Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases

Journal of Biological Chemistry

Volumn 285, Issue 28, 2010, Pages 21560-21566

  Tomasic, Ivan B ^a   Metcalf, Matthew C ^a   Guce, Abigail I ^a   Clark, Nathaniel E ^a   Garman, Scott C ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AMINO ACID SEQUENCE; ANTIGENICITY; ENZYME REPLACEMENT THERAPY; FABRY DISEASE; GALACTOSIDASES; INTERCONVERSIONS; LYSOSOMAL ENZYMES; LYSOSOMAL STORAGE DISORDER; PROTEIN ENGINEERING; RATIONAL DESIGN; SCHINDLER; WILD-TYPE ENZYMES;

AMINO ACIDS; BIOCHEMICAL ENGINEERING; CATALYSTS; DISEASE CONTROL; GENETIC ENGINEERING; ORGANIC ACIDS;

ENZYMES;

ALPHA GALACTOSIDASE; ALPHA N ACETYLGALACTOSAMINIDASE; AMINO ACID; LYSOSOME ENZYME;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIGENICITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; FABRY DISEASE; GENETIC TRANSFECTION; HUMAN; INSECT CELL; LYSOSOME STORAGE DISEASE; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PURIFICATION; SCHINDLER DISEASE; X RAY CRYSTALLOGRAPHY;

ALPHA-GALACTOSIDASE; ALPHA-N-ACETYLGALACTOSAMINIDASE; AMINO ACID SEQUENCE; CARBOHYDRATE METABOLISM; CARBOHYDRATES; CRYSTALLOGRAPHY, X-RAY; FABRY DISEASE; GLYCOPROTEINS; HUMANS; KINETICS; LYSOSOMAL STORAGE DISEASES; LYSOSOMES; MOLECULAR SEQUENCE DATA; PROTEIN FOLDING; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 77954351425     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.118588     Document Type: Article

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