Urocortin prevents indomethacin-induced small intestinal lesions in rats through activation of CRF2 receptors

Digestive Diseases and Sciences

Volumn 55, Issue 6, 2010, Pages 1570-1580

  Kubo, Yoshikazu ^a   Kumano, Aiko ^a   Kamei, Kohei ^a   Amagase, Kikuko ^a   Abe, Naoko ^a   Takeuchi, Koji ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Corticotropin releasing factor (CRF); CRFR1; CRFR2; Indomethacin induced small intestinal lesion; Urocortin

Indexed keywords

5 CHLORO 4 [N (CYCLOPROPYLMETHYL) N PROPYLAMINO] 2 METHYL 6 (2,4,6 TRICHLOROANILINO)PYRIMIDINE; ASTRESSIN; ASTRESSIN 2B; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MYELOPEROXIDASE; UNCLASSIFIED DRUG; UROCORTIN I;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENTEROBACTERIACEAE INFECTION; ENZYME ACTIVITY; INTESTINAL DYSMOTILITY; INTESTINE INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMALL INTESTINAL LESION; UPREGULATION;

ANILINE COMPOUNDS; ANIMALS; BACTERIAL TRANSLOCATION; CORTICOTROPIN-RELEASING HORMONE; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTROINTESTINAL AGENTS; GASTROINTESTINAL MOTILITY; INDOMETHACIN; INJECTIONS, INTRAVENOUS; INTESTINE, SMALL; MALE; NITRIC OXIDE SYNTHASE TYPE II; PEPTIC ULCER; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; PEROXIDASE; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RNA, MESSENGER; TIME FACTORS; UROCORTINS;

EID: 77954423628     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-009-0930-1     Document Type: Article

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