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Volumn 82, Issue 1, 2010, Pages

Stop-and-go kinetics in amyloid fibrillation

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID FIBRIL; EXPONENTIAL DISTRIBUTIONS; FIBRIL GROWTH; GROWTH TIME; HUMAN DISEASE; IN-VITRO; MARKOVIAN MODEL; PROTEIN AGGREGATION; REAL TIME MEASUREMENTS; STOP-AND-GO; TOTAL INTERNAL REFLECTION FLUORESCENCE MICROSCOPY; TWO-STATE;

EID: 77954321040     PISSN: 15393755     EISSN: 15502376     Source Type: Journal    
DOI: 10.1103/PhysRevE.82.010901     Document Type: Article
Times cited : (43)

References (28)
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  • 2
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    • F. Chiti and C. M. Dobson, Annu. Rev. Biochem. 75, 333 (2006). 10.1146/annurev.biochem.75.101304.123901
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  • 3
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    • 10.1038/nature05695
    • M. R. Sawaya, Nature (London) 447, 453 (2007). 10.1038/nature05695
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  • 7
    • 0032877134 scopus 로고    scopus 로고
    • in edited by R. Wetzel (Elsevier Academic Press, San Diego
    • F. Ferrone, in Methods in Enzymology, edited by, R. Wetzel, (Elsevier Academic Press, San Diego, 1999), p. 256.
    • (1999) Methods in Enzymology , pp. 256
    • Ferrone, F.1
  • 18
    • 77954322868 scopus 로고    scopus 로고
    • The finite sampling frequency implies that the exact time of a state transition (growth stop ) can be anywhere in the interval between two observations. Therefore, an upper and lower bound of the time spent in a particular state is simple given by choosing either the "outer" or the "inner" observation points.
    • The finite sampling frequency implies that the exact time of a state transition (growth stop) can be anywhere in the interval between two observations. Therefore, an upper and lower bound of the time spent in a particular state is simple given by choosing either the "outer" or the "inner" observation points.
  • 19
    • 77954318648 scopus 로고    scopus 로고
    • -1, where g 100nm/min is the average observed elongation rate (see table I), R5nm is the fibril radius, and Vglu 4 nm3 is the volume of a fibrillated glucagon peptide. This rate is several orders of magnitude larger than the observed transition rates.
    • -1, where g 100nm/min is the average observed elongation rate (see table I), R5nm is the fibril radius, and Vglu 4 nm3 is the volume of a fibrillated glucagon peptide. This rate is several orders of magnitude larger than the observed transition rates.
  • 21
    • 77954347225 scopus 로고    scopus 로고
    • note
    • -.
  • 26
    • 0347987853 scopus 로고    scopus 로고
    • 10.1038/nature02264
    • D. J. Selkoe, Nature (London) 426, 900 (2003). 10.1038/nature02264
    • (2003) Nature (London) , vol.426 , pp. 900
    • Selkoe, D.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.