Reactivity of a humanized antibody (hPankoMab) towards a tumor-related MUC1 epitope (TA-MUC1) with various human carcinomas

Pathology Research and Practice

Volumn 206, Issue 8, 2010, Pages 585-589

  Fan, Xiao Na ^a   Karsten, Uwe ^b   Goletz, Steffen ^b   Cao, Yi ^a  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b GLYCOTOPE GMBH   (Germany)

Author keywords

Carcinoma; Humanized antibody; In vivo; MUC1; PankoMab

Indexed keywords

CANCER ANTIBODY; EPITOPE; MUCIN 1; PANKOMAB; TUMOR RELATED MUC1 EPITOPE; UNCLASSIFIED DRUG; MONOCLONAL ANTIBODY; MUC1 PROTEIN, HUMAN; TUMOR ANTIGEN;

ADENOCARCINOMA; ARTICLE; BINDING SITE; BREAST CANCER; CANCER CELL; CARCINOMA; CELL SURFACE; CHONDROSARCOMA; COLORECTAL CANCER; CONTROLLED STUDY; CYTOPLASM; FEMALE; FIBROSARCOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CANCER; LIVER CANCER; LUNG CANCER; MALIGNANT FIBROUS HISTIOCYTOMA; MALIGNANT NEOPLASTIC DISEASE; NASOPHARYNX CANCER; OSTEOSARCOMA; SARCOMA; SQUAMOUS EPITHELIUM; STOMACH CANCER; THYROID CARCINOMA; TISSUE SECTION; UROGENITAL TRACT TUMOR; UTERINE CERVIX CARCINOMA; ANTIBODY SPECIFICITY; DIAGNOSTIC USE; IMMUNOLOGY;

ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGENS, NEOPLASM; CARCINOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MUCIN-1;

EID: 77954349368     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2010.03.006     Document Type: Article

References (23)

1. Karsten U., von Mensdorff-Pouilly S., Goletz S. What makes MUC1 a tumor antigen?. Tumor Biol. 2005, 26:217-220.
2. Karsten U., Diotel C., Klich G., Paulsen H., Goletz S., Mueller S., Hanisch F.G. Enhanced binding of antibodies to the DTR motif of MUC1 tandem repeat peptide is mediated by site-specific glycosylation. Cancer Res. 1998, 58:2541-2549.
3. Norum L.F., Sauren A.M., Rye P.D., Nustad K. New immunoassays for MUC1 in the breast cancer. Tumor Biol. 2001, 22:216-222.
4. Zotter S., Hageman P.C., Lossnitzer A., Moor W.J., Hilgers J. Tissue and tumor distribution of human polymorphic epithelial mucin. Cancer Rev. 1988, 11/12:55-101.
5. Girling A., Bartkova J., Burchell J., Gendler S., Gillett C., Taylor-Papadimitriou J. A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas. Int. J. Cancer 1989, 43:1072-1076.
6. Ho S.B., Niehans G.A., Lyftogt C., Yan P.S., Cherwitz D.L., Gum E.T., Dahiya R., Kim Y.S. Heterogeneity of mucin gene expression in normal and neoplastic tissues. Cancer Res. 1993, 53:641-651.
7. Danielczyk A., Stahn R., Faulstich D., Loeffler A., Maerten A., Karsten U., Goletz S. PankoMab: a potent new generation anti-tumour MUC1 antibody. Cancer Immunol. Immunother. 2006, 55:1337-1347.
8. Fritz A., Jack A., Parkin D.M. International Classification of Diseases for Oncology (ICD-O) 2000, World Health Organization. 3rd ed.
9. Kuemmel A., Single K., Bittinger F., Faldum A., Schmidt L.H., Sebastian M., Micke P., Taube C., Buhl R., Wiewrodt R. TA-MUC1 epitope in non-small cell lung cancer. Lung Cancer 2009, 63:98-105.
10. Ma C.K., Zarbo R.J., Frierson H.F., Lee M.W. Comparative immunohistochemical study of primary and metastatic carcinomas of the liver. Am. J. Clin. Pathol. 1993, 99:551-557.
11. Cao Y., Karsten U., Otto G., Bannasch P. Expression of MUC1, Thomsen-Friedenreich antigen, Tn, sialosyl-Tn, and α2,6-linked sialic acid in hepatocellular carcinomas and preneoplastic hepatocellular lesions. Virchows Arch. 1999, 434:503-509.
12. Hayes D.F., Zurawski V.R., Kufe D.W. Comparison of circulating CA15-3 and carcinoembryonic antigen in patients with breast cancer. J. Clin. Oncol. 1986, 4:1542-1550.
13. Safi F., Kohler I., Rottinger E., Beger H. The value of the tumor marker CA15-3 in diagnosing and monitoring breast cancer. Cancer 1991, 68:574-582.
14. Dian D., Janni W., Kuhn C., Mayr D., Karsten U., Mylonas I., Friese K., Jeschke U. Evaluation of a novel anti-mucin 1 (MUC1) antibody (PankoMab) as a potential diagnostic tool in human ductal breast cancer; comparison with two established antibodies. Onkologie 2009, 32:238-244.
15. Wreesmann V.B., Sieczka E.M., Socci N.D., Hezel M., Belbin T.J., Childs G., Patel S.G., N: Patel K., Tallini G., Prystowsky M., Shaha A.R., Kraus D., Shah J.P., Rao P.H., Ghossein R., Singh B. Genome-wide profiling of papillary thyroid cancer identifies MUC1 as independent prognostic marker. Cancer Res. 2004, 64:3780-3789.
16. Abrosimov A., Saenko V., Meirmanov S., Nakashima M., Rogounovitch T., Shkurko O., Lushnikov E., Mitsutake N., Namba H., Yamashita S. The cytoplasmic expression of MUC1 in papillary thyroid carcinoma of different histological variants and its correlation with cyclin D1 overexpression. Endocr. Pathol. 2007, 18:68-75.
17. Cao Y., Blohm D., Ghadimi B.M., Stosiek P., Xing P.X., Karsten U. Mucins (MUC1 and MUC3) of gastrointestinal and breast epithelia reveal different and heterologeneous tumor-associated aberrations in glycosylation. J. Histochem. Cytochem. 1997, 45:1547-1557.
18. Carrato C., Balague C., de Bolos C., Gonzalez E., Gambus G., Planas J., Perini J.M., Andreu D., Real F.X. Differential apomucin expression in normal and neoplastic human gastrointestinal tissues. Gastroenterology 1994, 107:160-172.
19. Cao Y., Schlag P.M., Karsten U. Immunodetection of epithelial mucin (MUC1, MUC3) and mucin-associated glycotopes (TF, Tn, and sialosyl-Tn) in benign and malignant lesions of colon epithelium: apolar localization corresponds to malignant transformation. Virchows Arch. 1997, 431:159-166.
20. Cao Y., Karsten U., Hilgers J. Immunohistochemical characterization of a panel of 56 antibodies with normal human small intestine, colon, and breast tissues. Tumor Biol. 1998, 19(Suppl. 1):88-99.
21. Kusafuka K., Takizawa Y., Iida Y., Iida Y., Ebihara M., Onitsuka T., Kameya T. Primary nasopharyngeal mucoepidermoid carcinoma in Japanese patients: two case reports with histochemical and immunohistochemical analysis and a review of the literature. Virchows Arch. 2007, 450:343-348.
22. Cao Y., Karsten U., Zerban H., Bannasch P. Expression of MUC1, Thomsen-Friedenreich-related antigens, and cytokeratin 19 in human renal cell carcinomas and tubular clear cell lesions. Virchows Arch. 2000, 436:119-126.
23. Walsh M.D., Hohn B.G., Thong W., Devine P.L., Gardiner R.A., Samaratunga M.L., McGuckin M.A. Mucin expression by transitional cell carcinomas of the bladder. Br. J. Urol. 1994, 73:256-262.