Does the added benefit of ondansetron over dexamethasone, to control post-operative nausea and vomiting, justify the added cost in patients undergoing tonsillectomy and adenotonsillectomy?

Journal of the Pakistan Medical Association

Volumn 60, Issue 7, 2010, Pages 559-561

  Rabbani, Mohammad Zafar ^a   Khan, Mohammad Nasir Ayub ^a   Qureshi, Rashid ^a   Zubair, Muhammad ^a   Pervez, Mohammad Bin ^b  

^a SHIFA INTERNATIONAL HOSPITAL   (Pakistan)

^b AGA KHAN UNIVERSITY   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; ONDANSETRON; ANTIEMETIC AGENT;

ADENOTONSILLECTOMY; ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL TRIAL; COMPARATIVE EFFECTIVENESS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COST BENEFIT ANALYSIS; DRUG COST; DRUG EFFICACY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTION SICKNESS; POSTOPERATIVE NAUSEA AND VOMITING; PRESCHOOL CHILD; SCHOOL CHILD; TONSILLECTOMY; ADENOID; COMPARATIVE STUDY; EAR NOSE THROAT SURGERY; ECONOMICS; PAKISTAN;

ADENOIDS; ADOLESCENT; ADULT; ANTIEMETICS; CHILD; CHILD, PRESCHOOL; COST-BENEFIT ANALYSIS; DEXAMETHASONE; FEMALE; HUMANS; MALE; ONDANSETRON; OTORHINOLARYNGOLOGIC SURGICAL PROCEDURES; PAKISTAN; POSTOPERATIVE NAUSEA AND VOMITING; TONSILLECTOMY; YOUNG ADULT;

EID: 77954508598     PISSN: 00309982     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Kooij FO, Klok T, Hollmann MW, Kal JE. Automated reminders increase adherence to guidelines for administration of prophylaxis for postoperative nausea and vomiting. Eur J Anaesthesiol 2009; 27: 187-91.
2. Diemunsch P, Joshi GP, Brichant JF. Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting. Br J Anaesth 2009; 103: 7-13.
3. Bolton CM, Myles PS, Nolan T, Sterne JA. Prophylaxis of postoperative vomiting in children undergoing tonsillectomy: a systematic review and metaanalysis. Br J Anaesth 2006; 97: 593-604.
4. Nam M, Yoon H. Effect of ondansetron combined with dexamethasone on postoperative nausea & vomiting and pain of patients with laparoscopic hysterectomy. J Korean Acad Nurs 2009; 39: 44-52.
5. Apfel CC, Korttila K, Abdalla M, Kerger H, Turan A, Vedder I, et al. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med 2004; 350: 2441-51.
6. Dagtekin O, Wiese P, Wolter K, Hermann MM, Pietruck C, Kampe S. Haloperidol versus haloperidol plus ondansetron for the prophylaxis of postoperative nausea and vomiting after ophthalmologic surgery. Pharmacology 2009; 83: 205-10.
7. Bano F, Zafar S, Aftab S, Haider S. Dexamethasone plus ondansetron for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a comparison with dexamethasone alone. J Coll Physicians Surg Pak 2008; 18: 265-9.
8. Bailey CR. Management of outpatient ear, nose and throat surgery. Curr Opin Anaesthesiol 2001; 14: 617-21.
9. Edler AA, Mariano ER, Golianu B, Kuan C, Pentcheva K. An analysis of factors influencing postanaesthesia recovery after paediatric ambulatory tonsillectomy and adenoidectomy. Anesth Analg 2007; 104: 784-9.
10. Kim MS, Cote CJ, Cristoloveanu C, Roth AG, Vornor P, Jannings MA, et al. There is no dose-escalation response to dexamethasone (0.0625-1.0 mg/kg) in paediatric tonsillectomy or adenotonsillectomy patients for preventing vomiting, reducing pain, shortening time to first liquid intake, or the Incidence of voice change. Anesth Analg 2007; 104: 1052-8.
11. Subramaniam B, Madan R, Sadhasiram S, Sennaraj B, Tamilselvan P, Jagan D, et al. Dexamethasone is a cost-effective alternative to ondansetron in preventing PONV after paediatric strabismus repair. Br J Anaesth 2001; 86: 84-9.
12. White PF, Sacan O, Nuangchamnong N, Sun T, Eng MR. The relationship between patient risk factors and early versus late postoperative emetic symptoms. Anesth Analg 2008; 107: 459-63.
13. Czarnetzki C, Elia N, Lysakowshi C, Dumont L, Landis BN, Giger R, et al. Dexamethasone and risk of nausea and vomiting and postoperative bleeding after tonsillectomy in children: a randomized trial. JAMA 2008; 300: 2621-30.
14. Bennett AM, Emery PJ. A significant reduction in paediatric post-tonsillectomy vomiting through audit. Ann R Coll Surg Engl 2008; 90: 226-30.
15. McKean S, Kochilas X, Kelleher R, Dockery M. Use of intravenous steroids at induction of anaesthesia for adult tonsillectomy to reduce post-operative nausea and vomiting and pain: a double-blind randomized controlled trial. Clin Otolaryngol 2006; 31: 36-40.
16. Fazel MR, Yegane-Moghaddam A, Forghani Z, Aghadoost D, Mahdian M, Fakharian E. The effect of dexamethasone on postoperative vomiting and oral intake after adenotonsillectomy. Int J Pediatr Otorhinolaryngol 2007; 71: 1235-8.