A flexible unified approach to the analysis of pre-clinical combination studies

Statistics in Medicine

Volumn 29, Issue 16, 2010, Pages 1746-1756

  Harbron, Chris ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Additivity; Drug combinations; Interaction index; Synergy

Indexed keywords

ARTICLE; COMPUTER PROGRAM; CONFIDENCE INTERVAL; DATA ANALYSIS; DOSE RESPONSE; DRUG ANTAGONISM; DRUG POTENCY; DRUG POTENTIATION; HEALTH STATISTICS; HUMAN; IN VITRO STUDY; LINEAR SYSTEM; MONOTHERAPY; STATISTICAL ANALYSIS; STATISTICAL MODEL;

ALGORITHMS; BIOSTATISTICS; DRUG ANTAGONISM; DRUG COMBINATIONS; DRUG EVALUATION, PRECLINICAL; DRUG INTERACTIONS; DRUG SYNERGISM; INHIBITORY CONCENTRATION 50;

EID: 77954302840     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.3916     Document Type: Article

References (23)

1. Bell A, Machado SG. Assessing synergy or antagonism for drug combinations. Nature Reviews Drug Discovery 2004; 3. DOI: 10.1038/nrd1416-c1.
2. Greco W, Unkelbach H-D, Pöch G, Sühnel J, Kundi M, Bödeker W. Consensus on concepts and terminology for combined-action assessment: the Saariselkä agreement. Archives of Complex Environmental Studies 1992; 4:65-69.
3. R: A Language and Environment for Statistical Computing. Available from: http://www.R-project.org.
4. SAS. Available from: http://www.sas.com.
5. Laska EM, Meisner M, Tang D-I. Classification of the effectiveness of combination treatments. Statistics in Medicine 1997; 16:2211-2228.
6. Food and Drug Administration. Fixed-combination prescription drugs for humans. 21 CFR 300.50, Food and Drug Administration, 2009.
7. Carter WH, Wampler GL, Stablein DM, Campbell ED. Drug activity and therapeutic synergism in cancer treatment. Cancer Research 1982; 42:2963-2971.
8. Venditti JM, Humphreys SR, Mantel N, Goldin A. Combined treatment of advanced leukemia (L1210) in mice with amethopterin and 6-mercaptopurine. Journal of the National Cancer Institute 1956; 17:631-638.
9. Mantel N. Therapeutic synergism. Cancer Chemotherapy Reports, Part II 1974; 4:147-149.
10. Hill AV. The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curve. Journal of Physiology 1910; 40:4-7.
11. Hewlett PS. Measurements of the potencies of drug mixtures. Biometrics 1969; 25:477-487.
12. Berenbaum MC. What is synergy? Pharmacological Reviews 1989; 41:93-141.
13. Greco WR, Bravo G, Parsons JC. The search for synergy: a critical review from a response surface perspective. Pharmacological Reviews 1995; 47:331-385.
14. Chou T-C. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacological Reviews 2006; 58:621-681.
15. Machado SG, Robinson GA. A direct, general approach based on isobolograms for assessing the joint action of drugs in pre-clinical experiments. Statistics in Medicine 1994; 13:2289-2309.
16. Lee JJ, Kong M, Ayers GD, Lotan R. Interaction index and different methods for determining drug interaction in combination therapy. Journal of Biopharmaceutical Statistics 2007; 17:461-480. (Pubitemid 46699662)
17. Greco WR, Park HS, Rustum YM. Applications of a new approach for the quantitation of drug synergism to the combination of cis- diamminedichloroplatimun and 1-β-D-arabionfuranosylcytosine. Cancer Research 1990; 50:5318-5327.
18. Carter WH, Gennings C, Stainswalis JG, Campbell ED, White KL. A statistical approach to the construction and analysis of isobolograms. Journal of the American College of Toxicology 1988; 7:963-973. (Pubitemid 19038035)
19. Dawson KS, Carter WH, Gennings C. A statistical test for detecting and characterizing departures from additivity in drug/chemical combinations. Journal of Agricultural, Biological and Environmental Statistics 2000; 5:342-359.
20. Gennings C, Carter WH, Campain JA, Bae D-S, Yang RSH. Statistical analysis of interactive cytotoxicity in human epidermal keratinocytes following exposure to a mixture of four metals. Journal of Agricultural, Biological, and Environmental Statistics 2002; 7:58-73. (Pubitemid 44261726)
21. Chou TC, Chou JH. Distinction between multiple ligand exclusivity and competitiveness in receptor binding topology. The FASEB Journal 1988; 2:A1778.
22. Chou TC, Talalay P. Quantitative analysis of dose-effect relationships the combined effects of multiple drugs or enzyme inhibitors. Advances in Enzyme Regulation 1984; 22:27-55.
23. Straetemans R, O'Brien T, Wouters L, Van Dun J, Janicot M, Bijnens L, Burzykowski T, Aerts M. Design and analysis of drug combination experiments. Biometrical Journal 2005; 47:299-308. (Pubitemid 40977269)