Simple preparation of dimeric cinchona alkaloid derivatives on polystyrene supports and a highly enantioselective catalytic heterogeneous dimerization of ketenes

Advanced Synthesis and Catalysis

Volumn 352, Issue 9, 2010, Pages 1434-1440

  Jumde, Ravindra P ^a   Mandoli, Alessandro ^a   De Lorenzi, Federica ^a   Pini, Dario ^a   Salvadori, Piero ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Asymmetric catalysis; Cinchona alkaloids; Click chemistry; Ketene dimerization; Supported catalysts

Indexed keywords

EID: 77954303369     PISSN: 16154150     EISSN: 16154169     Source Type: Journal    
DOI: 10.1002/adsc.201000165     Document Type: Article

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58. For the sake of comparison, the use of QD-TMS under the literature conditions (5mol%) provides P= 7.9 @ 97% ee (see Table 2); the reduction of the catalyst loading to 1 mol% allows some increase in the productivity, albeit at the expenses of product yield (50% ) and enantiomeric purity (P=25 @ 93% ee, this work).