Reducing Clostridium difficile through early identification of clusters and the use of a standardised set of interventions

Journal of Hospital Infection

Volumn 75, Issue 4, 2010, Pages 277-281

  Hardy, K J ^a,b   Gossain, S ^a   Thomlinson, D ^a   Pillay, D G ^a   Hawkey, P M ^a,b  

^a UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Clostridium difficile; Control; Ribotyping

Indexed keywords

ANTIBIOTIC AGENT;

ARTICLE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; HUMAN; INFECTION CONTROL; MAJOR CLINICAL STUDY; RIBOTYPING; STANDARDIZATION; CLOSTRIDIUM INFECTIONS; CROSS INFECTION; DISEASE OUTBREAKS; EARLY DIAGNOSIS; GENETICS; INCIDENCE; ISOLATION AND PURIFICATION; PEPTOCLOSTRIDIUM DIFFICILE; PROCEDURES; UNITED KINGDOM;

CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; CROSS INFECTION; DISEASE OUTBREAKS; EARLY DIAGNOSIS; GREAT BRITAIN; HUMANS; INCIDENCE; INFECTION CONTROL; RIBOTYPING;

EID: 77954538302     PISSN: 01956701     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhin.2009.12.004     Document Type: Article

References (16)

1. Redelings M.D., Sorvillo F., Mascola L. Increase in Clostridium difficile-related mortality rates, United States, 1999-2004. Emerg Infect Dis 2007, 13:1417-1419.
2. Deaths involving Clostridium difficile; England and Wales, 2003-07. Health Stat Q 2008, 39:67-76.
3. Weiss K., Boisvert A., Chagnon M., et al. Multipronged intervention strategy to control an outbreak of Clostridium difficile infection (CDI) and its impact on the rates of CDI from 2002 to 2007. Infect Control Hosp Epidemiol 2009, 30:156-162.
4. Gerding D.N., Muto C.A., Owens R.C. Measures to control and prevent Clostridium difficile infection. Clin Infect Dis 2008, 46(Suppl. 1):S43-S49.
5. Muto C.A., Blank M.K., Marsh J.W., et al. Control of an outbreak of infection with the hypervirulent Clostridium difficile BI strain in a university hospital using a comprehensive "bundle" approach. Clin Infect Dis 2007, 45:1266-1273.
6. Debast S.B., Vaessen N., Choudry A., Wiegers-Ligtvoet E.A., van den Berg R.J., Kuijper E.J. Successful combat of an outbreak due to Clostridium difficile PCR ribotype 027 and recognition of specific risk factors. Clin Microbiol Infect 2009, 15:427-434.
7. Salgado C.D., Mauldin P.D., Fogle P.J., Bosso J.A. Analysis of an outbreak of Clostridium difficile infection controlled with enhanced infection control measures. Am J Infect Control 2009, 37:458-464.
8. Department of Health Working Party Clostridium difficile infection: how to deal with the problem 2009, DoH, London.
9. Stubbs S.L., Brazier J.S., O'Neill G.L., Duerden B.I. PCR targeted to the 16S-23S rRNA gene intergenic spacer region of Clostridium difficile and construction of a library consisting of 116 different PCR ribotypes. J Clin Microbiol 1999, 37:461-463.
10. Vonberg R.P., Kuijper E.J., Wilcox M.H., et al. Infection control measures to limit the spread of Clostridium difficile. Clin Microbiol Infect 2008, 14(Suppl. 5):2-20.
11. Beaulieu M., Thirion D.J., Williamson D., Pichette G. Clostridium difficile-associated diarrhea outbreaks: the name of the game is isolation and cleaning. Clin Infect Dis 2006, 42:725-729.
12. Pear S.M., Williamson T.H., Bettin K.M., Gerding D.N., Galgiani J.N. Decrease in nosocomial Clostridium difficile-associated diarrhea by restricting clindamycin use. Ann Intern Med 1994, 120:272-277.
13. Pepin J., Saheb N., Coulombe M.A., et al. Emergence of fluoroquinolones as the predominant risk factor for Clostridium difficile-associated diarrhea: a cohort study during an epidemic in Quebec. Clin Infect Dis 2005, 41:1254-1260.
14. Fowler S., Webber A., Cooper B.S., et al. Successful use of feedback to improve antibiotic prescribing and reduce Clostridium difficile infection: a controlled interrupted time series. J Antimicrob Chemother 2007, 59:990-995.
15. Valiquette L., Cossette B., Garant M.P., Diab H., Pepin J. Impact of a reduction in the use of high-risk antibiotics on the course of an epidemic of Clostridium difficile-associated disease caused by the hypervirulent NAP1/027 strain. Clin Infect Dis 2007, 45(Suppl. 2):S112-S121.
16. Belmares J., Johnson S., Parada J.P., et al. Molecular epidemiology of Clostridium difficile over the course of 10 years in a tertiary care hospital. Clin Infect Dis 2009, 49:1141-1147.