Novel somatic mutations in heterotrimeric G proteins in melanoma

Cancer Biology and Therapy

Volumn 10, Issue 1, 2010, Pages 33-37

  Cárdenas Navia, L Isabel ^a   Cruz, Pedro ^a   Lin, Jimmy C ^b   Rosenberg, Steven A ^c   Samuels, Yardena ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

GNAZ; GNG10; Heterotrimeric G proteins; Melanoma

Indexed keywords

G PROTEIN ALPHA SUBUNIT Q; G PROTEIN COUPLED RECEPTOR; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BLUE NEVUS; CONTROLLED STUDY; GENE SEQUENCE; HUMAN; HUMAN TISSUE; MELANOMA; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; ONCOGENE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SOMATIC MUTATION; TUMOR GROWTH; UVEA MELANOMA;

EID: 77954406265     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.10.1.11949     Document Type: Article

References (30)

1. Oldham WM, Hamm HE. Heterotrimeric G protein activation by G-protein-coupled receptors. Nat Rev Mol Cell Biol 2008; 9:60-71.
2. Goldsmith ZG, Dhanasekaran DN. G protein regulation of MAPK networks. Oncogene 2007; 26:3122-42.
3. Dorsam RT, Gutkind JS. G-protein-coupled receptors and cancer. Nat Rev Cancer 2007; 7:79-94.
4. Gutkind JS. Cell growth control by G protein-coupled receptors: from signal transduction to signal integration. Oncogene 1998; 17:1331-42.
5. Juneja J, Casey PJ. Role of G12 proteins in oncogenesis and metastasis. Br J Pharmacol 2009; 158:32-40.
6. Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM, et al. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature 2009; 457:599-602.
7. Lamba S, Felicioni L, Buttitta F, Bleeker FE, Malatesta S, Corbo V, et al. Mutational profile of GNAQQ209 in human tumors. PLoS One 2009; 4:6833.
8. Dalgliesh GL, Furge K, Greenman C, Chen L, Bignell G, Butler A, et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 463:360-3.
9. Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, et al. Evolution of the mammalian G protein alpha subunit multigene family. Nat Genet 1992; 1:85-91.
10. Casey PJ, Fong HK, Simon MI, Gilman AG. Gz, a guanine nucleotide-binding protein with unique biochemical properties. J Biol Chem 1990; 265:2383-90.
11. Ho MK, Wong YH. G(z) signaling: emerging divergence from G(i) signaling. Oncogene 2001; 20:1615-25.
12. Meng J, Casey PJ. Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells. J Biol Chem 2002; 277:43417-24.
13. Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB. Crystal structure of a G-protein beta gamma dimer at 2.1 A resolution. Nature 1996; 379:369-74.
14. Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA. Expression cDNA cloning of a transforming gene encoding the wild-type Galpha12 gene product. Mol Cell Biol 1993; 13:762-8. (Pubitemid 23040240)
15. Xu N, Bradley L, Ambdukar I, Gutkind JS. A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells. Proc Natl Acad Sci USA 1993; 90:6741-5. (Pubitemid 23207289)
16. Kelly P, Moeller BJ, Juneja J, Booden MA, Der CJ, Daaka Y, et al. The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proc Natl Acad Sci USA 2006; 103:8173-8.
17. Kelly P, Stemmle LN, Madden JF, Fields TA, Daaka Y, Casey PJ. A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion. J Biol Chem 2006; 281:26483-90.
18. Cheong SC, Chandramouli GV, Saleh A, Zain RB, Lau SH, Sivakumaren S, et al. Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure. Oral Oncol 2009; 45:712-9.
19. Clar H, Langsenlehner U, Krippl P, Renner W, Leithner A, Gruber G, et al. A polymorphism in the G protein beta3-subunit gene is associated with bone metastasis risk in breast cancer patients. Breast Cancer Res Treat 2008; 111:449-52.
20. Eisenhardt A, Siffert W, Rosskopf D, Musch M, Mosters M, Roggenbuck U, et al. Association study of the G-protein beta3 subunit C825T polymorphism with disease progression in patients with bladder cancer. World J Urol 2005; 23:279-86.
21. Sheu SY, Gorges R, Ensinger C, Ofner D, Farid NR, Siffert W, et al. Different genotype distribution of the GNB3 C825T polymorphism of the G protein beta3 subunit in adenomas and differentiated thyroid carcinomas of follicular cell origin. J Pathol 2005; 207:430-5.
22. Sheu SY, Handke S, Brocker-Preuss M, Gorges R, Frey UH, Ensinger C, et al. The C allele of the GNB3 C825T polymorphism of the G protein beta3-subunit is associated with an increased risk for the development of oncocytic thyroid tumours. J Pathol 2007; 211:60-6.
23. Lehnerdt GF, Franz P, Bankfalvi A, Grehl S, Jahnke K, Lang S, et al. Association study of the G-protein beta3 subunit C825T polymorphism with disease progression an overall survival in patients with head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 2008; 17:3203-7.
24. Asada K, Miyamoto K, Fukutomi T, Tsuda H, Yagi Y, Wakazono K, et al. Reduced expression of GNA11 and silencing of MCT1 in human breast cancers. Oncology 2003; 64:380-8.
25. Hubbard KB, Hepler JR. Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins. Cell Signal 2006; 18:135-50.
26. Cronin JC, Wunderlich J, Loftus SK, Prickett TD, Wei X, Ridd K, et al. Frequent mutations in the MITF pathway in melanoma. Pigment Cell Melanoma Res 2009; 22:435-44.
27. Palavalli LH, Prickett TD, Wunderlich JR, Wei X, Burrell AS, Porter-Gill P, et al. Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma. Nat Genet 2009; 41:518-20.
28. Prickett TD, Agrawal NS, Wei X, Yates KE, Lin JC, Wunderlich JR, et al. Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. Nat Genet 2009; 41:1127-32.
29. Gordon D, Abajian C, Green P. Consed: a graphical tool for sequence finishing. Genome Res 1998; 8:195-202. (Pubitemid 28177231)
30. Bhangale TR, Stephens M, Nickerson DA. Automating resequencing-based detection of insertion-deletion polymorphisms. Nat Genet 2006; 38:1457-62.