Potential mechanisms of failure in the sudden infant death syndrome

Current Pediatric Reviews

Volumn 6, Issue 1, 2010, Pages 39-47

  Harper, Ronald M ^a   Kinney, Hannah C ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Apnea; Brainstem; Cerebellum; Chemoreception; Hypotension; Serotonin

Indexed keywords

CASPASE 3; GLIAL FIBRILLARY ACIDIC PROTEIN; MUSCARINIC RECEPTOR; NEUROPEPTIDE; NEUROTRANSMITTER; NICOTINIC RECEPTOR; OREXIN; TRYPTOPHAN HYDROXYLASE;

ADRENERGIC SYSTEM; AIRWAY OBSTRUCTION; APNEA; APOPTOSIS; AROUSAL; ARTICLE; ASTROCYTE; AUTOPSY; BASAL GANGLION; BLOOD PRESSURE REGULATION; BODY POSTURE; BRADYCARDIA; BRAIN CORTEX; BRAIN INJURY; BRAIN REGION; BRAIN STEM; BREATHING; CARDIOVASCULAR FUNCTION; CEREBELLUM; ELECTROENCEPHALOGRAM; ENCEPHALOMALACIA; GLIOSIS; HEART ARRHYTHMIA; HIPPOCAMPUS; HUMAN; HYPOGLOSSAL NUCLEUS; HYPOTENSION; HYPOTHALAMUS; HYPOXIA; MEDULLA OBLONGATA; MESENCEPHALON; MOTOR CONTROL; MUSCLE CONTRACTION; MUSCLE TONE; MYELINATION; NERVOUS SYSTEM FUNCTION; NEUROPATHOLOGY; PONS; PRIORITY JOURNAL; QT PROLONGATION; REGULATORY MECHANISM; REM SLEEP; RESPIRATION CONTROL; RESPIRATORY FAILURE; RISK REDUCTION; SENSORY STIMULATION; SEROTONINERGIC SYSTEM; SHOCK; SOLITARY TRACT NUCLEUS; SUDDEN INFANT DEATH SYNDROME; THERMAL CONDUCTIVITY; VAGUS NERVE DORSAL NUCLEUS; VESTIBULAR NUCLEUS; WHITE MATTER;

EID: 77954331782     PISSN: 15733963     EISSN: None     Source Type: Journal    
DOI: 10.2174/157339610791317214     Document Type: Article

References (93)

1. Willinger M, James LS, Catz C. Defining the sudden infant death syndrome (SIDS): Deliberations of an expert panel convened by the National Institute of Child Health and Human Development. Pediatr Pathol 1991; 11: 677-84.
2. Harper RM, Leake B, Hoffman H, et al. Periodicity of sleep states is altered in infants at risk for the sudden infant death syndrome. Science 1981; 213: 1030-32.
3. Schechtman VL, Harper RM, Wilson AJ, Southall DP. Sleep state organization in normal infants and victims of the sudden infant death syndrome. Pediatrics 1992; 89: 865-70.
4. Kluge KA, Harper RM, Schechtman VL, Wilson AJ, Hoffman HJ, Southall DP. Spectral analysis assessment of respiratory sinus arrhythmia in normal infants and infants who subsequently died of sudden infant death syndrome. Pediatr Res 1988; 24: 677-82.
5. Schechtman VL, Raetz SL, Harper RK, et al. Dynamic analysis of cardiac R-R intervals in normal infants and in infants who subsequently succumbed to the sudden infant death syndrome. Pediatr Res 1992; 31: 606-12.
6. Schechtman VL, Lee MY, Wilson AJ, Harper RM. Dynamics of respiratory patterning in normal infants and infants who subsequently died of the sudden infant death syndrome. Pediatr Res 1996; 40: 571-77.
7. Hoppenbrouwers T, Jensen D, Hodgman J, Harper R, Sterman M. Body movements during Quiet Sleep (QS) in subsequent siblings of sids. Clin Resear 1982; 30: A136.
8. Kato I, Groswasser J, Franco P, et al. Developmental characteristics of apnea in infants who succumb to sudden infant death syndrome. Am J Respir Crit Care Med 2001; 164: 1464-69.
9. Harper RM. Sudden infant death syndrome: A failure of compensatory cerebellar mechanisms? Pediatr Res 2000; 48: 140-2.
10. Harper RM, Bandler R. Finding the failure mechanism in Sudden Infant Death Syndrome. Nat Med 1998; 4: 157-58.
11. Kinney HC, Thach BT. The sudden infant death syndrome. N Engl J Med 2009; 361: 795-805.
12. Kinney HC, Richerson GB, Dymecki SM, Darnall RA, Nattie EE. The brainstem and serotonin in the sudden infant death syndrome. Annu Rev Pathol 2009; 4: 517-50.
13. Sahni R, Fifer WP, Myers MM. Identifying infants at risk for sudden infant death syndrome. Curr Opin Pediatr 2007; 19: 145-49.
14. Hunt CE, Brouillette RT. Sudden infant death syndrome: 1987 perspective. J Pediatr 1987; 110: 669-78.
15. Guyenet PG, Bayliss DA, Stornetta RL, Fortuna MG, Abbott SBG, DePuy SD. Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity. Respir Physiol Neurobiol 2009; 168: 59-68.
16. Cechetto DF, Shoemaker JK. Functional neuroanatomy of autonomic regulation. Neuroimage 2009; 47: 795-803.
17. Siegel JM. The neurobiology of sleep. Semin Neurol 2009; 29: 277-96.
18. Ulrich-Lai YM, Herman JP. Neural regulation of endocrine and autonomic stress responses. Nat Rev Neurosci 2009; 10: 397-409.
19. Fuller PM, Gooley JJ, Saper CB. Neurobiology of the sleep-wake cycle: Sleep architecture, circadian regulation, and regulatory feedback. J Biol Rhythms 2006; 21: 482-93.
20. Doi A, Ramirez J-M. Neuromodulation and the orchestration of the respiratory rhythm. Respir Physiol Neurobiol 2008; 164: 96-104.
21. Trelease RB, Sieck GC, Marks JD, Harper RM. Respiratory inhibition induced by transient hypertension during sleep in unrestrained cats. Exp Neurol 1985; 90: 173-86.
22. Marks JD, Harper RM. Differential inhibition of the diaphragm and posterior cricoarytenoid muscles induced by transient hypertension across sleep states in intact cats. Exp Neurol 1987; 95: 730-42.
23. American Thoracic Society. Idiopathic congenital central hypoventilation syndrome: Diagnosis and management. Am J Respir Crit Care Med 1999; 160: 368-73.
24. Meny RG, Carroll JL, Carbone MT, Kelly DH. Cardiorespiratory recordings from infants dying suddenly and unexpectedly at home. Pediatrics 1994; 93: 44-49.
25. Poets CF, Meny RG, Chobanian MR, Bonofiglo RE. Gasping and other cardiorespiratory patterns during sudden infant deaths. Pediatr Res 1999; 45: 350-54.
26. Ludbrook J. Haemorrhage and shock. In: Hainsworth R, Mark A, Edrs. Cardiovascular reflex control in health and disease. London: Saunders 1993; pp. 463-90.
27. Ledwidge M, Fox G, Matthews T. Neurocardiogenic syncope: A model for SIDS. Arch Dis Child 1998; 78: 481-83.
28. Southall DP, Stevens V, Franks CI, Newcombe RG, Shinebourne EA, Wilson AJ. Sinus tachycardia in term infants preceding sudden infant death. Eur J Pediatr 1988; 147: 74-8.
29. Kato I, Franco P, Groswasser J, et al. Incomplete arousal processes in infants who were victims of sudden death. Am J Respir Crit Care Med 2003; 168: 1298-303.
30. Schechtman VL, Harper RM, Kluge KA, Wilson AJ, Hoffman HJ, Southall DP. Cardiac and respiratory patterns in normal infants and victims of the sudden infant death syndrome. Sleep 1988; 11: 413-24.
31. Fukumizu M, Kohyama J. Central respiratory pauses, sighs, and grosses body movements during sleep in children. Physiol Behav 2004; 82: 721-26.
32. Kohyama J, Shimohira M, Itoh M, Fukumizu M, Iwakawa Y. Phasic muscle activity during REM sleep in infancy-normal maturation and contrastive abnormality in SIDS/ALTE and West syndrome. J Sleep Res 1993; 2: 241-49.
33. Fleming PJ, Levine MR, Azaz Y, Wigfield R, Stewart AJ. Interactions between thermoregulation and the control of respiration in infants: possible relationship to sudden infant death. Acta Paediatr Suppl 1993; 82(Suppl 389): 57-9.
34. Chong A, Murphy N, Matthews T. Effect of prone sleeping on circulatory control in infants. Arch Dis Child 2000; 82: 253-56.
35. Yiallourou SR, Walker AM, Horne RS. Prone sleeping impairs circulatory control during sleep in healthy term infants: Implications for SIDS. Sleep 2008; 31: 1139-46.
36. Fifer WP, Greene M, Hurtado A, Myers MM. Cardiorespiratory responses to bidirectional tilts in infants. Early Hum Dev 1999; 55: 265-79.
37. Fifer WP, Myers MM. Sudden fetal and infant deaths: Shared characteristics and distinctive features. Semin Perinatol 2002; 26: 89-96.
38. Kinney HC, Myers MM, Belliveau RA, et al. Subtle autonomic and respiratory dysfunction in sudden infant death syndrome associated with serotonergic brainstem abnormalities: A case report. J Neuropathol Exp Neurol 2005; 64: 689-94.
39. Giuditta M, Ruggiero DA, Del Bo A. Anatomical basis for the fastigial pressor response. Blood Press 2003; 12: 175-80.
40. Hernandez JP, Xu F, Frazier DT. Medial vestibular nucleus mediates the cardiorespiratory responses to fastigial nuclear activation and hypercapnia. J Appl Physiol 2004; 97: 835-42.
41. Blood-Siegfried J, Rambaud C, Nyska A, Germolec DR. Evidence for infection, inflammation and shock in sudden infant death: Parallels between a neonatal rat model of sudden death and infants who died of sudden infant death syndrome. Innate Immun 2008; 14: 145-52.
42. Schwartz PJ. The congenital long QT syndromes from genotype to phenotype: Clinical implications. J Intern Med 2006; 259: 39-47.
43. Franco P, Groswasser J, Scaillet S, et al. QT interval prolongation in future SIDS victims: A polysomnographic study. Sleep 2008; 31: 1691-99.
44. Schwartz PJ, Stramba-Badiale M, Segantini A, et al. Prolongation of the QT interval and the sudden infant death syndrome. N Engl J Med 1998; 338: 1709-14.
45. Schwartz PJ. Cardiac sympathetic innervation and the sudden infant death syndrome. A possible pathogenetic link. Am J Med 1976; 60: 167-72.
46. Surges R, Thijs RD, Tan HL, Sander JW, Medscape. Sudden unexpected death in epilepsy: Risk factors and potential pathomechanisms. Nat Rev Neurol 2009; 5: 492-504.
47. Lutherer LO, Lutherer BC, Dormer KJ, Janssen HF, Barnes CD. Bilateral lesions of the fastigial nucleus prevent the recovery of blood pressure following hypotension induced by hemorrhage or administration of endotoxin. Brain Res 1983; 269: 251-57.
48. Kumar R, Macey PM, Woo MA, Alger JR, Harper RM. Diffusion tensor imaging demonstrates brainstem and cerebellar abnormalities in congenital central hypoventilation syndrome. Pediatr Res 2008; 64: 275-80.
49. Gronli JO, Santucci BA, Leurgans SE, Berry-Kravis EM, Weese-Mayer DE. Congenital central hypoventilation syndrome: PHOX2B genotype determines risk for sudden death. Pediatr Pulmonol 2008; 43: 77-86.
50. Lijowska AS, Reed NW, Chiodini BA, Thach BT. Sequential arousal and airway-defensive behavior of infants in asphyxial sleep environments. J Appl Physiol 1997; 83: 219-28.
51. Harper RM, Sauerland EK. The role of the tongue in sleep apnea. In: Guilleminault C, Dement WC, editors. Sleep Apnea Syndromes. New York: Alan R. Liss 1978; pp. 219-34.
52. Remmers JE, deGroot WJ, Sauerland EK, Anch AM. Pathogenesis of upper airway occlusion during sleep. J Appl Physiol 1978; 44: 931-38.
53. Henderson-Smart DJ, Read DJ. Reduced lung volume during behavioral active sleep in the newborn. J Appl Physiol 1979; 46: 1081-85.
54. Tonkin SL, Gunn TR, Bennet L, Vogel SA, Gunn AJ. A review of the anatomy of the upper airway in early infancy and its possible relevance to SIDS. Early Hum Dev 2002; 66: 107-21.
55. Tonkin SL, Vogel SA, Bennet L, Gunn AJ. Apparently life threatening events in infant car safety seats. BMJ 2006; 333: 1205-6.
56. Pattyn A, Morin X, Cremer H, Goridis C, Brunet JF. The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. Nature 1999; 399: 366-70.
57. Pattyn A, Goridis C, Brunet JF. Specification of the central noradrenergic phenotype by the homeobox gene Phox2b. Mol Cell Neurosci 2000; 15: 235-43.
58. Dauger S, Pattyn A, Lofaso F, et al. Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways. Development (Cambridge, England) 2003; 130: 6635-42.
59. Dubreuil V, Ramanantsoa N, Trochet D, et al. A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons. Proc Natl Acad Sci USA 2008; 105: 1067-72.
60. Spengler CM, Gozal D, Shea SA. Chemoreceptive mechanisms elucidated by studies of congenital central hypoventilation syndrome. Respir Physiol 2001; 129: 247-55.
61. Weese-Mayer DE, Berry-Kravis EM, Ceccherini I, Rand CM. Congenital central hypoventilation syndrome (CCHS) and sudden infant death syndrome (SIDS): Kindred disorders of autonomic regulation. Respir Physiol Neurobiol 2008; 164: 38-48.
62. Weese-Mayer DE, Ackerman MJ, Marazita ML, Berry-Kravis EM. Sudden Infant Death Syndrome: Review of implicated genetic factors. Am J Med Genet A 2007; 143A: 771-88.
63. Ni H, Schechtman VL, Zhang J, Glotzbach SF, Harper RM. Respiratory responses to preoptic/anterior hypothalamic warming during sleep in kittens. Reprod Fertil Dev 1996; 8: 79-86.
64. Richard CA, Rector DM, Harper RK, Harper RM. Optical imaging of the ventral medullary surface across sleep-wake states. Am J Physiol 1999; 277: R1239-45.
65. Tomycz ND, Haynes RL, Schmidt EF, Ackerson K, Kinney HC. Novel neuropathologic findings in the Haddad syndrome. Acta Neuropathol 119: 261-69.
66. Tryba AK, Pena F, Ramirez JM. Gasping activity in vitro: A rhythm dependent on 5-HT2A receptors. J Neurosci 2006; 26: 2623-34.
67. Toppin VA, Harris MB, Kober AM, Leiter JC, St-John WM. Persistence of eupnea and gasping following blockade of both serotonin type 1 and 2 receptors in the in situ juvenile rat preparation. J Appl Physiol 2007; 103: 220-27.
68. Jouvet M. Neurophysiology of the states of sleep. Physiol Rev 1967; 47: 117-77.
69. Wikler A. Pharmacologic dissociation of behavior and EEG sleep patterns in dogs; morphine, n-allylnormorphine, and atropine. Proc Soc Exp Biol Med 1952; 79: 261-65.
70. Vanderwolf CH, Baker GB. Evidence that serotonin mediates non-cholinergic neocortical low voltage fast activity, non-cholinergic hippocampal rhythmical slow activity and contributes to intelligent behavior. Brain Res 1986; 374: 342-56.
71. Kinney HC, Filiano JJ. Brain research in the Sudden Infant Death Syndrome. In: Byard RW, Krous HF, editors. Sudden Infant Death Syndrome; A Diagnostic Approach. London: Arnold 2001.
72. Kinney HC. Neuropathology provides new insight in the pathogenesis of the sudden infant death syndrome. Acta Neuropathol 2009; 117: 247-55.
73. Rickert CH, Gros O, Nolte KW, Vennemann M, Bajanowski T, Brinkmann B. Leptomeningeal neurons are a common finding in infants and are increased in sudden infant death syndrome. Acta Neuropathol 2009; 117: 275-82.
74. Panigrahy AM, Filiano JM, Sleeper LAS, et al. Decreased serotonergic receptor binding in rhombic lip-derived regions of the medulla oblongata in the sudden infant death syndrome. J Neuropath Exp Neurol 2000; 59: 377-84.
75. Kinney HCM, Randall LLRM, Sleeper LAES, et al. Serotonergic brainstem abnormalities in northern plains indians with the sudden infant death syndrome. J Neuropath Exp Neurol 2003; 62: 1178-91.
76. Paterson DS, Trachtenberg FL, Thompson EG, et al. Multiple serotonergic brainstem abnormalities in sudden infant death syndrome. JAMA 2006; 296: 2124-32.
77. Duncan JR, Paterson DS, Hoffman JM, et al. Brainstem serotonergic deficiency in sudden infant death syndrome. JAMA 2010; 303: 430-37.
78. Ozawa Y, Okado N. Alteration of serotonergic receptors in the brain stems of human patients with respiratory disorders. Neuropediatrics 2002; 33: 142-49.
79. Machaalani R, Say M, Waters K. Serotoninergic receptor 1A in the sudden infant death syndrome brainstem medulla and associations with clinical risk factors. Acta Neuropathol 2009; 117: 257-65.
80. Duncan JR, Garland M, Myers MM, et al. Prenatal nicotine-exposure alters fetal autonomic activity and medullary neurotransmitter receptors: implications for sudden infant death syndrome. J Appl Physiol 2009; 107: 1579-90.
81. Waters KA, Meehan B, Huang JQ, Gravel RA, Michaud J, Cote A. Neuronal apoptosis in sudden infant death syndrome. Pediatr Res 1999; 45: 166-72.
82. Cruz-Sanchez FF, Lucena J, Ascaso C, Tolosa E, Quinto L, Rossi ML. Cerebellar cortex delayed maturation in sudden infant death syndrome. J Neuropathol Exp Neurol 1997; 56: 340-46.
83. Kinney HC, McHugh T, Miller K, Belliveau RA, Assmann SF. Subtle developmental abnormalities in the inferior olive: An indicator of prenatal brainstem injury in the sudden infant death syndrome. J Neuropathol Exp Neurol 2002; 61: 427-41.
84. Kinney HC, Brody BA, Finkelstein DM, Vawter GF, Mandell F, Gilles FH. Delayed central nervous system myelination in the sudden infant death syndrome. J Neuropathol Exp Neurol 1991; 50: 29-48.
85. Henderson LA, Macey PM, Richard CA, Runquist ML, Harper RM. Functional magnetic resonance imaging during hypotension in the developing animal. J Appl Physiol 2004; 97: 2248-57.
86. Gozal D, Dong XW, Rector DM, Harper RM. Maturation of kitten ventral medullary surface activity during pressor challenges. Dev Neurosci 1995; 17: 236-45.
87. Liu Q, Fehring C, Lowry TF, Wong-Riley MT. Postnatal development of metabolic rate during normoxia and acute hypoxia in rats: Implication for a sensitive period. J Appl Physiol 2009; 106: 1212-22.
88. Liu Q, Wong-Riley MT. Postnatal changes in the expressions of serotonin 1A, 1B, and 2A receptors in ten brain stem nuclei of the rat: implication for a sensitive period. Neuroscience 165: 61-78.
89. Liu Q, Lowry TF, Wong-Riley MT. Postnatal changes in ventilation during normoxia and acute hypoxia in the rat: Implication for a sensitive period. J Physiol 2006; 577: 957-70.
90. Liu Q, Wong-Riley MT. Developmental changes in the expression of GABAA receptor subunits alpha1, alpha2, and alpha3 in the rat pre-Botzinger complex. J Appl Physiol 2004; 96: 1825-31.
91. Anderson ME, Johnson DC, Batal HA. Sudden Infant Death Syndrome and prenatal maternal smoking: rising attributed risk in the Back to Sleep era. BMC Med 2005; 3: 4.
92. Duncan JR, Paterson DS, Kinney HC. The development of nicotinic receptors in the human medulla oblongata: inter-relationship with the serotonergic system. Auton Neurosci 2008; 144: 61-75.
93. Bulterys MG, Greenland S, Kraus JF. Chronic fetal hypoxia and sudden infant death syndrome: interaction between maternal smoking and low hematocrit during pregnancy. Pediatrics 1990; 86: 535-40.