Synthesis and GABAA receptor activity of A-homo analogues of neuroactive steroids

European Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2010, Pages 3063-3069

  Dansey, María V ^a   Di Chenna, Pablo H ^a   Veleiro, Adriana S ^a   Krištofíková, Zdena ^b   Chodounska, Hana ^c   Kasal, Alexander ^c   Burton, Gerardo ^a  

^a Ciudad Universitaria ^*  (Argentina)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (Czech Republic)

^c INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

A homopregnane; GABAA receptor; Neurosteroid; Aminobutyric acid

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3ALPHA HYDROXY A HOMO 5 PREGNEN 20 ONE; 3BETA HYDROXY A HOMO 5 PREGNEN 20 ONE; 3BETA HYDROXY A HOMO 5ALPHA H PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4ALPHA HYDROXY A HOMO 5 PREGNEN 20 ONE; FRUCTOSE; KETONE; METHANOL DERIVATIVE; NEUROACTIVE STEROID; NEUROSTEROID; OXIDIZING AGENT; PREGNANE DERIVATIVE; SODIUM PEROXIDE; TERT BUTYLBICYCLOPHOSPHOROTHIOATE; UNCLASSIFIED DRUG; FUSED HETEROCYCLIC RINGS; HYDROXIDE; HYDROXIDE ION; TERT-BUTYLBICYCLOPHOSPHOROTHIONATE;

ARTICLE; BINDING AFFINITY; CATALYSIS; CATALYST; CHEMICAL BOND; CHIRALITY; CONTROLLED STUDY; DRUG CONFORMATION; DRUG SYNTHESIS; EPOXIDATION; MICROWAVE IRRADIATION; REACTION ANALYSIS; RECEPTOR BINDING; RING OPENING; STEREOCHEMISTRY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG EFFECT; MALE; METABOLISM; MICROWAVE RADIATION; PROTEIN BINDING; RAT; SYNTHESIS; WISTAR RAT;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; HYDROXIDES; MALE; MICROWAVES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PREGNENES; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTORS, GABA-A;

EID: 77954349521     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.03.037     Document Type: Article

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