Synergistic interaction between TS-polysaccharide and hyaluronic acid: Implications in the formulation of eye drops

International Journal of Pharmaceutics

Volumn 395, Issue 1-2, 2010, Pages 122-131

  Uccello Barretta, Gloria ^a   Nazzi, Samuele ^a   Zambito, Ylenia ^a   Di Colo, Giacomo ^a   Balzano, Federica ^a   Sansò, Marco ^b  

^a UNIVERSITY OF PISA   (Italy)

^b Farmigea SpA   (Italy)

Author keywords

Eye drop excipient; Mucoadhesion; Nuclear magnetic resonance; Ocular bioavailability; Polymer interaction; Precorneal residence

Indexed keywords

DICLOFENAC; EXCIPIENT; EYE DROPS; HYALURONIC ACID; KETOTIFEN FUMARATE; MUCIN; POLYSACCHARIDE; ANTIALLERGIC AGENT; KETOTIFEN; KETOTIFEN FUMARATE OPHTHALMIC SOLUTION; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL INTERACTION; CHEMICAL REACTION; CONTROLLED STUDY; DRUG FORMULATION; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RABBIT; TAMARIND; TEAR FILM; VISCOMETRY; ADHESION; ANIMAL; BIOAVAILABILITY; BLINKING; CHEMISTRY; CORNEA; FLOW KINETICS; MEDICINAL CHEMISTRY; METABOLISM; PERMEABILITY; PLANT SEED; TOPICAL DRUG ADMINISTRATION; VISCOSITY;

ADHESIVENESS; ADMINISTRATION, TOPICAL; ANIMALS; ANTI-ALLERGIC AGENTS; BIOLOGICAL AVAILABILITY; BLINKING; CHEMISTRY, PHARMACEUTICAL; CORNEA; CYCLOOXYGENASE INHIBITORS; DICLOFENAC; DRUG COMPOUNDING; EXCIPIENTS; HYALURONIC ACID; KETOTIFEN; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MUCINS; OPHTHALMIC SOLUTIONS; PERMEABILITY; POLYSACCHARIDES; RABBITS; RHEOLOGY; SEEDS; TAMARINDUS; VISCOSITY;

EID: 77954309814     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.05.031     Document Type: Article

References (40)

1. Ali Y., Lehmussaari K. Industrial perspective in ocular drug delivery. Adv. Drug Deliv. Rev. 2006, 58:1258-1268.
2. Bottari F., Di Colo G., Nannipieri E., Saettone M.F., Serafini M.F. Evaluation of a dynamic permeation technique for studying drug-macromolecule interaction. J. Pharm. Sci. 1975, 64:946-949.
3. Burgalassi S., Nicosia N., Monti D., Falcone G., Boldrini E., Chetoni P. Larch arabinogalactan for dry eye protection and treatment of corneal lesions: investigation in rabbits. J. Ocul. Pharmacol. Ther. 2007, 23:541-549.
4. Burgalassi S., Raimondi L., Pirisino R., Banchelli G., Boldrini E., Saettone M.F. Effect of xyloglucan (tamarind seed polysaccharide) on conjunctival cell adhesion to laminin and on corneal epithelium wound healing. Eur. J. Ophthalmol. 2000, 10:71-76.
5. Camber O. An in vitro model for determination of drug permeability through the cornea. Acta Pharm. 1985, 22:335-342.
6. Chrai S.S., Robinson J.R. Ocular evaluation of methylcellulose vehicle in albino rabbits. J. Pharm. Sci. 1974, 63:1218-1223.
7. Clausen A.E., Bernkop-Schnürch A. In vitro evaluation of the permeation-enhancing effect of thiolated polycarbophil. J. Pharm. Sci. 2000, 89:1253-1261.
8. Clausen A.E., Bernkop-Schnürch A. Thiolated carboxymethylcellulose: in vitro evaluation of its permeation-enhancing effect on peptide drugs. Eur. J. Pharm. Biopharm. 2001, 51:25-32.
9. Cowman M.K., Hittner D.M., Feder-Davis J. 13C-NMR studies of hyaluronan: conformational sensitivity to varied environments. Macromolecules 1996, 29:2894-2950.
10. Di Colo G., Zambito Y., Zaino C., Sansò M. Selected polysaccharides at comparison for their mucoadhesiveness and effect on precorneal residence of different drugs in the rabbit model. Drug Dev. Ind. Pharm. 2009, 35:941-949.
11. Doughty M.J. Assessment of the effects of cetypyridium chloride on water content of the collagen-keratocyte matrix of the mammalian corneal stroma ex vivo. Biochim. Biophys. Acta 1999, 1426:449-458.
12. Freeman R., Wittekoek S. Selective determination of relaxation times in high resolution NMR. J. Magn. Reson. 1969, 1:238-276.
13. Ghelardi E., Tavanti A., Celandroni F., Lupetti A., Blandizzi C., Boldrini E., Campa M., Senesi S. Effect of a novel mucoadhesive polysaccharide obtained from tamarind seeds on the intraocular penetration of gentamicin and ofloxacin in rabbits. J. Antimicrob. Chemother. 2000, 46:831-834.
14. Ghelardi E., Tavanti A., Davini P., Celandroni F., Salvetti S., Parisio E., Boldrini E., Senesi S., Campa M. A mucoadhesive polymer extracted from tamarind seed improves the intraocular penetration and efficacy of rufloxacin in topical treatment of experimental bacterial keratitis. Antimicrob. Agents Chemother. 2004, 48:3396-3401.
15. Gibaldi M., Perrier D. Pharmacokinetics 1982, Dekker, New York. 2nd Ed.
16. Gidley M.J., Lillford P.J., Rowlands D.W., Lang P., Dentini M., Crescenzi V., Edwards M., Fanutti C., Grant Reid J.S. Structure and solution properties of tamarind-seed polysaccharide. Carbohydr. Res. 1991, 214:299-314.
17. Greaves J.L., Wilson C.G. Treatment of diseases of the eye with mucoadhesive delivery systems. Adv. Drug Deliv. Rev. 1993, 11:349-383.
18. Hägerström H., Edsman K. Limitations of the rheological mucoadhesion method: The effect of the choice of conditions and the rheological synergism parameter. Eur. J. Pharm. Sci. 2003, 18:349-357.
19. Hassan E.E., Gallo J.M. A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength. Pharm. Res. 1990, 7:491-495.
20. Hills B.P., Cano C., Belton P.S. Proton NMR relaxation studies of aqueous polysaccharide systems. Macromolecules 1991, 24:2944-2950.
21. Hui H.W., Robinson J.R. Ocular drug delivery of progesterone using a bioadhesive polymer. Int. J. Pharm. 1985, 26:203-213.
22. Lallemand F., Furrer P., Felt-Baeyens O., Gex-Fabry M., Dumont J.M., Besseghir K., Gurny R. A novel water-soluble cyclosporine A prodrug: ocular tolerance and in vivo kinetics. Int. J. Pharm. 2005, 295:7-14.
23. Lee V.H.L., Robinson J.R. Review: topical ocular drug delivery: recent developments and future challenges. J. Ocular Pharmacol. 1986, 2:67-108.
24. Maurice D.M. Cornea and sclera. The Eye 1984, vol. Ib:1-158. Academic Press, London. 3rd Ed.
25. Midelfart A. The effect of amiloride on Na, K and water in bovine corneal epithelium. Exp. Eye Res. 1987, 45:751-762.
26. Monti D., Chetoni P., Burgalassi S., Najarro M., Saettone M.F. Increased corneal hydration induced by potential ocular penetration enhancers: assessment by differential scanning calorimetry (DSC) and by desiccation. Int. J. Pharm. 2002, 232:139-147.
27. Neuhaus D., Williamson M. The Nuclear Overhauser Effect in Structural and Conformational Analysis 1989, VCH Publisher, New York.
28. Patton T.F., Robinson J.R. Ocular evaluation of polyvinylalcohol vehicle in rabbits. J. Pharm. Sci. 1975, 64:1312-1316.
29. Rolando M., Valente C. Establishing the tolerability and performance of tamarind seed polysaccharide (TSP) in treating dry eye syndrome: results of a clinical study. BMC Ophtalmol. 2007, 7:5-13.
30. Saettone M.F., Chetoni P., Cerbai R., Mazzanti G., Braghiroli L. Evaluation of ocular permeation enhancers: in vitro/vivo toxic activity. Int. J. Pharm. 1996, 42:103-113.
31. Saettone M.F., Giannaccini B., Barattini F., Tellini N. The validity of rabbits for investigations on ophthalmic vehicles: a comparison of four different vehicles containing tropicamide in humans and rabbits. Pharm. Acta Helv. 1982, 57:47-55.
32. Saettone M.F., Giannaccini B., Ravecca S., La Marca F., Tota G. Polymer effects on ocular bioavailability-the influence of different liquid vehicles on the mydriatic response of tropicamide in humans and rabbits. Int. J. Pharm. 1984, 20:187-202.
33. Saettone M.F., Giannaccini B., Teneggi A., Savigni P., Tellini N. Vehicle effects on ophthalmic bioavailability: the influence of different polymers on the activity of pilocarpine in rabbit and man. J. Pharm. Pharmacol. 1982, 34:464-466.
34. Trueblood J.H., Rossomondo R.M., Wilson L.A., Carlton W.H. Corneal contact times of ophthalmic vehicles. Evaluation by microscintigraphy. Arch. Ophthalmol. 1975, 93:127-130.
35. Uccello-Barretta G., Nazzi S., Balzano F., Di Colo G., Zambito Y., Zaino C., Sansò M., Salvadori E., Benvenuti M. Enhanced affinity of ketotifen toward tamarind seed polysaccharide in comparison with hydroxyethylcellulose and hyaluronic acid: a nuclear magnetic resonance investigation. Bioorg. Med. Chem. 2008, 16:7371-7376.
36. Valensin G., Sabatini G., Tiezzi E. Advanced Magnetic Resonance Techniques in Systems of High Molecular Complexity 1986, 69-76. Birkhauser, Boston. N. Niccolai, G. Valensin (Eds.).
37. Wilson C.G. Topical drug delivery in the eye. Exp. Eye Res. 2004, 78:737-743.
38. Winfield A.J., Jessiman D., Williams A., Esakowitz L. A study of the causes of non-compliance by patients prescribed eyedrops. Br. J. Ophthalmol. 1990, 74:477-480.
39. Zaki I., Fitzgerald P., Hardy J.G., Wilson C.G. A comparison of the effects of viscosity on the precorneal residence of solutions in rabbit and man. J. Pharm. Pharmacol. 1986, 38:463-466.
40. Zambito Y., Zaino C., Burchielli S., Carelli V., Serafini M.F., Di Colo G. Novel quaternary ammonium chitosan derivatives for the promotion of intraocular drug absorption. J. Drug Del. Sci. Technol. 2007, 17:19-24.