Effects of γ-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures

Epilepsy Research

Volumn 86, Issue 2-3, 2009, Pages 113-123

  Wahab, Abdul ^a   Heinemann, Uwe ^a   Albus, Klaus ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Alfaxalone; Epilepsy; In vitro seizure model; Muscimol; Nipecotic acid; Tonic clonic seizure like events

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOPYRIDINE; ALFAXALONE; ARECAIDINE; BACLOFEN; BENZODIAZEPINE; MAGNESIUM; MUSCIMOL; NEUROSTEROID; NIPECOTIC ACID; PHENOBARBITAL; POTASSIUM; TAURINE;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HIPPOCAMPUS; NERVE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; SEIZURE; SEIZURE SUSCEPTIBILITY; TISSUE CULTURE;

ACTION POTENTIALS; ANIMALS; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; GABA AGONISTS; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; MEMBRANE POTENTIALS; NEURONS; ORGAN CULTURE TECHNIQUES; RATS; RATS, WISTAR; SYNAPTIC TRANSMISSION;

EID: 70349487692     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2009.05.008     Document Type: Article

References (68)

1. Albus K., Wahab A., and Heinemann U. Standard antiepileptic drugs fail to block epileptiform activity in rat organotypic hippocampal slice cultures. Br. J. Pharmacol. 154 (2008) 709-724
2. Arts W.F., Brouwer O.F., Peters A.C., Stroink H., Peeters E.A., Schmitz P.I., van Donselaar C.A., and Geerts A.T. Course and prognosis of childhood epilepsy: 5-year follow-up of the Dutch study of epilepsy in childhood. Brain 127 (2004) 1774-1784
3. Ben-Ari Y. Excitatory actions of GABA during development: the nature of the nurture. Nat. Rev. Neurosci. 3 (2002) 728-739
4. Brandt C., Volk H.A., and Loscher W. Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus. Epilepsia 45 (2004) 1488-1497
5. Brewer G.J., Torricelli J.R., Evege E.K., and Price P.J. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J. Neurosci. Res. 35 (1993) 567-576
6. Bruckner C., and Heinemann U. Effects of standard anticonvulsant drugs on different patterns of epileptiform discharges induced by 4-aminopyridine in combined entorhinal cortex-hippocampal slices. Brain Res. 859 (2000) 15-20
7. Chen G., Trombley P.Q., and van den Pol A.N. Excitatory actions of GABA in developing rat hypothalamic neurons. J. Physiol. 494 Pt 2 (1996) 451-464
8. Cherubini E., Gaiarsa J.L., and Ben-Ari Y. GABA: an excitatory transmitter in early postnatal life. Trends Neurosci. 14 (1991) 515-519
9. + in rat hippocampus. J. Neurophysiol. 87 (2002) 87-102
10. Daval J.L., and Sarfati A. Effects of bicuculline-induced seizures on benzodiazepine and adenosine receptors in developing rat brain. Life Sci. 41 (1987) 1685-1693
11. Dzhala V.I., and Staley K.J. Excitatory actions of endogenously released GABA contribute to initiation of ictal epileptiform activity in the developing hippocampus. J. Neurosci. 23 (2003) 1840-1846
12. Dzhala V.I., Talos D.M., Sdrulla D.A., Brumback A.C., Mathews G.C., Benke T.A., Delpire E., Jensen F.E., and Staley K.J. NKCC1 transporter facilitates seizures in the developing brain. Nat. Med. 11 (2005) 1205-1213
13. Feng H.J., Bianchi M.T., and Macdonald R.L. Pentobarbital differentially modulates alpha1beta3delta and alpha1beta3gamma2L GABAA receptor currents. Mol. Pharmacol. 66 (2004) 988-1003
14. A-receptor function and allosteric modulation during development of status epilepticus. J. Neurophysiol. 99 (2008) 1285-1293
15. A receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands. J. Psychopharmacol. 21 (2007) 384-391
16. A channels in newborn rat hippocampal neurons. J. Steroid Biochem. Mol. Biol. 104 (2007) 35-44
17. Gomez-Di Cesare C.M., Smith K.L., Rice F.L., and Swann J.W. Axonal remodeling during postnatal maturation of CA3 hippocampal pyramidal neurons. J. Comp. Neurol. 384 (1997) 165-180
18. A receptor internalization during seizures. Epilepsia 48 Suppl 5 (2007) 109-113
19. Heinemann U., Dreier J., Leschinger A., Stabel J., Draguhn A., and Zhang C. Effects of anticonvulsant drugs on hippocampal neurons. Hippocampus 4 (1994) 291-296
20. Heinemann U., and Lux H.D. Undershoots following stimulus induced rises of extracellular potassium concentration in cerebral cortex of cat. Brain Res. 93 (1975) 63-76
21. Honmou O., Kocsis J.D., and Richerson G.B. Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro. Epilepsy Res. 20 (1995) 193-202
22. Iannetti P., Spalice A., and Parisi P. Calcium-channel blocker verapamil administration in prolonged and refractory status epilepticus. Epilepsia 46 (2005) 967-969
23. Isaev D., Isaeva E., Khazipov R., and Holmes G.L. Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro. J. Neurophysiol. 94 (2005) 2987-2992
24. Isaev D., Isaeva E., Khazipov R., and Holmes G.L. Shunting and hyperpolarizing GABAergic inhibition in the high-potassium model of ictogenesis in the developing rat hippocampus. Hippocampus 17 (2007) 210-219
25. Jandova K., Pasler D., Antonio L.L., Raue C., Ji S., Njunting M., Kann O., Kovacs R., Meencke H.J., Cavalheiro E.A., Heinemann U., Gabriel S., and Lehmann T.N. Carbamazepine-resistance in the epileptic dentate gyrus of human hippocampal slices. Brain 129 (2006) 3290-3306
26. A receptors. J. Neurosci. 17 (1997) 7532-7540
27. Khalilov I., Khazipov R., Esclapez M., and Ben-Ari Y. Bicuculline induces ictal seizures in the intact hippocampus recorded in vitro. Eur. J. Pharmacol. 319 2-3 (1997) R5-6
28. Khalilov I., Holmes G.L., and Ben Ari Y. In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures. Nat. Neurosci. 6 (2003) 1079-1085
29. Khazipov R., Khalilov I., Tyzio R., Morozova E., Ben Ari Y., and Holmes G.L. Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus. Eur. J. Neurosci. 19 (2004) 590-600
30. Kilb W., Sinning A., and Luhmann H.J. Model-specific effects of bumetanide on epileptiform activity in the in-vitro intact hippocampus of the newborn mouse. Neuropharmacology 53 (2007) 524-533
31. A receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem. Neuropharmacology 43 (2002) 685-694
32. Lamsa K., and Kaila K. Ionic mechanisms of spontaneous GABAergic events in rat hippocampal slices exposed to 4-aminopyridine. J. Neurophysiol. 78 (1997) 2582-2591
33. A activation inhibits AMPA-kainate receptor-mediated bursting in the newborn (P0-P2) rat hippocampus. J. Neurophysiol. 83 (2000) 359-366
34. Loscher W. Animal models of intractable epilepsy. Prog. Neurobiol. 53 (1997) 239-258
35. Loscher W., and Schmidt D. Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs. Epilepsia 47 (2006) 1253-1284
36. Luhmann H.J., and Prince D.A. Postnatal maturation of the GABAergic system in rat neocortex. J. Neurophysiol. 65 (1991) 247-263
37. Lux H.D., and Neher E. The equilibration time course of (K+) 0 in cat cortex. Exp. Brain Res. 17 (1973) 190-205
38. Mazarati A.M., Baldwin R.A., Sankar R., and Wasterlain C.G. Time-dependent decrease in the effectiveness of antiepileptic drugs during the course of self-sustaining status epilepticus. Brain Res. 814 (1998) 179-185
39. Mihalek R.M., Banerjee P.K., Korpi E.R., Quinlan J.J., Firestone L.L., Mi Z.P., Lagenaur C., Tretter V., Sieghart W., Anagnostaras S.G., Sage J.R., Fanselow M.S., Guidotti A., Spigelman I., Li Z., DeLorey T.M., Olsen R.W., and Homanics G.E. Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor delta subunit knockout mice. Proc. Natl. Acad. Sci. USA 96 (1999) 12905-12910
40. Nagao T., Alonso A., and Avoli M. Epileptiform activity induced by pilocarpine in the rat hippocampal-entorhinal slice preparation. Neuroscience 72 (1996) 399-408
41. A receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus. J. Neurosci. 25 (2005) 7724-7733
42. Noraberg J., Kristensen B.W., and Zimmer J. Markers for neuronal degeneration in organotypic slice cultures. Brain Res. Brain Res. Protoc. 3 (1999) 278-290
43. Oby E., Caccia S., Vezzani A., Moeddel G., Hallene K., Guiso G., Said T., Bingaman W., Marchi N., Baumgartner C., Pirker S., Czech T., Lo R.G., and Janigro D. In vitro responsiveness of human-drug-resistant tissue to antiepileptic drugs: insights into the mechanisms of pharmacoresistance. Brain Res. 1086 (2006) 201-213
44. Patrylo P.R., Spencer D.D., and Williamson A. GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis. J. Neurophysiol. 85 (2001) 1533-1542
45. Pfeiffer M., Draguhn A., Meierkord H., and Heinemann U. Effects of gama-aminobutyric (GABA) agonists and GABA uptake inhibitors on pharmacosensitive and pharmacoresistant epileptiform activity in vitro. Br. J. Pharmacol. 119 (1996) 569-577
46. A receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons. J. Neurophysiol. 96 (2006) 846-857
47. Psarropoulou C., and Descombes S. Differential bicuculline-induced epileptogenesis in rat neonatal, juvenile and adult CA3 pyramidal neurons in vitro. Dev Brain Res. 117 (1999) 117-120
48. 2+ in intact immature brain structures. Eur. J. Neurosci. 16 (2002) 850-860
49. Quilichini P.P., Diabira D., Chiron C., Milh M., Ben-Ari Y., and Gozlan H. Effects of antiepileptic drugs on refractory seizures in the intact immature corticohippocampal formation in vitro. Epilepsia 44 (2003) 1365-1374
50. Remy S., and Beck H. Molecular and cellular mechanisms of pharmacoresistance in epilepsy. Brain 129 (2006) 18-35
51. A receptor-mediated responses in spinal neurons. J. Neurosci. 16 (1996) 82-91
52. Romo-Parra H., Trevino M., Heinemann U., and Gutierrez R. GABA actions in hippocampal area CA3 during postnatal development: differential shift from depolarizing to hyperpolarizing in somatic and dendritic compartments. J. Neurophysiol. 99 (2008) 1523-1534
53. Schmidt D., and Loscher W. Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms. Epilepsia 46 (2005) 858-877
54. - ion channels modulated by multiple drug-binding sites. Trends Pharmacol. Sci. 13 (1992) 446-450
55. Solis J.M., and Nicoll R.A. Postsynaptic action of endogenous GABA released by nipecotic acid in the hippocampus. Neurosci. Lett. 147 (1992) 16-20
56. A receptor delta subunit. J. Neurophysiol. 90 (2003) 903-910
57. A receptors. Science 269 (1995) 977-981
58. Stoppini L., Buchs P.A., and Muller D. A simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods 37 (1991) 173-182
59. Summers M.A., Moore J.L., and McAuley J.W. Use of verapamil as a potential P-glycoprotein inhibitor in a patient with refractory epilepsy. Ann. Pharmacother. 38 (2004) 1631-1634
60. Swann J.W., and Brady R.J. Penicillin-induced epileptogenesis in immature rat CA3 hippocampal pyramidal cells. Brain Res. 314 (1984) 243-254
61. B-mediated inhibition and induction of epileptiform discharges in the neonatal rat hippocampus. Eur. J. Neurosci. 19 (2004) 3227-3234
62. Treiman D.M., Meyers P.D., Walton N.Y., Collins J.F., Colling C., Rowan A.J., Handforth A., Faught E., Calabrese V.P., Uthman B.M., Ramsay R.E., and Mamdani M.B. A comparison of four treatments for generalized convulsive status epilepticus Veterans Affairs status epilepticus cooperative study group. N. Engl. J. Med. 339 (1998) 792-798
63. Wahab A., Albus K., and Heinemann U. Effects of GABA agonists and a GABA uptake inhibitor on pharmacoresistant epileptiform activity in hippocampal slice cultures. Abstr. Soc. Neursci. 161 (2007) 1
64. Wells J.E., Porter J.T., and Agmon A. GABAergic inhibition suppresses paroxysmal network activity in the neonatal rodent hippocampus and neocortex J. Neurosci. 20 (2000) 8822-8830
65. Whittington M.A., Traub R.D., and Jefferys J.G.R. Erosion of inhibition contributes to the progression of low magnesium bursts in rat hippocampal slices. J. Physiol. London 468 (1995) 723-734
66. Wong T., Zhang X.L., Asl M.N., Wu C.P., Carlen P.L., and Zhang L. Postnatal development of intrinsic GABAergic rhythms in mouse hippocampus. Neuroscience 134 (2005) 107-120
67. B receptor activation on epileptiform activity in hippocampal slices. Neuropharmacology 40 (2001) 131-138
68. Yu Z.Y., Wang W., Fritschy J.M., Witte O.W., and Redecker C. Changes in neocortical and hippocampal GABAA receptor subunit distribution during brain maturation and aging. Brain Res. 1099 (2006) 73-81