Synthesis and preliminary biological evaluation of novel taspine derivatives as anticancer agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2010, Pages 2798-2805

  Zhang, Jie ^a   Zhang, Yanmin ^a   Shan, Yuanyuan ^a   Li, Na ^a   Ma, Wei ^a   He, Langchong ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Antiangiogenesis; Anticancer activity; Antiproliferative activity; Taspine derivatives

Indexed keywords

2 METHOXY 5 (METHOXYCARBONYL)PHENYL 2 [2 (DIMETHYLAMINO)ETHYL] 5 HYDROXY 4 METHOXYBENZOATE; 6 [2 [(3 CHLORO 4 FLUOROPHENYL)AMINO] 2 OXOETHOXY] 3,3' DIMETHOXY N,N1 DIMETHYL 6' (2 MORPHOLIN 4 YLETHOXY)BIPHENYL 2,2' DICARBOXAMIDE; 6 [2 [(3 CHLORO 4 FLUOROPHENYL)AMINO] 2 OXOETHOXY] 5,5' DIMETHOXY N,N' DIMETHYL 6' (2 MORPHOLIN 4 YLETHOXY)BIPHENYL 2,2' DICARBOXAMIDE; 6 [2 [(3 CHLORO 4 FLUOROPHENYL)AMINO] 2 OXOETHOXY] 5,5' DIMETHOXY N,N' DIMETHYL 6' (2 PIPERAZIN 1 YLETHOXY)BIPHENYL 2,2' DICARBOXAMIDE; 6 [2 [(3 CHLORO 4 FLUOROPHENYL)AMINO] 2 OXOETHOXY] 6' HYDROXY 5,5' DIMETHOXYN,N' DIMETHYLBIPHENYL 2,2' DICARBOXAMIDE; 6 HYDROXY 5,5' DIMETHOXY N,N1 DIMETHYL 6' (2 MORPHOLIN 4 YLETHOXY)BIPHENYL 2,2' DICARBOXAMIDE; 6,6' DIHYDROXY 5,5' DIMETHOXY N,N' DIMETHYLBIPHENYL 2,2' DICARBOXAMIDE; ANGIOGENESIS INHIBITOR; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; METHYL 2 [2 (DIMETHYLAMINO)ETHYL] 5 (3 HYDROXY 4 METHOXYBENZOYLOXY) 4 METHOXYBENZOATE; METHYL 2 [2 [(3 CHLORO 4 FLUOROPHENYL)AMINO]ETHYL] 5 [(3 HYDROXY 4 METHOXYBENZOYL) OXY] 4 METHOXYBENZOATE; METHYL 5 [(3 HYDROXY 4 METHOXYBENZOYL)OXY] 4 METHOXY 2 (2 MORPHOLIN 4 YLETHYL)BENZOATE; TASPINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN CACO 2; COMPUTER MODEL; CYTOTOXICITY; DRUG SOLUBILITY; DRUG SYNTHESIS; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION; UMBILICAL CORD;

ALKALOIDS; ANTINEOPLASTIC AGENTS; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DISCOVERY; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 77954348591     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.03.001     Document Type: Article

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