT. Subthalamic infusion of an NMDA antagonist prevents basal ganglia metabolic changes and nigral degeneration in a rodent model of Parkinson's disease. Ann Neurol 2001 49 : 525 529.
    • (2001) Ann Neurol , vol.49 , pp. 525-529
    • Blandini, F.1    Nappi, G.2    Greenamyre, J.T.3
  • 39
    • 0037064165 scopus 로고    scopus 로고
    • Subthalamic GAD gene therapy in a Parkinson's disease rat model
    • Luo J, Kaplitt MG, Fitzsimons HL et al. Subthalamic GAD gene therapy in a Parkinson's disease rat model. Science 2002 298 : 425 429.
    • (2002) Science , vol.298 , pp. 425-429
    • Luo, J.1    Kaplitt, M.G.2    Fitzsimons, H.L.3
  • 40
    • 0029764836 scopus 로고    scopus 로고
    • 6-hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat. A possible mechanism for restoration of the nigrostriatal circuit mediated by glial cell line-derived neurotrophic factor
    • Bowenkamp KE, David D, Lapchak PL et al. 6-hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat. A possible mechanism for restoration of the nigrostriatal circuit mediated by glial cell line-derived neurotrophic factor. Exp Brain Res 1996 111 : 1 7.
    • (1996) Exp Brain Res , vol.111 , pp. 1-7
    • Bowenkamp, K.E.1    David, D.2    Lapchak, P.L.3
  • 41
    • 0034698409 scopus 로고    scopus 로고
    • Recovery from methamphetamine induced long-term nigrostriatal dopaminergic deficits without substantia nigra cell loss
    • Harvey DC, Lacan G, Tanious SP, Melega WP. Recovery from methamphetamine induced long-term nigrostriatal dopaminergic deficits without substantia nigra cell loss. Brain Res 2000 871 : 259 270.
    • (2000) Brain Res , vol.871 , pp. 259-270
    • Harvey, D.C.1    Lacan, G.2    Tanious, S.P.3    Melega, W.P.4
  • 42
    • 0025153263 scopus 로고
    • Decreased tyrosine hydroxylase messenger RNA in the surviving dopamine neurons of the substantia nigra in Parkinson's disease: An in situ hybridization study
    • Javoy-Agid F, Hirsch EC, Dumas S, Duyckaerts C, Mallet J, Agid Y. Decreased tyrosine hydroxylase messenger RNA in the surviving dopamine neurons of the substantia nigra in Parkinson's disease: an in situ hybridization study. Neuroscience 1990 38 : 245 253.
    • (1990) Neuroscience , vol.38 , pp. 245-253
    • Javoy-Agid, F.1    Hirsch, E.C.2    Dumas, S.3    Duyckaerts, C.4    Mallet, J.5    Agid, Y.6
  • 43
    • 0342445426 scopus 로고    scopus 로고
    • The vulnerability of nigral neurons to Parkinson's disease is unrelated to their intrinsic capacity for dopamine synthesis: An in situ hybridization study
    • Kingsbury AE, Marsden CD, Foster OJ. The vulnerability of nigral neurons to Parkinson's disease is unrelated to their intrinsic capacity for dopamine synthesis: an in situ hybridization study. Mov Disord 1999 14 : 206 218.
    • (1999) Mov Disord , vol.14 , pp. 206-218
    • Kingsbury, A.E.1    Marsden, C.D.2    Foster, O.J.3
  • 44
    • 0346664440 scopus 로고    scopus 로고
    • Anatomic and neurophysiological methods for the targeting and lesioning of the subthalamic nucleus: Cuban experience and review
    • Lopez-Flores G, Miguel-Morales J, Teijeiro-Amador J et al. Anatomic and neurophysiological methods for the targeting and lesioning of the subthalamic nucleus: cuban experience and review. Neurosurgery 2003 52 : 817 830.
    • (2003) Neurosurgery , vol.52 , pp. 817-830
    • Lopez-Flores, G.1    Miguel-Morales, J.2    Teijeiro-Amador, J.3
  • 45
    • 69449095866 scopus 로고    scopus 로고
    • Therapeutic efficacy of unilateral subthalamotomy in Parkinson's disease: Results in 89 patients followed for up to 36 months
    • Alvarez L, Macias R, Pavon N et al. Therapeutic efficacy of unilateral subthalamotomy in Parkinson's disease: results in 89 patients followed for up to 36 months. J Neurol Neurosurg Psychiatry 2009 80 : 979 985.
    • (2009) J Neurol Neurosurg Psychiatry , vol.80 , pp. 979-985
    • Alvarez, L.1    MacIas, R.2    Pavon, N.3
  • 46
    • 0141780837 scopus 로고    scopus 로고
    • Electrophysiological and metabolic evidence that high-frequency stimulation of the subthalamic nucleus bridles neuronal activity in the subthalamic nucleus and the substantia nigra reticulata
    • Tai CH, Boraud T, Bezard E, Bioulac B, Gross C, Benazzouz A. Electrophysiological and metabolic evidence that high-frequency stimulation of the subthalamic nucleus bridles neuronal activity in the subthalamic nucleus and the substantia nigra reticulata. FASEB J 2003 17 : 1820 1830.
    • (2003) FASEB J , vol.17 , pp. 1820-1830
    • Tai, C.H.1    Boraud, T.2    Bezard, E.3    Bioulac, B.4    Gross, C.5    Benazzouz, A.6
  • 47
    • 26044453539 scopus 로고    scopus 로고
    • Subthalamic high frequency stimulation resets subthalamic firing and reduces abnormal oscillations
    • Meissner W, Leblois A, Hansel D et al. Subthalamic high frequency stimulation resets subthalamic firing and reduces abnormal oscillations. Brain 2005 128 : 2372 2382.
    • (2005) Brain , vol.128 , pp. 2372-2382
    • Meissner, W.1    Leblois, A.2    Hansel, D.3
  • 48
    • 36849094497 scopus 로고    scopus 로고
    • Continuous high-frequency stimulation in freely moving rats: Development of an implantable microstimulation system
    • Harnack D, Meissner W, Paulat R et al. Continuous high-frequency stimulation in freely moving rats: development of an implantable microstimulation system. J Neurosci Methods 2008 167 : 278 291.
    • (2008) J Neurosci Methods , vol.167 , pp. 278-291
    • Harnack, D.1    Meissner, W.2    Paulat, R.3
  • 49
    • 1642346342 scopus 로고    scopus 로고
    • Long-term stimulation of the subthalamic nucleus in hemiparkinsonian rats: Neuroprotection of dopaminergic neurons
    • Maesawa S, Kaneoke Y, Kajita Y et al. Long-term stimulation of the subthalamic nucleus in hemiparkinsonian rats: neuroprotection of dopaminergic neurons. J Neurosurg 2004 100 : 679 687.
    • (2004) J Neurosurg , vol.100 , pp. 679-687
    • Maesawa, S.1    Kaneoke, Y.2    Kajita, Y.3
  • 50
    • 33750459096 scopus 로고    scopus 로고
    • Protection of nigral cell death by bilateral subthalamic nucleus stimulation
    • Temel Y, Visser-Vandewalle V, Kaplan S et al. Protection of nigral cell death by bilateral subthalamic nucleus stimulation. Brain Res 2006 1120 : 100 105.
    • (2006) Brain Res , vol.1120 , pp. 100-105
    • Temel, Y.1    Visser-Vandewalle, V.2    Kaplan, S.3
  • 51
    • 34547730784 scopus 로고    scopus 로고
    • Survival of midbrain dopaminergic cells after lesion or deep brain stimulation of the subthalamic nucleus in MPTP-treated monkeys
    • Wallace BA, Ashkan K, Heise CE et al. Survival of midbrain dopaminergic cells after lesion or deep brain stimulation of the subthalamic nucleus in MPTP-treated monkeys. Brain 2007 130 : 2129 2145.
    • (2007) Brain , vol.130 , pp. 2129-2145
    • Wallace, B.A.1    Ashkan, K.2    Heise, C.E.3
  • 52
    • 39149124879 scopus 로고    scopus 로고
    • Placebo-controlled chronic high-frequency stimulation of the subthalamic nucleus preserves dopaminergic nigral neurons in a rat model of progressive Parkinsonism
    • Harnack D, Meissner W, Jira JA, Winter C, Morgenstern R, Kupsch A. Placebo-controlled chronic high-frequency stimulation of the subthalamic nucleus preserves dopaminergic nigral neurons in a rat model of progressive Parkinsonism. Exp Neurol 2008 210 : 257 260.
    • (2008) Exp Neurol , vol.210 , pp. 257-260
    • Harnack, D.1    Meissner, W.2    Jira, J.A.3    Winter, C.4    Morgenstern, R.5    Kupsch, A.6
  • 53
    • 7744240445 scopus 로고    scopus 로고
    • The effects of electrode material, charge density and stimulation duration on the safety of high-frequency stimulation of the subthalamic nucleus in rats
    • Harnack D, Winter C, Meissner W, Reum T, Kupsch A, Morgenstern R. The effects of electrode material, charge density and stimulation duration on the safety of high-frequency stimulation of the subthalamic nucleus in rats. J Neurosci Methods 2004 138 : 207 216.
    • (2004) J Neurosci Methods , vol.138 , pp. 207-216
    • Harnack, D.1    Winter, C.2    Meissner, W.3    Reum, T.4    Kupsch, A.5    Morgenstern, R.6
  • 54
    • 0033999764 scopus 로고    scopus 로고
    • High frequency stimulation of the subthalamic nucleus influences striatal dopaminergic metabolism in the naive rat
    • Paul G, Reum T, Meissner W et al. High frequency stimulation of the subthalamic nucleus influences striatal dopaminergic metabolism in the naive rat. Neuroreport 2000 11 : 441 444.
    • (2000) Neuroreport , vol.11 , pp. 441-444
    • Paul, G.1    Reum, T.2    Meissner, W.3
  • 55
    • 0035145422 scopus 로고    scopus 로고
    • High frequency stimulation of the subthalamic nucleus increases the extracellular contents of striatal dopamine in normal and partially dopaminergic denervated rats
    • Bruet N, Windels F, Bertrand A, Feuerstein C, Poupard A, Savasta M. High frequency stimulation of the subthalamic nucleus increases the extracellular contents of striatal dopamine in normal and partially dopaminergic denervated rats. J Neuropathol Exp Neurol 2001 60 : 15 24.
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 15-24
    • Bruet, N.1    Windels, F.2    Bertrand, A.3    Feuerstein, C.4    Poupard, A.5    Savasta, M.6
  • 56
    • 0038674399 scopus 로고    scopus 로고
    • High-frequency stimulation of the subthalamic nucleus enhances striatal dopamine release and metabolism in rats
    • Meissner W, Harnack D, Reese R et al. High-frequency stimulation of the subthalamic nucleus enhances striatal dopamine release and metabolism in rats. J Neurochem 2003 85 : 601 609.
    • (2003) J Neurochem , vol.85 , pp. 601-609
    • Meissner, W.1    Harnack, D.2    Reese, R.3
  • 57
    • 33644784694 scopus 로고    scopus 로고
    • Dopamine efflux in the rat striatum evoked by electrical stimulation of the subthalamic nucleus: Potential mechanism of action in Parkinson's disease
    • Lee KH, Blaha CD, Harris BT et al. Dopamine efflux in the rat striatum evoked by electrical stimulation of the subthalamic nucleus: potential mechanism of action in Parkinson's disease. Eur J Neurosci 2006 23 : 1005 1014.
    • (2006) Eur J Neurosci , vol.23 , pp. 1005-1014
    • Lee, K.H.1    Blaha, C.D.2    Harris, B.T.3
  • 58
    • 0037047454 scopus 로고    scopus 로고
    • Deep brain stimulation of subthalamic neurons increases striatal dopamine metabolism and induces contralateral circling in freely moving 6-hydroxydopamine-lesioned rats
    • Meissner W, Harnack D, Paul G et al. Deep brain stimulation of subthalamic neurons increases striatal dopamine metabolism and induces contralateral circling in freely moving 6-hydroxydopamine-lesioned rats. Neurosci Lett 2002 328 : 105 108.
    • (2002) Neurosci Lett , vol.328 , pp. 105-108
    • Meissner, W.1    Harnack, D.2    Paul, G.3
  • 59
    • 0035843916 scopus 로고    scopus 로고
    • Striatal dopaminergic metabolism is increased by deep brain stimulation of the subthalamic nucleus in 6-hydroxydopamine lesioned rats
    • Meissner W, Reum T, Paul G et al. Striatal dopaminergic metabolism is increased by deep brain stimulation of the subthalamic nucleus in 6-hydroxydopamine lesioned rats. Neurosci Lett 2001 303 : 165 168.
    • (2001) Neurosci Lett , vol.303 , pp. 165-168
    • Meissner, W.1    Reum, T.2    Paul, G.3
  • 60
    • 5444243568 scopus 로고    scopus 로고
    • Deep brain stimulation
    • Epub 2004 Aug 19. Review
    • Breit S, Schulz JB, Benabid AL. Deep brain stimulation. Cell Tissue Res 2004 318 : 275 288. Epub 2004 Aug 19. Review.
    • (2004) Cell Tissue Res , vol.318 , pp. 275-288
    • Breit, S.1    Schulz, J.B.2    Benabid, A.L.3
  • 61
    • 77952950786 scopus 로고    scopus 로고
    • Dopaminergic cells in the periaqueductal gray matter of MPTP-treated monkeys and mice; Patterns of survival and effect of deep brain stimulation and lesion of the subthalamic nucleus
    • Shaw VE, Keay KA, Ashkan K, Benabid AL, Mitrofanis J. Dopaminergic cells in the periaqueductal gray matter of MPTP-treated monkeys and mice; patterns of survival and effect of deep brain stimulation and lesion of the subthalamic nucleus. Parkinsonism Relat Disord. 2010. 16 : 338 344.
    • (2010) Parkinsonism Relat Disord. , vol.16 , pp. 338-344
    • Shaw, V.E.1    Keay, K.A.2    Ashkan, K.3    Benabid, A.L.4    Mitrofanis, J.5
  • 62
    • 77952852437 scopus 로고    scopus 로고
    • Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss
    • Spieles-Engemann AL, Behbehani MM, Collier TJ et al. Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss. Neurobiol Dis 2010. 39 : 105 115.
    • (2010) Neurobiol Dis , vol.39 , pp. 105-115
    • Spieles-Engemann, A.L.1    Behbehani, M.M.2    Collier, T.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.