Natural products drug discovery: Accelerating the clinical candidate development using reverse pharmacology approaches

Indian Journal of Experimental Biology

Volumn 48, Issue 3, 2010, Pages 220-227

  Patwardhan, Bhushan ^a   Vaidya, Ashok D B ^b  

^a UNIVERSITY OF PUNE   (India)

^b Kasturba Health Society   (India)

Author keywords

Ayurveda; Ethnopharmacology; Herbal drugs; Natural products; Reverse pharmacology; Traditional medicine

Indexed keywords

BIOLOGICAL PRODUCT;

ANIMAL; ARTICLE; AYURVEDA; CHEMISTRY; DRUG DEVELOPMENT; DRUG SCREENING; ECONOMICS; HUMAN; METHODOLOGY; PHARMACOLOGY;

ANIMALS; BIOLOGICAL PRODUCTS; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; MEDICINE, AYURVEDIC; PHARMACOLOGY;

EID: 77954295707     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Harvey A L, Medicines from nature: Are natural products still relevant to drug discovery? Trends Pharmacol Sci, 20 (1999) 196.
2. Gupta R, Gabrielsen B & Ferguson S M, Nature's medicines: Traditional knowledge and intellectual property management. Case studies from the National Institutes of Health (NIH) USA, Curr Drug Discov Technol, 2 (2005) 203.
3. Holland BK. Prospecting for drugs in ancient texts, Nature, 369 (1994) 702.
4. Verdine G L, The combinatorial chemistry of nature, Nature, 384(1996) 11.
5. Patwardhan B, Vaidya, A D B & Chorghade M, Ayurveda and natural products drug discovery, Curr Sci, 86 (2004) 10.
6. Koehn F E & Carter G T, The evolving role of natural products in drug discovery, Nat Rev Drug Discov, 4 (2005) 206.
7. Patwardhan B, Ayurveda: The 'Designer' medicine: A review of ethnopharmacology and bioprospecting research, Indian Drugs, 37 (2000) 14.
8. Seamon K B, Padgett W & Daly J W, Forskolin: Unique diterpene activator of adenylate cyclase in membranes and in intact cells, Proc Natl Acad Sci USA, 78 (1981) 3363.
9. Das B, Tandon V, Lyndem L M, Gray A I & Ferro V A, Phytochemicals from Flemingia vestita (Fabaceae) and Stephania glabra (Menispermeaceae) alter cGMP concentration in the cestode Raillietina echinobothrida, Comp Biochem Physiol C Toxicol Pharmacol, 149 (2009) 397.
10. Kong W, Wei J, Abidi P, et al., Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins, Nat Med, 10 (2004) 1344.
11. Patwardhan B, Ghooi R B & David S B, A new anaerobic inhibitor of herbal origin, Indian J Pharm Sci, 50 (1988) 2.
12. Saraf M N, Ghooi R B & Patwardhan B K, Studies on the mechanism of action of Semecarpus anacardium in rheumatoid arthritis, J Ethnopharmacol, 25 (1989) 159.
13. Selvam C, Jachak S M & Bhutani K K, Cyclooxygenase inhibitory flavonoids from the stem bark of Semecarpus anacardium Linn, Phytother Res, 18 (2004) 582.
14. Paul A T, Gohil V M & Bhutani K K, Modulating TNF-alpha signaling with natural products, Drug Discov Today, 11 (2006)725.
15. Birari R B & Bhutani K K, Pancreatic lipase inhibitors from natural sources: unexplored potential, Drug Discov Today, 12, (2007) 879.
16. Gautam R & Jachak S M, Recent developments in anti-inflammatory natural products, Med Res Rev, 29 (2009) 767.
17. Hughes B, 2007 FDA drug approvals: a year of flux, Nat Rev Drug Discov, 7 (2008) 107.
18. Schmid E F & Smith D A, Is pharmaceutical R&D just a game of chance or can strategy make a difference? Drug Discov Today, 9 (2004) 18.
19. Frantz S, Pharma faces major challenges after a year of failures and heated battles, Nat Rev Drug Discov, 6 (2007) 5.
20. The pharmaceuticals industry from bad to awful, The Economist, (2004).
21. DiMasi J A & Paquette C, The economics of follow-on drug research and development: trends in entry rates and the timing of development, Pharmacoeconomics, 22 (2004) 1.
22. Kweder S, Worldwide withdrawal by Merck & Co., Inc. of Vioxx. In: Office of New Drugs CfDEaR, (US Food and Drug Administration., ed. Washington DC: Committee on Finance, United States Senate) 2004.
23. Patwardhan B & Mashelkar R A, Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward? Drug Discov Today, 14 (2009) 804.
24. Patwardhan B, Traditional Medicine: Modern Approach For Affordable Global Health. In: Commission on Intellectual Property Rights IaPHC, [World Health Organization (WHO). Geneva: WHO] 2005.
25. Vaidya A D & Devasagayam T P, Current Status of Herbal Drugs in India: An Overview, J Clin Biochem Nutr, 41 (2007) 1.
26. Vaidya A D B, Reverse pharmacological correlates of ayurvedic drug actions, Indian J Pharmacol, 38 (2006) 4.
27. Ramalingaswami V, Satyavati G V, Sir Ram Nath Chopra, Indian J Med Res, 76 (1982) Suppl:V-VI.
28. Sen G & Bose, K C, Rauwolfia serpentina, a new Indian drug for insanity and high blood pressure, Ind Med World, 2 (1931) 7.
29. Svensson T H, Effect of chronic treatment with tricyclic antidepressant drugs on identified brain noradrenergic and serotonergic neurons, Ada Psychiatr Scand (Suppl), 280 (1980)121.
30. Satyavati G V, Gum guggul (Commiphora mukul) the success story of an ancient insight leading to a modern discovery, Indian J Med Res, 87 (1988) 327.
31. Padma T V, Ayurveda, Nature, 436 (2005) 486.
32. Klayman D L, Qinghaosu (artemisinin): an antimalarial drug from China, Science, 228 (1985) 1049.
33. Satyanarayana K, Current IP Management Issues for Health and Agriculture in India, in Intellectual Property Management in Health and Agricultural Innovation: A Handbook of Best Practices, edited by A F Krattiger, R T Mahoney and L Nelsen, (Oxford, U.K., and PIPRA: Davis, U.S.A.: MIHR) (2007).
34. Mashelkar R A, Global Voices Of Science: India's R&D: Reaching for the Top, Science, 307 (2005) 3.
35. Patwardhan B & Gautam M, Botanical immunodrugs: scope and opportunities, Drug Discov Today, 10 (2005) 495.
36. Gautam M, Diwanay S, Gairola S, Shinde Y, Patki P & Patwardhan B, Immunoadjuvant potential of Asparagus racemosus aqueous extract in experimental system, J Ethnopharmacol, 91 (2004) 251.
37. Gautam M, Gairola S, Jadhav S & Patwardhan B, Ethnopharmacology in vaccine adjuvant discovery, Vaccine, 26 (2008) 5239.
38. Bani S, Gautam M, Sheikh F A, et al, Selective Thl up-regulating activity of Withania somnifera aqueous extract in an experimental system using flow cytometry, J Ethnopharmacol, 107 (2006) 107.
39. Gautam M, Diwanay S S, Gairola S, Shinde Y S, Jadhav S S & Patwardhan B K, Immune response modulation to DPT vaccine by aqueous extract of Withania somnifera in experimental system, Int Immunopharmacol, 4 (2004) 841.
40. Vaidya R A, The inhibitory effect of the cowhage plant Mucuna pruriens and L-Dopa on Chlorpromazine-induced hyperprolactinemia in man, Neurol India, 26 (1978) 1.
41. Vaidya R A, Activity of bromoergocryptine, Mucuna pruriens and L-Dopa in the control of hyperprolactinemia, Neurol India, 26 (1978) 4.
42. Manyam B V, Dhanasekaran M & Hare T A, Neuroprotective effects of the antiparkinson drug Mucuna pruriens, Phytother Res, 18 (2004) 706.
43. Zimmermann G R, Lehar J & Keith C T, Multi-target therapeutics: when the whole is greater than the sum of the parts, Drug Discov Today, 12 (2007) 34.
44. Vaidya R A, Vaidya A D, Patwardhan B, Tillu G & Rao Y, Ayurvedic pharmacoepidemiology: a proposed new discipline, J Assoc Physic India, 51 (2003) 528.
45. Chandrasekaran A N, Porkodi R & Madhavan R, Study of Ayurvedic drugs in rheumatoid arthritis comparing with Auranofin, The Indian Practitioner, (1994)XLVII:13.
46. Chennaiah S, Qadri S S, Reddy C V, Rama Rao S V, Shyamsunder G & Raghuramulu N, Incorporation of Cestrum diurnum leaf improves intestinal Ca transport in broilers, J Steroid Biochem Mol Biol, 103 (2007) 645.
47. Bansod K V, Efficacy of Topicure on wounds in canines, Indian Vet J, 80 (2003) 1.
48. Verpoorte R, Choi Y H & Kim H K, Ethnopharmacology and systems biology: a perfect holistic match, J Ethnopharmacol, 100 (2005) 53.
49. Fonnebo V, Grimsgaard S, Walach H, et al, Researching complementary and alternative treatments-the gatekeepers are not at home, BMC Med Res Methodol, 7 (2007) 7.
50. Chopra A, Lavin P, Patwardhan B & Chitre D, A 32-Week Randomized, Placebo-Controlled Clinical Evaluation of RA-11, an Ayurvedic Drug, on Osteoarthritis of the Knees, J Clin Rheumatol, 10 (2004) 236.
51. Sumantran V N, Kulkarni A, Boddul S, et al, Chondroprotective potential of root extracts of Withania somnifera in osteoarthritis, J Biosci, 32 (2007) 299.
52. Chopra Aea, Validating safety & efficacy of Ayurvedic derived botanical formulations: A clinical arthritis model of NMITLI. in 5th Oxford International Conference on the Science of Botanicals (ICSB), (University of Mississippi at Oxford, USA) 2006.
53. Kayombo E J, Uiso F C, Mbwambo Z H, Mahunnah R L, Moshi M J & Mgonda Y H, Experience of initiating collaboration of traditional healers in managing HIV and AIDS in Tanzania, J Ethnobiol Ethnomed, 3 (2007) 6.
54. Nandakumar D N, Nagaraj V A, Vathsala P G, Rangarajan P & Padmanaban G, Curcumin-artemisinin combination therapy for malaria, Antimicrob Agents Chemother 50, (2006) 1859.
55. Atal C K, Dubey R K & Singh J, Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism, J Pharmacol Exp Ther, 232 (1985) 258.
56. Deocaris C C, Widodo N, Wadhwa R & Kaul S C, Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology, J Transl Med, 6 (2008) 14.
57. Bhushan P, Kalpana J & Arvind C, Classification of human population based on HLA gene polymorphism and the concept of Prakriti in Ayurveda, J Altern Complement Med, 11 (2005)349.
58. Zycher B, DiMasi J A & Milne C P, The Truth About Drug Innovation: Thirty-Five Summary Case Histories on Private Sector Contributions to Pharmaceutical Science (Manhattan Institute for Policy Research, Manhattan) 2008.
59. Cooper E L, Ayurveda and eCAM: A Closer Connection, Evid Based Complement Alternat Med, 5 (2008) 121.
60. Cooper E L, Ayurveda is Embraced by eCAM, Evid Based Complement Alternat Med, 5 (2008) 1.