Systemic spironucleosis in 2 immunodeficient rhesus macaques (Macaca mulatta)

Veterinary Pathology

Volumn 47, Issue 3, 2010, Pages 488-494

  Bailey, C ^a   Kramer, J ^a   Mejia, A ^a   MacKey, J ^a   Mansfield, K G ^a   Miller, Andrew D ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Macaca mulatta; Protozoan infections; Simian immunodeficiency virus; Spironucleus

Indexed keywords

ANIMAL; ANIMAL PARASITOSIS; ARTICLE; CASE REPORT; CLASSIFICATION; DIPLOMONADIDA; FEMALE; IMMUNOCOMPROMISED PATIENT; ISOLATION AND PURIFICATION; MACACA; MALE; MONKEY DISEASE; PARASITOLOGY; PATHOLOGY; PHYLOGENY; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME;

ANIMALS; DIPLOMONADIDA; FEMALE; IMMUNOCOMPROMISED HOST; MACACA MULATTA; MALE; MONKEY DISEASES; PHYLOGENY; PROTOZOAN INFECTIONS, ANIMAL; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME;

ADENOVIRIDAE; CERCOPITHECINE HERPESVIRUS 15; CERCOPITHECINE HERPESVIRUS 8; MACACA MULATTA; MAMMALIA; MUS; PROTOZOA; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS; SPIRONUCLEUS; SPIRONUCLEUS MELEAGRIDIS; VERTEBRATA;

EID: 77954514013     PISSN: 03009858     EISSN: 15442217     Source Type: Journal    
DOI: 10.1177/0300985810363704     Document Type: Article

References (31)

1. Biagini GA, McIntyre PS, Finlay BJ, Lloyd D.: Carbohydrate and amino acid fermentation in the free-living primitive protozoon Hexamita sp. Appl Environ Microbiol 64:203-207, 1998.
2. Biagini GA, Yarlett N., Ball GE, Billetz AC, Lindmark DG, Martinez MP, Lloyd D., Edwards MR: Bacterial-like energy metabolism in the amitochondriate protozoon Hexamita inflata. Mol Biochem Parasitol 128:11-19, 2003.
3. Boorman GA, Lina PH, Zurcher C., Nieuwerkerk HT: Hexamita and Giardia as a cause of mortality in congenitally thymus-less (nude) mice. Clin Exp Immunol 15:623-627, 1973.
4. Cooper GL, Charlton BR, Bickford AA, Nordhausen R.: Hexamita meleagridis (Spironucleus meleagridis) infection in chukar partridges associated with high mortality and intracellular trophozoites. Avian Dis 48:706-710, 2004.
5. daCunha A., Muniz J.: Nota sobre os parasitas intestinaes do Macacus rhesus con a descripcao de uma nova especie de Octomitus. Mem Inst Oswaldo Cruz 5:34-35, 1929.
6. Desrosiers RC: The simian immunodeficiency viruses. Annu Rev Immunol 8:557-578, 1990.
7. Ferguson HW, Moccia RD: Disseminated hexamitiasis in Siamese fighting fish. J Am Vet Med Assoc 177:854-857, 1980.
8. Flatt RE, Halvorsen JA, Kemp RL: Hexamitiasis in a laboratory mouse colony. Lab Anim Sci 28:62-65, 1978.
9. Harper FD: Hexamita species present in some avian species in South Wales. Vet Rec 128:130, 1991.
10. Hashimoto T., Hasegawa M.: Origin and early evolution of eukaryotes inferred from the amino acid sequences of translation elongation factors 1alpha/Tu and 2/G. Adv Biophys 32:73-120, 1996.
11. Hussain AZ: Morphometric evaluation of the small intestines and caeca of pheasants infected with Hexamita and Trichomonas species. Vet Rec 148:484-485, 2001.
12. Institute of Laboratory Animal Resources, Committee on Infectious Diseases of Mice and Rats: Companion Guide to Infectious Diseases of Mice and Rats. National Academy Press, Washington, DC, 1991.
13. Kaup F., Matz-Rensing K., Kuhn E., Hunerbein P., Stahl-Hennig C., Hunsmann G.: Gastrointestinal pathology in rhesus monkeys with experimental SIV infection. Pathobiology 66:159-164, 1998.
14. King NW, Chalifoux LV, Ringler DJ, Wyand MS, Sehgal PK, Daniel MD, Letvin NL, Desrosiers RC, Blake BJ, Hunt RD: Comparative biology of natural and experimental SIVmac infection in macaque monkeys: a review. J Med Primatol 19:109-118, 1990.
15. Kolisko M., Cepicka I., Hampl V., Leigh J., Roger AJ, Kulda J., Simpson AG, Flegr J.: Molecular phylogeny of diplomonads and enteromonads based on SSU rRNA, alpha-tubulin and HSP90 genes: implications for the evolutionary history of the double karyomastigont of diplomonads. BMC Evol Biol 8:205, 2008.
16. Kondova I., Simon MA, Klumpp SA, MacKey J, Widmer G, Domingues HG, Persengiev SP, O'Neil SP: Trichomonad gastritis in rhesus macaques (Macaca mulatta) infected with simian immunodeficiency virus. Vet Pathol 42:19-29, 2005.
17. Kuhn EM, Matz-Rensing K., Stahl-Hennig C., Makoschey B., Hunsmann G., Kaup FJ: Intestinal manifestations of experimental SIV-infection in rhesus monkeys (Macaca mulatta): a histologic and ultrastructural study. Zentralbl Veterinarmed B 44:501- 512, 1997.
18. Kunstyr I.: Infectious form of Spironucleus (Hexamita) muris: banded cysts. Lab Anim 11:185-188, 1977.
19. Kunstyr I., Ammerpohl E., Meyer B.: Experimental spironucleosis (hexamitiasis) in the nude mouse as a model for immunologic and pharmacologic studies. Lab Anim Sci 27:782-788, 1977.
20. Lackner AA: Pathology of simian immunodeficiency virus induced disease. Curr Top Microbiol Immunol 188:35-64, 1994.
21. Larkin MA, Blackshields G., Brown NP, Chenna R., McGettigan PA, McWilliam H., Valentin F., Wallace IM, Wilm A., Lopez R., Thompson JD, Gibson TJ, Higgins DG: Clustal W and Clustal X version 2.0. Bioinformatics 23:2947-2948, 2007.
22. Letvin NL, O'Connell MJ, Blake BJ, King NW: Hematogenous hexamitiasis in a macaque monkey with an immunodeficiency syndrome. J Infect Dis 149:828, 1984.
23. Levine ND: Protozoan parasites of nonhuman primates as zoonotic agents. Lab Anim Care 20:377-382, 1970.
24. Poppe T., Mo TA, Iversen L.: Disseminated hexamitosis in sea-caged Atlantic salmon Salmo salar. Dis Aquat Organ 14:91-97, 1992.
25. Poynton SL, Fard MR, Jenkins J., Ferguson HW: Ultrastructure of Spironucleus salmonis n comb (formerly Octomitus salmonis sensu Moore 1922, Davis 1926, and Hexamita salmonis sensu Ferguson 1979), with a guide to Spironucleus species. Dis Aquat Organ 60:49-64, 2004.
26. Poynton SL, Morrison CM: Morphology of diplomonad flagellates: Spironucleus torosa N sp from Atlantic cod Gadus morhua L, and haddock Melanogrammus aeglefinus (L) and Hexamita salmonis Moore from brook trout Salvelinus fontinalis (Mitchill). J Protozool 37:369-383, 1990.
27. Sterud E., Mo TA, Poppe TT: Systemic spironucleosis in sea-farmed Atlantic salmon Salmo salar, caused by Spironucleus barkhanus transmitted from feral Arctic char Salvelinus alpinus? Dis Aquat Organ 33:63-66, 1998.
28. Sterud E., Poppe T., Borno G.: Intracellular infection with Spironucleus barkhanus (Diplomonadida: Hexamitidae) in farmed Arctic char Salvelinus alpinus. Dis Aquat Organ 56:155-161, 2003.
29. Toft JD II: The pathoparasitology of the alimentary tract and pancreas of nonhuman primates: a review. Vet Pathol Suppl 7:44-92, 1982.
30. Wenrich D.: A species of Hexamita (Protozoa, Flagellata) from the intestine of a monkey (Macacus rhesus). J Parasitol 19:225-229, 1933.
31. Wood AM, Smith HV: Spironucleosis (Hexamitiasis, Hexamitosis) in the ring-necked pheasant (Phasianus colchicus): detection of cysts and description of Spironucleus meleagridis in stained smears. Avian Dis 49:138-143, 2005.