Genetic variant associated with aggressive not indolent prostate cancer

Cancer Biology and Therapy

Volumn 9, Issue 12, 2010, Pages 957-958

  Kirkland, C Tyler ^a   Price, Douglas K ^a   Figg, William D ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Author: please provide 5 7 key words

Indexed keywords

PROSTATE SPECIFIC ANTIGEN;

CANCER RISK; CANCER SCREENING; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GLEASON SCORE; HUMAN; NOTE; PROSTATE CANCER; SINGLE NUCLEOTIDE POLYMORPHISM;

GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSTATIC NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 77954398151     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.9.12.12137     Document Type: Note

References (8)

1. Etzioni R, Tsodikov A, Mariotto A, Szabo A, Falcon S, Wegelin J, et al. Quantifying the role of PSA screening in the US prostate cancer mortality decline. Cancer Causes Control 2008; 19:175-81.
2. rd Buys SS, Chia D, Church TR, et al. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med 2009; 360:1310-9.
3. Schroder FH, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V, et al. Screening and prostatecancer mortality in a randomized European study. N Engl J Med 2009; 360:1320-8.
4. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin 2009; 59:225-49.
5. Xu J, Zheng SL, Isaacs SD, Wiley KE, Wiklund F, Sun J, et al. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. Proc Natl Acad Sci USA 2010; 107:2136-40.
6. Kader AK, Sun J, Isaacs SD, Wiley KE, Yan G, Kim ST, et al. Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients. Prostate 2009; 69:1195-205.
7. Lin X. Functions of heparan sulfate proteoglycans in cell signaling during development. Development 2004; 131:6009-21.
8. Sanderson RD, Yang Y, Kelly T, MacLeod V, Dai Y, Theus A. Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies. J Cell Biochem 2005; 96:897-905.