Giant keratoacanthoma of the upper extremity treated with Mohs micrographic surgery: A case report and review of current treatment modalities

Journal of Clinical and Aesthetic Dermatology

Volumn 2, Issue 8, 2009, Pages 22-25

  Garcia Zuazaga, Jorge ^a   Ke, Malcolm ^a   Lee, Patrick ^b  

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CANCER SURGERY; CASE REPORT; CLINICAL FEATURE; FEMALE; HUMAN; KERATOACANTHOMA; MOHS MICROGRAPHIC SURGERY; SKIN BIOPSY; SQUAMOUS CELL CARCINOMA; SURGICAL TECHNIQUE; TUMOR GROWTH; TUMOR VOLUME;

EID: 77954276889     PISSN: 19412789     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Schwartz RA. Keratoacanthoma. J Am Acad Dermatol. 1994;30(1):1-19.
2. Schwartz RA. Keratoacanthoma: a clinico-pathologic enigma. Dermatol Surg. 2004;30(2 Pt 2):326-333.
3. Pickrell K, Villarreal-Rios A, Neale H. Giant keratoacanthomas. Ann Plast Surg. 1979;3(2):172-176.
4. Bart RS, Popkin GL, Kopf AW, Gumport SL. Giant keratoacanthoma: a problem in diagnosis and management. J Dermatol Surg. 1975;1(2):49-55.
5. Smoller BR, Kwan TH, Said JW, Banks-Schlegel S. Keratoacanthoma and squamous cell carcinoma of the skin: immunohistochemical localization of involucrin and keratin proteins. J Am Acad Dermatol. 1986;14(2 Pt 1):226-234.
6. Sleater JP, Beers BB, Stephens CA, Hendricks JB. Keratoacanthoma: a deficient squamous cell carcinoma? Study of bcl-2 expression. J Cutan Pathol. 1994;21(6): 514-519.
7. Hu W, Cook T, Oh CW, et al. Expression of the cyclin-dependent kinase inhibitor p27 in keratoacanthoma. J Am Acad Dermatol. 2000;42(3):473-475.
8. Goldenhersh MA, Olsen TG. Invasive squamous cell carcinoma initially diagnosed as a giant keratoacanthoma. J Am Acad Dermatol. 1984;10(2 Pt 2):372-378.
9. Pagani WA, Lorenzi G, Lorusso D. Surgical treatment for aggressive giant keratoacanthoma of the face. J Dermatol Surg Oncol. 1986;12(3):282-284.
10. Larson PO. Keratoacanthomas treated with Mohs' micrographic surgery (chemosurgery). A review of forty-three cases. J Am Acad Dermatol. 1987;16(5 Pt 1):1040-1044.
11. Shriner DL, McCoy DK, Goldberg DJ, Wagner RF Jr. Mohs micrographic surgery. J Am Acad Dermatol. 1998;39(1): 79-97.
12. Gray RJ, Medland NB. Topical 5-fluorouracil as primary therapy for keratoacanthoma. Ann Plast Surg. 2000;44(1): 82-85.
13. Parker CM, Hanke CW. Large keratoacanthomas in difficult locations treated with intralesional 5-fluorouracil. J Am Acad Dermatol. 1986;14(5 Pt 1):770-777.
14. Grob JJ, Suzini F, Richard MA, at al. Large kerato-acanthomas treated with intralesional interferon alfa-2a. J Am Acad Dermatol. 1993;29(2 Pt 1):237-241.
15. de Visscher JG, van der Wal KG, Blanken R, Willemse F. Treatment of giant keratoacanthoma of the skin of the lower lip with intralesional methotrexate: a case report. J Oral Maxillofac Surg. 2002;60(1):93-95.
16. Spieth K, Gille J, Kaufmann R. Intralesional methotrexate as effective treatment in solitary giant keratoacanthoma of the lower lip. Dermatology. 2000;200(4):317-319.
17. Melton JL, Nelson BR, Stough DB, et al. Treatment of keratoacanthomas with intralesional methotrexate. J Am Acad Dermatol. 1991;25(6 Pt 1):1017-1023.
18. Santoso-Pham JC, Shelley ED, Shelley WB. Aggressive giant keratoacanthoma of the face treated with intra-muscular methotrexate and triamcinolone acetonide. Cutis. 1997;59(6):329-332.
19. Edelman BA, Jacobs JB, Rotterdam H, Auerbach R. Giant keratoacanthoma: an atypical presentation. Otolaryngol Head Neck Surg. 1990;103(3):472-475.
20. Goette DK, Odom RB. Successful treatment of keratoacanthoma with intralesional fluorouracil. J Am Acad Dermatol. 1980;2(3):212-216.
21. Goldschmidt H, Sherwin WK. Radiation therapy of giant aggressive keratoacanthomas. Arch Dermatol. 1993; 129(9):1162-1165.
22. Donahue B, Cooper JS, Rush S. Treatment of aggressive keratoacanthomas by radiotherapy. J Am Acad Dermatol. 1990;23(3 Pt 1):489-493.
23. Radakovic-Fijan S, Honigsmann H, Tanew A. Efficacy of topical photodynamic therapy of a giant keratoacanthoma demonstrated by partial irradiation. Br J Dermatol. 1999;141(5):936-938.
24. Fritsch C, Batz J, Bolsen K, et al. Ex vivo application of delta-aminolevulinic acid induces high and specific porphyrin levels in human skin tumors: possible basis for selective photodynamic therapy. Photochem Photobiol. 1997;66(1):114-118.
25. Thiele JJ, Ziemer M, Fuchs S, Elsner P. Combined 5-fluorouracil and Er:YAG laser treatment in a case of recurrent giant keratoacanthoma of the lower leg. Dermatol Surg. 2004;30(12 Pt 2):1556-1560.