Analysis of an outbreak of Clostridium difficile infection controlled with enhanced infection control measures

American Journal of Infection Control

Volumn 37, Issue 6, 2009, Pages 458-464

  Salgado, Cassandra D ^a   Mauldin, Patrick D ^b   Fogle, Pamela J ^b   Bosso, John A ^b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

antibiotic use; Colostridium difficile; infection control

Indexed keywords

CEFAZOLIN; CEFEPIME; CEFTRIAXONE; CLINDAMYCIN; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; GATIFLOXACIN; LEVOFLOXACIN; PIPERACILLIN PLUS TAZOBACTAM;

ANTIBIOTIC THERAPY; ARTICLE; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTION; DIARRHEA; DISEASE TRANSMISSION; EPIDEMIC; HOSPITAL INFECTION; HUMAN; INFECTION CONTROL; MAJOR CLINICAL STUDY; NONHUMAN;

ANTI-BACTERIAL AGENTS; BACTERIAL TOXINS; CLOSTRIDIUM DIFFICILE; CROSS INFECTION; DISEASE OUTBREAKS; DRUG UTILIZATION; ENTEROCOLITIS, PSEUDOMEMBRANOUS; HANDWASHING; HUMANS; INFECTION CONTROL; PATIENT ISOLATION; SANITATION;

EID: 67651040290     PISSN: 01966553     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajic.2008.11.010     Document Type: Article

References (25)

1. McFarland L.V., Mulligan M.E., Kwok R.Y., and Stamm W.E. Nosocomial acquisition of Clostridium difficile infection. N Eng J Med 320 (1989) 204
2. Kyne L., Hamel M.B., Polavaram R., and Kelly C.P. Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile. Clin Infect Dis 34 (2002) 346
3. Miller M.A., Hyland M., Ofner-Agostini M., Gourdeau M., and Ishak M. Canadian Hospital Epidemiology Committee. Canadian Nosocomial Infection Surveillance Program. Morbidity, mortality, and healthcare burden of nosocomial Clostridium difficile-associated diarrhea in Canadian hospitals. Infect Control Hosp Epidemiol 23 (2002) 137
4. McFarland L.V., Surawicz C.M., Rubin M., Fekety R., Elmer G.W., and Greeberg R.N. Recurrent Clostridium difficile disease: epidemiology and clinical characteristics. Infect Control Hosp Epidemiol 20 (1999) 43
5. Wilcox M.H., Cunniffee J.G., Trundle C., and Redpath C. Financial burden of hospital-acquired Clostridium difficile infection. J Hosp Infect 34 (1996) 23
6. Olsen M.M., Shanholtzer C.J., Lee J.T., and Gerding D.N. Ten years of prospective Clostridium difficile-associated disease surveillance and treatment at the Minneapolis VA Medical Center, 1982-1991. Infect Control Hosp Epidemiol 15 (1994) 371
7. Muto C.A., Pokrywka M., Shutt K., Mendelsohn A.B., Nouri K., Posey K., et al. A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use. Infect Control Hosp Epidemiol 26 (2005) 273
8. Loo V.G., Poirier L., Miller M.A., Oughton M., Libman M.D., Michaud S., et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Eng J Med 353 (2005) 2442-2449
9. McDonald L.C., Killgore G.E., Thompson A., Owens Jr. R.C., Kazakova S.V., Sambol S.P., et al. An epidemic, toxic gene-variant strain of Clostridium difficile. N Eng J Med 353 (2005) 2433-2441
10. Gerding D.N., Johnson S., Peterson L.R., Mulligan M.E., and Silva J. Clostridium difficile-associated diarrhea and colitis. Infect Control Hosp Epidemiol 16 (1995) 459
11. Sunenshine R.H., and McDonald L.C. Clostridium difficile-associated disease: new challenges from an established pathogen. Cleveland Clinic J Med 73 (2006) 187-197
12. Bignardi G.E. Risk factors for Clostridium difficile infection. J Hosp Infect 40 (1998) 1-15
13. Barbut F., and Petit J.C. Epidemiology of Clostridium difficile-associated infections. Clin Microbiol Infect 7 (2001) 405-410
14. Lai K., Melvin Z.S., Menard M.J., Kotilainen H.R., Baker S., et al. Clostridium difficile-associated diarrhea: epidemiology, risk factors, and infection control. Infect Control Hosp Epidemiol 18 (1997) 628
15. Yip C., Loeb M., Salama S., Moss L., and Olde J. Quinolone use as a risk factor for nosocomial Clostridium difficile-associated diarrhea. Infect Control Hosp Epidemiol 22 (2001) 572
16. Gaynes R., Rimland D., Killum E., Lowery H.K., Johnson T.M., Killgore G., et al. Outbreak of Clostridium difficile infection in a long-term care facility: association with gatifloxacin use. Clin Infect Dis 38 (2004) 640
17. Muto C.A., Blank M.K., Marsh J.W., Vergis E.N., O'Leary M.M., Shutt K.A., et al. Control of an outbreak of infection with the hypervirulent Clostridium difficile BI strain in a university hospital using a comprehensive "bundle" approach. Clin Infect Dis 45 (2007) 1266-1273
18. Helfenstein U. Box-Jenkins modeling in medical research. Stat Methods Med Res 5 (1996) 3-22
19. Durbin J., and Watson G.S. Testing for serial correlation in least-squares regression. Biometrica 38 (1951) 159-177
20. Fowler S., Webber A., Cooper B.S., Phimster A., Price K., Carter Y., et al. Successful use of feedback to improve antibiotic prescribing and reduce Clostridium difficile infection: a controlled interrupted time series. J Antimicrob Chemother 59 (2007) 990-995
21. Valiquette L., Cossette B., Garant M.P., Diab H., and Pepin J. Impact of reduction in the use of high-risk antibiotics on the course of an epidemic of Clostridium difficile-associated disease caused by the hypervirulent NAP1/027 strain. Clin Infect Dis 45 (2007) S112-S121 3
22. McCusker M.E., Harris A.D., Perencevich E., and Roghmann M.C. Fluoroquinolone use and Clostridium difficile-associated diarrhea. Emerg Infect Dis 9 (2003) 730
23. Pepin J., Saheb N., Coulombe M.A., Alary M.E., Corriveau M.P., Authier S., et al. Emergence of fluoroquinolones as the predominate risk factor for Clostridium difficile-associated diarrhea: a cohort study during an epidemic in Quebec. Clin Infect Dis 41 (2005) 1254-1260
24. Koopman J.S., and Longini Jr. I.M. The ecological effects of individual exposures and nonlinear disease dynamics in populations. Am J Pub Health 84 (1994) 836-842
25. Blakely T.A., and Woodward A.J. Ecological effects in multi-level studies. J Epidemiol Community Health 54 (2000) 367-374