Spur cells and spur cell anemia in hospitalized patients with advanced liver disease: Incidence and correlation with disease severity and survival

Hepatology Research

Volumn 40, Issue 2, 2010, Pages 161-170

  Vassiliadis, Themistoklis ^a   Mpoumponaris, Alexander ^a   Vakalopoulou, Sofia ^a   Giouleme, Olga ^a   Gkissakis, Dimitrios ^a   Grammatikos, Nikolaos ^a   Soufleris, Konstantinos ^a   Kakafika, Anna ^a   Tziomalos, Konstantinos ^a   Patsiaoura, Kaliopi ^a   Papanikolaou, Vassilios ^a   Evgenidis, Nikolaos ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Acanthocytes; Cirrhosis; Hemolytic anemia; Spur cells

Indexed keywords

BILIRUBIN; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ACANTHOCYTOSIS; ACQUIRED HEMOLYTIC ANEMIA; ADULT; AGED; ARTICLE; BLOOD SMEAR; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEMOGLOBIN BLOOD LEVEL; HEPATIC COMA; HOSPITAL PATIENT; HUMAN; INTERNATIONAL NORMALIZED RATIO; LIVER CIRRHOSIS; LIVER DISEASE; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RETICULOCYTE COUNT; SEPSIS; SPUR CELL ANEMIA; SURVIVAL; SURVIVAL RATE;

EID: 77954379310     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2009.00590.x     Document Type: Article

References (46)

1. Cooper RA. Hemolytic syndromes and red cell membrane abnormalities in liver disease. Semin Hematol 1980, 17:103-12.
2. Cooper RA, Diloy-Puray M, Lando P, Greenberg MS. An analysis of lipoproteins, bile acids, and red cell membranes associated with target cells and spur cells in patients with liver disease. J Clin Invest 1972, 51:3182.
3. Cooper RA, Kimball DB, Durocher JR. Role of the spleen in membrane conditioning and hemolysis of spur cells in liver disease. N Engl J Med 1974, 290:1279-84.
4. Malik P, Bogetti D, Sileri P. Spur-cell anaemia in alcoholic cirrhosis: cure by orthotopic liver transplantation and recurrence after liver graft failure. Int Surg 2002, 87:201-4.
5. Chitale AA, Sterling RK, Post AB, Silver BJ, Mulligan DC, Schulak JA. Resolution of spur cell anemia with liver transplantation: a case report and review of the literature. Transplantation 1998, 65:993-5.
6. Jarrold T, Vilter RW. Haematologic observations in patients with chronic hepatic insufficiency. J Clin Invest 1949, 28:286-92.
7. Sheehy TW, Berman A. The anemia of cirrhosis. J Lab Clin Med 1960, 56:72-6.
8. Krasnow SE, Walsh JR, Zimmermann HJ, Heller P. Megaloblastic anaemia in alcoholic cirrhosis. Arch Intern Med 1957, 100:870-80.
9. Conrad ME, Barton JC. Anemia and iron kinetics in alcoholism. Semin Hematol 1980, 17:149-63.
10. Kimber C, Deller DJ, Ibbotson RH, Lander H. The mechanism of anaemia in chronic liver disease. Q J Med 1965, 34:33-64.
11. Subhiyah BW, A1-Hindawi AY. Red cell survival and splenic accumulation of radio-chromium in liver cirrhosis with splenomegaly. Br J Haematol 1967, 13:773-8.
12. Deller DJ, Kimber CL, Ibbotson RH. Folic acid deficiency in cirrhosis of the liver. Am J Dig Dis 1965, 10:35-42.
13. Colman N, Herbert V. Hematologic complications of alcoholism:overview. Semin Haematol 1980, 17:164-76.
14. Ohki I, Dan K, Kuriya S, Nomura T. A study on the mechanism of anemia and leucopenia in liver cirrhosis. Jpn J Med 1988, 27:155-9.
15. Miller CB, Jones RJ, Piantadosi S, Abetoff MD, Spivak JL. Decreased erythropoietin response in patients with the anemia of cancer. N Engl J Med 1990, 322:1689-92.
16. Siciliano M, Tomasello D, Milani A, Ricerca BM, Storti S, Rossi L. Reduced serum levels of immunoreactive erythropoietin in patients with cirrhosis and chronic anemia. Hepatology 1995, 22:1132-5.
17. Cooper RA, Gulbrandsen CL. The relationship between serum lipoproteins and red cell membranes in abetalipoproteinemia: deficiency of lecithin:cholesterol acyltransferase. J Clin Lab Med 1971, 78:323-30.
18. Hardie RJ. Acanthocytosis and neurological impairment- a review. Q J Med 1989, 71:291-5.
19. Redman CM, Huima T, Robbins E. Effect of phosphatidylserine on the shape of McLeod red cell acanthocytes. Blood 1989, 74:1826-35.
20. Perillie PE, Tembrevilla C. Red-cell changes in hypothyroidism. Lancet 1975, 2:1151-2.
21. Mant MJ, Faragher BS. The haematology of anorexia nervosa. Br J Haematol 1972, 23:737-49.
22. Smith JA, Lonergan ET, Sterlin K. Spur cell anemia: hemolytic anemia with red cells resembling acanthocytes in alcoholic cirrhosis. N Engl J Med 1964, 271:396-8.
23. Doll D, Doll J. Spur cell anemia. South Med J 1982, 75:1205-10.
24. Cynamon HA, Isenberg JN, Gustavson LP, Gourley W. Erythrocyte lipid alterations in pediatric cholestatic liver disease: spur cell anemia of infancy. J Pediatr Gastroenterol Nutr 1985, 4:542-9.
25. Marti{dotless}n M, de Las Heras D. Spur-cell anaemia in a patient with cirrhosis. J Hepatol 2004, 41:167.
26. Sousa JM, Giraldez A, De Blas JM. Spur cell anemia in hepatic cirrhosis: incidence, prognosis and reversibility after liver transplantation. Journal of Hepatology 2002, 36:64.
27. Cooper RA, Dilou-Puray M, Lando P. An analysis of lipoproteins, bile acids and red cell membranes associated with target cells and spur cells in patients with liver disease. J Clin Invest 1972, 51:3182-92.
28. Cooper RA, Arner EC, Wiley JS. Modification of red cell membrane structure by cholesterol-rich lipid dispension. J Clin Invest 1975, 55:115-26.
29. McBride JA, Jacobs HS. Abnormal kinetics of red cell membrane cholesterol in acanthocytes: studies in genetic and experimental abetalipoproteinemia and spur cell anemia. Br J Haematol 1970, 18:383-97.
30. Allen DW, Manning N. Abnormal phospholipid metabolism in spur cell anemia: decreased fatty acid incorporation into phosphatidylethanolamine and increased incorporation into acylcarnitine in spur cell anemia erythrocytes. Blood 1994, 84:1283-7.
31. Allen DW, Manning N. Cholesterol-loading of membranes of normal erythrocytes inhibit phospholipid repair and arachidonoyl-CoA: 1-palmitoyl-sn-glycero-3-phosphocholine acyl transferase. A model of spur cell anemia. Blood 1996, 87:3489-93.
32. Arienti G, Carlini E, Scionti L. Liver alcoholic cirrhosis and spur-cell (acanthocytic) anaemia. A study of erythrocyte ghost composition and fluidity. Scand J Gastroenterol 1995, 30:1204-9.
33. Godin DV, Gray GR, Frohloich J. Erythrocyte membrane alteration in lecithin: cholesterol acyltransferase deficiency. Scand J Lab Clin Invest 1978, 38(150):): 162-8. Suppl
34. Duhamel G, Forgez P, Nalpas B. Spur cells in patients with alcoholic liver cirrhosis are associated with reduced plasma levels of apoA-II, HDL3 and LDL. J Lipid Res 1983, 24:1612-25.
35. Tietge UJ, Boker KH, Bahr MJ. Lipid parameters predicting liver function in patients with cirrhosis and after liver transplantation. Hepatogastroenterology 1998, 45:2255-60.
36. Guarini P, Stanzial AM, Olivieri O. Erythrocyte membrane lipids and serum selenium in post-viral and alcoholic cirrhosis. Clin Chim Acta 1998, 270:139-50.
37. Cicognani C, Malavolti M, Morselli-Labate AM. Serum lipid and lipoprotein patterns in patients with liver cirrhosis and chronic active hepatitis. Arch Intern Med 1997, 157:792-6.
38. Pascoe A, Kerlin P, Steadman C. Spur cell anaemia and hepatic iron stores in patients with alcoholic liver disease undergoing orthotopic liver transplantation. Gut 1999, 45:301-5.
39. Silber R, Amorosi E, Lhowe J. Spur-shaped erythrocytes in Laenecs cirrhosis. N Engl J Med 1966, 275:634-43.
40. Cooper RA. Anemia with spur cells: a red cell defect acquired in serum and modified in circulation. J Clin Invest 1972, 51:3182-92.
41. Salvioli G, Rioli G, Lugli R. Membrane lipid composition of red blood cells in liver disease: regression of spur cell anemia after infusion of polyunsaturated phosphatidylcholine. Gut 1978, 19:844-50.
42. Aihara K, Azuma H, Ikeda Y. 2001, 351-5. 73
43. Fossaluzza V, Rossi P. Flunarizine treatment for spur cell anaemia. Br J Haematol 1983, 55:715-17.
44. Brandhagen D, Alvarez W, Therneau T. Iron overload in cirrhosis-HFE genotypes and outcome after liver transplantation. Hepatology 2000, 31:456-60.
45. Sundaram V, Al-Osaimi A, Lewis J. Severe prolongation of the INR in spur cell anemia of cirrhosis: true-true and related? Dig Dis Sci 2006, 51:1203-5.
46. Zieve L. Jaundice, hyperlipidaemia and haemolytic anaemia: a heretofore unrecognized syndrome associated with alcoholic fatty liver and cirrhosis. Ann Intern Med 1958, 48:471-96.