Injection of human mesenchymal stem cells improves healing of scarred vocal folds: Analysis using a xenograft model

Laryngoscope

Volumn 120, Issue 7, 2010, Pages 1370-1375

  Svensson, Bengt ^a   Nagubothu, R Srinivasa ^b   Cedervall, Jessica ^b   Le Blanc, Katarina ^b   Ährlund Richter, Lars ^b   Tolf, Anna ^b   Hertegård, Stellan ^b  

^a ÖSTERSUND HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Mesenchymal stem cells; Scarring; Viscoelasticity; Vocal fold

Indexed keywords

COLLAGEN TYPE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DNA PROBE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LAMINA PROPRIA; MEASUREMENT; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; RABBIT; SCAR FORMATION; THICKNESS; VISCOELASTICITY; VISCOSITY; VOCAL CORD DISORDER; WOUND HEALING; XENOGRAFT; YOUNG MODULUS;

ANIMALS; CELL SURVIVAL; CICATRIX; COLLAGEN TYPE I; HUMANS; INJECTIONS; MESENCHYMAL STEM CELL TRANSPLANTATION; MUCOUS MEMBRANE; RABBITS; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS; VOCAL CORDS; WOUND HEALING;

EID: 77954420770     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1002/lary.20926     Document Type: Article

References (30)

1. Benninger MS, Alessi D, Archer S, et al. Vocal fold scarring; current concepts and management. Otolaryngol Head and Neck Surg 1996; 115:474-482.
2. Hertegard S, Dahlqvist A, Goodyear E. Viscoelasticity in scarred rabbit vocal folds after hyaluronan injection-short term results. Acta Otolaryngologica 2006;126:758-763.
3. Ford CN, Bless DM, Loftus JM. Role of injectable collagen in the treatment of glottic insufficiency: a study of 119 patients. Ann Otol Rhinol Laryngol 1992;101:237-247.
4. Remacle M, Lawson G, Delos M, Jamart J. Correcting vocal fold immobility by autologous collagen injection for voice rehabilitation. A short-term study. Ann Otol Rhinol Laryngol 1999;108:788-793.
5. Neuenschwander MC, Sataloff RT, Abaza MM, Hawkshaw MJ, Reiter D, Spiegel JR. Management of vocal fold scar with autologous fat implantation: perceptual results. J Voice 2001;15:295-304. (Pubitemid 32525705)
6. Shindo ML, Zaretsky LS, Rice DH. Autologous fat injection for unilateral vocal fold paralysis. Ann Otol Rhinol Laryngol 1996;105:602-606.
7. Hansen JK, Thibeault SL, Walsh JF, Shu XZ, Prestwich GD. In vivo engineering of the vocal fold extracellular matrix with injectable hyaluronic acid hydrogels: early affects on tissue repair and biomechanics in a rabbit model. Ann Otol Rhinol Laryngol 2005;114:662-670.
8. Tsunoda K, Kondou K, Kimitaka K, et al. Autologous transplantation of fascia into the vocal fold: long term result of type-1 transplantation and the future. Laryngoscope 2005;115(12 pt 2 suppl 108):1-10.
9. Hirano S, Bless DM, Rousseau B, et al. Prevention of vocal fold scarring by topical injection of hepatocyte growth factor in a rabbit model. Laryngoscope 2004;114:548-556 (Pubitemid 38391923)
10. Chhetri DK, Head C, Revazova E, Bhuta S, Berke GS. Lamina propria replacement therapy with cultured autologous fibroblasts for vocal fold scars. Otolaryngol Head Neck Surg 2004;131:864-870. (Pubitemid 39575943)
11. Kanemaru S, Nakamura T, Omori K, et al. Regeneration of the vocal fold using autologous mesenchymal stem cells. Ann Otol Rhinol Laryngol 2003;112:915-920. (Pubitemid 37429633)
12. Kanemaru S, Nakamura T, Yamashita M, et al. Destiny of autologous bone marrow derived stromal cells implanted in the vocal fold. Ann Otol Rhinol Laryngol 2005;114:907-912.
13. Liechty KW, MacKenzie TC, Shaaban AF, et al. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med 2000;6:1282-1286.
14. Azizi SA, Stokes D, Augelli BJ, DiGirolamo C, Prockop DJ. Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats-similarities to astrocyte grafts. Proc Natl Acad Sci USA 1998;95:3908-3913. (Pubitemid 28173227)
15. Wang EC, Damrose EJ, Mendelsohn AH, et al. Distribution of class I and II human leukocyte antigens in the larynx. Otolaryngol Head Neck Surg 2006;134:280-287. (Pubitemid 43187129)
16. Hertegard S, Cedervall J, Svensson B, et al. Viscoelastic and histological properties in scarred rabbit vocal folds after mesenchymal stem cell injection. Laryngoscope 2006;116:1248-1254. (Pubitemid 44317959)
17. Le Blanc K, Tammik L, Sundberg B, Haynesworth SE, Ringden O. Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol 2003;57:11-20. (Pubitemid 38019084)
18. Cedervall J, Ahrlund-Richter L, Svensson B, et al. Injection of embryonic stem cells into scarred rabbit vocal folds enhances healing and improves viscoelasticity: short-term results. Laryngoscope 2007;117:2075-2081. (Pubitemid 350059395)
19. Chan RW, Gray SD, Titze IR. The importance of hyaluronic acid in vocal fold biomechanics. Otolaryngol Head Neck Surg 2001;124:607-614.
20. Hertegard S, Dahlqvist A, Laurent C, Borzacchiello A, Ambrosio L. Viscoelastic properties of rabbit vocal folds after augmentation. Otolaryngol Head Neck Surg 2003;128:401-406. (Pubitemid 36351054)
21. Hertegard S, Larsson H, Nagubothu SR, Tolf A, Svensson B. Elasticity measurements in scarred rabbit vocal folds using air pulse stimulation. Logoped Phoniatr Vocol In press.
22. Le Blanc K, Ringden O. Immunobiology of human mesenchymal stem cells and future use in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2005;11:321-334
23. Chen L, Tredget EE, Wu PY, Wu Y. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS ONE 2008;3:e1886.
24. Fu X, Fang L, Li X, Cheng B, Sheng Z. Enhanced wound-healing quality with bone marrow mesenchymal stem cells autografting after skin injury. Wound Repair Regen 2006;14:325-335.
25. Lin CD, Allori AC, Macklin JE, et al. Topical lineage-negative progenitor-cell therapy for diabetic wounds Plast Reconstr Surg 2009;123:421-423.
26. Francois S, Mouiseddine M, Mathieu N. Human mesenchymal stem cells favour healing of the cutaneous radiation syndrome in a xenogenic transplant model. Ann Hematol 2007;86:1-8.
27. Sato K, Sakamoto K, Nakashima T. Expression and distribution of CD44 and hyaluronic acid in human vocal fold mucosa. Ann Otol Rhinol Laryngol 2006;115:741-748. (Pubitemid 44582868)
28. Rousseau B, Hirano S, Chan RW, et al. Characterization of chronic vocal fold scarring in a rabbit model. J Voice 2004;18:116-124. (Pubitemid 38333018)
29. Rousseau B, Hirano S, Scheidt TD, et al. Characterization of vocal fold scarring in a canine model. Laryngoscope 2003;113:620-627. (Pubitemid 36406908)
30. Hirano S, Minamiguchi S, Yamashita M, Ohno T, Kanemaru S, Kitamura M. Histologic characterization of human scarred vocal folds. J Voice 2009;23:399-407.