Free vs total pregnancy-associated plasma protein A (PAPP-A) as a predictor of 1-year outcome in patients presenting with non-ST-elevation acute coronary syndrome

Clinical Chemistry

Volumn 56, Issue 7, 2010, Pages 1158-1165

  Lund, Juha ^a   Wittfooth, Saara ^a   Qin, Qiu Ping ^a   Ilva, Tuomo ^a   Porela, Pekka ^a   Pulkki, Kari ^b   Pettersson, Kim ^a   Voipio Pulkki, Liisa Maria ^a,c  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

FREE PREGNANCY ASSOCIATED PLASMA PROTEIN A; HEPARIN; PREGNANCY ASSOCIATED PLASMA PROTEIN A; TOTAL PREGNANCY ASSOCIATED PLASMA PROTEIN A; TROPONIN I; UNCLASSIFIED DRUG;

ACUTE CORONARY SYNDROME; ADULT; AGED; ARTICLE; CONTROLLED STUDY; ELECTROCARDIOGRAM; FEMALE; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; NON ST ELEVATION ACUTE CORONARY SYNDROME;

ACUTE CORONARY SYNDROME; AGED; BIOLOGICAL MARKERS; ELECTROCARDIOGRAPHY; EOSINOPHIL MAJOR BASIC PROTEIN; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; PROGNOSIS; PROTEIN SUBUNITS;

EID: 77954353996     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2009.136960     Document Type: Article

References (23)

1. Lund J, Qin QP, Ilva T, Pettersson K, Voipio-Pulkki LM, Porela P, Pulkki K. Circulating pregnancyassociated plasma protein A predicts outcome in patients with acute coronary syndrome but no troponin I elevation. Circulation 2003;108:1924-6. (Pubitemid 37296534)
2. Lund J, Qin QP, Ilva T, Nikus K, Eskola M, Porela P, et al. Pregnancy-associated plasma protein A: a biomarker in acute ST-elevation myocardial infarction (STEMI). Ann Med 2006;38:221-8. (Pubitemid 43675587)
3. Heeschen C, Dimmeler S, Hamm CW, Fichtlschrerer S, Simoons ML, Zeiher AM, et al. Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis. J Am Coll Cardiol 2005;45:229-37.
4. Elesber AA, Conover CA, Denktas AE, Lennon RJ, Holmes DR Jr, Overgaard MT, et al. Prognostic value of circulating pregnancy-associated plasma protein levels in patients with chronic stable angina. Eur Heart J 2006;27:1678-84.
5. Etter C, Straub Y, Hersberger M, Räz HR, Kistler T, Kiss D, et al. Pregnancy-associated plasma protein-A is an independent short-time predictor of mortality in patients on maintenance haemodialysis. Eur Heart J 2010;31:354-9.
6. Boldt HB, Overgaard MT, Laursen LS, Weyer K, Sottrup-Jensen L, Oxvig C. Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin. Biochem J 2001;358:359-67. (Pubitemid 32826352)
7. Gérard N, Delpuech T, Oxvig C, Overgaard MT, Monget P. Proteolytic degradation of IGF-binding protein (IGFBP)-2 in equine ovarian follicles: involvement of pregnancy-associated plasma protein-A (PAPP-A) and association with dominant but not subordinated follicles. J Endocrinol 2004;182:457-66. (Pubitemid 39276213)
8. Lawrence JB, Oxvig C, Overgaard MT, Sottrup-Jensen L, Gleich GJ, Hays LG, et al. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A. Proc Natl Acad Sci U S A 1999;96:3149-53.
9. Laursen LS, Overgaard MT, Søe R, Boldt HB, Sottrup-Jensen L, Giudice LC, et al. Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A. FEBS Lett 2001;504:36-40.
10. Oxvig C, Sand O, Kristensen T, Gleich GJ, Sottrup-Jensen L. Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein. J Biol Chem 1993;268:12243-6.
11. Wittfooth S, Qin QP, Lund J, Tierala I, Pulkki K, Takalo H, Pettersson K. Immunofluorometric point-of-care assays for the detection of acute coronary syndrome-related noncomplexed pregnancy-associated plasma protein A. Clin Chem 2006;52:1794-801. (Pubitemid 44330716)
12. Overgaard MT, Haaning J, Boldt HB, Olsen IM, Laursen LS, Cristiansen M, et al. Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor. J Biol Chem 2000;275:31128-33.
13. Bayes-Genis A, Conover CA, Overgaard MT, Bailey KR, Christiansen M, Holmes DR Jr, et al. Pregnancy-associated plasma protein A as a marker of acute coronary syndromes. N Engl J Med 2001;345:1022-9.
14. Cosin-Sales J, Christiansen M, Kaminski P, Oxvig C, Overgaard MT, Cole D, et al. Pregnancy-associated plasma protein A and its endogenous inhibitor, the proform of eosinophil major basic protein (proMBP), are related to complex stenosis morphology in patients with stable angina pectoris. Circulation 2004;109:1724-8. (Pubitemid 38500673)
15. Qin QP, Kokkala S, Lund J, Tamm N, Voipio-Pulkki L-M, Pettersson K. Molecular distinction of circulating pregnancy-associated plasma protein A in myocardial infarction and pregnancy. Clin Chem 2005;51:75-83. (Pubitemid 40028321)
16. Terkelsen CJ, Oxvig C, Nørgaard BL, Glerup S, Poulsen TS, Lassen JF, et al. Temporal course of pregnancy-associated plasma protein-A in angioplasty-treated ST-elevation myocardial infarction patients and potential significance of concomitant heparin administration. Am J Cardiol 2009;103:29-35.
17. Tertti R, Wittfooth S, Porela P, Airaksinen KEJ, Metsärinne K, Pettersson K. Intravenous administration of low molecular weight and unfractionated heparin elicits a rapid increase in serum pregnancy-associated plasma protein A. Clin Chem 2009;55:1214-7.
18. Apple FS. A new season for cardiac troponin assays: it's time to keep a scorecard. Clin Chem 2009;55:1303-6.
19. Ilva T, Eriksson S, Lund J, Porela P, Mustonen H, Pettersson K, et al. Improved early risk stratification and diagnosis of myocardial infarction, using a novel troponin I assay concept. Eur J Clin Invest 2005;35:112-6. (Pubitemid 40222813)
20. US Food and Drug Administration. Guidance for industry and FDA staff: criteria for assessment of C-reactive protein (CRP), high sensitivity C-reactive protein (hsCRP), and cardiac C-reactive protein (cCRP) assays. 2005 Sep 22. http://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/GuidanceDocuments/ ucm077167.htm (Accessed April 2010).
21. Hedberg P, Ylitalo K, Puukka M. Highly sensitive determination of C-reactive protein on the Innotrac Aio! immunoanalyzer. Scand J Clin Lab Invest 2004;64:677-86. (Pubitemid 39425307)
22. Keller T, Zeller T, Peetz D, Tzikas S, Roth A, Czyz E, et al. Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med 2009;361:868-77.
23. Venge P, Johnston N, Lindahl B, James S. Normal plasma levels of cardiac troponin I measured by the high-sensitivity cardiac troponin I access prototype assay and the impact on the diagnosis of myocardial ischemia. J Am Coll Cardiol 2009;54:1165-72.