Angiogenesis: A new physiological role for N-arachidonoyl serine and GPR55?

British Journal of Pharmacology

Volumn 160, Issue 7, 2010, Pages 1580-1582

  Ho, W Sv ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

acyl amino acids; angiogenesis; endocannabinoid; endothelium; extracellular signal regulated kinases; GPR55; migration; proliferation; vascular endothelial growth factor

Indexed keywords

AMINO ACID; CANNABINOID 1 RECEPTOR; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 55; MITOGEN ACTIVATED PROTEIN KINASE; N ARACHIDONOYL SERINE; PERTUSSIS TOXIN; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN C;

ANGIOGENESIS; CALCIUM MOBILIZATION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; IN VITRO STUDY; METASTASIS; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; NOTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR GROWTH; VASODILATATION;

ANIMALS; ARACHIDONIC ACIDS; CELL MOVEMENT; CELL PROLIFERATION; ENDOTHELIUM, VASCULAR; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTORS, G-PROTEIN-COUPLED; SERINE; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTORS; VASODILATION;

EID: 77954343608     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00788.x     Document Type: Note

References (12)

1. Blázquez C, Casanova ML, Planas A, Gómez Del Pulgar T, Villanueva C, Fernández-Aceñero MJ et al. (2003). Inhibition of tumor angiogenesis by cannabinoids. FASEB J 17:529 531.
2. Bradshaw HB, Walker JM (2005). The expanding field of cannabimimetic and related lipid mediators. Br J Pharmacol 144:459 465.
3. + channels. J Pharmacol Exp Ther 328:351 356.
4. Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA et al. (2002). International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev 54:161 202.
5. Huang SM, Bisogno T, Petros TJ, Chang SY, Zavitsanos PA, Zipkin RE et al. (2001). Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. J Biol Chem 276:42639 42644.
6. Lauckner JE, Jensen JB, Chen HY, Lu HC, Hille B, Mackie K (2008). GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current. Proc Natl Acad Sci USA 105:2699 2704.
7. Milman G, Maor Y, Abu-Lafi S, Horowitz M, Gallily R, Batkai S et al. (2006). N-arachidonoyl l-serine, an endocannabinoid-like brain constituent with vasodilatory properties. Proc Natl Acad Sci USA 103:2428 2433.
8. o-coupled receptor distinct from CB1, CB2 or EDG-1. Eur J Pharmacol 489:21 27.
9. Parmar N, Ho WS (2010). N-arachidonoyl glycine, an endogenous lipid that acts as a vasorelaxant via nitric oxide and large conductance calcium-activated potassium channels. Br J Pharmacol DOI: 10.1111/j.1476-5381.2009.00622 Epub ahead of print.
10. Portella G, Laezza C, Laccetti P, De Petrocellis L, Di Marzo V, Bifulco M (2003). Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis. FASEB J 17:1771 1773.
11. Ross RA (2009). The enigmatic pharmacology of GPR55. Trends Pharmacol Sci 30:156 163.
12. Zhang X, Maor Y, Wang JF, Kunos G, Groopman JE (2010). Endocannabinoid-like N-arachidonoyl serine is a novel proangiogenic mediator. Br J Pharmacol 160:1583 1594.