TLRs and Bcl-2 family proteins in neutrophils of oral cavity cancer patients

Folia Histochemica et Cytobiologica

Volumn 47, Issue 4, 2009, Pages 615-619

  Jablonska, Ewa ^a   Garley, Marzena ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Apoptosis; Cancer; Neutrophils; Toll like receptors

Indexed keywords

CASPASE 9; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BCL 2; PROTEIN MCL 1; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 6;

ADULT; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; COLORIMETRY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MOUTH CARCINOMA; NEUTROPHIL; POLYMORPHONUCLEAR CELL; PROTEIN EXPRESSION; PROTEIN FAMILY; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; WESTERN BLOTTING;

EID: 77954419445     PISSN: 02398508     EISSN: None     Source Type: Journal    
DOI: 10.2478/v10042-008-0118-8     Document Type: Article

References (16)

1. Zeromski J, Mozer-Lisewska I, Kaczmarek M. Significance of Toll-like receptors expression in tumor growth and spreading: a short review. Cancer Microenv. 2008;1:37-42.
2. Hayashi F, Means TK, Luster AD. Toll-like receptors stimu- late human neutrophil function. Blood. 2003;102:2660-2669.
3. Jablonska E, Marcinczyk M. TLR2 expression in relation to IL-6 and IL-1 and their natural regulators production by PMN and PBMC in patients with Lyme Disease. Mediator Inflamm. 2006;3207:1-6.
4. Farhat K, Riekenberg S, Heine H, Debarry J, Lang R, Mages J, et al. Hetero-dimeryzation of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signals. J Leukoc Biol. 2008;83:692-701.
5. S, Benna JL, Dang PhMC, Pedruzzi E, Gougerot-Pocidalo AM, Elbim C. Inhibition of neutrophil apoptosis by TLR agonist in whole blood: involvement of the phospho- inositide 3-kinase/Akt and NF-kB signaling pathways, lead- ing to increased levels of Mcl-1, A1, and phosphorylated Bad. J Immunol. 2005;174:3633-3642.
6. Jablonska E, Marcinczyk M, Jablonski J. Toll-like receptors types 2 and 6 and the apoptotic process in human neutrophils. Arch Immunol Ther Exp. 2006;54:137-142.
7. Parker LC, Whyte MKB, Dower SK, Sabroe I. The expression and roles of Toll-like receptors in the biology of the human neutrophil. J Leukoc Biol. 2005;77:886-892.
8. Maianski MA, Maianski AN, Kuijpers TW, Roos D. Apoptosis of neutrophils. Acta Haematol. 2004;111:56-66.
9. J, Goldstein LA, Gastman BR, Froelich ChJ, Yin X-M, Rabinowich H. Degradation of Mcl-1 by granzyme B. J Biol Chem. 2004;279:22020-22029.
10. Derouet M, Thomas L, Moulding DA, Akgul C, Cross A, Moots RJ, et al. Sodium salicylate promotes neutrophil apop- tosis by stimulating caspase-dependent turnover of Mcl-1. J Immunol. 2006;176:957-965.
11. E, Garley A, Jablonski J. The expression of intrinsic and extrinsic pathway proteins in neutrophils of oral cavi- ty cancer patients- preliminary study. Arch Immunol Ther Exp. 2009 (in press).
12. Jablonska E, Jablonski J, Marcinczyk M, Grabowska Z, Piotrowski L. The release of soluble forms of TRAIL and DR5 by neutrophils of oral cavity cancer patients. Folia Hist Cytobiol. 2008:46:5-11.
13. Huang B, Zhao J, Li H, He K-L, Chen Y, Mayer L, et al. Toll like receptors on tumor cells facilitate evasion of immune serveillance. Cancer Res. 2005;65:5009-5014.
14. Simons MP, Moore JM, Kemp TJ, Griffith TS. Identification of the Myco-bacterial subcomponents involved in the release of tumor necrosis factor-related apoptosis-inducing ligand from human neutrophils. Infect Immun. 2007;75:1265-1271.
15. Teng MS, Brandwein-Gensler MS, Teixeira MS, Martignetti JA, Duffey DC. A study of TRAIL receptors in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg. 2005;131:407-412.
16. He W, Liu Q, Wang L, Cao X. TLR4 signalling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance. Mol Immunol. 2007;44:2850-2859.