Characterisation of the expression of the renin-angiotensin system in primary and immortalised human renal proximal tubular cells

Nephron - Experimental Nephrology

Volumn 116, Issue 3, 2010, Pages

  Shalamanova, Liliana ^a   Wilkinson, Mark C ^b   McArdle, Frank ^a   Jackson, Malcolm J ^a   Rustom, Rana ^a,b  

^a School of Veterinary Science University of Liverpool Leahurst Campus   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Angiotensin receptors; Human proximal tubular cells; Primary human renal proximal tubular cell; Renin angiotensin system

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN II; ANGIOTENSIN II [3-8]; CANDESARTAN; DIPEPTIDYL CARBOXYPEPTIDASE; RENIN;

ARTICLE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANGIOTENSINOGEN; BENZIMIDAZOLES; CELL LINE; GENE EXPRESSION; HUMANS; KIDNEY TUBULES, PROXIMAL; OXIDATIVE STRESS; PEPTIDYL-DIPEPTIDASE A; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ANGIOTENSIN; RENIN; RENIN-ANGIOTENSIN SYSTEM; RNA, MESSENGER; TETRAZOLES;

EID: 77954260591     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000318176     Document Type: Article

References (34)

1. Remuzzi G, Benigni A, Remuzzi A: Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes. J Clin Invest 2006; 116: 288-296.
2. Bohle A, Mackensen-Haen S, von Gise H, Grund KE, Wehrmann M, Batz C, Bogenschütz O, Schmitt H, Nagy J, Müller C, Müller G: The consequences of tubulo-interstitial changes for renal function in glomerulopathies. A morphometric and cytological analysis. Pathol Res Pract 1990; 186: 135-144.
3. Gesualdo L, Ranieri E, Monno R, Rossiello MR, Colucci M, Semeraro N, Grandaliano G, Schena FP, Ursi M, Cerullo G: Angiotensin IV stimulates plasminogen activator inhibitor- 1 expression in proximal tubular epithelial cells. Kidney Int 1999; 56: 461-470.
4. Mezzano SA, Ruiz-Ortega M, Egido J: Angiotensin II and renal fibrosis. Hypertension 2001; 38: 635-638.
5. Raij L: The pathophysiologic basis for blocking the renin-angiotensin system in hypertensive patients with renal disease. Am J Hypertens 2005; 18: 95S-99S.
6. van Kats JP, Schalekamp MA, Verdouw PD, Duncker DJ, Danser AH: Intrarenal angiotensin II: interstitial and cellular levels and site of production. Kidney Int 2001; 60: 2311-2317.
7. Navar LG, Harrison-Bernard LM, Wang CT, Cervenka L, Mitchell KD: Concentrations and actions of intraluminal angiotensin II. J Am Soc Nephrol 1999; 10(Suppl 11):S189-S195.
8. Braam B, Mitchell KD, Fox J, Navar LG: Proximal tubular secretion of angiotensin II in rats. Am J Physiol 1993; 264:F891-F898.
9. Burnier M, Brunner HR: Angiotensin II receptor antagonists. Lancet 2000; 355: 637-645.
10. Zhuo J, Moeller I, Jenkins T, Chai SY, Allen AM, Ohishi M, Mendelsohn FA: Mapping tissue angiotensin-converting enzyme and angiotensin AT1, AT2 and AT4 receptors. J Hypertens 1998; 16: 2027-2037.
11. Chan LY, Leung JC, Tang SC, Choy CB, Lai KN: Tubular expression of angiotensin II receptors and their regulation in IgA nephropathy. J Am Soc Nephrol 2005; 16: 2306-2317.
12. Mukoyama M, Nakajima M, Horiuchi M, Sasamura H, Pratt RE, Dzau VJ: Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors. J Biol Chem 1993; 268: 24539-24542.
13. Gesualdo L, Grandaliano G, Schena FP: Angiotensin IV and renal diseases. Contrib Nephrol 2001: 63-71.
14. Chabrashvili T, Kitiyakara C, Blau J, Karber A, Aslam S, Welch WJ, Wilcox CS: Effects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expression. Am J Physiol Regul Integr Comp Physiol 2003; 285:R117-R124.
15. Carey RM: Update on the role of the AT2 receptor. Curr Opin Nephrol Hypertens 2005; 14: 67-71.
16. Shalamanova L, McArdle F, Amara AB, Jackson MJ, Rustom R: Albumin overload induces adaptive responses in human proximal tubular cells through oxidative stress but not via angiotensin II type 1 receptor. Am J Physiol Renal Physiol 2007; 292:F1846-F1857.
17. Chai SY, Fernando R, Peck G, Ye SY, Mendelsohn FA, Jenkins TA, Albiston AL: The angiotensin IV/AT4 receptor. Cell Mol Life Sci 2004; 61: 2728-2737.
18. Ardaillou R, Chansel D: Synthesis and effects of active fragments of angiotensin II. Kidney Int 1997; 52: 1458-1468.
19. Handa RK: Characterization and signaling of the AT(4) receptor in human proximal tubule epithelial (HK-2) cells. J Am Soc Nephrol 2001; 12: 440-449.
20. Swanson GN, Hanesworth JM, Sardinia MF, Coleman JK, Wright JW, Hall KL, Miller- Wing AV, Stobb JW, Cook VI, Harding EC, et al: Discovery of a distinct binding site for angiotensin II (3-8), a putative angiotensin IV receptor. Regul Pept 1992; 40: 409-419.
21. Su Z, Zimpelmann J, Burns KD: Angiotensin-( 1-7) inhibits angiotensin ii-stimulated phosphorylation of map kinases in proximal tubular cells. Kidney Int 2006; 69: 2212-2218.
22. Li N, Zimpelmann J, Cheng K, Wilkins JA, Burns KD: The role of angiotensin converting enzyme 2 in the generation of angiotensin 1-7 by rat proximal tubules. Am J Physiol Renal Physiol 2005; 288:F353-F362.
23. Lely AT, Hamming I, van Goor H, Navis GJ: Renal ACE2 expression in human kidney disease. J Pathol 2004; 204: 587-593.
24. Grobe JL, Mecca AP, Mao H, Katovich MJ: Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension. Am J Physiol Heart Circ Physiol 2006; 290:H2417-H2423.
25. Pereira RM, Dos Santos RA, Teixeira MM, Leite VH, Costa LP, da Costa Dias FL, Barcelos LS, Collares GB, Simoes e Silva AC: The renin-angiotensin system in a rat model of hepatic fibrosis: evidence for a protective role of angiotensin-(1-7). J Hepatol 2007; 46: 674-681.
26. Liu BC, Sun J, Chen Q, Luo DD, Ma KL, Ruan XZ: Effect of irbesartan on angiotensin IIinduced hypertrophy of human proximal tubular cells. Chin Med J (Engl) 2004; 117: 547-551.
27. Benigni A, Corna D, Zoja C, Longaretti L, Gagliardini E, Perico N, Coffman TM, Remuzzi G: Targeted deletion of angiotensin II type 1A receptor does not protect mice from progressive nephropathy of overload proteinuria. J Am Soc Nephrol 2004; 15: 2666-2674.
28. Kehlen A, Gohring B, Langner J, Riemann D: Regulation of the expression of aminopeptidase A, aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 in renal carcinoma cells and renal tubular epithelial cells by cytokines and cAMP-increasing mediators. Clin Exp Immunol 1998; 111: 435-441.
29. Chertin B, Rolle U, Cascio S, McDermot M, O'Briain S, Farkas A, Puri P: Upregulation of angiotensin II receptors in reflux nephropathy. J Pediatr Surg 2002; 37: 251-255.
30. Ma J, Nishimura H, Fogo A, Kon V, Inagami T, Ichikawa I: Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction. Kidney Int 1998; 53: 937-944.
31. Lai KN, Leung JC, Lai KB, To WY, Yeung VT, Lai FM: Gene expression of the renin-angiotensin system in human kidney. J Hypertens 1998; 16: 91-102.
32. Loghman-Adham M, Soto CE, Inagami T, Cassis L: The intrarenal renin-angiotensin system in autosomal dominant polycystic kidney disease. Am J Physiol Renal Physiol 2004; 287:F775-F788.
33. De Haij S, Adcock IM, Bakker AC, Gobin SJ, Daha MR, van Kooten C: Steroid responsiveness of renal epithelial cells. Dissociation of transrepression and transactivation. J Biol Chem 2003; 278: 5091-5098.
34. Martin MM, Willardson BM, Burton GF, White CR, McLaughlin JN, Bray SM, Ogilvie JW Jr, Elton TS: Human angiotensin II type 1 receptor isoforms encoded by messenger RNA splice variants are functionally distinct. Mol Endocrinol 2001; 15: 281-293.