Structure-activity relationships of neuroactive steroids acting on the GABAA receptor

Current Medicinal Chemistry

Volumn 16, Issue 4, 2009, Pages 455-472

  Veleiro, Adriana S ^a   Burton, Gerardo ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Anticonvulsant; GABAA receptor; Neuroactive steroids; Neurosteroids; Structure activity relationship

Indexed keywords

17 PHENYL 5ALPHA ANDROST 16 EN 3ALPHA OL; 17ALPHA AZA D HOMOSTEROID DERIVATIVE; 17BETA ALKYNYL DERIVATIVE; 17BETA CARBONITRILE; 2 ISOPROPYLMORPHOLINE DERIVATIVE; 22 BROMOALKYNYL DERIVATIVE; 3ALPHA AMINO 5ALPHA PREGAN 20 ONE; 3ALPHA HYDROXY 3BETA TRIFLUOROMETHYL 19 NOR 5BETA PREGNAN 20 ONE; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3ALPHA,21 DIHYDROXY 5 ALPHA PREGNAN 20 ONE; 3BETA CARBOXAMIDOMETHYL; 3BETA HYDROXYMETHYL; 3BETA METHYL DERIVATIVE; 4 AMINOBUTYRIC ACID RECEPTOR; ALFAXALONE; ALKYNYL PREGNANEDIOL DERIVATIVE; ALLOTETRAHYDRODEOXYCORTICOSTERONE; ANDROSTERONE; AZASTEROID DERIVATIVE; CHLORINE 36; ELTANOLONE; FLUORINATED STEROID; GANAXOLONE; MINAXOLONE; OXETANE DERIVATIVE; PREGNANEDIOL DERIVATIVE; STEROID; TERTIARY AMINE; TETRAHYDRODEOXYCORTICOSTERONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR;

ANTICONVULSANT ACTIVITY; ANXIETY DISORDER; BINDING AFFINITY; BINDING SITE; BRAIN ELECTROPHYSIOLOGY; CEREBELLUM; CLINICAL TRIAL; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; DRUG TARGETING; DRUG WITHDRAWAL; EPILEPSY; HUMAN; INSOMNIA; MEMBRANE BINDING; NONHUMAN; PHARMACOPHORE; PROTEIN EXPRESSION; PROTEIN TARGETING; REVIEW; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SYNAPTIC MEMBRANE; SYNAPTOSOME; URTICARIA; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; PHYSIOLOGY;

ANIMALS; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, GABA-A; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 63449142463     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986709787315522     Document Type: Review

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