메뉴 건너뛰기




Volumn 3, Issue 1, 2010, Pages 71-82

Targeted therapies in lung cancer

Author keywords

Adenocarcinoma; Lung cancer; Molecular pathogenesis; Squamous; Tyrosine kinase inhibitors

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 [3 CHLORO 4 (2 PYRIDINYLMETHOXY)ANILINO] 3 CYANO 6 (4 DIMETHYLAMINOCROTONAMIDO) 7 ETHOXYQUINOLINE; 5 (4 BROMO 2 CHLOROANILINO) 4 FLUORO 1 METHYL 1H BENZIMIDAZOLE 6 CARBOHYDROXAMIC ACID 2 HYDROXYETHYL ESTER; ANTINEOPLASTIC AGENT; AXITINIB; BEVACIZUMAB; CANERTINIB; CEDIRANIB; CETUXIMAB; DEFOROLIMUS; ERLOTINIB; EVEROLIMUS; GEFITINIB; IMATINIB; LAPATINIB; LONAFARNIB; MATUZUMAB; MOTESANIB; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; PANITUMUMAB; RAPAMYCIN; SORAFENIB; SUNITINIB; TEMSIROLIMUS; TIPIFARNIB; TRASTUZUMAB; UNINDEXED DRUG; VANDETANIB; VATALANIB;

EID: 77954495172     PISSN: 18759181     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.path.2010.04.001     Document Type: Review
Times cited : (31)

References (68)
  • 1
    • 67650874081 scopus 로고    scopus 로고
    • Cancer statistics, 2009
    • Jemal A., Siegel R., Ward E., et al. Cancer statistics, 2009. CA Cancer J Clin 2009, 59(4):225-249.
    • (2009) CA Cancer J Clin , vol.59 , Issue.4 , pp. 225-249
    • Jemal, A.1    Siegel, R.2    Ward, E.3
  • 2
    • 68849123063 scopus 로고    scopus 로고
    • Lung cancer trials probe effects of maintenance therapy, targeted agents
    • Hampton T. Lung cancer trials probe effects of maintenance therapy, targeted agents. JAMA 2009, 302(6):616-618.
    • (2009) JAMA , vol.302 , Issue.6 , pp. 616-618
    • Hampton, T.1
  • 3
    • 34247891719 scopus 로고    scopus 로고
    • A translational view of the molecular pathogenesis of lung cancer
    • Sato M., Shames D.S., Gazdar A.F., et al. A translational view of the molecular pathogenesis of lung cancer. J Thorac Oncol 2007, 2(4):327-343.
    • (2007) J Thorac Oncol , vol.2 , Issue.4 , pp. 327-343
    • Sato, M.1    Shames, D.S.2    Gazdar, A.F.3
  • 4
    • 59949084951 scopus 로고    scopus 로고
    • Clinical cancer advances 2008: major research advances in cancer treatment, prevention, and screening-a report from the American Society of Clinical Oncology
    • Winer E., Gralow J., Diller L., et al. Clinical cancer advances 2008: major research advances in cancer treatment, prevention, and screening-a report from the American Society of Clinical Oncology. J Clin Oncol 2009, 27(5):812-826.
    • (2009) J Clin Oncol , vol.27 , Issue.5 , pp. 812-826
    • Winer, E.1    Gralow, J.2    Diller, L.3
  • 5
    • 73349105243 scopus 로고    scopus 로고
    • Resistance to targeted therapies: refining anticancer therapy in the era of molecular oncology
    • Ellis L.M., Hicklin D.J. Resistance to targeted therapies: refining anticancer therapy in the era of molecular oncology. Clin Cancer Res 2009, 15(24):7471-7478.
    • (2009) Clin Cancer Res , vol.15 , Issue.24 , pp. 7471-7478
    • Ellis, L.M.1    Hicklin, D.J.2
  • 6
    • 54549094903 scopus 로고    scopus 로고
    • Somatic mutations affect key pathways in lung adenocarcinoma
    • Ding L., Getz G., Wheeler D., et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008, 455(7216):1069-1075.
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1069-1075
    • Ding, L.1    Getz, G.2    Wheeler, D.3
  • 8
    • 1542503746 scopus 로고    scopus 로고
    • Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 1
    • Giaccone G., Herbst R.S., Manegold C., et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 1. J Clin Oncol 2004, 22(5):777-784.
    • (2004) J Clin Oncol , vol.22 , Issue.5 , pp. 777-784
    • Giaccone, G.1    Herbst, R.S.2    Manegold, C.3
  • 9
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
    • Herbst R.S., Prager D., Hermann R., et al. TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 2005, 23(25):5892-5899.
    • (2005) J Clin Oncol , vol.23 , Issue.25 , pp. 5892-5899
    • Herbst, R.S.1    Prager, D.2    Hermann, R.3
  • 10
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • Thatcher N., Chang A., Parikh P., et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005, 366(9496):1527-1537.
    • (2005) Lancet , vol.366 , Issue.9496 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3
  • 11
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch T.J., Bell D., Sordella R., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004, 350(21):2129-2139.
    • (2004) N Engl J Med , vol.350 , Issue.21 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.2    Sordella, R.3
  • 12
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
    • Paez J.G., Janne P., Lee J., et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004, 304(5676):1497-1500.
    • (2004) Science , vol.304 , Issue.5676 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.2    Lee, J.3
  • 13
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W., Miller V., Zakowski M., et al. EGF receptor gene mutations are common in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 2004, 101(36):13306-13311.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.36 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 14
    • 33847323129 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in lung cancer
    • Sharma S.V., Bell D., Settleman J., et al. Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer 2007, 7(3):169-181.
    • (2007) Nat Rev Cancer , vol.7 , Issue.3 , pp. 169-181
    • Sharma, S.V.1    Bell, D.2    Settleman, J.3
  • 15
    • 34548849132 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutation testing in lung cancer: searching for the ideal method
    • Pao W., Ladanyi M. Epidermal growth factor receptor mutation testing in lung cancer: searching for the ideal method. Clin Cancer Res 2007, 13(17):4954-4955.
    • (2007) Clin Cancer Res , vol.13 , Issue.17 , pp. 4954-4955
    • Pao, W.1    Ladanyi, M.2
  • 16
    • 55949097252 scopus 로고    scopus 로고
    • Genetic predictors of MEK dependence in non-small cell lung cancer
    • Pratilas C.A., Hanrahan A., Halilovic E., et al. Genetic predictors of MEK dependence in non-small cell lung cancer. Cancer Res 2008, 68(22):9375-9383.
    • (2008) Cancer Res , vol.68 , Issue.22 , pp. 9375-9383
    • Pratilas, C.A.1    Hanrahan, A.2    Halilovic, E.3
  • 17
    • 68549140332 scopus 로고    scopus 로고
    • Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC
    • Linardou H., Dahabreh I., Bafaloukos D., et al. Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC. Nat Rev Clin Oncol 2009, 6(6):352-366.
    • (2009) Nat Rev Clin Oncol , vol.6 , Issue.6 , pp. 352-366
    • Linardou, H.1    Dahabreh, I.2    Bafaloukos, D.3
  • 18
    • 0035883542 scopus 로고    scopus 로고
    • Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung
    • Ahrendt S.A., Decker P.A., Alawi E.A., et al. Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung. Cancer 2001, 92(6):1525-1530.
    • (2001) Cancer , vol.92 , Issue.6 , pp. 1525-1530
    • Ahrendt, S.A.1    Decker, P.A.2    Alawi, E.A.3
  • 19
    • 24944497744 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    • Eberhard D.A., Johnson B., Amler L., et al. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 2005, 23(25):5900-5909.
    • (2005) J Clin Oncol , vol.23 , Issue.25 , pp. 5900-5909
    • Eberhard, D.A.1    Johnson, B.2    Amler, L.3
  • 20
    • 53249145767 scopus 로고    scopus 로고
    • Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma
    • Riely G.J., Kris M., Rosenbaum D., et al. Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. Clin Cancer Res 2008, 14(18):5731-5734.
    • (2008) Clin Cancer Res , vol.14 , Issue.18 , pp. 5731-5734
    • Riely, G.J.1    Kris, M.2    Rosenbaum, D.3
  • 21
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W., Miller V., Politi K., et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005, 2(3):e73.
    • (2005) PLoS Med , vol.2 , Issue.3
    • Pao, W.1    Miller, V.2    Politi, K.3
  • 22
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman J.A., Zejnullahu K., Mitsudomi T., et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007, 316(5827):1039-1043.
    • (2007) Science , vol.316 , Issue.5827 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3
  • 23
    • 34147107009 scopus 로고    scopus 로고
    • Second-generation epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
    • Sequist L.V. Second-generation epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Oncologist 2007, 12(3):325-330.
    • (2007) Oncologist , vol.12 , Issue.3 , pp. 325-330
    • Sequist, L.V.1
  • 24
    • 48049116431 scopus 로고    scopus 로고
    • EGFR assays in lung cancer
    • Dacic S. EGFR assays in lung cancer. Adv Anat Pathol 2008, 15(4):241-247.
    • (2008) Adv Anat Pathol , vol.15 , Issue.4 , pp. 241-247
    • Dacic, S.1
  • 25
    • 34248147439 scopus 로고    scopus 로고
    • Stratification of non-small cell lung cancer patients for therapy with epidermal growth factor receptor inhibitors: the EGFR fluorescence in situ hybridization assay
    • Varella-Garcia M. Stratification of non-small cell lung cancer patients for therapy with epidermal growth factor receptor inhibitors: the EGFR fluorescence in situ hybridization assay. Diagn Pathol 2006, 1:19.
    • (2006) Diagn Pathol , vol.1 , pp. 19
    • Varella-Garcia, M.1
  • 26
    • 76349090221 scopus 로고    scopus 로고
    • Clinicopathological predictors of EGFR/KRAS mutational status in primary lung adenocarcinomas
    • Dacic S., Shuai Y., Yousem S., et al. Clinicopathological predictors of EGFR/KRAS mutational status in primary lung adenocarcinomas. Mod Pathol 2010, 23(2):159-168.
    • (2010) Mod Pathol , vol.23 , Issue.2 , pp. 159-168
    • Dacic, S.1    Shuai, Y.2    Yousem, S.3
  • 27
    • 49149127726 scopus 로고    scopus 로고
    • Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy
    • Hirsch F.R., Herbst R.S., Olsen C., et al. Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy. J Clin Oncol 2008, 26(20):3351-3357.
    • (2008) J Clin Oncol , vol.26 , Issue.20 , pp. 3351-3357
    • Hirsch, F.R.1    Herbst, R.S.2    Olsen, C.3
  • 28
    • 34548781376 scopus 로고    scopus 로고
    • Validation of chromogenic in situ hybridization for detection of EGFR copy number amplification in nonsmall cell lung carcinoma
    • Sholl L.M., John lafrate A., Chou Y., et al. Validation of chromogenic in situ hybridization for detection of EGFR copy number amplification in nonsmall cell lung carcinoma. Mod Pathol 2007, 20(10):1028-1035.
    • (2007) Mod Pathol , vol.20 , Issue.10 , pp. 1028-1035
    • Sholl, L.M.1    John lafrate, A.2    Chou, Y.3
  • 29
    • 34248344725 scopus 로고    scopus 로고
    • Clinical utility of epidermal growth factor receptor expression for selecting patients with advanced non-small cell lung cancer for treatment with erlotinib
    • Clark G.M., Zborowski D.M., Culbertson J.L., et al. Clinical utility of epidermal growth factor receptor expression for selecting patients with advanced non-small cell lung cancer for treatment with erlotinib. J Thorac Oncol 2006, 1(8):837-846.
    • (2006) J Thorac Oncol , vol.1 , Issue.8 , pp. 837-846
    • Clark, G.M.1    Zborowski, D.M.2    Culbertson, J.L.3
  • 30
    • 39749191925 scopus 로고    scopus 로고
    • Epidermal growth factor receptor immunohistochemistry: comparison of antibodies and cutoff points to predict benefit from gefitinib in a phase 3 placebo-controlled study in advanced nonsmall-cell lung cancer
    • Hirsch F.R., Dziaddziuszko R., Thatcher N., et al. Epidermal growth factor receptor immunohistochemistry: comparison of antibodies and cutoff points to predict benefit from gefitinib in a phase 3 placebo-controlled study in advanced nonsmall-cell lung cancer. Cancer 2008, 112(5):1114-1121.
    • (2008) Cancer , vol.112 , Issue.5 , pp. 1114-1121
    • Hirsch, F.R.1    Dziaddziuszko, R.2    Thatcher, N.3
  • 31
    • 33751056966 scopus 로고    scopus 로고
    • Clinicopathologic features and prognostic implications of epidermal growth factor receptor (EGFR) gene copy number and protein expression in non-small cell lung cancer
    • Jeon Y.K., Sung S.W., Chung J.H., et al. Clinicopathologic features and prognostic implications of epidermal growth factor receptor (EGFR) gene copy number and protein expression in non-small cell lung cancer. Lung Cancer 2006, 54(3):387-398.
    • (2006) Lung Cancer , vol.54 , Issue.3 , pp. 387-398
    • Jeon, Y.K.1    Sung, S.W.2    Chung, J.H.3
  • 32
    • 77649140830 scopus 로고    scopus 로고
    • Assessment of EGFR mutation status in lung adenocarcinoma by immunohistochemistry using antibodies specific to the two major forms of mutant EGFR
    • Brevet M., Arcila M., Ladanyi M. Assessment of EGFR mutation status in lung adenocarcinoma by immunohistochemistry using antibodies specific to the two major forms of mutant EGFR. J Mol Diagn 2010, 12(2):169-176.
    • (2010) J Mol Diagn , vol.12 , Issue.2 , pp. 169-176
    • Brevet, M.1    Arcila, M.2    Ladanyi, M.3
  • 33
    • 65649128973 scopus 로고    scopus 로고
    • Mutation-specific antibodies for the detection of EGFR mutations in non-small-cell lung cancer
    • Yu J., Kane S., Wu J., et al. Mutation-specific antibodies for the detection of EGFR mutations in non-small-cell lung cancer. Clin Cancer Res 2009, 15(9):3023-3028.
    • (2009) Clin Cancer Res , vol.15 , Issue.9 , pp. 3023-3028
    • Yu, J.1    Kane, S.2    Wu, J.3
  • 34
    • 33746034167 scopus 로고    scopus 로고
    • Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib
    • Jackman D.M., Yeap B., Sequist L., et al. Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib. Clin Cancer Res 2006, 12(13):3908-3914.
    • (2006) Clin Cancer Res , vol.12 , Issue.13 , pp. 3908-3914
    • Jackman, D.M.1    Yeap, B.2    Sequist, L.3
  • 35
    • 27944499351 scopus 로고    scopus 로고
    • EGFR and erbB2 mutation status in Japanese lung cancer patients
    • Sasaki H., Shimizu S., Endo K., et al. EGFR and erbB2 mutation status in Japanese lung cancer patients. Int J Cancer 2006, 118(1):180-184.
    • (2006) Int J Cancer , vol.118 , Issue.1 , pp. 180-184
    • Sasaki, H.1    Shimizu, S.2    Endo, K.3
  • 36
    • 20444498630 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
    • Cappuzzo F., Hirsch F., Rossi E., et al. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst 2005, 97(9):643-655.
    • (2005) J Natl Cancer Inst , vol.97 , Issue.9 , pp. 643-655
    • Cappuzzo, F.1    Hirsch, F.2    Rossi, E.3
  • 37
    • 27244443759 scopus 로고    scopus 로고
    • Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study
    • Hirsch F.R., Varella-Garcia M., McCoy J., et al. Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study. J Clin Oncol 2005, 23(28):6838-6845.
    • (2005) J Clin Oncol , vol.23 , Issue.28 , pp. 6838-6845
    • Hirsch, F.R.1    Varella-Garcia, M.2    McCoy, J.3
  • 38
    • 75249084998 scopus 로고    scopus 로고
    • Randomized, placebo-controlled, phase II study of sequential erlotinib and chemotherapy as first-line treatment for advanced non-small-cell lung cancer
    • Mok T.S.K., Wu Y.L., Yu C.J., et al. Randomized, placebo-controlled, phase II study of sequential erlotinib and chemotherapy as first-line treatment for advanced non-small-cell lung cancer. J Clin Oncol 2009, 27(30):5080-5087.
    • (2009) J Clin Oncol , vol.27 , Issue.30 , pp. 5080-5087
    • Mok, T.S.K.1    Wu, Y.L.2    Yu, C.J.3
  • 39
    • 52049090365 scopus 로고    scopus 로고
    • Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21
    • Zhu C.Q., da Cunha Santos G., Ding K., et al. Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21. J Clin Oncol 2008, 26(26):4268-4275.
    • (2008) J Clin Oncol , vol.26 , Issue.26 , pp. 4268-4275
    • Zhu, C.Q.1    da Cunha Santos, G.2    Ding, K.3
  • 40
    • 60549110433 scopus 로고    scopus 로고
    • MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients
    • Cappuzzo F., Janne P.A., Skokan M., et al. MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients. Ann Oncol 2009, 20(2):298-304.
    • (2009) Ann Oncol , vol.20 , Issue.2 , pp. 298-304
    • Cappuzzo, F.1    Janne, P.A.2    Skokan, M.3
  • 41
    • 51449104064 scopus 로고    scopus 로고
    • Dual MET-EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer
    • Tang Z., Du R., Jiang S., et al. Dual MET-EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer. Br J Cancer 2008, 99(6):911-922.
    • (2008) Br J Cancer , vol.99 , Issue.6 , pp. 911-922
    • Tang, Z.1    Du, R.2    Jiang, S.3
  • 42
    • 1842509828 scopus 로고    scopus 로고
    • Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer
    • Miller V.A., Kris M.G., Shah N., et al. Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer. J Clin Oncol 2004, 22(6):1103-1109.
    • (2004) J Clin Oncol , vol.22 , Issue.6 , pp. 1103-1109
    • Miller, V.A.1    Kris, M.G.2    Shah, N.3
  • 43
    • 41149097557 scopus 로고    scopus 로고
    • Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib
    • Miller V.A., Riely G.J., Zakowski M.F., et al. Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib. J Clin Oncol 2008, 26(9):1472-1478.
    • (2008) J Clin Oncol , vol.26 , Issue.9 , pp. 1472-1478
    • Miller, V.A.1    Riely, G.J.2    Zakowski, M.F.3
  • 44
    • 33646381931 scopus 로고    scopus 로고
    • Gefitinib therapy in advanced bronchioloalveolar carcinoma: Southwest Oncology Group Study S0126
    • West H.L., Franklin W.A., McCoy J., et al. Gefitinib therapy in advanced bronchioloalveolar carcinoma: Southwest Oncology Group Study S0126. J Clin Oncol 2006, 24(12):1807-1813.
    • (2006) J Clin Oncol , vol.24 , Issue.12 , pp. 1807-1813
    • West, H.L.1    Franklin, W.A.2    McCoy, J.3
  • 45
    • 40049100818 scopus 로고    scopus 로고
    • Prognostic and therapeutic implications of EGFR and KRAS mutations in resected lung adenocarcinoma
    • Marks J.L., Broderick S., Zhou Q., et al. Prognostic and therapeutic implications of EGFR and KRAS mutations in resected lung adenocarcinoma. J Thorac Oncol 2008, 3(2):111-116.
    • (2008) J Thorac Oncol , vol.3 , Issue.2 , pp. 111-116
    • Marks, J.L.1    Broderick, S.2    Zhou, Q.3
  • 46
    • 46249096082 scopus 로고    scopus 로고
    • Lung adenocarcinoma: modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis
    • Motoi N., Szoke J., Riely G.J., et al. Lung adenocarcinoma: modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis. Am J Surg Pathol 2008, 32(6):810-827.
    • (2008) Am J Surg Pathol , vol.32 , Issue.6 , pp. 810-827
    • Motoi, N.1    Szoke, J.2    Riely, G.J.3
  • 47
    • 58049205542 scopus 로고    scopus 로고
    • Correlation between morphology and EGFR mutations in lung adenocarcinomas: significance of the micropapillary pattern and the hobnail cell type
    • Ninomiya H., Hiramatsu M., Inamura K., et al. Correlation between morphology and EGFR mutations in lung adenocarcinomas: significance of the micropapillary pattern and the hobnail cell type. Lung Cancer 2009, 63(2):235-240.
    • (2009) Lung Cancer , vol.63 , Issue.2 , pp. 235-240
    • Ninomiya, H.1    Hiramatsu, M.2    Inamura, K.3
  • 48
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    • Shigematsu H., Lin L., Takahashi T., et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 2005, 97(5):339-346.
    • (2005) J Natl Cancer Inst , vol.97 , Issue.5 , pp. 339-346
    • Shigematsu, H.1    Lin, L.2    Takahashi, T.3
  • 49
    • 62249156223 scopus 로고    scopus 로고
    • Morphologic features of adenocarcinoma of the lung predictive of response to the epidermal growth factor receptor kinase inhibitors erlotinib and gefitinib
    • Zakowski M.F., Hussain S., Pao W., et al. Morphologic features of adenocarcinoma of the lung predictive of response to the epidermal growth factor receptor kinase inhibitors erlotinib and gefitinib. Arch Pathol Lab Med 2009, 133(3):470-477.
    • (2009) Arch Pathol Lab Med , vol.133 , Issue.3 , pp. 470-477
    • Zakowski, M.F.1    Hussain, S.2    Pao, W.3
  • 50
    • 34548182258 scopus 로고    scopus 로고
    • Mucinous differentiation correlates with absence of EGFR mutation and presence of KRAS mutation in lung adenocarcinomas with bronchioloalveolar features
    • Finberg K.E., Sequist L., Joshi V., et al. Mucinous differentiation correlates with absence of EGFR mutation and presence of KRAS mutation in lung adenocarcinomas with bronchioloalveolar features. J Mol Diagn 2007, 9(3):320-326.
    • (2007) J Mol Diagn , vol.9 , Issue.3 , pp. 320-326
    • Finberg, K.E.1    Sequist, L.2    Joshi, V.3
  • 51
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A., Gray R., Perry M.C., et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006, 355(24):2542-2550.
    • (2006) N Engl J Med , vol.355 , Issue.24 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 52
    • 70350120598 scopus 로고    scopus 로고
    • Histologic considerations for individualized systemic therapy approaches for the management of non-small cell lung cancer
    • West H., Harpole D., Travis W. Histologic considerations for individualized systemic therapy approaches for the management of non-small cell lung cancer. Chest 2009, 136(4):1112-1118.
    • (2009) Chest , vol.136 , Issue.4 , pp. 1112-1118
    • West, H.1    Harpole, D.2    Travis, W.3
  • 53
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson D.H., Fehrenbacher L., Novotny W.F., et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004, 22(11):2184-2191.
    • (2004) J Clin Oncol , vol.22 , Issue.11 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 54
    • 0030034745 scopus 로고    scopus 로고
    • High incidence of the t (2;5)(p23;q35) translocation in anaplastic large cell lymphoma and its lack of detection in Hodgkin's disease. Comparison of cytogenetic analysis, reverse transcriptase-polymerase chain reaction, and P-80 immunostaining
    • Lamant L., Megetto F., al Saati T., et al. High incidence of the t (2;5)(p23;q35) translocation in anaplastic large cell lymphoma and its lack of detection in Hodgkin's disease. Comparison of cytogenetic analysis, reverse transcriptase-polymerase chain reaction, and P-80 immunostaining. Blood 1996, 87(1):284-291.
    • (1996) Blood , vol.87 , Issue.1 , pp. 284-291
    • Lamant, L.1    Megetto, F.2    al Saati, T.3
  • 55
    • 0028198206 scopus 로고
    • Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
    • Morris S.W., Kirstein M.N., Valentine M.B., et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 1994, 263(5151):1281-1284.
    • (1994) Science , vol.263 , Issue.5151 , pp. 1281-1284
    • Morris, S.W.1    Kirstein, M.N.2    Valentine, M.B.3
  • 56
    • 36849065315 scopus 로고    scopus 로고
    • Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
    • Rikova K., Guo A., Zeng Q., et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 2007, 131(6):1190-1203.
    • (2007) Cell , vol.131 , Issue.6 , pp. 1190-1203
    • Rikova, K.1    Guo, A.2    Zeng, Q.3
  • 57
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    • Soda M., Choi Y.L., Enomoto M., et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007, 448(7153):561-566.
    • (2007) Nature , vol.448 , Issue.7153 , pp. 561-566
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3
  • 58
    • 48249114422 scopus 로고    scopus 로고
    • EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
    • Koivunen J.P., Mermel C., Zejnullahu K., et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res 2008, 14(13):4275-4283.
    • (2008) Clin Cancer Res , vol.14 , Issue.13 , pp. 4275-4283
    • Koivunen, J.P.1    Mermel, C.2    Zejnullahu, K.3
  • 59
    • 58149382583 scopus 로고    scopus 로고
    • A mouse model for EML4-ALK-positive lung cancer
    • Soda M., Takada S., Takeuchi K., et al. A mouse model for EML4-ALK-positive lung cancer. Proc Natl Acad Sci U S A 2008, 105(50):19893-19897.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.50 , pp. 19893-19897
    • Soda, M.1    Takada, S.2    Takeuchi, K.3
  • 60
    • 70349336416 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
    • Shaw A.T., Yeap B.W., Mino-kenudson M., et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol 2009, 27(26):4247-4253.
    • (2009) J Clin Oncol , vol.27 , Issue.26 , pp. 4247-4253
    • Shaw, A.T.1    Yeap, B.W.2    Mino-kenudson, M.3
  • 61
    • 69349083935 scopus 로고    scopus 로고
    • Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population
    • Rodig S.J., Mino-Kenudson M., Dacic S., et al. Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population. Clin Cancer Res 2009, 15(16):5216-5223.
    • (2009) Clin Cancer Res , vol.15 , Issue.16 , pp. 5216-5223
    • Rodig, S.J.1    Mino-Kenudson, M.2    Dacic, S.3
  • 62
    • 63949087355 scopus 로고    scopus 로고
    • EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset
    • Inamura K., Takeuchi K., Togashi Y., et al. EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset. Mod Pathol 2009, 22(4):508-515.
    • (2009) Mod Pathol , vol.22 , Issue.4 , pp. 508-515
    • Inamura, K.1    Takeuchi, K.2    Togashi, Y.3
  • 63
    • 77649091118 scopus 로고    scopus 로고
    • A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry
    • Mino-Kenudson M., Chirieac L.R., Law K., et al. A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry. Clin Cancer Res 2010, 16(5):1561-1571.
    • (2010) Clin Cancer Res , vol.16 , Issue.5 , pp. 1561-1571
    • Mino-Kenudson, M.1    Chirieac, L.R.2    Law, K.3
  • 64
    • 20144386787 scopus 로고    scopus 로고
    • Somatic mutations of the HER2 kinase domain in lung adenocarcinomas
    • Shigematsu H., Takahashi T., Nomura M., et al. Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res 2005, 65(5):1642-1646.
    • (2005) Cancer Res , vol.65 , Issue.5 , pp. 1642-1646
    • Shigematsu, H.1    Takahashi, T.2    Nomura, M.3
  • 65
    • 4944232647 scopus 로고    scopus 로고
    • Lung cancer: intragenic ERBB2 kinase mutations in tumours
    • Stephens P., Hunter C., Bignell G., et al. Lung cancer: intragenic ERBB2 kinase mutations in tumours. Nature 2004, 431(7008):525-526.
    • (2004) Nature , vol.431 , Issue.7008 , pp. 525-526
    • Stephens, P.1    Hunter, C.2    Bignell, G.3
  • 66
    • 0037037832 scopus 로고    scopus 로고
    • Clinical impact of novel treatment strategies
    • Giaccone G. Clinical impact of novel treatment strategies. Oncogene 2002, 21(45):6970-6981.
    • (2002) Oncogene , vol.21 , Issue.45 , pp. 6970-6981
    • Giaccone, G.1
  • 67
    • 34250199746 scopus 로고    scopus 로고
    • MDM2 polymorphism, survival, and histology in early-stage non-small-cell lung cancer
    • Heist R.S., Zhou W., Chirieac L.R., et al. MDM2 polymorphism, survival, and histology in early-stage non-small-cell lung cancer. J Clin Oncol 2007, 25(16):2243-2247.
    • (2007) J Clin Oncol , vol.25 , Issue.16 , pp. 2243-2247
    • Heist, R.S.1    Zhou, W.2    Chirieac, L.R.3
  • 68
    • 0036124253 scopus 로고    scopus 로고
    • Trastuzumab in the treatment of non-small cell lung cancer
    • Azzoli C.G., Krug L.M., Miller V.A., et al. Trastuzumab in the treatment of non-small cell lung cancer. Semin Oncol 2002, 29(1 Suppl 4):59-65.
    • (2002) Semin Oncol , vol.29 , Issue.1 SUPPL 4 , pp. 59-65
    • Azzoli, C.G.1    Krug, L.M.2    Miller, V.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.