Zeroing in on the target

Pediatric Diabetes

Volumn 11, Issue 1, 2010, Pages 2-3

  Polychronakos, Constantin ^a  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTO IMMUNE REEGULATOR PROTEIN; CRE RECOMBINASE; HLA ANTIGEN; INSULIN; INSULIN 2; REGULATOR PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

AUTOIMMUNE DISEASE; DISEASE MODEL; DNA MODIFICATION; GENE DELETION; GENETIC PREDISPOSITION; IMMUNOREACTIVITY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TOLERANCE TEST; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; NOTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; T CELL DEPLETION; THYMUS;

ANIMALS; AUTOANTIGENS; DIABETES MELLITUS, TYPE 1; HUMANS; IMMUNE TOLERANCE; INSULIN; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, KNOCKOUT; THYMUS GLAND;

EID: 77954432627     PISSN: 1399543X     EISSN: 13995448     Source Type: Journal    
DOI: 10.1111/j.1399-5448.2010.00641.x     Document Type: Note

References (5)

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2. Vafiadis P, Bennett ST, Todd JA, Nadeau J, Grabs R, Goodyer CG, Wickramasinghe S, Colle E, Polychronakos C. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet 1997, 15:289-92.
3. Kyewski B, Klein L. A central role for central tolerance. Annu Rev Immunol 2006, 24:571-606.
4. Chentoufi AA, Polychronakos C. Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes 2002, 51(5):1383-90. May;
5. Faideau B, Lotton C, Lucas B, Tardivel I, Elliott JF, Boitard C, Carel JC. Tolerance to proinsulin-2 is due to radioresistant thymic cells. J Immunol 2006, 177:53-60.