Osteoclast-forming suppressing compounds from the medicinal mushroom Agrocybe chaxingu Huang (Agaricomycetideae)

International Journal of Medicinal Mushrooms

Volumn 12, Issue 2, 2010, Pages 151-155

  Choi, Jae Hoon ^a   Abe, Nobuo ^a   Kodani, Shinya ^a   Masuda, Kikuko ^b   Koyama, Tomoyuki ^b   Yazawa, Kazunaga ^b   Takahashi, Mamoru ^c   Kawagishi, Hirokazu ^a  

^a SHIZUOKA UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF MARINE SCIENCE AND TECHNOLOGY   (Japan)

^c Kougen Co Ltd   (Japan)

Author keywords

Agaricomycetideae; Agrocybe chaxingu; edible and medicinal mushrooms; osteoclast formation suppressing substance

Indexed keywords

AGROCYBE CHAXINGU EXTRACT; CEREVISTEROL; ERGOSTEROL; ERGOSTEROL PEROXIDE; FUNGAL EXTRACT; STEROID; UNCLASSIFIED DRUG;

AGROCYBE CHAXINGU; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; MASS SPECTROMETRY; MOUSE; MUSHROOM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OSTEOCLAST;

AGROCYBE CHAXINGU; BASIDIOMYCOTA;

EID: 77954485187     PISSN: 15219437     EISSN: 19404344     Source Type: Journal    
DOI: 10.1615/IntJMedMushr.v12.i2.50     Document Type: Article

References (12)

1. Woo JT, Kawatani M, Kato M, Shinki T, Yonezawa T, Kanoh N, Nakagawa H, Takami M, Lee KH, Stern PH, Nagai K,Osada H. Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proc Natl Acad Sci U S A. 2006;103:4729-4734
2. Kawagishi H, Akachi T, Ogawa T, Masuda K, Yamaguchi K, Yazawa K, Takahashi M. Chaxine A, an osteoclast- forming suppressing substance, from the mushroom Agrocybe chaxingu. Heterocycles. 2006;69:253-258
3. Kawagishi H, Hota K, Masuda K, Yamaguchi K, Yazawa K, Shibata K, Uzuka N, Matahira Y. Osteoclast-forming suppressive compounds from Makomotake, Zizania lati- folia infected with Ustilago esculenta. Biosci Biotechnol Biochem. 2006;70:2800-2802
4. Wani MR, Fuller K, Kim NS, Choi Y, Chambers T. Prostaglandin E2 cooperates with TRANCE in osteoclast induction from hemopoietic precursors: synergistic activation of differentiation, cell spreading, and fusion. Endocrinology. 1999;140:1927-1935
5. Takami M, Woo JT, Nagai K. Osteoblastic cells induce fusion and activation of osteoclasts through a mechanism independent of macrophage-colony-stimulating factor production. Cell Tissue Res. 1999;298:327-334
6. Sgarbi DB, da Silva AJ, Carlos IZ, Silva CL, Angluster J, Alviano CS. Isolation of ergosterol peroxide and its reversion to ergosterol in the pathogenic fungus Sporothrix schenckii. Mycopathologia. 1997;139:9-14.
7. Yu S, Deng Z, Van Ofwegen L, Proksch P, Lin W. 5,8-Epidioxysterols and related derivatives from a Chinese soft coral Sinularia flexibilis. Steroids. 2006;71:955-959
8. Ceccherelli P, Fringuelli R, Madruzza GF. Cerevisterol and ergosterol peroxide from Acremonium luzulae. Phytochemistry. 1975;14:1434.
9. Zhang Y, Mills GL, Nair MG. Cyclooxygenase inhibitory and antioxidant compounds from the fruiting body of an edible mushroom, Agrocybe aegerita. Phytomedicine. 2003;10:386-390
10. Takei T, Yoshida M, Ohnishi-Kameyama M, Kobori M. Ergosterol peroxide, an apoptosis-inducing component isolated from Sarcodon aspratus (Berk.) S. Ito. Biosci Biotechnol Biochem. 2005;69:212-215
11. Gao H, Hong K, Zhang X, Liu HW, Wang NL, Zhuang L, Yao XS. New steryl esters of fatty acids from the mangrove fungus Aspergillus awamori. Helv Chim Acta. 2007;90:1165-1178
12. Kawagishi H, Katsumi R, Sazawa T, Mizuno T, Hagiwara T, Nakamura T. Cytotoxic steroids from the mushroom Agaricus blazei. Phytochemistry. 1988;27: 2777-2779