The link between psychosis and aggression in persons with dementia: A systematic review

Psychiatric Quarterly

Volumn 81, Issue 2, 2010, Pages 97-110

  Shub, Denis ^a,b   Ball, Valdesha ^a   Abbas, Asghar Ali Ali ^a   Gottumukkala, Aruna ^a   Kunik, Mark E ^a,b,c  

^a MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c EDUCATION AND CLINICAL CENTER   (United States)

Author keywords

Aggression; Dementia; Psychosis

Indexed keywords

AGED; AGGRESSION; AGITATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CROSS-SECTIONAL STUDY; DATA ANALYSIS; DEMENTIA; DISEASE ASSOCIATION; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MEDICAL RECORD REVIEW; PSYCHOSIS; RANDOMIZED CONTROLLED TRIAL; REVIEW; SYSTEMATIC REVIEW;

AGED; AGGRESSION; CROSS-SECTIONAL STUDIES; DEMENTIA; HUMANS; LONGITUDINAL STUDIES; PSYCHOTIC DISORDERS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 77954459635     PISSN: 00332720     EISSN: 15736709     Source Type: Journal    
DOI: 10.1007/s11126-009-9121-7     Document Type: Review

References (35)

1. Lyketsos C, Steinberg M, Tschanz J: Mental and behavioral disturbances in dementia: Findings from theCache County study on memory in aging. American Journal of Psychiatry 157:708-714, 2000
2. Lyketsos CG, Lopez O, Jones B, et al.: Prevalence of neuropsychiatric symptoms in dementia and mildcognitive impairment: Results from the Cardiovascular Health Study. Journal of the American MedicalAssociation 288:1475-1483, 2002
3. Donaldson C, Tarrier N, Burns A: The impact of the symptoms of dementia on caregivers. BritishJournal of Psychiatry 170:62-68, 1997.
4. Steele C, Rovner B, Chase GA, et al.: Psychiatric symptoms and nursing home placement of patientswith Alzheimer's disease. American Journal of Psychiatry 147:1049-1051, 1990
5. APA Work Group on Alzheimer's Disease and Other Dementias, Rabins P, Blacker D, et al.: Americanpsychiatric association practice guideline for the treatment of patients with Alzheimer's disease andother dementias, second edition. American Journal of Psychiatry 164(12 Suppl):5-56, 2007.
6. Lyketsos CG, Steele C, Galik E, et al.: Physical aggression in dementia patients and its relationship todepression. American Journal of Psychiatry 156:66-71, 1999
7. von Elm E, Altman DG, Egger M, et al.: STROBE Initiative. The Strengthening the Reporting ofObservational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observationalstudies. Annals of Internal Medicine 147:573-577, 2007
8. Petrovic M, Hurt C, Collins D, et al.: Clustering of behavioural and psychological symptoms indementia: A European Alzheimer's Disease Consortium (EADC) study. Acta Clinica Belgica 62:426-432, 2007
9. Mizrahi R, Starkstein SE, Jorge R, et al.: Phenomenology and clinical correlates of delusions inAlzheimer disease. American Journal of Geriatric Psychiatry 14:573-581, 2006 (Pubitemid 44036481)
10. Rapoport MJ, van Reekum R, Freedman M, et al.: Relationship of psychosis to aggression, apathy andfunction in dementia. International Journal of Geriatric Psychiatry 16:123-130, 2001
11. Aarsland D, Cummings JL, Yenner G, et al.: Relationship of aggressive behavior to other neuropsychiatricsymptoms in patients with Alzheimer's disease. American Journal of Psychiatry 153:243-247,1996
12. Brodaty H, Draper B, Saab D, et al.: Psychosis, depression and behavioural disturbances in Sydneynursing home residents: Prevalence and predictors. International Journal of Geriatric Psychiatry 16:504-512, 2001
13. Kunik ME, Snow-Turek AL, Iqbal N, et al.: Contribution of psychosis and depression to behavioraldisturbances in geropsychiatric inpatients with dementia. Journals of Gerontology, Series A, BiologicalSciences and Medical Sciences 54:M157-M161, 1999
14. Tractenberg RE, Weiner MF, Patterson MB, et al.: Comorbidity of psychopathological domains incommunity-dwelling persons with Alzheimer's disease. Journal of Geriatric Psychiatry and Neurology16(2):94-99, 2003.
15. Devanand DP, Jacobs DM, Tang MX, et al.: The course of psychopathologic features in mild tomoderate Alzheimer disease. Archives of General Psychiatry 54:257-263, 1997
16. Levy ML, Cummings JL, Fairbanks LA, et al.: Longitudinal assessment of symptoms of depression,agitation, and psychosis in 181 patients with Alzheimer's disease. American Journal of Psychiatry153:1438-1443, 1996
17. Sultzer DL, Davis SM, Tariot PN, et al.:Clinical symptom responses to atypical antipsychotic medicationsin Alzheimer's disease: Phase 1 outcomes from the CATIE-AD effectiveness trial. AmericanJournal of Psychiatry 165:844-854, 2008.
18. Street JS, Clark WS, Gannon KS, et al.: Olanzapine treatment of psychotic and behavioral symptoms inpatients with Alzheimer disease in nursing care facilities: A double-blind, randomized, placebo-controlledtrial. The HGEU study group. Archives of General Psychiatry 57:968-976, 2000
19. Mintzer JE, Tune LE, Breder CD, et al.: Aripiprazole for the treatment of psychoses in institutionalizedpatients with Alzheimer dementia: A multicenter, randomized, double-blind, placebo-controlledassessment of three fixed doses. American Journal of Geriatric Psychiatry 15:918-931, 2007.
20. De Deyn PP, Carrasco MM, Deberdt W, et al.: Olanzapine versus placebo in the treatment of psychosiswith or without associated behavioral disturbances in patients with Alzheimer's disease. InternationalJournal of Geriatric Psychiatry 19:115-126, 2004
21. Devanand DP, Marder K, Michaels KS, et al.: A randomized, placebo-controlled dose-comparison trialof haloperidol for psychosis and disruptive behaviors in Alzheimer's disease. American Journal ofPsychiatry 155:1512-1520, 1988
22. Streim JE, Porsteinsson AP, Breder CD, et al.: A randomized, double-blind, placebo-controlled study ofaripiprazole for the treatment of psychosis in nursing home patients with Alzheimer disease. AmericanJournal of Geriatic Psychiatry 16:537-550, 2008
23. Tariot PN, Schneider L, Katz IR, et al.: Quetiapine treatment of psychosis associated with dementia: adouble-blind, randomized, placebo-controlled clinical trial. American Journal of Geriatric Psychiatry14:767-776, 2006
24. Freund-Levi Y, Basun H, Cederholm T, et al.: Omega-3 supplementation in mild to moderate Alzheimer'sdisease: Effects on neuropsychiatric symptoms. International Journal of Geriatric Psychiatry23:161-169, 2008.
25. Deberdt WG, Dysken MW, Rappaport SA, et al.: Comparison of olanzapine and risperidone in thetreatment of psychosis and associated behavioral disturbances in patients with dementia. AmericanJournal of Geriatric Psychiatry 13:722-730, 2005
26. Sink KM, Holden KF, Yaffe K: Pharmacological treatment of neuropsychiatric symptoms of dementia:A review of the evidence. Journal of the American Medical Association 293:596-608, 2005. (Pubitemid 40171242)
27. Wooltorton E: Risperidone (Risperdal). Increased rate of cerebrovascular events in dementia trials.Canadian Medical Association Journal 167:1269-1270, 2002
28. Wooltorton E: Olanzapine (Zyprexa): Increased incidence of cerebrovascular events in dementia trials.Canadian Medical Association Journal 170:1395, 2004
29. Talerico KA, Evans LK, Strumpf NE: Mental health correlates of aggression in nursing home residentswith dementia. Gerontologist 42:169-177, 2002.
30. Folstein MF: Differential diagnosis of dementia. The clinical process. Psychiatric Clinics of NorthAmerica 20:45-57, 1997.
31. Schneider LS, Pollock VE, Lyness SA: A meta-analysis of controlled trial of neuroleptic treatment indementia. Journal of the American Geriatric Society 38:553-563, 1990.
32. Zubenko GS, Moosy J, Martinez AJ, et al.: Neuropathologic and neurochemical correlates of psychosesin primary dementia. Archives of Neurology 48:619-624, 1991.
33. Schneider LS, Katz IR, Park S, et al.: Psychosis of Alzheimer disease: Validity of the construct andresponse to risperidone. American Journal of Geriatric Psychiatry 1:414-425, 2003.
34. Cook S, Miyahara S, Bacanu S, et al.: Psychotic symptoms in Alzheimer disease: Evidence for subtypes.American Journal of Geriatric Psychiatry 11:406-413, 2003.
35. Wilkosz P, Kodavali C, Weamer E, et al.: Prediction of psychosis onset in Alzheimer disease: The roleof depression symptom severity and the HTR2A T102C polymorphism. American Journal of MedicalGenetics Part B (Neuropsychiatric Genetics) 144B:1054-1062, 2007