Severe anaphylaxis to the antiseptic polyhexanide

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 65, Issue 8, 2010, Pages 1068-1070

  Kautz, O ^a   Schumann, H ^a   Degerbeck, F ^a   Venemalm, L ^a   Jakob, T ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

chlorhexidine; IgE; polyaminopropylbiguanide; polyhexamethylenebiguanide; polyhexanide

Indexed keywords

ANTIINFECTIVE AGENT; CHLORHEXIDINE; IMMUNOGLOBULIN E; POLYHEXANIDE; UNCLASSIFIED DRUG; BIGUANIDE DERIVATIVE; POLY(HEXAMETHYLENEBIGUANIDE); TOPICAL ANTIINFECTIVE AGENT;

AGED; ANAPHYLAXIS; ARTICLE; CASE REPORT; DISEASE SEVERITY; DRUG HYPERSENSITIVITY; FEMALE; HUMAN; PRIORITY JOURNAL; SKIN IRRITATION; SKIN TEST; BLOOD; CHEMICALLY INDUCED; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX; TOPICAL DRUG ADMINISTRATION; VERY ELDERLY;

ADMINISTRATION, TOPICAL; AGED, 80 AND OVER; ANAPHYLAXIS; ANTI-INFECTIVE AGENTS, LOCAL; BIGUANIDES; FEMALE; HUMANS; IMMUNOGLOBULIN E; SEVERITY OF ILLNESS INDEX;

EID: 77954320756     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2009.02299.x     Document Type: Article

References (6)

1. Rietkötter J, Körber A, Grabbe S, Dissemond J. Eradication of methicillin-resistant Staphylococcus aureus in a chronic wound by a new polyhexanide hydrogel. J Eur Acad Dermatol Venereol 2007 21 : 1416 1417.
2. Olivieri J, Eigenmann PA, Hauser C. Severe anaphylaxis to a new disinfectant: polyhexanide, a chlorhexidine polymer. Schweiz Med Wochenschr 1998 128 : 1508 1511.
3. Ferrarini A, Baggi M, Flückiger R, Bianchetti MG. Intraoperative anaphylaxis to a chlorhexidine polymer in childhood. Paediatr Anaesth 2006 16 : 705. (abstract).
4. Krautheim AB, Jermann TH, Bircher AJ. Chlorhexidine anaphylaxis: case report and review of the literature. Contact Dermatitis 2004 50 : 113 116.
5. Pham NH, Weiner JM, Reisner GS, Baldo BA. Anaphylaxis to chlorhexidine. Case report. Implication of immunoglobulin E antibodies and identification of an allergenic determinant. Clin Exp Allergy 2000 30 : 1001 1007.
6. Garvey LH, Krøigaard M, Poulsen LK, Skov PS, Mosbech H, Venemalm L et al. IgE-mediated allergy to chlorhexidine. J Allergy Clin Immunol 2007 120 : 409 415.