A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis

Clinical and Vaccine Immunology

Volumn 17, Issue 7, 2010, Pages 1155-1158

  Lopes, Livia Cristina Liporagi ^a,b   Guimarães, Allan J ^a   De Cerqueira, Mariana Duarte ^a,b   Gómez, Beatriz L ^c   Nosanchuk, Joshua D ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c Unidad de Biología Celular y Molecular   (Colombia)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN; FUNGUS ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY H1C; NITRIC OXIDE; UNCLASSIFIED DRUG; IMMUNOGLOBULIN G; MEMBRANE PROTEIN;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FUNGUS GROWTH; HISTOPLASMA CAPSULATUM; HISTOPLASMOSIS; HOST PATHOGEN INTERACTION; INFECTION RESISTANCE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HISTOPLASMA; IMMUNOLOGY; IMMUNOTHERAPY; PROCEDURES; SURVIVAL RATE; TREATMENT FAILURE;

ANIMALS; ANTIBODIES, MONOCLONAL; HISTOPLASMA; HISTOPLASMOSIS; HOST-PATHOGEN INTERACTIONS; IMMUNOGLOBULIN G; IMMUNOTHERAPY; MEMBRANE PROTEINS; MICE; SURVIVAL RATE; TREATMENT FAILURE;

EID: 77954382075     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00033-10     Document Type: Article

References (10)

1. Beenhouwer, D. O., E. M. Yoo, C. W. Lai, M. A. Rocha, and S. L. Morrison. 2007. Human immunoglobulin G2 (IgG2) and IgG4, but not IgG1 or IgG3, protect mice against Cryptococcus neoformans infection. Infect. Immun. 75: 1424-1435.
2. Casadevall, A. 1995. Antibody immunity and invasive fungal infections. Infect. Immun. 63:4211-4218.
3. Casadevall, A., and L. A. Pirofski. 2007. Antibody-mediated protection through cross-reactivity introduces a fungal heresy into immunological dogma. Infect. Immun. 75:5074-5078.
4. Couppie, P., C. Aznar, B. Carme, and M. Nacher. 2006. American histoplasmosis in developing countries with a special focus on patients with HIV: diagnosis, treatment, and prognosis. Curr. Opin. Infect. Dis. 19:443-449.
5. Gomez, B. L., J. I. Figueroa, A. J. Hamilton, S. Diez, M. Rojas, A. Tobon, A. Restrepo, and R. J. Hay. 1999. Detection of the 70-kilodalton histoplasma capsulatum antigen in serum of histoplasmosis patients: correlation between antigenemia and therapy during follow-up. J. Clin. Microbiol. 37:675-680.
6. Gomez, B. L., J. I. Figueroa, A. J. Hamilton, B. L. Ortiz, M. A. Robledo, A. Restrepo, and R. J. Hay. 1997. Development of a novel antigen detection test for histoplasmosis. J. Clin. Microbiol. 35:2618-2622.
7. Goodwin, R. A., Jr., J. L. Shapiro, G. H. Thurman, S. S. Thurman, and R. M. Des Prez. 1980. Disseminated histoplasmosis: clinical and pathologic correlations. Medicine (Baltimore) 59:1-33.
8. Guimaraes, A. J., S. Frases, F. J. Gomez, R. M. Zancope-Oliveira, and J. D. Nosanchuk. 2009. Monoclonal antibodies to heat shock protein 60 alter the pathogenesis of Histoplasma capsulatum. Infect. Immun. 77:1357-1367.
9. Nosanchuk, J. D., J. N. Steenbergen, L. Shi, G. S. Deepe, Jr., and A. Casadevall. 2003. Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum. J. Clin. Invest. 112:1164-1175.
10. Shi, L., P. C. Albuquerque, E. Lazar-Molnar, X. Wang, L. Santambrogio, A. Gacser, and J. D. Nosanchuk. 2008. A monoclonal antibody to Histoplasma capsulatum alters the intracellular fate of the fungus in murine macrophages. Eukaryot. Cell 7:1109-1117.