A nonlinear mixed effects modelling analysis of topiramate pharmacokinetics in patients with epilepsy

Biological and Pharmaceutical Bulletin

Volumn 33, Issue 7, 2010, Pages 1176-1182

  Vovk, Tomaž ^a   Jakovljević, Mihajlo B ^b   Kerec Kos, Mojca ^a   Janković, Slobodan M ^b   Mrhar, Aleš ^a   Grabnar, Iztok ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIVERSITY OF KRAGUJEVAC   (Serbia)

Author keywords

Epilepsy; NONMEM; Population pharmacokinetics; Therapeutic drug monitoring; Topiramate

Indexed keywords

AMINOTRANSFERASE; BENZODIAZEPINE; BROMAZEPAM; CARBAMAZEPINE; CLONAZEPAM; CLOZAPINE; CREATININE; DIAZEPAM; RISPERIDONE; TOPIRAMATE; VALPROIC ACID;

ABDOMINAL DISEASE; ADOLESCENT; ADULT; AGE; ALOPECIA; AMINOTRANSFERASE BLOOD LEVEL; APPETITE; ARTICLE; ATAXIA; BLURRED VISION; CHILD; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; CONFUSION; CONTROLLED STUDY; CREATININE CLEARANCE; DEPRESSION; DIZZINESS; DOSE CALCULATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG MONITORING; DRUG RESPONSE; EPILEPSY; FATIGUE; FEMALE; FLUORESCENCE ANALYSIS; HALLUCINATION; HEADACHE; HEMATOMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERGLYCEMIA; INSOMNIA; MALE; MATHEMATICAL MODEL; MEMORY DISORDER; MONOTHERAPY; MUSCLE TONE; NAUSEA; NEPHROLITHIASIS; NERVOUSNESS; NONLINEAR SYSTEM; PATIENT CARE; PRESCHOOL CHILD; QUALITY OF LIFE; RASH; SCHOOL CHILD; SIDE EFFECT; SOMNOLENCE; SPEECH DISORDER; STATISTICAL ANALYSIS; STEADY STATE; SYNCOPE; TOTAL QUALITY MANAGEMENT; TREMOR; WEIGHT GAIN; WEIGHT REDUCTION;

ADOLESCENT; ADULT; ANTICONVULSANTS; BAYES THEOREM; CHILD; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG MONITORING; EPILEPSY; FEMALE; FRUCTOSE; HALF-LIFE; HUMANS; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 77954480747     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.33.1176     Document Type: Article

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